Nature Immunology - Along with a back-to-back published paper from Zielisnki and co. in this issue of Nature Immunology, this paper shows that NaCl affects CD8+ T cell function by...

Nature Immunology - Zehn and colleagues review the cellular fates and precursor trajectories that allow antigen-specific CD8+ T cells to persist in the face of chronic infection and cancer.

Nature Immunology - The identity of stem-cell memory progenitor cells has been unclear. Lugli and colleagues use high-dimensional approaches to identify two new progenitor populations of human T...

Transfer of mitochondria via nanotubes from bone marrow stem cells to CD8+ T cells augments cellular metabolism, empowering engineered T cells and tumor-infiltrating lymphocytes to counteract...

Nature Immunology - Single-cell-sequencing techniques enable the decades-old T helper subset dogma to be re-examined in an unsupervised manner, bringing nuance to the definition of known subsets...

Dr. now seeks to utilize samples from cancer patients in combination with genomic technologies to study stem-like T cells in detail and reveal unprecedented aspects of their biology.

Nature Immunology - Tissue-resident memory T (TRM) cells are distributed throughout the body as relatively sessile populations. Mackay and colleagues find that the tissue in which TRM cells are...

Nature Immunology - Effector CD8+ T cells with cytotoxic ability are crucial for immunotherapy success. Two studies show that salt (NaCl) supplementation can enhance the effector function of CD8+ T...

npj Precision Oncology - Hippocrates (Kos, c.460–c.370 BC) reminds us that “It is more important to know what sort of person has a disease than to know what sort of disease a person...

Crusty, a new browser-based software developed at Humanitas Research Hospital, will make it easier and faster to analyze multidimensional data...

In this issue of Cancer Cell, Espinosa-Carrasco et al. show that the efficacy of cancer immunotherapies depends upon the formation of intratumoral immune triads between antigen-presenting cells and...

Nature Medicine - CAR T cells targeting PSMA and engineered to be resistant to immunosuppressive TGFβ signaling exhibit dose-dependent toxicity and expansion following infusion, with some...

The landscape and function of the immune infiltrate of intrahepatic cholangiocarcinoma (iCCA), a rare, yet aggressive tumor of the biliary tract, remains poorly characterized, limiting development of...

Nature Communications - The tumor immune microenvironment is an important prognostic determinant in colorectal cancer (CRC). Here the authors show that tumor infiltrating neutrophils expressing...

The study opens a new chapter in the field of neuroimmunology, with implications for neurodevelopmental and neurodegenerative diseases, especially Alzheimer’s...

Abstract. CD4+CD25hiFOXP3+ regulatory T cells (Treg) play major roles in the maintenance of immune tolerance, prevention of inflammation, and tissue homeostasis and repair. In contrast with these...

Nature Biomedical Engineering - Barcoding cells with microparticles that emit near-infrared laser light enables the use of flow cytometry to track the dynamics of single cells by using more markers...

Nature - Stress-associated catecholamines promote CD8+ T cell exhaustion through the β1-adrenergic receptor, and blocking β-adrenergic signalling may help restore anti-tumour...

The group applies high-dimensional and single-cells approaches to dissect immune responses, with the final goal of enhancing cancer immunotherapy

Special Lecture: Enrico Lugli, PhD Group Leader, Head of Facility Humanitas Research Hospital gives a talk on: "Memory T-cell Responses in Human Cancer" Hosted by Stanford Medicine, The Department of...

CRUSTY is a web-tool for clustering analysis designed for high-dimensional single-cell data.

Key Points. Infusions of donor memory T-cells after haplo-HSCT lead to engraftment, persistence, and prominent expansion of selected T-cell clones.Infused

Nature Immunology - Human primary and metastatic tumors harbor CD4+ Treg cells that can suppress antitumor immune responses. Bonnal et al. identify an intratumoral type 1 Treg-like CD4+ T cell...

COURSE OVERVIEW This workshop would like to promote training and interaction between scientists and professionals working in the field of single-cell genomics in order to spark scientific exchange...

Gut and choroid plexus vascular barriers form a gut-brain axis involved in the modulation of systemic inflammation.

Cazzetta et al. show that NKG2A expression identifies a subset of human self-renewable Vδ2 T cells “educated” to perform the highest effector functions in the clearance of cancer cells. The develop...

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Nature Immunology - In contrast with the classical dogma that the pathways generating either memory or ‘exhausted’ T cells are strictly segregated, data now identify a clonally distinct...