Caring Cross @caring_cross Twitter profile

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Caring Cross

@caring_cross

2 years

A first in human study of anti-HIV CAR-T started yesterday with the first participant/partner infused yesterday at UC Davis (NCT04648046) PIs: Drs S Deeks ⁦ @UCSFMedicine ⁩ and M Abedi ⁦ @UCDavisHealth ⁩ - please visit our website and support our work

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@caring_cross

2 years

New report of a bone transplant transplant approach yielding a true cure to HIV. We are so excited to see these advances, and look for way to bring them to all. @amfAR @DAREtoCureHIV @defeatHIV #IAS22 @AIDS_conference #AIDS2022

Fourth patient seemingly cured of HIV - BBC News

A man who has had HIV since the 1980s had a bone marrow transplant from a donor resistant to the virus.

www.bbc.com

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@caring_cross

2 years

Recommendations for a path to an #HIVcure published by Deeks, et al., for the Intl AIDS Society. This is one of THE references for where the field is headed #genetherapy #BNAb #CARTcell @iasociety @disclosurehiv @UNAIDS @IAS_conference

Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021

Nature Medicine - An effective and scalable cure strategy is a top priority for the HIV research field; this Review discusses recent advances, knowledge gaps, and priority research areas for the...

www.nature.com

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Caring Cross

@caring_cross

1 year

Excitement is building for #HIVCure —-First two patients receive CAR T cell therapy for HIV @amfAR @DAREtoCureHIV @CIRMnews @UCDavisMed @UCSF @UCDavisGT globalgti

First two patients receive CAR T cell therapy for HIV

Nature Medicine - Nature Medicine explores the latest translational and clinical research news, with a phase 1/2 trial of a dual CAR T cell therapy that targets gp120.

www.nature.com

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Caring Cross

@caring_cross

2 years

M Porteus ⁦ @StanfordMed ⁩ presenting Crispr based correction of globin to potentially cure #sicklecell #PMFG2022 ⁦ @ConquerSCD ⁩ ⁦ @SidraMedicine ⁩ ⁦ @SickleInAfrica ⁩ ⁦ @SCCConsortium ⁩

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@caring_cross

2 years

⁦ @UmojaBiopharma ⁩ making the case for direct in vivo CAR-T therapy using an engineered lentiviral particle that targets and a rapa responsive payload to drive T expansion #ASGCT22 #CARTcell #immunotherapy -the future of in vivo therapy is here…

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@caring_cross

4 years

Interest in a permanent “cure” is growing. Let’s defeat HIV! New HIV Gene Therapy, CAR-T Treatments Could be on the Horizon for Patients

New HIV Gene Therapy, CAR-T Treatments Could be on the Horizon for Patients

Could gene therapy provide a solution to HIV? A new research project aims to find out.

www.biospace.com

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Caring Cross

@caring_cross

1 year

Thanks to @pozmagazine for a great article describing our current HIV Cure research

Researchers Explore CAR-T Therapy as a Potential Cure for HIV

A “living drug” could potentially eliminate HIV-infected cells, allowing for long-term remission without antiretroviral therapy.

www.poz.com

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@caring_cross

17 days

Just back from an inspiring @AACR where Drs. Rouce ( @TexasChildrens ), Kekre ( @OttawaHospital ) and Orentas (Caring Cross) presented an Education Session on "Alternative Manufacturing and Delivery Models to Improve Access to CAR-T" #AACR2024 #hope #action @bcmhouston @uOttawa

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@caring_cross

2 years

Uganda! Sickle Cell Disease patient & advocates education and outreach day @jcrc_official1 full house to hear about red cell & plasma exchange, bone marrow transplant & gene therapy @UAGurkan @globalgti @SickleInAfrica @NHLBI_BLOODDir @ConquerSCD @SCDFoundation @SCCConsortium

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@caring_cross

2 years

Tanznia! Meeting with the Advanced Therapy Group and dedicated patient advocates. @globalgti @Muhimur_ @SickleInAfrica @ConquerSCD

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@caring_cross

11 days

Please join us for our upcoming Scientific Seminar! Presenter: Dr. Rayne Rouce ( @TexasChildrens ) Date: Friday, April 19, 2024 Time: 3:00 PM EST Register: #HealthcareInnovation #GeneModification #HealthcareCommunity #Science @bcmhouston

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Caring Cross

@caring_cross

2 years

Board Mtg ⁦ @jcrc_official1 ⁩ and lab tours w/Dr F Ssali- actively decolonizing medicine-they will implement gene therapy for sickle cell disease and HIV & bring cutting edge research & care where needed most ⁦ @ConquerSCD ⁩ ⁦ @globalgti ⁩ ⁦ @SickleInAfrica ⁩

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@caring_cross

3 years

An AMAZING report from @fredhutch - this is the first demonstrated (yes it’s in a macaque) anti-HIV CAR-T approach in vivo - sheds bright light on the immense potential of this approach. Kudos to Drs Barber-Axthelm, @HPKiem , Peterson

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Caring Cross

@caring_cross

2 years

We are in Uganda to celebrate Moses Supercharger living positively with HIV for 30 years and fiercely spreading knowledge understanding and hope. Let’s cure HIV! @UNAIDS @DAREtoCureHIV @londonpatient @defeatHIV @amfAR @CissyKityo @JNkengasong

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@caring_cross

2 years

Our Board of Directors has expanded to include Drs Julie Makani, Crystal Mackall, Deus Bazira, & Nirav Shah: high-impact leaders who will help guide our mission to bring curative cell and gene therapies to all who would benefit @DeusBazira @juliemakani @MackallLab @niravshahmd

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@caring_cross

2 years

This open access @Nature paper reports new insights as to how Anti-HIV broadly neutralizing antibodies may lead to control, change, and maybe one day a long-term drop in viral load-2 patients showed a prolonged beneficial effect @RockefellerUniv @globalgti

Prolonged viral suppression with anti-HIV-1 antibody therapy

Nature - A clinical study shows that immunotherapy with anti-HIV-1 antibodies maintains prolonged viral suppression after anti-retroviral treatment is discontinued and affects the size and...

www.nature.com

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Caring Cross

@caring_cross

2 years

Timothy Ray Brown said he does not want to be the only one. This trial at UC-Davis is a challenge/ lots of time & tests are asked of the participant. We can’t learn if CAR-T could be a path to durable cure without you. It’s a first in human trial: and a new approach.

UCDavis_Gene_Therapy

@UCDavisGT

2 years

UC Davis - Could CAR T cells offer hope for an HIV cure? ENP Newswire - Powered by Dow Jones· GB|March 25, 2022·12:00am #HIV #CART #clinicaltrials

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@caring_cross

2 years

Wonderful to meet the team at ImmunoAct and see their impressive facilities in Mumbai, India. Happy Diwali ! ⁦⁦ @globalgti ⁩ #CARTcells #affordable ⁦ @ASGCTherapy ⁩ 🪔

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Caring Cross

@caring_cross

1 year

We just posted a new video presenting the mechanism of action of our anti-HIV CAR-T cell, intended for all audiences! Thanks to Kim Anthony-Gonda, Karine Dubé, and @UUtah animation lab @globalgti @CIRMnews

Watch our presentation (video) | Caring Cross

Stay informed with presentations from conferences on the topic of finding cures for HIV, cancer, genetic diseases, and other serious disorders.

caringcross.org

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Caring Cross

@caring_cross

1 year

Thanks to Dr. Rutishauser for presenting at our Dec 16 event entitled: Learn and apply: Harnessing features of effective antiviral T cell responses to enhance adoptive T cell therapies for HIV You may access it in our Members Area; membership is FREE 👉

Become a Member today (free to join) | Caring Cross

Are you passionate about improving human health and ensuring that advanced medicinal cures become accessible to all patients in need? Join today.

caringcross.org

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Caring Cross

@caring_cross

2 years

Latest Whitepaper “Regulatory considerations for Decentralized Manufacturing in personalized cell therapies…” by Dr Xiaobin Liu -frm FDA, current ICT (Innovative Cellular Therapies) VP-visit the Whitepapers section under “Stay Informed” tab on our website

Caring Cross | Creating Access to Cures

We believe that every person in the world should be able to access advanced medicines at an affordable cost. Join us today.

caringcross.org

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@caring_cross

1 year

While @NIH had a strong showing w/Drs Collins, Gibbons, Mensah, and Kilmarks - the @Tzembassyusdc @sicklecellmuhas @OfficialJCRC leaders in Africa were ones preparing for gene therapy at the Global Partnerships for SCD: Science at the US Africa Summit mtg today @globalgti

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@caring_cross

1 year

“…we are at a crossroads in the cell and gene therapy industry…decentralization will make cell and gene therapies more attainable for more patients…” -Ø Åmellem, Thermo Fisher director of cell therapy @globalgti @amfAR @thermofisher @Cytiva in

Decentralizing the Manufacturing of Cell and Gene Therapies

In cell and gene therapies, access and cost limit the use of these treatments. “Historically, the genesis of cell therapy and later cell and gene therapy emerged in academic centers combining...

www.genengnews.com

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@caring_cross

2 years

Excellent article @benryanwriter on what looks like the 4th individual cured of HIV by #HSCT Along with 2 natural non-progressors evidence mounts for biological cures ! @globalgti @WeillCornell @kvbesien

Scientists have possibly cured HIV in a woman for the first time

Following a cutting-edge treatment four years ago, the “New York patient” is now off of HIV medication and remains “asymptomatic and healthy,” researchers say.

www.nbcnews.com

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@caring_cross

1 year

The National Alliance of Sickle Cell Centers is helping to set standards of care, and to improve practice in all centers nationwide @ConquerSCD @FundSickleCell @SCDFoundation #ASH22 @nascc_org

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@caring_cross

18 days

Exciting news from Bloomberg on our Fiocruz-Caring Cross partnership #CAR -T #HealthcareInnovation #GlobalHealth

Brazil Finds a Way Around Gene Therapy’s High Price

Hi, it’s Gabriel in Sao Paulo. Brazil will soon manufacture its own cancer-fighting gene therapies to make these treatments more affordable. But first…

www.bloomberg.com

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@caring_cross

2 years

It’s official! @Cytiva is enabling our mission to bring CART therapy to LMICs -these new workflows will make place-of-care mfg a reality for all who need curative cell and gene therapies

Cytiva supports Caring Cross to develop CAR-T cell therapy for people with HIV in low-to-middle-i...

Cytiva and Caring Cross are sharing their expertise to develop at CAR-T cell therapy for HIV.

www.cytivalifesciences.com

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@caring_cross

3 years

Today at @IAS2021 meeting the HIV Cure& Gene Therapy Forum featured talks by @Jenome77 Drs Jen Adair from @fredhutch and @globalgti Cissy Kitto @JcrcUganda and H-P Kiem @HPKiem introduced by M McCune from @gatesfoundation @melindagates @BillGates and P Cannon from @KeckMedUSC

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@caring_cross

3 years

A new gene therapy approach to HIV therapy- using gene modified T cells to create a virus resistant immune system- here featuring an endoribonuclease with proclivity for HIV sequences @MolTherapy @CureHIVNOW @amfAR #cureHIV

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@caring_cross

2 years

The first patient has now been dosed with Crispr corrected CD34 stem cells- pathway to a cure for sickle cell? ⁦ @GraphiteBio ⁩ ⁦ @StanfordMed ⁩ ⁦ @SidraMedicine ⁩ #PMFG2022 ⁦ @ConquerSCD ⁩ ⁦ @SickleInAfrica ⁩ ⁦ @SCDFoundation ⁩

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@caring_cross

2 months

In London at Tanzania House to learn about the science and economics of bringing cures to sickle cell disease. At the @globalgti call today we heard from Dr Stella Malangahe @sicklecellmuhas @nih_nhlbi there have been 8 HSCT for SCD in TZ. History made! 8 Cures! @SCDFoundation

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@caring_cross

1 year

Vector BioMed has launched! The first B corp to be spun out of Caring Cross. With preferential pricing and access for Caring Cross projects this is an essential step in providing the tools to make cell and gene therapy accessible to all

Biomanufacturing Company Vector BioMed Launches with Mission to Provide Access to High-Quality...

/PRNewswire/ -- Vector BioMed, a biomanufacturing company specializing in the manufacture of lentiviral vectors, today announced its launch and first financing...

www.prnewswire.com

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@caring_cross

1 year

Two publications with @caring_cross authors today, Dr. Anthony-Gonda continues to deepen our understanding of antiHIV CAR-T and our @globalgti colleagues in real world CAR-T mfg in India @cmcvelloreoff

Decentralized manufacturing of anti CD19 CAR-T cells using CliniMACS Prodigy®: real-world experie...

Bone Marrow Transplantation -

www.nature.com

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Caring Cross

@caring_cross

1 year

Hear our Executive Director, Boro Dropulic discuss the Caring Cross model to innovate, broaden access, and lower costs for cell and gene therapy, focusing on new approaches for CART for #HIVcure on @HealthProRadio Health Professionals Radio @globalgti

Caring Cross - CAR-T as a Potential Cure for HIV

Caring Cross is a non-profit advancing CAR-T and stem cell gene therapies for HIV and blood disorders. We also work to improve accessibility and affordability for all patients.

healthprofessionalradio.com.au

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@caring_cross

1 year

Nice quick review of current (mostly commercial) approaches to direct in vivo gene therapy

‘In vivo’ cell therapy: expanding beyond CAR-T

At least five startups have emerged with new ways to genetically modify immune cells within the body, an approach that, if successful, could widen the field of CAR-T treatment.

www.biopharmadive.com

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@caring_cross

1 year

“Of all the forms of inequality, injustice in health care is the most shocking and most inhumane.” Attributed to Dr Martin Luther King Jr., at the Medical Committee of Human Rights convention, Chicago 1966. Dr. Charlene Galarneau dug a little deeper and found the actual quote….

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@caring_cross

2 years

Want to see the most refined real-world images of the HIV envelope protein? check out this elegant open access pub @UWMedicine @globalgti @UWMedChem

Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice

Looking at native HIV virions using cryo-ET shows how Env interacts with Gag and reveals variability in Env conformations that is relevant for understanding interactions with antibodies.

www.cell.com

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@caring_cross

1 year

Starting 2023 our CIRM sponsored work to make low-cost high efficacy #CAR -Tcells with multiple specificities begins-so excited to partner with @UCDavisMed Prof Bill Murphy @UCDavisGT @UCDavisHealth @CIRMnews Curative therapies should be available to all

UC Davis partners with Caring Cross and CIRM to develop immunotherapy for cancer patients

Immunologist William Murphy discusses CAR T-cell cancer therapy and his work with Caring Cross, CIRM and UC Davis researchers to find novel cures to leukemia and lymphoma.

health.ucdavis.edu

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Caring Cross

@caring_cross

3 years

Our founder, Boro, describing CAR-T approaches aimed at lowering costs for all -on Health Professional Radio. Great podcast and YouTube platform @HeathProRadio #CARTcell #immunotherapy

Caring Cross - Poised To Reduce Cost Burden of CAR-T Cell Therapy

Dr. Boro Dropulic, Co-Founder & Executive Director of Caring Cross, discusses reducing cost burden of CAR-T Cell Therapy

healthprofessionalradio.com.au

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@caring_cross

1 year

Dr J Siliciano presented an amazing overview of T cell clonal dynamics and how this can lead over time to non-suppressible viremia #CROI2023 #CROI23 @globalgti @DAREtoCureHIV @CureHIVNOW

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@caring_cross

2 years

Our colleagues @ISCTglobal are putting on a great seminar series - CART manufacturing in your own featuring @DrPHanley @niravshahmd and a team from Brazil! The future starts now

Implementing a new clinical CAR T program: Manufacturing your own!

Implementing a New Clinical CAR T Program: Manufacturing Your Own! Webinar

www.isctglobal.org

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@caring_cross

2 years

Dr Peter Marks of the FDA links the earlier use of CAR-T in treatment pathways to cost and availability At Caring Cross we are working to bring down costs of cell and gene therapy -so they are available to all who need them

Earlier CAR-T treatment possible if price comes down, FDA official says

Expanded use of chimeric antigen receptor T cells for cancer treatment requires that less expensive therapies be developed faster using multiple manufacturing models, according to an FDA official.The...

www.healio.com

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@caring_cross

2 years

We have an exciting scientific seminar coming up this Friday, Oct 21 at 3pm EST: HIV cure research: implementation challenges and participant engagement in cutting-edge therapeutic studies Presenter: Dr. Michael Peluso from @UCSF Register now 👉

Register for our next LIVE event | Caring Cross

We present the latest research and innovations in advanced medicines with talks, videos, or discussion panels. Register for an event today.

caringcross.org

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@caring_cross

3 months

The global south is not waiting! Innovations in manufacturing and delivery for CAR-T and sickle cell disease are marching forward @NatureBiotech @globalgti @VertexPharma @bluebirdbio @OfficialJCRC @cmcvelloreoff @SickleInAfrica @ConquerSCD @nih_nhlbi

Reducing the costs of blockbuster gene and cell therapies in the Global South

Nature Biotechnology - Researchers in low- and middle-income countries are developing their own IP, scaling up local manufacturing, and looking for biomarkers — all in the hope of bringing...

www.nature.com

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Caring Cross

@caring_cross

3 years

At the International AIDS Society Mtg #IAS2021 the HIV Cure & Gene Therapy Session highlighted the potential of cell and gene therapies to control or eradicate HIV -the technology to bring this to pass is making rapid progress @NIAIDFunding @NIH @gatesfoundation @globalgti

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@caring_cross

2 years

Lentiviral gene addition & CRIsPR editing of B globin or regions involved in fetal globin silencing generates a new high efficiency #sicklecell disease therapeutic approach @inserm1163 @ASGCTherapy @globalgti @SickleInAfrica @SCCConsortium #CureSCD

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Caring Cross

@caring_cross

2 years

And this person from @caring_cross giving an intro lecture about cell and gene therapy approaches to a cure. An amazing event! Passion, interest, and a drive to cure shown by each attendee

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@caring_cross

2 years

The revolution is here- now- sickle cell disease outcomes greater than a year out following lentiglobin therapy (LV transduced HSCT) are very supportive of a gene therapy approach @globalgti @SickleInAfrica @SCCConsortium @TheBethesdaLabs

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@caring_cross

1 year

Data from M Peluso @UCSFMedicine as presented by J Siliciano @HopkinsMedicine encourages us that additive interventions can change viral load set points- can bNABs +CAR-T get us to a durable U state? @globalgti @DAREtoCureHIV @CureHIVNOW

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@caring_cross

2 years

Congrats to the visionary leadership at UC-Davis who have initiated on-site CAR-T manufacturing - bringing cures to patients faster @globalgti @jan_nolta @UCDavisMed @UCDavisGT @UCDavisGT

Jordan Pavlic

@JordanPavlic

2 years

I am so thankful to be able to do such amazing things as a part of this program. ❤️🧬🔬 #WomenInSTEM

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@caring_cross

2 years

Excellent piece on real world #sicklecell disease - and hope for a new center in Maryland, with @ChildrensNatl and @HopkinsMedicine working with local orgs- @ConquerSCD

How Local Families Cope With Sickle Cell: 'My Kids Are In Pain...'

In the U.S., more than 100,000 people are affected with sickle cell disease, but it primarily affects the African American community, occurring in about 1 out of every 365 births.

dcist.com

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@caring_cross

3 years

Wonderful summary from @PosAware of the @iasociety pre-conference on #HIV cure & #SickleCell disease @globalgti

Highlights from the 2021 HIV Cure and Gene Therapy Forum

www.positivelyaware.com

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@caring_cross

2 years

Pictured are our lead scientists in cell and gene therapies ( @KimAGonda ) and technologies (Z Zhu) as well as Dr Daniel Muyanja from Uganda @JCRC_official1 - two investigators from Uganda joined us to make sure we develop this program with international application in mind

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@caring_cross

10 months

On Jul 07, 2023, we continued our Cell and Gene Therapy educational series, and Dr. Kevin Curran presented: Exploring Cell Therapies, Focus on CAR-T You may access it in our Members Area; membership is FREE 👉

Become a Member today (free to join) | Caring Cross

Are you passionate about improving human health and ensuring that advanced medicinal cures become accessible to all patients in need? Join today.

caringcross.org

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Caring Cross

@caring_cross

1 year

Clinical trial begins using CAR T cells to potentially cure HIV

UC Davis Health researchers have dosed the second participant in their clinical trial looking to identify a potential cure for HIV utilizing CART-cell therapy.

www.newswise.com

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@caring_cross

1 year

We've just released the latest Whitepaper on our website: Distributive Manufacturing of CD19 CAR-T Cells Using CliniMACS Prodigy: Feasibility and Real-World Experience from India Download it now here 👉

Download our Whitepaper | Caring Cross

Get info on advanced medicines, engineering for manufacture & distribution, community engagement, and enabling affordable access.

caringcross.org

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Caring Cross

@caring_cross

1 year

This Friday at 3 PM ET Dr Matt Porteus ⁦ @StanfordMed ⁩ will present on “Gene Targeting of Hematopoietic Stem Cells” - must see! ⁦ @globalgti ⁩ ⁦ @ConquerSCD ⁩ ⁦ @SCDFoundation ⁩ ⁦ @SickleInAfrica ⁩ #genetherapy

Register for our next LIVE event | Caring Cross

We present the latest research and innovations in advanced medicines with talks, videos, or discussion panels. Register for an event today.

caringcross.org

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Caring Cross

@caring_cross

10 months

We lost a heroic warrior in Elizabeth Merab- and true advocate in our fight to end sickle cell disease @globalgti @SCDFoundation @SickleInAfrica @thecuresci

Award winning NMG journalist, Elizabeth Merab, passes away

https://nation.africa/

www.youtube.com

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Caring Cross

@caring_cross

1 year

More pediatric patients are making it to adulthood. All patients do better when cared for in specialized centers #ASH22 @ConquerSCD @SickleInAfrica @SCDFoundation @SickleCellMI

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@caring_cross

2 years

'How do you decide?' Cancer patients die waiting for CAR-T therapy- thanks to Kevin Curran #risingtidebio .com for highlighting the need for quicker process and better access. We are streamlining workflows for LIMCs that will address many of these issues

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@caring_cross

2 years

Access to life-saving therapy is a justice issue. Let’s make these therapies available to all in need

T-cell treatment eradicates cancer in some patients. Many don't have easy access to it.

CAR T-cell therapy eradicates cancer in some patients but remains inaccessible to people who live far from major cities with transplant centers.

www.nbcnews.com

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Caring Cross

@caring_cross

1 year

So pleased to support Moses Supercharger -we must commentate the history of the HIV epidemic, remembering the bravery of those who fought stigma and mobilized to share cures. Every nation/community needs to share & educate @globalgti @amfAR @UNAIDS @DAREtoCureHIV

Supercharger Moses

@SuperchargerMo1

1 year

Tweet with the amazing support from the Caring cross leadership,am happy to report that the Syllab (concrete roof of the ground floor of the HIV ARTseum is near completion!! Grand launch in on 9 November 2023.Special guest Dr Rimas,Dr Boro and my friend Dr Mcunne from BMGF

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Caring Cross

@caring_cross

2 years

Dr Daniel is shown explains red call and plasma exchange and Dr Francis is showing the new Gazelle devices that can give rapid Hgb status- no need to return next week @HemexHealth

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Caring Cross

@caring_cross

1 year

We could not agree more-excellent article by Ambroise Wonkam-the future of #curesicklecell is genetic therapy @globalgti @SickleInAfrica @SCDFoundation @ConquerSCD @HopkinsMedicine

The future of sickle cell disease therapeutics rests in genomics

Summary: Exploring genomics in sickle cell disease could identify new therapeutic targets, and will further our understanding of genetic risk and treatment of associated cardiovascular complications,...

journals.biologists.com

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Caring Cross

@caring_cross

3 years

New pub highlighting efforts of Gates Fndtn & Novartis to bring curative cell/gene therapy for SCD & HIV ⁦ @Novartis ⁩ ⁦ @gatesfoundation ⁩ Collaborative science to advance gene therapies in resource-limited parts of the world: Molecular Therapy

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@caring_cross

2 years

It’s First Friday! at 3 PM ET visit our website () and register for a free technology education seminar on CAR-T cells by Prof. Rimas Orentas. On the 19th is a Scientific Seminar by Dr. Michael Maschan presenting his phase I/II CAR-T cell trial in Moscow

Caring Cross | Creating Access to Cures

We believe that every person in the world should be able to access advanced medicines at an affordable cost. Join us today.

caringcross.org

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Caring Cross

@caring_cross

2 years

Our Scientific Director will be speaking at #PEGS22 tomorrow on moving CAR-T cells from leukemia to solid tumors in the “Strategies to Advance Cellular Immunotherapies” session hosted by @NCIResearchCtr @MitchellHo

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Caring Cross

@caring_cross

8 months

We continued our Cell and Gene Therapy educational series created by cell and gene industry expert Dr. Kevin Curran. Title: Biological details with lentiviral CAR-T Presenter: Kevin Curran, PhD Please register on our Events page now 👉

Register for our next LIVE event | Caring Cross

We present the latest research and innovations in advanced medicines with talks, videos, or discussion panels. Register for an event today.

caringcross.org

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Caring Cross

@caring_cross

1 year

Excellent piece by our colleague Fydor Urnov - cost is the issue! CRISPR Can Cure Disease by Editing a Person’s DNA. Now What?

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Caring Cross

@caring_cross

3 years

Great article about recent advances toward sickle cell disease cure ⁦ @nytimes ⁩ ⁦ @ginakolata ⁩ ⁦ @nih_nhlbi ⁩ ⁦ @GatesUS ⁩ ⁦ @gateshealth ⁩ The time is now to develop low cost cures for all! ⁦ @bluebirdbio ⁩ ⁦ @ScottDRamsey ⁩

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Caring Cross

@caring_cross

2 years

Dr Wisemann ⁦ @PennMedicine ⁩ delivered the George Stam lecture #ASGCT22 showing in vivo generation of CAR-T w/CD5 targeting lipid particles containing mRNA encoding CAR seqs. CD117 targeting of HSC with LNPs is next for sickle cell disease- in vivo gene therapy is here!

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Caring Cross

@caring_cross

1 year

Dr Doria-Rose @NIH sharing advances in broadly neutralizing antibodies - here is the current list #HIVcure

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Caring Cross

@caring_cross

2 years

Illustrating HIV biology and the search for a cure - check out this informative series brought to you by youth4cure @defeatHIV @globalgti @amfAR @DAREtoCureHIV

Immune-Based Strategies | Youth 4 Cure

youth4cure.ucsf.edu

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Caring Cross

@caring_cross

3 years

Hear our founder, Boro Dropulic, describe our approaches to HIV using CAR-T cells, in this informational podcast @HealthProRadio @amfar @CIRMnews #hivcure #CARtcell @iasociety @UCSFMedicine @UCDavisMed

Caring Cross - Development of CAR-T Therapy for HIV

Dr. Boro Dropulic, co-founder and Executive Director at Caring Cross, discusses their first initiative focused on chimeric antigen receptor (CAR) -T cell therapy for HIV

healthprofessionalradio.com.au

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Caring Cross

@caring_cross

2 years

Place of care CAR-T manufacturing is coming of age. In our latest publication CART19 produced in Cleveland,OH and Moscow,Russia show consistent high quality product that saves lives! #ASH21 #CARTcell @CWRUSOM

Multiple site place-of-care manufactured anti-CD19 CAR-T cells induce high remission rates in...

Nature Communications - Strategies to address the challenges associated with product manufacturing can improve chimeric antigen receptor (CAR) cell–based therapeutics. Here the authors report...

www.nature.com

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Caring Cross

@caring_cross

1 year

Our exciting impact talk, "HIV Cure Research: Scaling Up Participant-Centered Approaches, Strategic Socio-Behavioral Sciences and Ethics Research," will be happening later at 3 pm EST: Presenter: Karine Dube, DrPH / UCSD FREE to register 👉

Register for our next LIVE event | Caring Cross

We present the latest research and innovations in advanced medicines with talks, videos, or discussion panels. Register for an event today.

caringcross.org

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Caring Cross

@caring_cross

1 year

We continued with our Cell and Gene Therapy educational series created by industry expert Dr. Kevin Curran. AAV Gene Therapy Manufacturing Presenter: Kevin Curran, PhD Please register on our Events page now 👉

Register for our next LIVE event | Caring Cross

We present the latest research and innovations in advanced medicines with talks, videos, or discussion panels. Register for an event today.

caringcross.org

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Caring Cross

@caring_cross

2 years

Patient experience-touching and detailed- in #sickle cell gene therapy. CRISPR Cuts | Episode 36: Jimi Olaghere Opens Up About His Sickle Cell Disease and CRISPR Trial

CRISPR Cuts | Episode 36: Jimi Olaghere Opens Up About His Sickle Cell Disease and CRISPR Trial

Jimi has dealt with sickle cell disease, a genetic disorder with serious implications, his entire life. Undergoing a CRISPR gene editing trial turned his hope for a cure into reality with promising...

www.synthego.com

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Caring Cross

@caring_cross

1 year

Getting to the mechanism behind latency reversal in HIV. #HIVcure @globalgti

Depletion of HIV reservoir by activation of ISR signaling in resting CD4+ T cells

Immunology; Virology; Transcriptomics

www.cell.com

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Caring Cross

@caring_cross

2 years

We have an exciting technology education coming up this Friday, June 3 at 3pm EST: Molecular switches and logic gates for CAR-T (series 9/9). Presenter: Dr. Rimas Orentas It would be great if you could join us! Register on our Events page now 👇

Register for our next LIVE event | Caring Cross

We present the latest research and innovations in advanced medicines with talks, videos, or discussion panels. Register for an event today.

caringcross.org

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Caring Cross

@caring_cross

1 year

Training program that can ELIMINATE racial bias in clinical trial enrollment presented by Dr Carmen Guerra @PennMedicine @sitcancer #SITC2022 #SITC22 - invite her to speak, read her work, and invite change #noexcuses #equity #inclusion

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Caring Cross

@caring_cross

2 years

Nice detailed work from the @NIH POB on a bicistronic CD19.CD22 CAR-T clinical product. The little details matter @BloodJournal @HighfillSteven @NCI_CCR_PedOnc @NCIResearchCtr

CD19/22 CAR T cells in children and young adults with B-ALL: phase 1 results and development of a...

Shalabi et al report on a phase 1 trial of a bivalent chimeric antigen receptor (CAR) T-cell product targeting both CD19 and CD22, including some patients

ashpublications.org

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Caring Cross

@caring_cross

1 year

“We are concerned about the constant use of federal funds to support this notorious expression of segregation. Of all the forms of inequality, injustice in health is the most shocking and most inhuman because it often results in physical death…”

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Caring Cross

@caring_cross

2 years

The @CDCgov has created a one-pager to help prepare for the emergency department visits that come with pain crisis in #SickleCellDisease @ConquerSCD @thecuresci #WorldSickleCellDay2022

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Caring Cross

@caring_cross

1 year

Excellent approach. CD117 was a star at #ASH22

Vivien Sheehan

@vivien_liv

1 year

Outstanding poster from Beam Therapeutics at ASH! #ASH22 #SCD #GeneTherapy

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Caring Cross

@caring_cross

3 years

You can directly support the work of the Global Gene Therapy Initiative (GGTI) @globalgti on the Caring Cross website. It’s one of our current major projects #uganda #india #vellore #SickleCell @fredhutch @caring_cross

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Caring Cross

@caring_cross

3 years

Crispr based repair approach for #SickleCell launches - let’s keep the advances coming ! .

UC launches gene therapy trial to transform the treatment of sickle cell disease

Like the search-and-replace function of a computer, gene therapy could help cure people of sickle cell disease.

www.mercurynews.com

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Caring Cross

@caring_cross

5 months

Cell and Gene Therapies can be produced for a tenth of the current cost if point-of-care manufacturing is enabled. Out latest publication describes a major part of this solution for the generation of CAR-T -stay tuned for more @globalgti @Cytiva #ASH23

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Caring Cross

@caring_cross

4 months

Cell manufacturing team at the NIH with a great publication

Hannah W. Song, Ph.D.

@hannahwsong

4 months

A labor of love!! Bench to beside to bench, and with help from our industry partners we could one day get this back to the bedside to test whether negative selection could improve clinical outcomes. A huge team effort🥳

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Caring Cross

@caring_cross

6 months

A wonderful chance to celebrate expansion of the educational center, a place to remember the legacy of those who led the fight against #HIV #AIDS and to learn from Moses Supercharger #HIVcure #PEPFAR #UNAIDS #Amfar #caringcross

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Caring Cross

@caring_cross

2 years

At Caring Cross we are honored to participate in the work of IGI by serving on a number of committees and sharing our approach to bring curative cell and gene therapy to all those who would benefit. @doudna_lab @igisci

Innovative Genomics Institute

@igisci

2 years

"A cure is not really a cure if the people that need it can’t afford it." - Jennifer Doudna A new IGI task force is taking on the biggest issue for promising new genomic therapies: affordability. Learn more:

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Caring Cross

@caring_cross

2 years

“The first molecular disease has a molecular cure” F Collins’ lecture #ASGCT22 ⁦ @globalgti ⁩ ⁦ @nih_nhlbi ⁩ ⁦ @ConquerSCD ⁩ -Now let’s make it available to those who need it most!!

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Caring Cross

@caring_cross

2 years

Just a few patients- impressive results for #SCD LV- mediated transduction of CD34 cells with anti-sickling beta-globin @SickleInAfrica @globalgti @SCCConsortium

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Caring Cross

@caring_cross

1 year

We have an exciting impact talk coming up this Friday, Jan 20, at 3 pm EST: HIV Cure Research: Scaling Up Participant-Centered Approaches, Strategic Socio-Behavioral Sciences and Ethics Research Presenter: Karine Dube, DrPH / UCSD Register 👉

Register for our next LIVE event | Caring Cross

We present the latest research and innovations in advanced medicines with talks, videos, or discussion panels. Register for an event today.

caringcross.org

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Caring Cross

@caring_cross

10 months

Our scientific seminar - Exploring Cell Therapies, Focus on CAR-T- will happen later today at 3 pm EST! Presented by Dr. Kevin Curran And it's FREE to register on our Events page 👉 We look forward to seeing you later!

Register for our next LIVE event | Caring Cross

We present the latest research and innovations in advanced medicines with talks, videos, or discussion panels. Register for an event today.

caringcross.org

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Caring Cross

@caring_cross

1 year

An entire session on direct in vivo gene delivery at #PEGS23 including #abintusbio #sana - Dr Buchholz kicks us off! @PaulEhrlichGes @globalgti @NIH Already a busy biotech space

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Caring Cross

@caring_cross

2 years

Mose Supercharger teaches us ARVS are our real lover- and the second song Optimistic encourages all of us -TIMELINE FOR AN HIV CURE IS OUT MUSICALLY via @YouTube

TIMELINE FOR AN HIV CURE IS OUT MUSICALLY

This seven minutes production by Moses Supercharger with the Stigmaless band answers the biggest question asked by the 37 million people living with HIV.Kind...

www.youtube.com

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Caring Cross

@caring_cross

2 years

Our latest whitepaper by the Hon. Dr Mark Dybul has been published- please visit our site and get the free download of “Global Access to Human Gene Therapy: Lessons Learned from HIV” #AIDS2022 @DAREtoCureHIV @CureHIVNOW @UNAIDS @amfAR @defeatHIV @HIVGov

Download our Whitepaper | Caring Cross

Get info on advanced medicines, engineering for manufacture & distribution, community engagement, and enabling affordable access.

caringcross.org

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Caring Cross

@caring_cross

2 years

Congrats to @bluebirdbio on the approval of Zynteglo (beti-cel) The science is impressive. Given an estimated cost of 2.8 million, we want to see a low cost approach for sickle cell disease. Caring Cross is working to develop a low cost approach for all.

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