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Brunet Lab

@BrunetLab

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Aging lab @Stanford - Epigenomics and metabolism in #aging ; Brain aging and rejuvenation; Neural stem cells; C. elegans; African #killifish

Stanford, CA
Joined March 2010
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@BrunetLab
Brunet Lab
2 months
Incredibly excited to share our paper on the impact of partial reprogramming on neurogenic niches of the old brain (in mice)!! Massive congratulations to first-author Lucy Xu and all the authors!! 🌟🙌🍾
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@BrunetLab
Brunet Lab
4 years
Very excited that our study on the African killifish diapause is out today!! Huge congrats to Chi-Kuo Hu for spearheading all this! Also, many thanks to all contributors - @param_p_singh , @Planaria1 and others :) Diapause - a thread! 1/n
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@BrunetLab
Brunet Lab
10 months
Incredibly excited to share our paper on chromatin changes in neural stem cells during aging It revealed defects in cell migration with age! CONGRATS to @robinwyeo and @OliviaYZhou ! Awesome collaboration with @anshulkundaje and @Dunn_Lab ! 🎉🥂
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@BrunetLab
Brunet Lab
2 years
How do males shorten the lifespan of the opposite sex? (in worms) HUGE CONGRATS to Lauren Booth @lnbooth (now at Calico!) 🎉🍾⭐️ 👏 It's so awesome to see this paper out @NatureAging !!! A fun collaboration with Coleen Murphy's lab @ctmurphy1 !
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@BrunetLab
Brunet Lab
1 year
Can we build 'aging clocks' in different cell types to measure the impact of aging and 'rejuvenation'? ⏲️ Massive congrats to @MatttBuckley and @EricDSun !🍾🎉🙌 @NatureAging Great collaboration with #IrvWeissman @wysscoray @Goodell_Lab @Thomas_Rando !
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@BrunetLab
Brunet Lab
2 years
Excited to report that our paper on single-cell based 'aging clocks' for regenerative regions of the brain is on bioRxiv! HUGE congrats to Matt @MatttBuckley and Eric @EricDSun and to our fantastic collaborators at Baylor, UCLA, and Stanford! 🎉 A 🧵
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@BrunetLab
Brunet Lab
5 years
Our latest paper on aging fibroblasts is out! Thrilled to see the work published and huge congratulations to @Salah__Mahmoudi and all authors! In this work, we were curious about the changes in fibroblast populations during aging -1/8 (a thread!)
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@BrunetLab
Brunet Lab
2 years
Incredibly excited to share our new manuscript on the role of complex lipids during aging!! Massive congrats to Xiaoai @xiaoaizh for a tour-de-force, and a huge thank you to all authors and collaborators!
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@BrunetLab
Brunet Lab
1 year
Thrilled to share our new paper on how specific dietary lipids extend lifespan!! Huge congrats to Katha @KPapsdorf and all the authors!! Awesome collaboration with @SJD956 , @SnyderShot , @mengwang939 , and @William_Mair ! A 🧵...
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@BrunetLab
Brunet Lab
2 years
Thrilled to report our latest work on CRISPR-Cas9 screens to boost neural stem cells in old brains!! Massive CONGRATS to Tyson @ruetz_tyson and team for this tour de force and exciting results!!! 🙌 A thread (1/10):
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@BrunetLab
Brunet Lab
1 year
Very excited to share our recent paper on precise genome engineering in the killifish! Massive congrats to @clairebedbrook , @Ravi__Nath , and Rahul! Awesome collaboration with @KarlDeisseroth @eLife
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@BrunetLab
Brunet Lab
5 years
Cave fish have a mutation in the insulin receptor that makes them fat and helps them survive famine. The same mutation leads to insulin resistance and diabetes in humans. How do cavefish avoid the deleterious effects of insulin resistance? Cool study!!
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@BrunetLab
Brunet Lab
5 years
Latest paper from our lab! T cells infiltrate neurogenic regions from old individuals and negatively impact neural stem cells. Congrats to Ben Dulken, Matt Buckley, and Paloma Navarro - the dream team :)!! @nature #aging
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@BrunetLab
Brunet Lab
2 years
Very excited to report that our collaborative papers with @JaroszLab are on bioRxiv! We identify protein aggregates in the brain and six other tissues in aging 🐟 Congrats to @ItamarHarel , Yiwen Chen, and all authors!!
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@BrunetLab
Brunet Lab
2 years
Excited to share our latest review on aging in tissue stem cells and their niches!! It was fun writing it with @Goodell_Lab and @Thomas_Rando -– best collaborators! We compare the mechanisms of stem cell regulation in different organs during aging:
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@BrunetLab
Brunet Lab
3 years
Huge congrats to Andrew McKay for creating an automated feeding system for the African killifish 🐟🐠! This allows high-throughput lifespan and behavior studies and will open possibilities for drug screening for aging!! Killifish and aging: a thread
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@BrunetLab
Brunet Lab
6 years
Quiescent neural stem cells have large lysosomes filled with protein aggregates. Could a boost in lysosome function clear aggregates and improve stem cells in old age? Our lab's latest paper is out!
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@BrunetLab
Brunet Lab
5 years
A single cell transcriptomic atlas of 18 mouse organs during aging! Amazing resource for #aging ! Congrats to Tony Wyss-Coray @wysscoray and Steve Quake as well as the @StanfordMed and @czbiohub teams!!
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@BrunetLab
Brunet Lab
5 years
How is aging regulated in vertebrates? Are common themes emerging from genetic studies in mice, humans, and species with vastly different lifespans in nature? Our latest review is out! Huge congrats to @param_p_singh , @BADemmitt , and @Ravi__Nath !!
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@BrunetLab
Brunet Lab
3 years
Very excited to share our paper on chromatin changes in regenerative regions of the brain during aging!! Congratulations to @robinwyeo , all co-authors and collaborators @anshulkundaje and @Dunn_Lab 🎉👏 Chromatin and aging neural stem cells - a thread:
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@BrunetLab
Brunet Lab
5 years
Old cells have large cytoplasms, and this contributes to the defects in aging and senescence. Amazing paper by Angelika Amon!! Could cell size be used as a proxy to screen for compounds that delay aging?
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@BrunetLab
Brunet Lab
5 years
Is there a molecular signature of aging across tissues and species? An epigenomic and transcriptomic dataset in brain, heart, and liver of old mice reveals shared upregulation of inflammatory pathways. Our latest paper is out! Congrats @BBParis1984 !
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@BrunetLab
Brunet Lab
2 months
Interested in research on aging? We have a Research Assistant position open in our lab! Exciting projects on immune interactions in brain aging and communication mechanisms during aging This is a great position for someone interested in grad school!!
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@BrunetLab
Brunet Lab
2 years
Super excited to organize this upcoming meeting in Sicily on epigenetics and aging!! Come for the amazing talks, stay for the sun (and the gorgeous Etna!)🌋 🌞🌴 #aging #epigeneticclock #reprogramming #rejuvenation Submit an abstract!!
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@BrunetLab
Brunet Lab
5 months
EMBO meeting on aging! Super exciting program: And the meeting will take place in the gorgeous city of Nice, "baie des anges" (bay of angels) 🤩
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@BrunetLab
Brunet Lab
2 years
Fun lab retreat in beautiful Lake Tahoe last week!!
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@BrunetLab
Brunet Lab
2 years
Very excited to share our paper on bioRxiv on a method to precisely insert new genes in the short-lived African killifish!! 🐟🐠 HUGE congrats to @Ravi__Nath , @clairebedbrook , Rahul Nagvekar! 🎉 Awesome collaboration with @KarlDeisseroth !! A 🧵...
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@BrunetLab
Brunet Lab
6 years
Our latest review on how lipid metabolism interacts with chromatin modifications to delay aging! Congratulations to Katharina Papsdorf!
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@BrunetLab
Brunet Lab
5 years
Our latest review on how emerging 'rejuvenation' strategies can erase hallmarks of aging. Congratulations to @Salah__Mahmoudi and Lucy Xu!
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@BrunetLab
Brunet Lab
5 years
The Department of Genetics at Stanford University has two open faculty positions!! This is a fantastic opportunity to work in a super collegial, interdisciplinary, and inspiring environment!
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@BrunetLab
Brunet Lab
2 years
We are hiring!! Our lab at Stanford is looking for a Research Assistant to work on the mechanisms of aging! Come and join our team! 🙌
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@BrunetLab
Brunet Lab
3 years
Very excited about our new paper on the evolution of diapause – a 'suspended animation' state that allows survival in extreme conditions in the African killifish 🐟😀 CONGRATS to Param @param_p_singh and Adam @GAdamReeves1 and all co-authors! A 🧵
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@BrunetLab
Brunet Lab
2 years
Interested in brain aging and rejuvenation? We're hiring a Research Assistant in this area!! Terrific opportunity for someone who wants to go to Med School or Grad School Come and join our lab at Stanford! 🙌😀
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@BrunetLab
Brunet Lab
3 years
Interested in aging and brain 'rejuvenation'? Research Assistant position open in our lab to identify genes and lipids that promote regeneration in the brain! Great opportunity to do independent research and be part of a fun team 🎉😎 Please RT!
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@BrunetLab
Brunet Lab
1 year
Congratulations to Dr. Lucy Xu for a superb thesis defense on neural stem cell aging!!! And for properly sabering Champagne! 🍾🤩
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@BrunetLab
Brunet Lab
2 years
Paris!!
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@BrunetLab
Brunet Lab
5 years
Aged humans have clones of mutant cells in normal tissues (with mutation in p53 and Notch). This could predispose the tissue to cancer. But could it also alter tissue function during aging? Tantalizing study!!
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@BrunetLab
Brunet Lab
3 years
Are you interested in aging and longevity? We have another Research Assistant position available in our lab! This is to work across model systems 🐟🪱🐁 Great position for someone who wants to go do Med School or Grad School afterwards!
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@BrunetLab
Brunet Lab
3 years
We are recruiting a Lab Assistant to help with our killifish colony at Stanford! 🐠🐟 Exciting opportunity to participate in aging research! Please RT!
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@BrunetLab
Brunet Lab
2 months
Very excited to share our latest articles for the killifish! 🐟 1) The introduction to the killifish model 2) A protocol to probe chromatin accessibility in killifish embryos and tissues Gorgeous cover art by Rogelio Barajas!
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@BrunetLab
Brunet Lab
4 years
In more uplifting news - 3000 years of life and beauty!! 🌲🌲Sequencing of the giant sequoia genome reveals expansion of innate immune genes. Could this be involved in the exceptional robustness of this majestic species? 🤩
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@BrunetLab
Brunet Lab
3 years
Welcome to 3 fantastic new PIs (and their labs) at Stanford Genetics!! @jengreitz : Regulatory wiring of the genome @LivnatJerby : Multicellular dynamics in cancer @seresanu : Genome organization and dynamics So excited to see their cool science develop 😎✨😍
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@BrunetLab
Brunet Lab
1 year
Fantastic lab retreat at Lake Tahoe this week!! Snowshoeing in the forest with all the fresh snow was magical ❄️
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@BrunetLab
Brunet Lab
2 years
Excited to organize this FASEB meeting on Chromatin, Transcription and Epigenetics in Aging!! Come and learn the latest and greatest at the intersect between the chromatin field and the aging field Shout out to terrific co-organizer @giacomo_cavalli !
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@BrunetLab
Brunet Lab
9 months
Check out the table of content for the collection of African killifish protocols!! 🐠🐟 We welcome new protocols from the killifish community! If submitted soon they can be part of this table of content. Contact me!
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@BrunetLab
Brunet Lab
4 years
African killifish! 🐠
@AgingSciTalks
Aging Science Talks
4 years
Don't forget to join us on Tuesday for a talk from Anne Brunet on "The African killifish - a vertebrate model to study aging and ‘suspended animation’" #aging #suspendedanimation @BrunetLab
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@BrunetLab
Brunet Lab
9 months
Thank you so much, @cshperspectives !! A big thank you to @aemonten and @CMunkittrick from CSH!! It was a fantastic collaborative effort with amazing lab members and killifish groups around the world!! 🐠
@cshperspectives
Richard Sever
9 months
New lab manual on cutting-edge model system for aging - the African Turquoise Killifish - with @BrunetLab running the show
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@BrunetLab
Brunet Lab
4 years
What are the advantages of the different model systems used to study aging and longevity? Lots of cool species, including the African killifish!! 🐟
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@BrunetLab
Brunet Lab
3 years
Interested in the mechanisms of brain aging, with a focus on regenerative stem cells? Our lab has a Research Assistant position open!! Come and join our team at Stanford ()!
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@BrunetLab
Brunet Lab
3 years
Aperol Spritz night on California Avenue :)
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@BrunetLab
Brunet Lab
1 year
Interested in the African killifish to study aging and 'suspended animation'? 🐟🐟🐟🐟🐠 We have lab Assistant positions open for killifish husbandry and research at Stanford! Great positions before going to Graduate School!
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@BrunetLab
Brunet Lab
4 years
Exceptionally long-lived trees are not immortal. But they can live more than 4,000 years!! 🌲🌲🌲 Several mechanisms are involved, including stem cells that boost regeneration of their vascular tissues every year 🌲🌲🌲
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@BrunetLab
Brunet Lab
29 days
We have a job opening for a Lab Assistant II to work on the African killifish at Stanford! 🐟🐠 The killifish is an exciting new model to study aging and 'suspended animation'! Come join our team!!
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@BrunetLab
Brunet Lab
6 months
Joint faculty search between Arc Institute @ArcInstitute and Stanford Genetics! 😎 Broad area of interest: innovative approaches for genetics, genomics, other “omics”, and precision health Apply by December 1!
@arcinstitute
Arc Institute
7 months
Big news! We’ve launched an open rank search with @stanford Genetics Department. Have a background in basic, translational and/or clinical sciences in the broad areas of genetics, genomics, other “omics” or precision health? Apply now!
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@BrunetLab
Brunet Lab
2 years
Huge CONGRATS to Rahul for passing his Qual with flying colors!! 🙌🎉😀 Champagne!!🍾
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@BrunetLab
Brunet Lab
6 years
We just posted our lab's latest paper on BioRxiv @biorxivpreprint ! Inflammatory cytokines secreted by old fibroblasts underlie the inter-individual variability in reprogramming efficiency with aging.
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@BrunetLab
Brunet Lab
5 years
How does chromatin accessibility change during aging? A new method to purify old yeast cells reveals a decline in chromatin accessibility at regions that initiate DNA replication in old cells. Terrific paper from Scott McIsaac @calico !
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@BrunetLab
Brunet Lab
5 years
How does dietary restriction extend lifespan? It could at in part by modulating the innate immune system. Very cool paper by Keith Blackwell's lab! Congrats!!
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@BrunetLab
Brunet Lab
2 years
Our fantastic lab members and lab alumni at Cold Spring Harbor Aging Meeting 2022!! #cshlaging22 #cshlaging2022 !!🤩🙌 Have fun!!
@BBParis1984
Bérénice A. Benayoun, PhD
2 years
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@BrunetLab
Brunet Lab
5 years
Want to learn about the latest discoveries in the field of aging? The next Bay Area Aging Meeting (BAAM) will be at Stanford University on December 5!! Stay tuned for more info :)
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@BrunetLab
Brunet Lab
1 year
How does exercise impact various tissue stem cells (blood, brain, muscle) during aging? Awesome collaboration led by @Thomas_Rando lab and with @Goodell_Lab !!
@Thomas_Rando
Thomas Rando
1 year
I’m excited to share a recent publication from our lab, spearheaded by Ling Liu and in close collaboration with Anne Brunet ( @BrunetLab ) and Peggy Goodell ( @Goodell_Lab ). All about #aging , #exercise , and #stemcells !!
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@BrunetLab
Brunet Lab
5 years
How does diet influence organismal immunity? Intermittent fasting leads to a state of low metabolism (torpor), which is critical for a favorable response to infectious disease in mice. Cool study by Ajay Chawla's lab!!
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@BrunetLab
Brunet Lab
4 years
Happy 2020 party!!
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@BrunetLab
Brunet Lab
1 year
We are hiring three Research/Lab Assistants in our lab! Come and join our team to work with different model organisms and understand the mechanisms of aging and 'rejuvenation'! (drawing by Rogelio Barajas)
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@BrunetLab
Brunet Lab
2 years
We are very excited to organize this meeting on chromatin and aging! Fantastic line up of speakers! Join us in Sicily in early September!! 🤩
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@FASEBorg
FASEB
2 years
Our Transcription, Chromatin, and Epigenetics in Aging Conference, organized by @brunetlab and @giacomo_cavalli , features keynote speaker Shelley Berger @berger_lab , who will discuss epigenetic mechanisms of aging and cancer. Plan to join us! #TCESRC22
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@BrunetLab
Brunet Lab
7 months
Check out this new issue of CSH Protocols!! New protocols to study degeneration and regeneration during aging in the #killifish !! 🐠🐠🐟 Super cool work from the terrific killifish team at KU Leuven in Belgium @LabMoons , @StevenBergmans ! And beautiful cover 🤩
@aemonten
Alejandro Montenegro
7 months
A new issue of CSH Protocols is out! The cover image features the work of Vanhunsel, @StevenBergmans & @LabMoons ( @KU_Leuven ), who describe a paradigm to induce and study both de- and regeneration of retinal ganglion cells and their axons in killifish. Links below! ⬇️
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@BrunetLab
Brunet Lab
1 year
Very excited to share 3 protocols for the killifish! 🐟 Husbandry Breeding Lifespan Congrats to @clairebedbrook , @JingxunC , @Ravi__Nath , Rahul, Rishad, and Rogelio! Awesome painting by Rogelio Barajas!
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@BrunetLab
Brunet Lab
5 years
It was so awesome to be back in Nice after all these years!!! Great memories from graduate school!
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@BrunetLab
Brunet Lab
6 years
Are there shared epigenomic changes in different tissues during aging? Our lab's latest paper is on BioRxiv! Congrats to Bérénice @BBParis1984 (now Assistant Professor at USC) and all co-authors!
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@BrunetLab
Brunet Lab
2 years
Congratulations to all for best talk and best poster awards!!!🥇🙌 ⭐️ Super well done Natalie ⁦ @n_toothacre ⁩, Paloma ⁦ @palomasocas ⁩, Gianni, Merve, and ⁦ @OliviaYZhou ⁩!!! 🎉🍾 #TCESRC22
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@BrunetLab
Brunet Lab
5 years
Fun and memorable BrunetLab 2019 retreat in beautiful Lake Tahoe!!
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@BrunetLab
Brunet Lab
6 years
Are key chromatin modifications changing in human cells during aging? A new single cell assay reveals increased chromatin variability between old immune cells!
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@BrunetLab
Brunet Lab
3 years
Congratulations to our Research Assistant Chloe Kashiwagi for being accepted to Grad School 😎👏!! Our lab is looking for a new Research Assistant to participate in projects involving CRISPR/Cas9 screens and aging! Apply!!
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@BrunetLab
Brunet Lab
5 years
Very excited to be at the Stanford Department of Genetics retreat in Monterey!! Such a beautiful place on the ocean and an amazing group of people!
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@BrunetLab
Brunet Lab
5 years
Clearing senescent cells boosts the ability of neural stem cells to generate new neurons in middle-aged obese mice! Could this also work during normal aging (perhaps by reducing general inflammation)? Terrific work by @dianajurk !! …
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@BrunetLab
Brunet Lab
6 years
Could clearing senescent cells boost brain function? Senescent cells strikingly increase with age in the brain of neurodegeneration-prone mice, and killing these senescent cells restores cognitive ability. Cool study by the Baker lab!
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@BrunetLab
Brunet Lab
1 year
Fantastic talk by ⁦ @clairebedbrook ⁩ at the Bay Area Aging Meeting!! Tracking behavior in killifish throughout life!! 🐟 ⭐️👏
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@BrunetLab
Brunet Lab
6 years
Beautiful Mediterranean sunset in Sitges, Spain!! #CSAging
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@BrunetLab
Brunet Lab
3 years
Happy New Year 2021! Hope on the horizon!
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@BrunetLab
Brunet Lab
2 years
Holiday Party, British Club style!!! 🍸🇬🇧🎉
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@BrunetLab
Brunet Lab
6 years
Can removing senescent cells 'rejuvenate' old tissues? Senolytic compounds not only prevent physical decline with age but also restore function in an already old animal. Very cool study!
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@BrunetLab
Brunet Lab
1 year
Interested in the genetic mechanisms of neural stem cell aging? We have a Research Assistant position open in our team at Stanford: Come and join our team!! ☀️
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@BrunetLab
Brunet Lab
7 months
Congratulations @param_p_singh !!! Super well deserved!! 🐟🐟🐟🐠
@NIH_CommonFund
NIH Common Fund
7 months
Early-stage investigators proposed innovative high-impact research ideas for the @NIHDirector ’s New Innovator Award. See the projects the awardees will pursue: #NIHHighRisk
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@BrunetLab
Brunet Lab
8 months
Bay Area Aging Meeting at Stanford on December 7!! This will be a super exciting meeting! Register now!🤩🌟
@longlabstanford
Long Lab
8 months
The next Bay Area Aging Meeting will be Thurs Dec 7, 2023 at @Stanford , with keynote from the amazing @stevens1lab . @BrunetLab @UCSF @UCBerkeley @BuckInstitute Register now!
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@BrunetLab
Brunet Lab
5 years
Our lab is hiring a Research Assistant to work on the mechanisms of neural stem cell aging!! Great opportunity for someone who would like to go to graduate school or medical school afterwards! Please RT :)
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@BrunetLab
Brunet Lab
2 years
Excited that the FASEB meeting on "Transcription, Chromatin, Epigenetics in Aging" is starting this Sunday in Sicily!! 🤩 Can't wait to hear amazing talks on epigenetic clocks, reprogramming and aging, and other cool topics! Still time to register at
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@BrunetLab
Brunet Lab
6 years
The African killifish: an experimental system to study aging and suspended animation?
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@BrunetLab
Brunet Lab
5 years
Good-bye Bordeaux!! This was an amazing place for a sabbatical!
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@BrunetLab
Brunet Lab
5 years
C. elegans hermaphrodites can protect themselves from the detrimental effect of mating on lifespan. Self-sperm play a key role! Tons of congrats to Lauren @lnbooth !! Very exciting to see this study out! And fun interaction with @ctmurphy1 :)!! @eLife
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@BrunetLab
Brunet Lab
1 year
Lab Assistant positions to work on the African killifish in our lab at Stanford! 🐟🐟🐟 Cool model to study aging, age-related disease, and 'suspended animation'! 🤩 Apply here:
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@BrunetLab
Brunet Lab
5 years
Notre Dame de Paris, spirit of the city. Inspiring, gorgeous, and strong. Hope you resist this. Fluctuat nec mergitur.
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@BrunetLab
Brunet Lab
5 years
Obesity due to the loss of one copy of a gene (e.g. SIM1) can be reverted by enhancing the expression of the other copy using CRISPRa in vivo! Could this method be used for other disorders due to haploinsufficiency? Amazing study by @NadavAhituv !
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@BrunetLab
Brunet Lab
6 years
Interested in Aging and Metabolism? Cell Symposia is organizing a meeting on this topic in Spain in September 2018. Check it out!
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