Today we introduced Chroma, a generative model that creates new proteins & protein complexes given geometric & functional constraints. It learns to transform unstructured, random 3D shapes into
#protein
molecules, which can have tens of thousands of atoms.
Today we release Chroma, our generative model for protein design, open-source on Github with a Nature publication describing its biophysical and crystallographic validation. Chroma Conditioners enable one model to target multiple protein design objectives.
Our new machine learning model, Chroma, can generate extremely large and intricate proteins and
#protein
complexes in just a few minutes. Read the preprint on
@biorxivpreprint
and learn about our breakthrough in protein
#science
:
#ProteinEngineering
Nearly all existing protein-based therapeutics are created from a fraction of possible protein concepts. This is about to change. We are excited to share a publication in
@Nature
describing Chroma, an AI model that can program novel proteins.
Today, we announced the opening of our 70K sq ft CryoEM lab in Andover, Mass – among the largest privately owned labs of its kind in the U.S. – which will help drive faster and more efficient therapeutic development. Take an up-close look at the space:
As Pride Month comes to a close, we wanted to share this photo of Team Generate wearing freshly tie-dyed G:Pride shirts. Thanks again to our LGBTQ+ Affinity Group & Fun Committee, who invited us to celebrate inclusivity & add a vibrant touch to our fiercely united organization.
We are excited to share Chroma with the scientific community. As a next step, we’ll be submitting the technology that underlies Chroma for peer review. We look forward to enabling access to this model - stay tuned for more.
We're pleased to be an attending sponsor of the Machine Learning for Structural Biology Workshop at the 36th
@NeurIPSConf
. This workshop brings together academia and industry experts to advance the impact of
#machinelearning
in structural biology:
Proteins design is rapidly evolving as a result of recent advancements in diffusion models and generative AI. Our Head of Machine Learning John Ingraham covers this topic & more in an interview w/
@cenmag
:
Want to be part of a revolution? Our Machine Learning summer internship is calling. We're seeking passionate innovators who are driven to make an impact on human health. Your opportunity starts here:
Today, we released a preprint describing our
#machinelearning
model Chroma, which further validates our platform & capabilities. Learn how this breakthrough in protein
#science
opens a world of possibilities for future therapeutic treatments:
#TeamGenerate
Breaking news: We've just been named to
@Forbes
AI 50 List, which recognizes standout companies making the most interesting and effective use of artificial technology.
#ForbesAI50
Today we announced that we raised $273 million in Series C financing to advance our preclinical & clinical pipeline. We’re proud to have the confidence of our investors, including all Series B investors, who believe we are revolutionizing drug development:
Generate Biomedicines is partnering with
@Amgen
to leverage Generate’s pioneering
#generativebiology
platform to create life-saving
#protein
Tx. The agreement has a potential transaction value of $1.9 billion plus future royalties. Read more
#AI
Live from
#JPM23
: Watch
@bradloncar
's interview with our CEO,
@mike_nally
, to hear how we're moving from an artisanal craft of drug discovery to an engineerable endeavor by leveraging AI to computationally generate proteins, at scale, to create novel therapeutics.
📽️
@generate_biomed
's
@mike_nally
helps me wrap my human brain around how AI and machine learning might impact drug development in the future. It's a buzzy area, I'm trying to learn the substance behind it.
#JPM23
What an exciting way to mark our 4th birthday! This morning we were named to
@FierceBiotech
's Fierce 15 list that highlights companies that are poised to change the face of the industry. Read more here:
According to
@NatureBiotech
, $1.37 billion was invested in generative AI companies in 2022. With the advancements of breakthrough AI tools, including our model Chroma, it’s clear that a revolution in drug development is here. Read more:
How is
#AI
going to transform biology? During an
@endpts
panel at
#JPM23
, our CMO will join
@AKAarsalan
and other industry experts to share how AI will bring new medicines to patients faster and better tailored to their specific conditions.
#PatientFocusedDrugDevelopment
At Generate we are able to infer generalizable principles by applying
#machinelearning
to the data we generate & produce models that are more performant. Learn more about what it's like to work at Generate from Gevorg Grigoryan, Co-Founder & CTO.
#generativebiology
#AWS
#reInvent
Generate is honored to receive the 2021
@Citeline_Awards
Award for Most Innovative Start-Up Company -- a strong vote of confidence in our pioneering role in the field of generative biology to revolutionize drug discovery.
#AI
#machinelearning
#startup
#innovation
Yesterday, we had the privilege to chat with Nobel laureate and our BOD member,
@francesarnold
. It was inspiring to hear her reflect on this moment for generative AI and how we can leverage it to solve significant problems in medicine and beyond.
Frank Poelwijk talks about the dynamic, multidisciplinary team we've assembled. Interested in joining his group? Learn more about 2 positions: Scientist I/II Chemical Engineering and Principal Scientist/Assoc. and Director Quantitative HTP Experimentation:
#ICYMI
: Watch
@NoubarAfeyan
at
#CodeCon
share how instead of discovering biologic drugs, we're computer-generating them in an attempt to bring medicines to patients faster, cheaper, and better tailored to their specific conditions.
#FlagshipFounded
It's time for the 2nd installment in a series of articles from members of the Generate team who have been at the forefront of
#generativebiology
. Hear from our own
@gibsmk
,
@AndrewLBeam
, and Gevorg Grigoryan about the potential impact of
#generativebiology
On Friday, our Co-Founder & CTO
@ggrigoryanv
will present at the Machine Learning in Structural Biology Workshop during
@NeurIPSConf
. Gevorg will discuss our recent
@Nature
publication describing Chroma, our generative protein model. Learn more:
Thanks to
@BusinessInsider
and
@rtnarch
for recognizing
@generate_biomed
as one of the top biotech companies to watch over the next year. Generate is pioneering
#GenerativeBiology
and unlocking new medicines that will be more effective and available faster than ever before.
We’re pleased to announce that Dr. Alex Snyder has been named EVP of R&D. In her new role, Dr. Snyder will leverage her extensive clinical & scientific experience to accelerate our early-to-late-stage clinical pipeline of lifesaving medicines. Read more:
In this
@NatureBiotech
article,
@neilsavagewrite
discusses how language models like ChatGPT could support new therapeutics. Our Professor in Residence
@AndrewLBeam
points out that other techniques, such as diffusion models, may be a more direct path.
In an article in
@FortuneMagazine
,
@PauloConfinfo
asks, who's the next Moderna? Our own
@mike_nally
@gibsmk
share why Generative AI will transform the industry and lead to novel therapies generated reliably, predictably, & instantaneously:
Today,
@NoubarAfeyan
, our Co-founder & Board Chair, presented John Ingraham, Head of ML, w/ the Inaugural Chairman’s Award, which celebrates Generators who answer daring what if questions. John embodies this award daily by applying AI & ML to the field of protein engineering.
Through our new collaboration with
@MDAndersonNews
, we aim to harness the power of The Generate Platform to create optimized, potentially best-in-class oncology therapeutics that can rapidly advance into proof-of-concept trials. Learn more:
As part of
@Women_Wearables
' goal to support and empower women in tech,
@gibsmk
did an interview to share her perspective, highlighting the women who inspire her and where her passion for innovating at the intersection of machine learning and biology began. Read her story.
We're pleased to announce new data published in
@FrontiersIn
, in partnership with
@DanaFarber
, demonstrating our capability to computationally design and control protein space, to potentially reduce the effects of pre-existing immunity to biotherapeutics:
Live from
#JPM23
: Our CEO,
@mike_nally
, spoke with
@NYSE
to share how our ability to program and create new proteins will have revolutionary implications for developing novel therapeutics, which will ultimately transform human health.
#TheCure
(ious)
#AI
#ML
#ProteinEngineering
#TheCure
(ious) sneak peak:
@mike_nally
of
@generate_biomed
is “applying technology to science to help us understand biology in ways the human mind never could.” One spark of curiosity can lead to cures of the world’s greatest challenges.
One year ago today, we introduced Chroma, our generative AI model that creates novel proteins on-demand. Since then, we’ve entered an era of generative biology where proteins can be tailored to the specifics of any problem. Learn more:
What if you could design a ‘de novo’ protein, a protein that does not exist in nature, that could bind to a specific target with specific properties? Yesterday at
#CodeCon
,
@NoubarAfeyan
shared how Generate is doing just that. We are making the previously impossible, possible.
Kicking off the year with key clinical updates: first patient dosed with GB-0895 for mild-to-moderate asthma and advancement in our GB-0669 study for SARS-CoV-2. We’ve also expanded our relationship with
@Amgen
to push the boundaries of drug development.
We were one of only five pharma companies to be named on this list this year. Congrats to our whole team for the work they have done to advance our innovative
#generativebiology
platform.
#machinelearning
#AI
Read the article from
@Analyticsindiam
and learn how our
#ML
model Chroma gives us the ability to generate novel proteins, and generate them towards desired biological functions - developing proteins in a controlled fashion for targets that others cannot.
#ProteinEngineering
Dive into the cutting-edge world of generative AI with our CTO & Co-Founder
@ggrigoryanv
in an upcoming episode of
@VantAI
’s Generative AI in Drug Discovery series. Join
@mmbronstein
and
@befcorreia
as they gain expert perspective on the role of this technology in drug discovery.
📣 Join us for
@generate_biomed
's
@ggrigoryanv
talk on "Chroma: Illuminating protein space with a programmable generative model”, recently published in Nature, at the GenAI series hosted by
@mmbronstein
and
@befcorreia
!
📅 Jan 19, 2024; 11am ET / 5pm CET / 8am PST
🔗 Register for…
We're excited to share the first in a series of thought leadership articles. This one comes to you from
@gibsmk
,
@AndrewLBeam
, and Gevorg Grigoryan. Stay tuned for part 2 in this series and more articles on additional topics in the coming weeks and months
Great interview by
@strwbilly
with our CTO,
@ggrigoryanv
, about our
#ML
model, Chroma, and the exciting advances being made in
#proteinengineering
. These advances are bringing us closer to delivering better and more effective medicines to patients faster than ever before.
We're incredibly thankful and proud of our
#GenerateTeam
, who stepped up to help address housing instability and food insecurity in our local
#community
this
#Thanksgiving
. Because of their generosity, we were able to raise over $16K and donate two carloads of food.
#GivingBack
We believe biology will be the next industrial revolution. Interesting thought, right? If you’d like to hear more about it, then vote for us to participate in a panel discussion at
#SXSW2023
at .
We hit an exciting milestone - we have grown to more than 200 employees! We're thrilled to be building such a diverse and exciting team of Generators. If you're interested in changing the way new medicines are created, check out our open positions.
On Wednesday, Yue Liu will be speaking at the
@SLAS_Org
2023 International Conference & Exhibition. Hear her presentation about our integrated wet & dry lab capabilities & how we're using high-throughput assay data to optimize the function of ML-driven antibody design.
#SLAS2023
Recently our Generators came together to work with Project SOUP in our local community,
#SomervilleMA
to make grocery delivery bags for families in need. Thanks to Ali Bootwala for helping to spearhead our effort.
During JPM, cross-industry leaders discussed the scalability of AI and how it can solve productivity challenges. Our CEO,
@mike_nally
shares how we're turning biological problems into digital problems, creating the capacity to engineer optimal health outcomes.
With new
#COVID
variants emerging and uncertainty about effective therapies,
@g0ingmad
at
@business
talks about the need for a new treatment approach. At Generate, we are doing just that. We’re using
#AI
to develop a more potent antibody and plan to submit our first IND in 2023.
With each new round of Covid mutations, some antibody drugs have lost effectiveness and been pulled from the market. It’s quite possible doctors will soon have none left to choose from
Wondering how our
#ML
model Chroma can create new proteins & protein complexes given geometric & functional constraints? Read the latest from
@freethinkmedia
on how it learns to transform unstructured, random 3D shapes into large and complex proteins.
#ProteinEngineering
#AI
Boston-based startup
@generate_biomed
is further advancing our understanding and use of proteins by training an AI called “Chroma” to create proteins with structures no one has ever seen before.
Thank you to our first class of Ph.D. machine learning interns. Last week they presented their summer research to help the development of new kinds of
#MachineLearning
systems for protein therapeutic design. A special thanks to their Generate mentors.
#proteinbiology
We're thrilled to announce the appointment of Beth Grous as Chief People Officer. Beth will help build Generate’s HR function and champion people strategies across the business. Read more about the appointment and Beth's extensive leadership experience:
Live from
#JPM23
: Our CEO,
@mike_nally
, discussed with
@FlagshipPioneer
how we're revolutionizing drug discovery and development through our machine learning capabilities, and how the mindsets of our team support our fiercely united culture.
Mike Nally, CEO of
@generate_biomed
, explains how the company is leveraging computation to accelerate the pace of drug discovery and development. More from his interview at
#JPM23
here:
#FlagshipJPM
It’s great to be recognized for the potential of our platform to create entirely novel, de novo proteins that are specifically generated to address therapeutic needs.
@fastcompany
On May 15, our CTO
@ggrigoryanv
will join fellow innovators at the
@awscloud
Life Sciences Executive Symposium to share how Generate is making biology engineerable.
As active members of our community, we're cheering on colleagues running today's
@BostonMarathon
. Sean Martin and Tyson Fetzer will run to support causes they're passionate about, and when Lisa Wyman finishes, she'll be one of only 19 people to complete 22 consecutive marathons!
At Generate Biomedicines, we are focused on more than just
#science
. We're also generating connections. Our team set out on the Charles River for some kayaking and team building.
#TogetherWeGenerate
#TeamGenerate
Interested in working w/ one of the leading minds at the intersection of protein design,
#computationalbiology
, and ML? We're looking for a Head of
#DataScience
and Head of Computational
#Protein
Generation.
We're pleased to expand our leadership team and welcome Dimitris Agrafiotis as Chief Digital Officer. Dimitris will help us as we expand and scale our technology and
#generativebiology
platform. Read more:
#TeamGenerate
As we continue to grow, we’re expanding our leadership team with the addition of former Merck executive, Dr. Alex Snyder and former Goldman Sachs co-head of EMEA healthcare investment banking, Dr. Jason Silvers. Read more here
Generate is turning 4! It's been 4 years since Generate began pioneering the field of
#generativebiology
- a revolutionary approach to
#drugdevelopment
that allows us to program protein-based modalities for the first time.
#TeamGenerate
@NatureBiotech
gives an overview of the use of ML & generative models for protein design, including our model Chroma.
@ggrigoryanv
shares insights about our algorithmic toolbox & how our CryoEM facility is a critical component to developing therapeutics.
We enjoyed coming together and celebrating our passion for collaboratively inventing and innovating during our inaugural Science Day. Our
#GenerateTeam
brought forward more than 60 posters, and we spent the day engaging in meaningful discussions about
#AI
and
#drugdiscovery
.
#DYK
there is a 90% failure rate in drug development? Our Co-Founder and CIO,
@gibsmk
, shares how with
#AI
we are no longer predicting biology, but rather generating new biology which will help us develop faster, better, and more affordable therapeutics:
Daniel Leventhal, our Head of Immunogenicity, will deliver a keynote at the Next Generation Protein Therapeutics Summit on how generative AI is used to engineer therapeutic enzymes to evade unwanted immunogenicity.
We recently wrapped up our Machine Learning Summer Internship Program, where five ambitious grad students helped advance our ML technologies for therapeutic design. We’re grateful for their talents, creativity, and sense of fun while we worked towards improving human health.
Through our new collaboration with
@RoswellPark
, we aim to harness the power of The Generate Platform to discover & develop chimeric antigen receptor (CAR) T-cell therapies and armoring technologies for up to three oncology targets. Learn more:
Jason Silvers’ deep financial expertise, especially his strategic and transactional experience with Goldman Sachs, will help Generate advance into its next stage of growth. Learn more:
@bradloncar
of
@BiotechTVHQ
visited Boynton Yards to talk w/ our CEO
@mike_nally
about the transition for our industry as biology becomes engineerable. As Mike says, “when you start to program medicines, you change probabilities, speed and you change quality all at once.”
Proud of our colleagues Alexandra Snyder & Dinesh De Alwis for their commentary published today in
@NatureMedicine
on the impact of clinical holds on smaller biotechs and how they ultimately benefit patients by leading to better medicines.
Generative AI is capturing the spotlight at the
@JPMorgan
Healthcare Conference, and we’re at the forefront with our expanded collaboration with
@Amgen
. Read more in an interview with our CEO
@mike_nally
by
@GrinsteinJ
of
@GENbio
.
Amgen Opts-in on Generate:Biomedicines Collaboration for Drug Development
Amgen will make an undisclosed upfront payment and will pay up to $370 million in future milestones and royalties up to double digits for this new program. Learn more:
Check out our relentlessly curious junior generators who joined us for Bring Your Child to Work Day. We had plenty of experiments ready to get our children thinking like scientists and engineers – as these are our future leaders in STEM.
Check out today’s
@cenmag
article by
@LaurelOld
spotlighting the capabilities of Chroma, our open-source generative AI model used to design new therapeutics:
Congratulations to our own Sean Martin for his nomination to the 2022 Irish Legal 100, an annual compilation of the most distinguished legal professionals of Irish descent in the U.S. Check out his story as a fifth-generation Irish attorney:
Tomorrow, our Chief Medical Officer, Alex Snyder, will be presenting her latest
#oncology
research at the
@sitcancer
annual meeting. Watch her presentation describing post-progression response to checkpoint inhibitors in patients treated beyond progression.
#SITC2022
Our Co-Founder & Chief Strategy and Innovation Officer
@gibsmk
sat down with
#Wharton
MBA student-run podcasters at LifeSci Beat. To hear their conversation listen in
#ICYMI
Interested in learning more about Generate? Our CEO,
@mike_nally
gave an on-demand showcase presentation at the
@GENbio
"state of Biotech" conference. Watch the replay here:
"The technology of yesterday's science fiction is quietly becoming the reality of this moment. How?"
CEO
@Mike_Nally
explains what medicine will look like in the post-COVID world of tomorrow – and how companies like Generate are leading the way.
We’re honored to be nominated for “Best Startup” by the
@GalienFdn
Prix Galien USA Awards. Recognitions like these reflect our relentless pursuit to revolutionize drug discovery & development using generative AI. Congratulations to Team Generate.
The Galien Foundation is delighted to announce the 2023
#PrixGalien
USA Awards nominees for “Best Digital Health Solution," “Best Medical Technology,” "Incubators, Accelerators and Equity," and "Best Startup". Full list available here:
#TeamGenerate
recently hosted grad students from the
@UChicago
’s myCHOICE program, which seeks to expose biological science trainees to an array of career opportunities. Together with
@TesseraTx
, we provided a campus tour and hosted a panel discussion with members of leadership.
What do biotech entrepreneurs need to know as they plan to scale their ventures? Our Co-Founder Molly Gibson will answer this question and more at the
@MassBio
Align Summit – sharing lessons learned from scaling biotech companies, including Generate.
With 86% of drug development programs ending in failure and estimates of up to several billion dollars to bring a drug to market -
@ChemistryWorld
highlights how companies are tackling these challenges with AI. Read about our unique computational approach:
We’re honored to be recognized by the
@bioitworld
’s 2023 Innovative Practice Awards for our efforts to revolutionize drug discovery and development using The Generate Platform. Congratulations to the Generate team for this achievement.
5 years. 5 perspectives from founding to future. Inspired by our 5th anniversary, hear Team Generate offer their unique take on the generative biology revolution. Check out CEO
@mike_nally
's thoughts below and follow along as we share new perspectives each week.
Our very own
@gibsmk
will join other industry leaders tomorrow for a panel discussion about the role of
#AI
and
#ML
in drug discovery and development at the
@FierceBiotech
Summit. Check out the agenda here: