I still have too few words to express the heartbreak, but also need too many words to capture what
@taniguchiMD
was to us. He was a scientist’s scientist and a doctor’s doctor - simply the best. So instead, a tweetorial of things I learned from him over the last 8 years:
Two selfies, two BIG days.
#1
) walked OUT of
@MDAndersonNews
on my last day of residency, the best training program I could have imagined.
#2
) walked back IN to
@MDAndersonNews
, thrilled to start on faculty as an Asst. Prof. Physician Scientist in
#RadOnc
!
5. Be “one of the good ones.” He used this phrase to describe mentors, trainees, or collaborators. It had a specific meaning that those of us in his lab understood. My lab handbook opens with the following text - a detailed description of how to be “one of the good ones.”
1. Dream Big. One of our first meetings, he brainstormed with me. I would throw out an idea. “That’s too small. Dream Big,” he said. Another. “Bigger.” That’s getting expensive. “No problem.” It was always First, get excited about the science. Second, figure out how to do it.
Recently, a postdoc candidate reached out to me, but her work was more in line with Cullen’s - so I sent her to him. Last week, I got this follow up email from her. It’s remarkable because it’s NOT remarkable. This sounds just like mine and many others’ first encounters with him.
I watched him do this for one person after another - help them move towards what they were good at until they figured it out for themselves, and then the door was in front of them because he’d been pushing them towards it. I know many trainees will recognize this feeling.
4. Give honest feedback with kindness. While he was always a cheerleader and a sponsor in public, he wasn’t afraid to give (sometimes brutally) honest, constructive criticism, always in private and always face-to-face.
Study on Female Trainees in
#RadOnc
is out in IJROBP: . 95% of female trainees reported burnout, 80% reported "gender specific biases or obstacles", 30% reported unwanted sexual advances. Great work by
@S_W_R_O
&
@ARRO
w/ mentorship by
@reshmajagsi
!
But when he convinced me to teach a “Basic Biostatistics for Translational Researchers” course, he was right there in the front row of every class, taking notes.
2. Dream Big, Even for Those Who Can’t See Their Own Dreams Yet. From the very beginning, he always told me I was going to be a physician scientist someday. I would laugh and remind him that I didn’t even have a PhD — and I REALLY didn’t like mice. It didn’t matter to him.
1/ 🔬🧫Tumoral lactic acid bacteria can rewire tumor metabolism and drive cancer treatment response. Our
@cancercell
paper is finally out
#openaccess
online! 🦠🔬
3. Be Humble and Always Keep Learning. He ALWAYS told me that he was going to learn statistics. When we worked on a clinical trial together, he put me in the meetings with the CEO’s, the FDA, and told everyone I was the expert (dubious judgement).
Happy Graduation Day to the BEST class of co-residents I could ever have asked for. (Somehow) we made it! Can't wait to see what the future holds for this great crew.
@shanestecklein
@AmyMorenoMD
@PennyFangMD
New in
@JAMAOnc
today: Randomized Phase 2 Trial from
@mdandersonnews
shows 12-16Gy Single-Fraction RT Provides Superior Pain relief to 30Gy in 10fx in Patients With Nonspine Bone Metastases as early as 3 months (38% vs 21%)
I got plenty (“Sometimes when you say something you actually know, it comes across as a question or suggestion.” “I love the way you write, but your figures need a LOT of work.” “You can NOT put math OR statistical equations in presentations if you want people to listen.”)
Happy Mother’s Day to all the
#momsinmedicine
out there. Even though the days are never long enough, and you feel like you’re always failing at something, you are amazing! I’m a better doc b/c of them!
@S_W_R_O
#WomenWhoCurie
#radonc
Very important statement from
@AmericanBrachy
- brachytherapy for cervical cancer is not an elective procedure, and shouldn’t be replaced with EBRT if at all possible.
#brachytherapy
is a life-saving procedure.
#gyncsm
Just published
#OnlineFirst
: Expansion of Candidate HPV-Specific T Cells in the Tumor Microenvironment during Chemoradiotherapy Is Prognostic in HPV16+ Cancers by
@AnnKloppMD
,
@colbertle
, and colleagues.
Check out our new
#microbiome
paper looking at associations of patient-reported GI toxicity with gut microbiome diversity and composition in patients undergoing CRT for cervical cancer
🚨 ‼️ Applications now open for PAID summer science research opportunities
@MDAndersonNews
for high school, undergrad,
#gradstudents
,
#medstudents
! One of my fave things is the excitement, creativity and fun of our summer lab students.
Clinically, I'll focus on gyn cancers
#gyncsm
and palliative radiation
#pallonc
. My lab will focus on computational approaches to multi-platform biomarker discovery and validation for radiation response in HPV+ cancers. (We'll be hiring - DM me or email me!)
Check out our article now online looking at dose escalation for pancreatic cancer
#sbrt
! Trial currently underway escalating to 60Gy in 5fx.
#pancsm
@TaniguchiMD
@advancesOA
Full-text now available for our recent work demonstrating gut functional microbiome communities associated with more aggressive cervical cancers. We've spent a while on this approach to metagenome analysis and glad to share it with the twittersphere!
Accommodations are there to allow everyone equal opportunity, not equal outcome. It's about equity, not equality. And if you need a reminder as to what that is see below: /10
New Article confirming what we already know- Rates of cervical cancer screening down 40% during pandemic. We’re seeing large jump in symptomatic cancers vs. screen detected cancers in Rad Onc. How do we get the word out?
#gyncsm
#cervicalcancer
#gynonc
New in
#Lancet
today: Great that female faculty in academic medicine inc to nearly 50%, but tenure track and tenured female faculty remained flat at only 37% and 18%.
#ARM
#WomenWhoCurie
What do medstu's want? Pt contact, intellectual stim, and job flexibility. That nicely describes the core of RadOnc IMO. Women esp want job flexibility. We just need access to pitch the field!
@d_golden
#meded
#radonc
.
Paper out! Great work team! Selective EGLN Inhibition Enables Ablative Radiotherapy and Improves Survival in Unresectable Pancreatic Cancer | Cancer Research
@TNKFujimoto
@TaniguchiMD
@MDAndersonNews
No words can describe how proud I am
@SteveHahnMD
new FDA Commissioner. Humbled & honored to have called him “boss” for the past 2.5 yrs- servant leader, inspiring, charismatic, visionary, caring, generous soul - he will make a difference (as always)! With deep admiration!
Thanks
@Cancer_Cell
for letting us share our perspective. The
#COVID19
crisis is hard not only for our current patients but future patients affected by research shutdowns.
@b_harris_12
@tangming2005
This. Wet lab biologists are plenty smart enough to learn how to code. But learning to code without understanding foundations of biostatistics is useless/ dangerous. A chapter to introduce data quality, analysis design, interpretations of unsupervised analysis etc would be key.
@colbertle
Presents the work at
@MDAndersonNews
to provide rapid access to Radiation Therapy for patients with bony metastases: they shortened time to treatment and improved multidisciplinary care, using EMR to triage.
#pallonc18
We love PFS in oncology- not saying it shouldn’t be used or approved, but pts should know when a tx is approved/ offered that it may not improve OS or QoL and be allowed to say No Thanks.
#shareddecisionmaking
Great to be back in person for
#RadRes2022
in Hawaii! Poster session featuring several of our lab members presenting their hard during-COVID work. Brief poster walk:
But I'm also grateful for the real MVP's - my family. I literally could not have done this without you. Beyond excited for the future and excited to be starting a dream job I didn't know was possible!
#womenwhocurie
#momsinmedicine
#radonc
#gyncsm
#pallonc
Great grand rounds by my super talented
@MDAndersonNews
colleague
@shanestecklein
talking about the role of cholesterol metabolism in IBC and cool method of quantifying post radiation DNA damage repair!
#bcsm
#endcancer
So, I gave grand rounds at
@MDAndersonNews
today.
#medstudents
, lest you ever see someone give a big talk and think ”he/ she is just a good public speaker and I’m not,” know that I (and probably they) practiced this at least 538 times.
#realtalk
#meded
Do you love
#radonc
? Let's form a group of people
@ASTRO_org
: residents, jr attendings, mid-career, senior; Chairs, academics, private practice, hospital-based, free-standing, West, East, Midwest, South, Southeast, rural, suburban, and urban areas championing our field. 1/2
I know I’m not supposed to pick favorites, but this might be my favorite thing our lab is doing right now. Come visit Rui Wang at her poster to see how she’s growing patient derivoid cervical cancer organoids from non-invasive cytobrushes!
#RadRes2022
@VinayPrasadMD
@dlawtao
Completely agree- but I would also add that it’s not necessarily a failure of medical student/ resident educational systems, but a difficulty in finding people able/ willing to teach fundamental statistics in a way students can understand!
Great advice on establishing a mutually respectful environment in academic medicine from
@NarjustDumaMD
: 1)address issues within 24 hours 2) introduce all members of the team up front and by professional titles.
#ASCO19
Wonderful to see the latest adjuvant
#pancreaticcancer
data at ASCO. The PRODIGE-24 trial showed 54 month mOS for mFOLFIRINOX and almost doubling of DFS. I hope to see these kinds of numbers continue in pancreatic cancer trials!
Check out the consensus statement
@ARRO_org
put together to summarize
#radonc
#resident
feedback to
@acgme
from over 170 residents. Thanks to everyone who provided feedback.
The ARRO Exec Committee would like to share with
#radonc
residents & educators the consensus statement submitted to
@acgme
in response to the proposed residency accreditation revisions. Your feedback was vital in compiling this statement!
@ACROresident
MGM2 status... it’s not just for GBM anymore! MGMT methylation was associated w/ better OS and PFS even when accounting for IDH1/2 status in high risk LGG.
#btsm
@goharmanzar
perseveres despite an airline mishap and a lost poster! Outstanding work describing changes in the tumor T-cell repertoire before and after brachytherapy for cervical cancers. Brachy has important T-cell effects!
As scientists, we KNOW that a
“Commitment to…address racial inequities, including past and current racial discrimination and structural, systemic, and institutional racism in education.” Makes SCIENCE BETTER and drives innovation! Data provided in link.
**update** Paper submitted at hour 23.5/24!!
@biorxivpreprint
pending- will post! Only downside- high bar set for new Colbert Lab member
@MakMakMoose
- who now thinks we write a paper every day. Great teamwork led by
@bsv_chapman
!
Important thread below. Right now scientists are front and center, but after this pandemic passes, and labs have been shuttered,
#DontForgetTheScientists
.
A year ago, I was celebrating my birthday with a
#NOA
for my first
@NIH
R01 grant. Today, I, along with thousands of other scientists, have closed their labs to
#FlattentheCurve
, knowing full well that their research may never recover
Congratulations to the recipients of the 2020 Student Awards in Oslerian Medicine. These awards provide monetary support for the education of medical students whose performances and conduct exemplify those ideals of medical practice set forth by Sir William Osler.
When
@TaniguchiMD
asked me to speak at a research town hall 6 weeks ago, I was surprised & honored. He invited me with such enthusiasm—it was evidence of his sponsorship for trainees and building us up. He offered to review my slides just 3 days before his untimely passing 1️⃣/🧵