Sana Karam, MD, PhD @KaramLab Twitter profile

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Sana Karam, MD, PhD

@KaramLab

1 year

IT'S OUT:Our paper on elective nodal irradiation mitigates local and systemic immunity generated by combination radiation + immunotherapy in head and neck tumors. Link:

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Sana Karam, MD, PhD

@KaramLab

1 year

FINALLY, OUT: Our Trial Results with Neoadjuvant Durvalumab + SBRT in locally advanced HPV unrelated HNSCC. or .

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Sana Karam, MD, PhD

@KaramLab

1 year

COVER: Imagine a new way of treating HNSCC patients: THREE fractions of radiation, ONE cycle immunotherapy, smaller surgeries that spare organs. No adjuvant RT/CRT. Urging our collaborators in industry across the globe to support the cause!

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Sana Karam, MD, PhD

@KaramLab

1 year

A heartfelt thank you to the editors @Cancer_Cell for this opportunity...and thank you to @WingsofHopePCR for supporting this work. Here's hoping to translate this work to our PDAC patients in the near future💜

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Sana Karam, MD, PhD

@KaramLab

2 years

@Joyce_Karam Oh my gosh! How can the world stay in silence?! I can’t imagine the pain and agony felt by the family of this brave young woman…

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Sana Karam, MD, PhD

@KaramLab

1 year

JUST IN: Neoadjuvant Durvalumab + SBRT in locally advanced HPV unrelated HNSCC. or . Response is amazing and is still amazing even with expansion cohort that did not receive RT or CRT

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Sana Karam, MD, PhD

@KaramLab

2 years

My sister and I are both in NY. I’m giving a talk at the ImmunoRad Conf and she’s ( @Joyce_Karam ) covering UN’s General Assembly…and creating all the traffic! 🚗 We’ll settle for hello 👋🏽 and 🫂😘 virtually!

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Sana Karam, MD, PhD

@KaramLab

1 year

Congratulations to my beautiful Laurel on outstanding PhD defense and graduation…now on to finishing up that MD ⁦ @CU_MSTP ⁩ so you can continue to advance medicine through science… my heart is filled with pride and so much love for being a part of this beautiful journey ♥️

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Sana Karam, MD, PhD

@KaramLab

1 year

#AACR 2023, here comes the #KaramLab . Come check out some amazing science. Proud of my team!

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Sana Karam, MD, PhD

@KaramLab

11 months

Makes my day💕. My two ENT resident mentees, Justin & Tiffany, winning outstanding research presentations. The KaramLab is so proud of these two brilliant future surgeon scientists ⁦ @CUOTO ⁩ ⁦ @CUAnschutz ⁩.

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Sana Karam, MD, PhD

@KaramLab

1 year

I just found out that my head and neck attending from residency, Dr. William Harter, passed away. He's the reason I am a radiation oncologist. He was a most amazing human that embodied what it means to "doctor," to advocate, to mentor, and to care... I will miss you, Dr. Harter.

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Sana Karam, MD, PhD

@KaramLab

1 year

JUST IN: Radiation with, PD1-IL2v, significantly reduces primary tumor AND metastatic burden of orthotopic PDAC. PD1-IL2v: an immunocytokine with engineered IL2v variant with abolished IL2Rα binding to PD1 expressing cells. 📷

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Sana Karam, MD, PhD

@KaramLab

1 year

From the women, and men, in the Karam Lab, a Happy International Women’s Day…

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Sana Karam, MD, PhD

@KaramLab

25 days

Congrats to future surgeon scientist, Dr. Justin Yu, in #KaramLab , T32 trainee, ENT resident @CUOTO , for an outstanding job on his recent publication using IL7 to stimulate immune memory in HNSCC. #tumorimmunology And you just wait to see his next one!

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Sana Karam, MD, PhD

@KaramLab

3 months

Congratulations to Jake Gadwa in #KaramLab @CUAnschutz_Immu for securing his F31, first submission, first year in PhD program, first class scientist. Many thanks to the #NIDCR for supporting the next generation of Head & Neck cancer scientists. So proud of you, Jake!

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Sana Karam, MD, PhD

@KaramLab

13 days

@WashURadOnc @WUSTLmed Thank you all for the congratulatory notes and best wishes. I am absolutely thrilled and look forward to working with everyone on the team at Wash U.

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Sana Karam, MD, PhD

@KaramLab

5 months

Happy Holidays from the KaramLab.🕊️ So lucky to have you guys!🩶 @CUAnschutz @curadonc @CUAnschutz_Immu @CUCancerBio @CUCancerCenter

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Sana Karam, MD, PhD

@KaramLab

10 months

Congratulations to Sophia Corbo in the #KaramLab ⁦ @CUCancerBio ⁩ on passing her Comps and advancing to doctoral candidacy! 🎉🎊🍾

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Sana Karam, MD, PhD

@KaramLab

9 months

@sitcancer Congrats to Shaquia on this outstanding honor! The #Karamlab is honored to call you a member and @CUAnschutz @CUCancerCenter @BK_radiation @CUMedicalSchool are very proud. Thank you for #sitcancer for recognizing this brilliant talent. 🌟💪🏽

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Sana Karam, MD, PhD

@KaramLab

1 year

Ho Ho Ho! Who knew axe throwing could be so much fun 🤩! Happy holidays from the Karam Lab!

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Sana Karam, MD, PhD

@KaramLab

2 years

Congrats to Sophia in the Karam Lab on being one of two PhD students to be awarded the T32 Otolaryngology training grant! Working on figuring out how Tregs get into HNSCC TME!

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Sana Karam, MD, PhD

@KaramLab

1 year

This is how we move needles. You go girl!💪

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Sana Karam, MD, PhD

@KaramLab

9 months

Just out from the #Karamlab

Selective targeting of IL2Rβγ combined with radiotherapy triggers CD8- and NK-mediated immunity,...

In aggressive models of head and neck cancer, Gadwa et al. demonstrate that radiation therapy combined with the immunocytokine PD1-IL2v elicits a robust anti-tumor immune response by invigorating...

www.cell.com

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Sana Karam, MD, PhD

@KaramLab

5 months

@CUCancerCenter @TheVFoundation So grateful to be the recipient of this incredible honor to be a V Scholar and named a Bob Bast Translational Awardee. Many thanks to @TheVFoundation #VictoryOverCancer , #CancerResearch , and to entire team @CUCancerCenter @CUAnschutz @WingsofHopePCR 🙏🏾

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Sana Karam, MD, PhD

@KaramLab

3 months

Ever wondered how fatty acid catabolism can affect immune response? Or how we can harness such effects? Fenofibrate! Another rockstar @RBRossMD from #KaramLab and with fabulous collaboration from @dalessandrolab , knocks the ball out of the park!

PPARα Agonism Enhances Immune Response to Radiotherapy While Dietary Oleic Acid Results in Counte...

AbstractPurpose:. Head and neck cancer (HNC) improvements are stagnant, even with advances in immunotherapy. Our previous clinical trial data show that altered fatty acid (FA) metabolism correlates...

aacrjournals.org

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Sana Karam, MD, PhD

@KaramLab

2 years

A GINORMOUS congratulations to Adam Mueller, MD, PhD @CavalierSabr @JeffersonUniv @RSNA @KaramLab for securing an ACS CDA, just 2 years out of residency, “Investigating ADAM10 mediated radiation resistance and EMT through Notch” in PDAC. As a mentor, I couldn't be prouder!👏🏽 🧪👨🏽‍🔬

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Sana Karam, MD, PhD

@KaramLab

1 year

@CUCancerCenter I am the one who is beyond lucky to be allowed to share this journey…

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Sana Karam, MD, PhD

@KaramLab

1 year

Everyone, check this out! @KimpleRandall @sueyom @Qle_stanford @imrtlee @YvonneMowery @MargalitMd @DanielMaMD @AndersonCarryn @jdschoenfeld1 @StokedStokes @DrAryaAmini

Prospective Phase 2 Study of Radiation Therapy Dose and Volume De-escalation for Elective Neck...

The required elective nodal dose and volumes for head and neck intensity modulated radiation therapy have largely been extrapolated from conventional radiation therapy fields. In this prospective,...

www.redjournal.org

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Sana Karam, MD, PhD

@KaramLab

2 months

JUST IN: Check out our recent work from the brilliant Laurel Darragh in the #KaramLab @MedCellPress on sensory denervation, CGRP release, & immune modulation in the context of radiation. Numerous translational hits. More to come.

Sensory nerve release of CGRP increases tumor growth in HNSCC by suppressing TILs - PubMed

1R01DE028282-01, 1R01DE028529-01, 1P50CA261605-01 (to S.D.K.), 1R01CA284651-01 (to S.D.K.), and F31 DE029997 (to L.B.D.).

pubmed.ncbi.nlm.nih.gov

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Sana Karam, MD, PhD

@KaramLab

6 months

Congratulations to Nick Olimpo in the #KaramLab for passing his comprehensive exam and advancing to doctoral candidacy @CUCancerBio . Well done, Nick!🥳

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Sana Karam, MD, PhD

@KaramLab

2 years

Congrats to the Karam Lab on publishing "EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment" in Nature Communications!

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Sana Karam, MD, PhD

@KaramLab

11 months

@cd_fuller @SprakerMDPhD @toddscarbrough @lab_pearson @ScarlessThyroid And what are we doing to vaccinate the boys and the men? Where are the studies to increase vax age for men? Where are the CDC guidelines? Where is the insurance coverage? This is a disease that should be eradicated not increasing in prevalence!

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Sana Karam, MD, PhD

@KaramLab

5 months

@NatureComms @fg_herrera @DemariaLab_WCM @Edradonc @immunorad2023 Thrilled to be in the company of the greatest! Let's talk RT & immune effects! 🙏🏾 #NatureComms for this invitation! @CUAnschutz @CUCancerCenter @TheVFoundation @VozeninC @rweichselbaum @aadel_chaudhuri @HenningWillers @ASTRO_org @curadonc @HSkinnerMDPhD @KimpleRandall @sitcancer

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Sana Karam, MD, PhD

@KaramLab

10 months

⁦ @RetickerFlynn ⁩ giving a fantastic talk on nodal Mets and distant Mets ⁦ @AACR ⁩ #AACR AHNS

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Sana Karam, MD, PhD

@KaramLab

1 year

@NatureCancer @ErezNeta @AlanaWelm @HuttLab @FendtLab @Bando_Lab @ranigeorgelab @IMalanchi Honored to be in the company of these amazing women. Thank you @NatureCancer for this recognition and for the celebration of international women’s day. Here’s to creating opportunities for many across the globe where hope may not seem tenable.🌸

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Sana Karam, MD, PhD

@KaramLab

2 years

At the Shared Resource Fair today @CUCancerCenter @CUAnschutz , a brilliant, beaming, Brooke Neupert from @Karamlab , showed off the power of the photons in modeling RT in preclinical models. So lucky to have you, Brooke manage the core! Huge thank you!

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Sana Karam, MD, PhD

@KaramLab

11 months

@ASTRO_org @nytimes should withdraw the radiophobic article AND owe it to the public to publish ASTRO’s release in their magazine. The inadvertent consequences of that misinformed article represent a colossal public health hazard.

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Sana Karam, MD, PhD

@KaramLab

2 years

@xrtGenomics @GeneCollector @imrtlee @rweichselbaum @HenningWillers @seanmmcbride @jdschoenfeld1 @DrHaddadRobert @sueyom Not surprised…what we cannot do is give up on the concept of combination immunotherapy and RT. There’s a lot of hope. We just need to design better trials. May the science be our guide.

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Sana Karam, MD, PhD

@KaramLab

2 years

Congrats to our superstar undergrad, Alex Nguyen, on a fantastic summer research fellowship in the KaramLab. Can't wait to have you back in November!

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Sana Karam, MD, PhD

@KaramLab

1 year

My warmest congratulations to Laurel Darragh @CU_MSTP @CUAnschutz for driving this "tour de force." She's unstoppable and I'm a very proud mentor...

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Sana Karam, MD, PhD

@KaramLab

1 year

@TeWilliamsMD @ASTRO_org @HenningWillers @KimpleRandall @guptalabunc @aadel_chaudhuri @max_diehn @pipcosper @AKesarwala @YvonneMowery @cwspeers @theabzlab May the science continue to blossom and guide our path🌸. Excited for our field, and our patients, as we embrace the uncertainty of our knowledge through scientific discovery. Let’s showcase it @ASTRO_org . Celebrate biology 👊🏽.

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Sana Karam, MD, PhD

@KaramLab

3 years

Congratulations to Dr. Milner on completion of your MD today! Looking forward to still seeing you on campus during your residency here in ophthalmology.

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Sana Karam, MD, PhD

@KaramLab

1 year

So grateful to the @WingsofHopePCR for supporting our pancreatic cancer research projects…lucky to be working with the greatest @dalessandrolab @KedlRoss @CUCancerCenter @CUAnschutz Stay tuned. More to come…

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Sana Karam, MD, PhD

@KaramLab

2 years

@rweichselbaum Awww. I take that praise as a huge badge of honor. Thank you so much, Ralph. 🙏🏾 Your questions were on pointe….

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Sana Karam, MD, PhD

@KaramLab

4 months

@CJTsaiMDPhD @imrtlee @xrtGenomics @MSK_RadOnc @MSKCancerCenter @DavidSherMD @DanielMaMD @henson_md @YaoCMKL And the importance of inflammation and overdosing--both chemo & RT. Questions: do we need two cycles of chemo? Can we develop blood biomarkers for selection? Can we include more advanced stage disease and integrate complete omission of elective anything?

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Sana Karam, MD, PhD

@KaramLab

3 months

@IBCradiation Thank you, THANK YOU, for the kind words and the invitation🙏🏾. It was my absolute privilege to speak to such an amazing group who is passionately advocating for IBC research, women's health, and pushing all of oncology care forward.

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Sana Karam, MD, PhD

@KaramLab

1 year

via @NYTimes a call for immediate action. Doctors, scientists, patients, and all healthcare providers EVERYWHERE, your voice is needed. Make it loud!

Drug Shortages Near an All-Time High, Leading to Rationing

A worrisome scarcity of cancer drugs has heightened concerns about the troubled generic drug industry. Congress and the White House are seeking ways to address widespread supply problems.

www.nytimes.com

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Sana Karam, MD, PhD

@KaramLab

11 months

@CJTsaiMDPhD @DrNikhilJoshiMD @JJCaudell @DrMLChua @HenningWillers @henson_md @cd_fuller @DanielMaMD @PBlanchardMD @ChristinaChapMD @DavidSherMD I would be shocked if any toxicity or efficacy data are related to such minor difference in dose…and if it is, then we’re doomed… Tradition, tradition….

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Sana Karam, MD, PhD

@KaramLab

1 year

@CJTsaiMDPhD @imrtlee @seanmmcbride @xrtGenomics @Lawson_Eng @DrJohndeAlmeida @YaoCMKL @Dr_AliHosni @ScottBratman Very kind of you to highlight this, Jillian. Thank you. I would add that the BLOOD analysis was surprisingly gave us the best hits, providing a powerful tool for prediction. And all patients on expansion cohort, once comfort zone established :), received no adjuvant treatment...

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Sana Karam, MD, PhD

@KaramLab

10 months

JUST IN from the brilliant Ben Van Court and Brooke Neupert in the #Karam lab Ever wondered why preclinical models fail in reproducibility and clinical translation for Head and Neck Cancer.

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Sana Karam, MD, PhD

@KaramLab

2 years

@DrMLChua @CJTsaiMDPhD @NRGonc @drlorenmell @sueyom @Qle_stanford @imrtlee @xrtGenomics @seanmmcbride @lillian_siu @ezrahahn @Dr_AliHosni I would caution about lumping all drugs in one basket. Anti-PD1 and anti-PDL1 are not the same drug… Even within the same category, say anti-PDL1, not all drugs are made equally.

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Sana Karam, MD, PhD

@KaramLab

1 year

@KimpleRandall @pipcosper @carmenbergom @AKesarwala @LisaSudmeier And thank you to all the selfless Randies on the planet who will go the extra million mile to support the cause on this day, and every day…for the true friendship that makes it all worth it…

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Sana Karam, MD, PhD

@KaramLab

10 months

Great and elegant Keynote by the dynamic super⭐️, Brian Brown ⁦ @AACR ⁩ #AACR -AHNS

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Sana Karam, MD, PhD

@KaramLab

2 years

@TylerSbrt @AmarUKishan @ndesai2005 @PottersMD I would also add, we learn from industry…and they learn from us… that dialogue is critical to advance radiation combinations to our patients. Even the NIH supports partnerships with industry…

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Sana Karam, MD, PhD

@KaramLab

1 year

In the context of Immunotherapy (IO), ENI: • reduces effectiveness of RT IO • increases mets,distant tumor growth • reduces systemic immunity • reduces antigen-specific T cells in Blood, distant DLN, & distant Tumor • decreases TIL's distantly

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Sana Karam, MD, PhD

@KaramLab

1 year

• sentinel DLN resection or irradiation eliminates regional metastasis • nodal resection before RT IO ablates response

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Sana Karam, MD, PhD

@KaramLab

2 years

@rweichselbaum @JReinerMD @smerconish It teaches you how to think. It’s the process. It’s synaptic pruning and neuron fitness… you get rid of the sciences and the liberal arts and medicine is nothing but vocational training…

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Sana Karam, MD, PhD

@KaramLab

4 months

@imrtlee @DavidSherMD Go, go go!!! And next one maybe a Javelin like study by with this dose & approach and maybe sanz elective anything !🙃 Let the gates of opportunities open. 🙌🏽 You figured out the dose. NOW the IO & other targeted therapies may have a shot. Maybe even single shot 8gy +io😉

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Sana Karam, MD, PhD

@KaramLab

1 year

@DrHaddadRobert @nicholslab1 @DrTonyEskander @DrJohndeAlmeida @duvvuri_md @DrNeilGross @Sadeghi11111 @imrtlee @sueyom Too complicated to answer on Twitter. We need to have a conference dedicated just to neoadjuvant treatment :) The devil is in the detail…what , where, how…

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Sana Karam, MD, PhD

@KaramLab

4 months

@xrtGenomics @JCO_ASCO @MSKCancerCenter @imrtlee This is paradigm shifting: lays the foundation for future trials aimed at reducing chronic IFN stimulation, especially in the context of other therapeutics & underscores the importance of over-treatment. Thank you for doing this work, for daring to challenge the SOC!💪👏

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Sana Karam, MD, PhD

@KaramLab

5 months

@imrtlee @rweichselbaum @DrewMoghanaki @AltorkiNasser @Mat_Guc @SchneidersFamke @JieDengMDPhD @theabzlab @max_diehn @ajuloorimd @SeanPitroda @_ShankarSiva @DoctorJSpicer Look forward to seeing the data, Nancy. The devil is always in the detail and always grateful to see translational science to explain any effect…🥂

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Sana Karam, MD, PhD

@KaramLab

11 days

@HenningWillers @rweichselbaum Kevin is on point! Can't wait to see ATRi in trials in HNSCC...As for ICIs, the devil is in the details, as he rightfully points out. Thanks for the live coverage, Henning!

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Sana Karam, MD, PhD

@KaramLab

2 years

@ParikhSimul @Barnes_J_M Talent comes in different shapes and forms😊. Here’s to diversity 🥂!

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Sana Karam, MD, PhD

@KaramLab

1 year

@GeneCollector I believe he was also irradiated…

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Sana Karam, MD, PhD

@KaramLab

1 year

@CJTsaiMDPhD @DavidSherMD @xrtGenomics @imrtlee @sueyom @seanmmcbride Couldn’t agree more. The science shall speak…in due time. And for the record, regional failure was observed in preclinical models….To be continued.

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Sana Karam, MD, PhD

@KaramLab

3 years

Although complement is mostly known for its role in response to bacterial infection, our latest article highlights role of the complement system in development of the regulatory T cell response in HNSCC #JITC #CancerResearch

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Sana Karam, MD, PhD

@KaramLab

7 months

@HenningWillers @ASTRO_org Independent of the rad bio or the mechanism, the empirical data are fantastic and represent a great moment for our patients. Going from 35 fractions to 20 is to be celebrated. Hoping we can push the needle further… but this is a step forward and the authors are to be🙏🏾

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Sana Karam, MD, PhD

@KaramLab

1 year

@andyjminn Except most had no tumor left at the time of surgery, especially once we established the right RT dose and time to surgery. Systemic effector memory was there PREOP. Give the immune system time after a kick and it knows what to do…

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Sana Karam, MD, PhD

@KaramLab

3 years

Congratulations to our graduate student, Laurel Darragh, for getting her F31 funded!

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Sana Karam, MD, PhD

@KaramLab

1 year

@NiuSanford Oh my gosh… I can’t even begin to imagine the pain of losing a child, Nina. Beautiful girl. Why does life has to be this unfair..I am so sorry… Big hug to you.

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Sana Karam, MD, PhD

@KaramLab

1 year

@DrNeilGross @NEJM @ASCO Ever wonder what would happen if you add just a tad of RT! Just uno dose… Maybe all will be CRs 🤔

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Sana Karam, MD, PhD

@KaramLab

7 months

@DavidSherMD @DrChowdharyMD @DrMLChua @DrGopalIyer @jdschoenfeld1 @KimpleRandall IMvoke010 also but that’s adjuvant…. Regardless, I hope we can figure out ways to give less, not more. Part of that will involve figuring out why the concurrent is failing… principle contribution analysis is necessary….

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Sana Karam, MD, PhD

@KaramLab

1 year

@curadonc The @KaramLab and @dalessandrolab are proud of you, Blake!

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Sana Karam, MD, PhD

@KaramLab

2 years

@Joyce_Karam Love the name… and the directness:)!

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Sana Karam, MD, PhD

@KaramLab

1 year

@DrMLChua @DavidSherMD @CJTsaiMDPhD @mikemejiamd @lachiemcd @henson_md @Dr_AliHosni @H_N_C_I_G @sueyom @naummalik @IJROBP Who isn’t a fan! How could one not be! @DavidSherMD rocks and so does this biologically sensible study. Keep it coming!

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Sana Karam, MD, PhD

@KaramLab

3 years

Use of radiation therapy in PDAC has come under scrutiny for leading to worse outcomes, our recent work by Adam Mueller and Miles Piper explains this result and highlights a combination therapy to make radiation more powerful without the negative effects.

Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal...

Stromal fibrosis activates prosurvival and proepithelial-to-mesenchymal transition (EMT) pathways in pancreatic ductal adenocarcinoma (PDAC). In patient tumors treated with neoadjuvant stereotactic...

pubmed.ncbi.nlm.nih.gov

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Sana Karam, MD, PhD

@KaramLab

3 years

Congratulations to our past fellow, Dr. Adam Mueller, for receiving his RSNA research scholar grant. Well deserved!

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Sana Karam, MD, PhD

@KaramLab

1 year

@theabzlab Define radiation immunotherapy, please. What’s the dose, fractionation? What’s the setting ng? What’s the IO? How many cycles? And what’s the sequencing. And maybe not the best discussion for Twitter.

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Sana Karam, MD, PhD

@KaramLab

2 years

@KimpleRandall @xrtGenomics @GeneCollector @imrtlee @rweichselbaum @HenningWillers @seanmmcbride @jdschoenfeld1 @DrHaddadRobert @sueyom Awww. Thank you. Coming soon…can’t wait to share.

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Sana Karam, MD, PhD

@KaramLab

2 years

@DrNabilSaba @myESMO @eaonc @WinshipAtEmory Why? Is there a single preclinical study that shows that? This is expected and predicted. I would be extremely cautious about drawing that conclusion. What failed is the trial design, within this combination, fractionation, coverage, and sequencing. NOT immunotherapy in HNSCC.

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Sana Karam, MD, PhD

@KaramLab

1 year

@PamelaKunzMD And let’s also try to question the need for surgery. As Ralph @rweichselbaum stated in another tweet, organ preservation is a good thing.

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Sana Karam, MD, PhD

@KaramLab

1 year

@Joyce_Karam Go Morocco 🇲🇦!!!!!

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Sana Karam, MD, PhD

@KaramLab

1 year

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Sana Karam, MD, PhD

@KaramLab

10 months

@DavidSherMD I was away from Twitter today and missed this masterpiece! Way to design sensible, biologically rational, trials! Thank you, Dr. Sher, for pushing the field forward.

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Sana Karam, MD, PhD

@KaramLab

2 years

@JulieSchwarz14 @JieDengMDPhD @aadel_chaudhuri @SprakerMDPhD @pipcosper @freddyeescorcia @ParikhSimul @rweichselbaum @KimpleRandall @Samuel_Bakhoum @AKesarwala @GeneCollector @DKirschMDPhD @max_diehn @kenpitter @SMarkovina2 @Katie_Spina @YvonneMowery @RPatelMDPHD @HSkinnerMDPhD @HMcGeeMDPhD That would be tragic…we need to emphasize more the basic science… mechanistic science…that is what pushes discovery. Translation unrooted in the basic will fail like the vast majority of trials… it’s a tough road but admitting and celebrating those is where success lies…

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Sana Karam, MD, PhD

@KaramLab

1 year

@IBCradiation @IBC_DanaFarber @MDAndersonNews @FilipaLynce Fillipa was my co-resident during internal medicine. So wonderful to see this brilliant, hardworking, big hearted woman push the research forward!

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Sana Karam, MD, PhD

@KaramLab

2 months

@CJTsaiMDPhD @RadMedPM @pmcancercentre @UHN @ldawsonmd @DKirschMDPhD @ScottBratman You are too kind. ❤️ Thank you so much for the invitation 🙏🏾

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Sana Karam, MD, PhD

@KaramLab

1 year

•CPS and PDL1 expression do not correlate with response •CD4 memory and CD8 memory cells in the blood are correlates •T cell infiltration is increased in responders, CD8 T cells are closer to cancer cells in responders •CD8:Treg ratio a strong correlate of response

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6

Sana Karam, MD, PhD

@KaramLab

1 year

@dalessandrolab @travisnemkov @doctorinigo @ecmatlas Congrats, Angelo and team!

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6

Sana Karam, MD, PhD

@KaramLab

7 months

@rweichselbaum @CJTsaiMDPhD @ASTRO_org You can say it, Ralph. If you don’t, who will. This is too important…

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Sana Karam, MD, PhD

@KaramLab

1 year

@UHN @DKirschMDPhD @DukeRadOnc @pmcancercentre @PMResearch_UHN @RadMedPM Congratulations, David. PMH made a fantastic choice. Looking forward to seeing the great things you will build and grow.

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Sana Karam, MD, PhD

@KaramLab

1 year

@ArndtVogel @CellRepMed @myESMO @OncoAlert Or with radiation…

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6

Sana Karam, MD, PhD

@KaramLab

1 year

New Treatment For Pancreatic Cancer—The Most Lethal Of Cancers—Offers Hope

“I’ve never been more hopeful about the possibility of improving the survival rate for this disease,” said researcher Sana Karam, who noted the animal study could change the way doctors treat the...

www.forbes.com

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Sana Karam, MD, PhD

@KaramLab

2 years

@GeneCollector @winsoncheung @MyriamChalabi @myESMO @OncoAlert @OncOutcomes @coloncanada BINGO! The power is in the biomarker. The response is very exciting, but predicted. Let’s think of other attractive alternatives that could likely generate the same response for these 🔥tumors and could be more applicable across global world…

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Sana Karam, MD, PhD

@KaramLab

2 months

@HenningWillers @theNCI @RRS_RadRes @ASTRO_org @_MichaelBaumann @SorenBentzen @rweichselbaum @TedHong9 @KrauseProf @gillies_mckenna @StevenLin_MDPhD @NCICTEP_ClinRes Oh no 😢 He was a class act and in addition to kindness and wit, he was such a global health advocate…

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6

Sana Karam, MD, PhD

@KaramLab

7 months

@seanmmcbride @DrMLChua I saw that. But look at @colbertle response… underperforming in both arms relative to SOC… But yeah, maybe also different TME

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Sana Karam, MD, PhD

@KaramLab

1 year

@cd_fuller @DrNeilGross @RajasekaranMD @JAMAOto @JAMANetwork @duvvuri_md @HNSurgeon @gentile_radonc @ShlomoKoyfmanMD @YvonneMowery @ASTRO_org @ASCO @CancerCareMASCC @isooworld De-escalate treatment…and maybe don’t do protons for HNSCC until we have evidence of superiority.

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5

Sana Karam, MD, PhD

@KaramLab

5 months

@CJTsaiMDPhD @DYerramilli_MD @AmyXuMDPhD @ErinGillespieMD @safaviaa @JoannaJavor @RadMedPM @ASTRO_org @RebeccaKSWong @ChadTangMD @drdavidpalma Congratulations, Jillian on such great work. Here’s to early integration of SBRT for oligoprpgressive disease.

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Sana Karam, MD, PhD

@KaramLab

1 year

@pipcosper Girl, this is AMAZING!!! CONGRATULATIONS, Pippa!♥️♥️♥️ With THIS you’re gonna get that R01 before age 60, which means you’ll have to renew😆 I know what we will be discussing for the next JC!🎊👊🏽🥳🎉👏🏾🙌🏽🎊💪🏽

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Sana Karam, MD, PhD

@KaramLab

3 months

@JNCI_Now @IBCradiation A step in the right direction. Kudos to the JNCI for doing this. May others follow suit.

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