If you missed the
#ASH23
Education Session by Dr.
@mana1981
on CAR-T vs BiTEs in LBCL, our manuscript discusses pros and cons and our sequencing algorithm. If available, our preference is for CAR-T given its curative potential in real-world cohorts.
#lymsm
The most important trial at
#ASH22
: NEUTRODIET, a randomized multicenter trial of 'neutropenic diet' vs normal diet after auto/alloSCT. No differences in infections, aGHVD or hospital days between arms. Less weight loss & better patient satisfaction in normal diet arm!
#tcellrx
All packed for Colorado! Elated to announce that I will be starting as an assistant professor at
@CUAnschutz
later this summer specializing in lymphoma and myeloma. See you soon, 5280 crew! cc
@CUHemeOnc
@CUHematology
Why
#primarycare
is one of the hardest jobs in medicine: a thread by a soon-to-be-graduating internal medicine resident.
#meded
#medtwitter
It's 4pm on a Wednesday afternoon in resident clinic. Next is a 20-minute appointment for a 60-year-old woman for "sinus infection."
(1/x)
Calling all trainees interested in
#hematology
:
The 2021
@ASH_hematology
Hematology Review Series is now open! It's a free online curriculum about a ton of hematology topics.
Big thanks to the whole crew at the ASH Trainee Council who helped develop it!
I was feeling overwhelmed by all the laypress articles about
#moralinjury
and
#burnout
in frontline health care workers during
#Covid_19
so I decided to do a deep dive into the literature on the mental health of workers during pandemics.
Here's what I found.
#thread
1/
Preparing for my first
@ASH_hematology
oral presentation at
#ASH22
! We have much more work to do for patients with relapsed lymphomas after CAR-T.
A huge thanks to my mentor Dr. Kline
@UChicagoHemOnc
and all of our participating centers.
#lymsm
#tcellrx
We are elated to announce the inaugural issue of Hematopoiesis, a new publication by the
@ASH_hematology
Trainee Council.
A re-imagining of the previous ASH TraineE-News newsletter, take a look at our fresh, new publication by and for
#hematology
trainees.
#thread
1/
Cracked open my mother's clinical oncology book from 1978 (just 327 pages!). Check out the chapter on "The Malignant Lymphomas, Multiple Myeloma, and Macroglobulinemia" and all these regimens! Totally fascinating.
#lymsm
#mmsm
Elated to announce that I was voted Vice Chair of the
@ASH_hematology
Trainee Council! I will be succeeding the illustrious
@Lachelle_Dawn
as Chair in June 2021. I'm eager to help ASH become an even more inclusive organization for all hematology trainees.
#hematologyproud
My husband this morning imagining out loud what my life must be like on consults:
"I cut this patient's arm off and now their hemoglobin is low. Could it be MDS?"
👀👀👀
My first year of being a lymphoma attending is simultaneously terrifying, exhilarating, and deeply humbling. ✨This✨ is drinking from the fire hose. Please tell me I'm not the only one. 😂😂
#lymsm
#hemetwitter
Calling all trainees interested in
#hematology
!
We are seeking writers for Hematopoiesis, our
@ASH_hematology
ASH Trainee Council publication by and for trainees:
All levels of trainees can contribute. Submit your articles here:
Our multicenter study of checkpoint inhibitor outcomes in the post-CAR-T setting is now published in full
@BloodAdvances
. Response rates & survival are poor with these agents and novel approaches (such as bispecifics) are needed.
#lymsm
#celltherapy
As a lymphoma doc, I am very interested in how active surveillance ("watch and worry") affects
#qualityoflife
in patients with indolent lymphomas. Follow along in this
#thread
for our recent paper looking at longitudinal QOL & PROs in this specific population.
#lymsm
1/
My first time at the
@ASH_hematology
HQ in D.C.! I'm representing the ASH Trainee Council at today's Committee on Training meeting to plan for ASH-a-Palooza at
#ASH22
. Get excited for NOLA!
#ASHTrainee
Late night publication of this phenomenal piece on
@inHouseMag
by an internal medicine resident and PhD anthropologist who lived in Wuhan on radical changes needed in our infection control practices.
#covid19
#covid4MDs
#PPE
#CoronavirusUSA
Excited to announce that I'll be co-hosting the inaugural LGBTQIA+ Community Networking Brunch at
#ASH22
! 🩸🏳️🌈🎉
Mark your calendars: Sunday, December 11, 2022, 11:15-12:15 PM.
Huge thanks to the
@ASH_hematology
DEI Committee for supporting this new event!
#ASHTrainee
Pembro+AVD in 1L cHL
#ASH23
:
- 50 pts, mF/U 2.3 yrs
- 2-yr PFS 97%, OS 100% (!!!), including adv-stage pts (look at those curves!)
- iPET2 not prognostic (and some EOT PET+ pts still without PD)
Will have to rethink PET with CPI (role for ctDNA!)
#lymsm
Elated to announce the
@JCOOP_ASCO
publication of our mixed-methods study of pandemic's impact on heme/onc trainees, with my co-author
@UDurani
and spearheaded by
@Lachelle_Dawn
. Full tweetorial thread to follow when partner piece is published.
#MedTwitter
Happy
@ash_hematology
week! After reviewing all the patient-reported outcomes (
#PROs
) abstracts at
#ASH21
this year, I'll be summarizing my top 20
#MajorPROs
abstracts in this
#thread
. Follow along for a slew of thought-provoking (and provocative!) studies.
After a year of hard work with the
@ASH_hematology
Trainee Council, we are elated to announce our new
#podcast
, Hematopoiesis!
Check out the teaser episode with
@Lachelle_Dawn
and I:
And stay tuned for the new Hematopoiesis newsletter in a few weeks!
Kite just announced a significant overall survival benefit (!!!) of axi-cel from the ZUMA-7 randomized trial as compared to ASCT in second-line high-risk DLBCL. Hoping to see the data at
#ASCO23
.
#lymsm
#celltherapy
HT
@Eddie_Cliff
Deeply honored that our
@ASH_hematology
#ASH22
abstract on outcomes of checkpoint inhibitors after post-CAR-T relapse will be featured in Highlights of ASH. Many thanks to all our collaborators. Manuscript is on the way! ✍🏽✍🏽
#lymsm
#celltherapy
Get ready for some serious tweeting at
#ASH22
! Check out the
@ASH_hematology
social media guide and be sure to follow all of us for live updates during the conference.
#ASHKudos
Check out our latest article on Hematopoiesis, the new
@ASH_hematology
ASH Trainee Council publication by and for trainees:
@CEKanakisMD
&
@KMirza
contribute a Morning Report review on the
#hemepath
basics of the bone marrow biopsy, with virtual slides!
As a lymphoma doc, I am particularly interested in how active surveillance ("watch and wait") affects QOL in patients with indolent lymphomas/CLL. Check out our just-published study in a real-world cohort! Thread coming tomorrow.
#lymsm
#qualityoflife
Elated to see our review of R-CHOP vs DA-R-EPOCH on the front cover of
@clinadvances
!
(tl;dr: I read all of the R-CHOP papers so that you don't have to -- Table 2 breaks it all down.)
#lymsm
You know
#ASH21
is back in full swing when you have drug ads waiting on your hotel door, a sick view from the hotel, and even an
@ASH_hematology
-branded ferris wheel. Get pumped for a great weekend!
Huge
#ASH23
meta-analysis by
@KRejeski
et al. demonstrating 1) 58% of CAR-T studies don't report NRM, and 2) 48% of CAR-T-associated NRM is caused by infections. Other interesting point: 6% of NRM caused by second cancers?
#lymsm
#mmsm
#celltherapy
In my (very) short tenure as a lymphoma doctor, I have tremendous respect for the first cycle effect in older folks receiving R-CHOP for DLBCL. Huge fan of prephase treatment and steroids to help mitigate, as well as anti-infective prophylaxis and a mid-C1 symptom check.
#lymsm
New standard of care for CLL/SLL: zanubrutinib with better PFS than ibrutinib (especially in patients with TP53 mutations), and also less toxic, with no cardiac deaths with zanu versus 2% in ibrutinib arm.
#lymsm
#leusm
#ASH22
Eagerly awaiting Dr.
@CwynKate
's
#17ICML
talk this morning
@icmlugano
on the management of primary & secondary CNS lymphomas. Wonderful consensus paper is now online, and the figures (included the CNS prophylaxis figure below) are phenomenal!
#lymsm
"This study suggests credit score may have a utility as a companion to traditional metrics used in identifying candidates for surgery residencies and fellowships..." 😱😱😱
Who on EARTH thought this study was a good idea?!
#meded
My last official
@ASH_hematology
ASH Trainee Council meeting. Handing over the reins to the illustrious Dr.
@beckyzon
, who is already driving multiple new initiatives for the hematology trainee community. Deeply honored to have worked with this phenomenal crew. 🥰🥰
#ASHTrainee
Applications for the
@ASH_hematology
ASH Trainee Council are now open! It's a phenomenal opportunity to shape the future of hematology training. Check out the link below for instructions on how to apply; applications are due April 29.
#ASHTrainee
Deeply grateful to all our co-investigators and my
@UCCancerCenter
fellowship mentor Dr. Kline for the opportunity to present our study of poor outcomes with checkpoint inhibitors in the post-CAR-T relapse setting at
@ASH_hematology
#ASH22
today.
#lymsm
Covering our inpatient BMT service this weekend so that our wonderful
@CUHematology
APPs can enjoy their annual retreat! Huge thanks to all our NPs and PAs for their expert management of our patients.
#weekendvibes
The one and only Dr.
@acweyand
(who I finally met!) giving a main stage ASH-a-Palooza talk about using social media as a hematologist.
#ASH22
#ASHTrainee
We are thrilled to announce that current 2nd-year fellow
@majorajay
will be serving as chief fellow for the 2021-2022 academic year! Dr. Major has been an incredible advocate for trainees at U of C & through the
@ASH_hematology
Trainee Council, we are a lucky fellowship program!
AFM13-complexed NK product for R/R CD30+ cHL at
#DenverASHReview
: 42 pts, no CRS/ICANS or GVH, ORR 97% (78% CR!), most of which had previous BV. DOR still not great due to NK persistence issues, but very promising early-phase data.
#lymsm
cc
@BradHaverkos
Best morning snack to begin the last day of
@ASH_hematology
#ASH22
. It was great to network with all you brilliant hematologists! Please do stay in touch (and will hopefully see some of you at
#ASCO23
.)
#lymsm
#mmsm
Rituximab for EBV+ after solid organ tplant to prevent PTLD
#ASH23
:
- 2168 pts (!!!), median time SOT➡️EBV+ 688d
- 1.6% of pts who received R got PTLD
- 10% of pts didn't get R got PTLD
- OR 0.15 for PTLD in pts who got post-SOT R
Huge cohort!
#lymsm
Excited to see all you
#ASH21
trainees at
@ASH_hematology
ASH-a-Palooza tomorrow! Quick reminder to register and pick up your badges at the convention center before heading over. Your vaccine status has to be verified beforehand.
#ASHTrainee
Phenomenal study
@ouholter
of at-home transfusion support during hospice. Transfusions = improved symptom burden, no hospice revocations, only 3 units given, and all pts died at home.
#ASH22
#hpm
#geripal
BsAb➡️CAR outcomes
@gloria_iacoboni
#ASH23
:
- 47 pts got BsAb before CAR apheresis
- median BsAb 98 days; median washout 43 days
- post-CAR: ORR 83% (no diff based on prev BsAb response), mPFS 6.6 mos, mOS NR
- no diff in PFS/OS re: washout timing
#lymsm
After our two recent publications
@JCOOP_ASCO
on the experience of hematology/oncology trainees and program directors during the
#COVID19
pandemic, let's dive into our findings and other literature re: how
#meded
can provide better support.
Follow the
#thread
! ⬇️⬇️⬇️
#fellowship
DLBCL is multiple diseases! Saving these slides from
#DAVAWhistler2022
on the evolving genetic landscape of DLBCL and rational targeted agents. Last slide is the basis for TEDDI-R in CNS lymphoma.
#lymsm
cc
@SoniSmithMD
PD1 before ASCT in R/R cHL
#ASH23
:
- 981 pts (!!), 20% PD1 / 32% BV before ASCT
- 2-yr PFS 93% with PD1 (vs 74% with BV & 72% with chemo); no diff in OS
- similar PFS & OS in PD1+BV vs PD1+chemo
Great confirmatory data. Love pembro-GVD!
#lymsm
There is a hidden curriculum within academic heme/onc which devalues clinician-educators and
#meded
research, despite pressing needs for both. Dedicated training pathways and grant support are vital components of this paradigm shift, particularly in the absence of strong mentors.
To meet future practice demands, oncologists must encourage individuals to pursue careers as educators & support existing clinician-educators.
@MeredithGiulia1
calls for more research & advocacy in this area in a recent
#ASCODailyNews
editorial 👩🏫
Okay, but getting a shout-out citation during the
@FDAOncology
ODAC meeting on pola-R-CHP was not on my 2023 bingo card. (Huge thanks to Dr.
@SoniSmithMD
for her mentorship on our paper!)
#lymsm
Hearing patient-reported outcomes being collected in almost every one of the
#ASH22
late-breaking abstracts is phenomenal. How far we've come as a hematology community. Looking forward to seeing the results in print!
@ASH_hematology
10-yr CLL12 follow-up results
#17ICML
- 363 pts with asympt CLL at increased risk randomized to placebo vs ibrutinib
- ibr arm with improved EFS/PFS/TTNT
- no diff in OS!
- much more cardiotox in ibr arm
Impressive study in the BTK era that supports watch & wait.
#lymsm
Happy
#ASH22
week! After reviewing all the patient-reported outcomes abstracts
@ash_hematology
this year, I'll be highlighting my top 20
#MajorPROs
abstracts starting tomorrow, with new additions I find down in
#NOLA
. Stay tuned!
#MajorPROsASH
Excited for this
#ASH21
plenary session! ctDNA for MRD monitoring in CNS lymphoma. Utility in both diagnosis of CNS involvement as well as detection of relapse.
#lymsm
#thread
🔽🔽🔽
Interested in seeing how quality of life changes in patients after receiving CAR-T? Check out this quick thread reviewing our
#ASH23
abstract about longitudinal PROs incorporated into a prospective CAR-T biobank registry.
#lymsm
#mmsm
#celltherapy
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