Incredibly excited to share our paper on the impact of partial reprogramming on neurogenic niches of the old brain (in mice)!!
Massive congratulations to first-author Lucy Xu and all the authors!! 🌟🙌🍾
Very excited that our study on the African killifish diapause is out today!!
Huge congrats to Chi-Kuo Hu for spearheading all this!
Also, many thanks to all contributors -
@param_p_singh
,
@Planaria1
and others :)
Diapause - a thread! 1/n
Incredibly excited to share our paper on chromatin changes in neural stem cells during aging
It revealed defects in cell migration with age!
CONGRATS to
@robinwyeo
and
@OliviaYZhou
! Awesome collaboration with
@anshulkundaje
and
@Dunn_Lab
! 🎉🥂
How do males shorten the lifespan of the opposite sex?
(in worms)
HUGE CONGRATS to Lauren Booth
@lnbooth
(now at Calico!) 🎉🍾⭐️ 👏 It's so awesome to see this paper out
@NatureAging
!!!
A fun collaboration with Coleen Murphy's lab
@ctmurphy1
!
Excited to report that our paper on single-cell based 'aging clocks' for regenerative regions of the brain is on bioRxiv!
HUGE congrats to Matt
@MatttBuckley
and Eric
@EricDSun
and to our fantastic collaborators at Baylor, UCLA, and Stanford! 🎉
A 🧵
Our latest paper on aging fibroblasts is out! Thrilled to see the work published and huge congratulations to
@Salah__Mahmoudi
and all authors!
In this work, we were curious about the changes in fibroblast populations during aging -1/8 (a thread!)
Incredibly excited to share our new manuscript on the role of complex lipids during aging!!
Massive congrats to Xiaoai
@xiaoaizh
for a tour-de-force, and a huge thank you to all authors and collaborators!
Thrilled to report our latest work on CRISPR-Cas9 screens to boost neural stem cells in old brains!!
Massive CONGRATS to Tyson
@ruetz_tyson
and team for this tour de force and exciting results!!! 🙌
A thread (1/10):
Cave fish have a mutation in the insulin receptor that makes them fat and helps them survive famine.
The same mutation leads to insulin resistance and diabetes in humans.
How do cavefish avoid the deleterious effects of insulin resistance?
Cool study!!
Latest paper from our lab!
T cells infiltrate neurogenic regions from old individuals and negatively impact neural stem cells.
Congrats to Ben Dulken, Matt Buckley, and Paloma Navarro - the dream team :)!!
@nature
#aging
Very excited to report that our collaborative papers with
@JaroszLab
are on bioRxiv!
We identify protein aggregates in the brain and six other tissues in aging 🐟
Congrats to
@ItamarHarel
, Yiwen Chen, and all authors!!
Excited to share our latest review on aging in tissue stem cells and their niches!!
It was fun writing it with
@Goodell_Lab
and
@Thomas_Rando
-– best collaborators!
We compare the mechanisms of stem cell regulation in different organs during aging:
Huge congrats to Andrew McKay for creating an automated feeding system for the African killifish 🐟🐠! This allows high-throughput lifespan and behavior studies and will open possibilities for drug screening for aging!!
Killifish and aging: a thread
Quiescent neural stem cells have large lysosomes filled with protein aggregates. Could a boost in lysosome function clear aggregates and improve stem cells in old age? Our lab's latest paper is out!
A single cell transcriptomic atlas of 18 mouse organs during aging!
Amazing resource for
#aging
!
Congrats to Tony Wyss-Coray
@wysscoray
and Steve Quake as well as the
@StanfordMed
and
@czbiohub
teams!!
How is aging regulated in vertebrates?
Are common themes emerging from genetic studies in mice, humans, and species with vastly different lifespans in nature?
Our latest review is out!
Huge congrats to
@param_p_singh
,
@BADemmitt
, and
@Ravi__Nath
!!
How does aging impact neural stem cells and their niches? Can neurogenic regions from old individuals be 'rejuvenated'?
Kudos to
@Paloma_Negredo
and
@robinwyeo
for their terrific review just out in
@CellStemCell
!!! 🎉👏
Very excited to share our paper on chromatin changes in regenerative regions of the brain during aging!! Congratulations to
@robinwyeo
, all co-authors and collaborators
@anshulkundaje
and
@Dunn_Lab
🎉👏
Chromatin and aging neural stem cells - a thread:
Old cells have large cytoplasms, and this contributes to the defects in aging and senescence.
Amazing paper by Angelika Amon!!
Could cell size be used as a proxy to screen for compounds that delay aging?
Is there a molecular signature of aging across tissues and species?
An epigenomic and transcriptomic dataset in brain, heart, and liver of old mice reveals shared upregulation of inflammatory pathways.
Our latest paper is out! Congrats
@BBParis1984
!
Interested in research on aging? We have a Research Assistant position open in our lab!
Exciting projects on immune interactions in brain aging and communication mechanisms during aging
This is a great position for someone interested in grad school!!
Super excited to organize this upcoming meeting in Sicily on epigenetics and aging!!
Come for the amazing talks, stay for the sun (and the gorgeous Etna!)🌋 🌞🌴
#aging
#epigeneticclock
#reprogramming
#rejuvenation
Submit an abstract!!
Very excited to share our paper on bioRxiv on a method to precisely insert new genes in the short-lived African killifish!! 🐟🐠
HUGE congrats to
@Ravi__Nath
,
@clairebedbrook
, Rahul Nagvekar! 🎉 Awesome collaboration with
@KarlDeisseroth
!!
A 🧵...
The Department of Genetics at Stanford University has two open faculty positions!!
This is a fantastic opportunity to work in a super collegial, interdisciplinary, and inspiring environment!
Very excited about our new paper on the evolution of diapause – a 'suspended animation' state that allows survival in extreme conditions in the African killifish 🐟😀
CONGRATS to Param
@param_p_singh
and Adam
@GAdamReeves1
and all co-authors! A 🧵
Interested in brain aging and rejuvenation? We're hiring a Research Assistant in this area!!
Terrific opportunity for someone who wants to go to Med School or Grad School
Come and join our lab at Stanford! 🙌😀
Very excited about our new study in
@biorxivpreprint
on how males induce the premature demise of the opposite sex
Huge CONGRATS to
@lnbooth
for spearheading this awesome work 😃 And terrific collaboration with
@ctmurphy1
and Cheng Shi!!
A thread --
Interested in aging and brain 'rejuvenation'? Research Assistant position open in our lab to identify genes and lipids that promote regeneration in the brain! Great opportunity to do independent research and be part of a fun team 🎉😎 Please RT!
Aged humans have clones of mutant cells in normal tissues (with mutation in p53 and Notch). This could predispose the tissue to cancer. But could it also alter tissue function during aging?
Tantalizing study!!
Are you interested in aging and longevity? We have another Research Assistant position available in our lab! This is to work across model systems 🐟🪱🐁 Great position for someone who wants to go do Med School or Grad School afterwards!
Very excited to share our latest articles for the killifish! 🐟
1) The introduction to the killifish model
2) A protocol to probe chromatin accessibility in killifish embryos and tissues
Gorgeous cover art by Rogelio Barajas!
In more uplifting news - 3000 years of life and beauty!! 🌲🌲Sequencing of the giant sequoia genome reveals expansion of innate immune genes. Could this be involved in the exceptional robustness of this majestic species? 🤩
Welcome to 3 fantastic new PIs (and their labs) at Stanford Genetics!!
@jengreitz
: Regulatory wiring of the genome
@LivnatJerby
: Multicellular dynamics in cancer
@seresanu
: Genome organization and dynamics
So excited to see their cool science develop 😎✨😍
Excited to organize this FASEB meeting on Chromatin, Transcription and Epigenetics in Aging!!
Come and learn the latest and greatest at the intersect between the chromatin field and the aging field
Shout out to terrific co-organizer
@giacomo_cavalli
!
Check out the table of content for the collection of African killifish protocols!! 🐠🐟
We welcome new protocols from the killifish community! If submitted soon they can be part of this table of content. Contact me!
Don't forget to join us on Tuesday for a talk from Anne Brunet on "The African killifish - a vertebrate model to study aging and ‘suspended animation’"
#aging
#suspendedanimation
@BrunetLab
Thank you so much,
@cshperspectives
!! A big thank you to
@aemonten
and
@CMunkittrick
from CSH!!
It was a fantastic collaborative effort with amazing lab members and killifish groups around the world!! 🐠
Interested in the mechanisms of brain aging, with a focus on regenerative stem cells? Our lab has a Research Assistant position open!! Come and join our team at Stanford ()!
Interested in the African killifish to study aging and 'suspended animation'? 🐟🐟🐟🐟🐠
We have lab Assistant positions open for killifish husbandry and research at Stanford!
Great positions before going to Graduate School!
Exceptionally long-lived trees are not immortal. But they can live more than 4,000 years!! 🌲🌲🌲 Several mechanisms are involved, including stem cells that boost regeneration of their vascular tissues every year 🌲🌲🌲
We have a job opening for a Lab Assistant II to work on the African killifish at Stanford! 🐟🐠
The killifish is an exciting new model to study aging and 'suspended animation'!
Come join our team!!
Joint faculty search between Arc Institute
@ArcInstitute
and Stanford Genetics! 😎
Broad area of interest: innovative approaches for genetics, genomics, other “omics”, and precision health
Apply by December 1!
Big news! We’ve launched an open rank search with
@stanford
Genetics Department. Have a background in basic, translational and/or clinical sciences in the broad areas of genetics, genomics, other “omics” or precision health? Apply now!
We just posted our lab's latest paper on BioRxiv
@biorxivpreprint
!
Inflammatory cytokines secreted by old fibroblasts underlie the inter-individual variability in reprogramming efficiency with aging.
How does chromatin accessibility change during aging?
A new method to purify old yeast cells reveals a decline in chromatin accessibility at regions that initiate DNA replication in old cells.
Terrific paper from Scott McIsaac
@calico
!
Excited about the killifish as a cool model for aging and 'suspended animation'? 🐟 Come and work with us at Stanford as a Lab Assistant!! Please RT😀🐟
#killifish
How does dietary restriction extend lifespan?
It could at in part by modulating the innate immune system. Very cool paper by Keith Blackwell's lab! Congrats!!
Want to learn about the latest discoveries in the field of aging?
The next Bay Area Aging Meeting (BAAM) will be at Stanford University on December 5!!
Stay tuned for more info :)
How does exercise impact various tissue stem cells (blood, brain, muscle) during aging? Awesome collaboration led by
@Thomas_Rando
lab and with
@Goodell_Lab
!!
How does diet influence organismal immunity?
Intermittent fasting leads to a state of low metabolism (torpor), which is critical for a favorable response to infectious disease in mice.
Cool study by Ajay Chawla's lab!!
We are hiring three Research/Lab Assistants in our lab!
Come and join our team to work with different model organisms and understand the mechanisms of aging and 'rejuvenation'!
(drawing by Rogelio Barajas)
Our Transcription, Chromatin, and Epigenetics in Aging Conference, organized by
@brunetlab
and
@giacomo_cavalli
, features keynote speaker Shelley Berger
@berger_lab
, who will discuss epigenetic mechanisms of aging and cancer. Plan to join us!
#TCESRC22
Check out this new issue of CSH Protocols!! New protocols to study degeneration and regeneration during aging in the
#killifish
!! 🐠🐠🐟
Super cool work from the terrific killifish team at KU Leuven in Belgium
@LabMoons
,
@StevenBergmans
!
And beautiful cover 🤩
A new issue of CSH Protocols is out!
The cover image features the work of Vanhunsel,
@StevenBergmans
&
@LabMoons
(
@KU_Leuven
), who describe a paradigm to induce and study both de- and regeneration of retinal ganglion cells and their axons in killifish. Links below! ⬇️
Very excited to share 3 protocols for the killifish! 🐟
Husbandry
Breeding
Lifespan
Congrats to
@clairebedbrook
,
@JingxunC
,
@Ravi__Nath
, Rahul, Rishad, and Rogelio!
Awesome painting by Rogelio Barajas!
Are there shared epigenomic changes in different tissues during aging?
Our lab's latest paper is on BioRxiv! Congrats to Bérénice
@BBParis1984
(now Assistant Professor at USC) and all co-authors!
Are key chromatin modifications changing in human cells during aging? A new single cell assay reveals increased chromatin variability between old immune cells!
Congratulations to our Research Assistant Chloe Kashiwagi for being accepted to Grad School 😎👏!!
Our lab is looking for a new Research Assistant to participate in projects involving CRISPR/Cas9 screens and aging! Apply!!
Clearing senescent cells boosts the ability of neural stem cells to generate new neurons in middle-aged obese mice! Could this also work during normal aging (perhaps by reducing general inflammation)?
Terrific work by
@dianajurk
!!
…
Could clearing senescent cells boost brain function?
Senescent cells strikingly increase with age in the brain of neurodegeneration-prone mice, and killing these senescent cells restores cognitive ability.
Cool study by the Baker lab!
Can removing senescent cells 'rejuvenate' old tissues?
Senolytic compounds not only prevent physical decline with age but also restore function in an already old animal. Very cool study!
Interested in the genetic mechanisms of neural stem cell aging?
We have a Research Assistant position open in our team at Stanford:
Come and join our team!! ☀️
Early-stage investigators proposed innovative high-impact research ideas for the
@NIHDirector
’s New Innovator Award. See the projects the awardees will pursue:
#NIHHighRisk
Our lab is hiring a Research Assistant to work on the mechanisms of neural stem cell aging!!
Great opportunity for someone who would like to go to graduate school or medical school afterwards!
Please RT :)
Excited that the FASEB meeting on "Transcription, Chromatin, Epigenetics in Aging" is starting this Sunday in Sicily!! 🤩
Can't wait to hear amazing talks on epigenetic clocks, reprogramming and aging, and other cool topics!
Still time to register at
C. elegans hermaphrodites can protect themselves from the detrimental effect of mating on lifespan. Self-sperm play a key role!
Tons of congrats to Lauren
@lnbooth
!! Very exciting to see this study out!
And fun interaction with
@ctmurphy1
:)!!
@eLife
Lab Assistant positions to work on the African killifish in our lab at Stanford! 🐟🐟🐟
Cool model to study aging, age-related disease, and 'suspended animation'! 🤩
Apply here:
Obesity due to the loss of one copy of a gene (e.g. SIM1) can be reverted by enhancing the expression of the other copy using CRISPRa in vivo!
Could this method be used for other disorders due to haploinsufficiency?
Amazing study by
@NadavAhituv
!