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Turajlic Lab @ The Crick Profile
Turajlic Lab @ The Crick

@TurajlicLab

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Cancer Dynamics Laboratory | The Francis Crick Institute, London @TheCrick | tweets by Samra Turajlic own views

Joined July 2019
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
1 year
We're extremely excited to share our work on the evolutionary trajectories of late-stage melanomas. This work was undertaken as part of the PEACE (Posthumous evaluation of advanced cancer environment) study, where patients generously agreed to posthumous autopsy
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
3 years
📰Out NOW in @CancerCell ‼️👉 🎉What underpins anti-PD-1 response in ccRCC? Results from ADAPTeR Phase II clinical trial, bulk/single-cell analysis of longitudinal tumour samples ⤵️(1/15) @royalmarsdenNHS @TheCrick @uclcancer
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
3 years
Two papers OUT NOW in @NatureCancer ‼️ What does the immune response in cancer patients look like after COVID-19 vaccination or SARS-CoV-2 infection? We present results from the #CAPTURE study. Two-part thread (vaccine & infection cohort findings) to follow... 🧵🧵 (1/4)
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
📢 Out NOW @TheLancet Neutralising antibodies vs Omicron after 3 vaccine doses in patients with cancer 💉Solid cancer: 37% had omicron NAbs post-2nd dose; 90% post-3rd 💉Blood cancer: 19% post-2nd; 56% post-3rd 💉 #CAPTUREstudy @royalmarsdenNHS @TheCrick
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
Spontaneous applause for ⁦ @MyriamChalabi ⁩ as she shows the waterfall plot in their study of neoadjuvant IO for dMMR CRC. Astounding! No disease recurrences at this stage. ⁦ @myESMO ⁩ ⁦ @HaanenJohn ⁩
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
The incredible, inexhaustible, ⁦ @peters_solange ⁩ - congratulations on another great meeting ⁦ @myESMO ⁩. #esmo2022 Model #president !
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
Thanks @myESMO for this amazing recognition- and congratulations to inspirational awardees Fatima Cardoso, Bernard Escudier and Karim Fizazi
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
#ESMO22 ⁦ @myESMO ⁩ great programme- congrats to ⁦ @CharlesSwanton ⁩ and ⁦ @FAndreMD ⁩! (and commiserations to ⁦ @DrChoueiri ⁩ and James Larkin for the losses on the football pitch- better get training…)
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
Our super-star colleague @fendler_annika , the first post-doctoral fellow in @TurajlicLab @TheCrick leaves us today after 3 years marked by incredible success. We are extremely proud that she is starting her own group @ChariteBerlin and, even better, working on kidney cancer!
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
4 years
our paper on the role of nonsense mediated decay in tumour immunogenicity @kevlitchfield @SwantonLab
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Escape from nonsense-mediated decay associates with anti-tumor immunogenicity

Nature Communications - The transcripts generated by frameshifts and indels in cancer are frequently degraded by nonsense mediated decay. Here, the authors show that some of these transcripts can...

www.nature.com
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
8 months
Huge congratulations to our colleague @stcshepherd for successfully defending his PhD thesis today! Watch this space for his work on #cancerevolution and #VHLdisease .
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
4 years
The idea came about 5 years ago as we considered ways to overcome intra-tumour heterogeneity in sampling @CharlesSwanton @nelsonralexand1 @andrew .rowan @kevlitchfield . We are now running a trial at @royalmarsdenNHS - for cancer evolution insights and diagnostic development.
@TheCrick
The Crick
@TheCrick
4 years
A team from our @Turajliclab , @Roche and @royalmarsdenNHS has developed a new tumour sampling method that shows a fuller picture of a tumour’s DNA, allowing for better, more personalised cancer treatment. 📰 Read the full story:
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
4 years
We are hiring! Please share this exciting opportunity for a senior computational scientist/bioinformatician to join our group at the @TheCrick to study cancer evolution for patient benefit.
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
Thank you @myESMO , ALL credit goes to the fantastic teams @TurajlicLab and @royalmarsdenNHS #Renal_and_Skin Unit; dream collaborators; supportive funders; and most of all patients and their families for their unreserved commitment to research.
@TheCrick
The Crick
@TheCrick
2 years
Huge congratulations to @SamraTurajlic ( @TurajlicLab ), Crick group leader and winner of the 2022 @myESMO Translational Research Award! 🥂
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
3 years
Our new pre-print What does the antibody & T-cell responses to SARS-CoV-2 look like in cancer patients? Interim report of CAPTURE study: prospective, longitudinal evaluation of 144 patients & 73 healthcare workers (HCWs) (1/7)
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
3 years
❓What could longitudinal sampling tell us about anti-PD1 responses in ccRCC? ✅Maintenance of TCRs in responders ✅Nivo binds pre-existing expanded CD8+ T-cells to enhance cytotoxicity ✅Most HERVs in bulk samples are expressed by immune cells Preprint👉
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Determinants of anti-PD1 response and resistance in clear cell renal cell carcinoma

Antigen recognition and T-cell mediated cytotoxicity in clear-cell renal cell carcinoma (ccRCC) remains incompletely understood. To address this knowledge gap, we analysed 115 multiregion tumour...

www.medrxiv.org
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
3 months
We are extremely proud of our colleague @Ben_Shum_ on successfully defending his MDRes thesis and the fantastic work he’s done on #melanomabiomarkers . Watch this space! Congratulations Ben!🥳🥳🥳 @TheCrick @ICR_London @royalmarsdenNHS @GenomicsEngland
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
4 years
So proud of our team @royalmarsdenNHS . 6 weeks from conception to first study participant for CAPTURE: Covid-19 antiviral response pan-tumour immune monitoring study. We aim to rapidly generate the data required to inform the care of cancer patients in the context of COVID19
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
The international community took >3 years to intervene in Bosnia- after >100,000 Bosnians, children included, died; 1000s were raped and tortured, and>2 million were forced to leave their homes. We must not let Ukraine become another Bosnia #StandWithUkriane
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
1 month
Hugely proud of our colleague @stcshepherd who was awarded his PhD today at the beautiful Guildhall #ICRGrad @ICR_London @TheCrick @royalmarsdenNHS . A fantastic clinician scientist and colleague. So much more to come! Congratulations Scott!!!🎉🎉🎉
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
6 months
Very proud that this work from ⁦ @TurajlicLab ⁩ ⁦ @TheCrick ⁩ ⁦ @royalmarsdenNHS ⁩ #Melanoma GECIP ⁦ @GenomicsEngland ⁩ ⁦ @ICR_London ⁩ was awarded the best poster award in the translational science section of ⁦ @myESMO ⁩ #ESMO2023 .
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
🔥Accepted @CancerCell : After 3 vaccine doses patients with cancer show neutralising antibody (NAb) & T cell responses against SARS-CoV-2 VOCs, but some blood cancer patients likely remain at risk‼️ Pre-print #CAPTUREStudy @royalmarsdenNHS @TheCrick 1/6
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
13 days
Particularly like my lanyard this year @KidneyCancer
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@KidneyCancer
Kidney Cancer
@KidneyCancer
15 days
We are en route to #IKCSEU24 in Spain! Tremendously excited to see everyone for this meeting, to connect, learn, and work towards better outcomes for #kidneycancer patients.
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
3 years
Out now👉: Rare case of CRS in a patient on anti-PD-1 likely related to BNT162b2💉 While it is CRUCIAL cancer patients are prioritised in vaccine programs, prospective monitoring of cancer patients remains important🚨 #CAPTUREstudy @royalmarsden @TheCrick
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
3 years
Great vaccinating with these guys @DrJonLim @lewisjwau Ben Shum- thanks to everyone in the hub for amazing support!
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
@ICR_London @royalmarsdenNHS @c_messiou @SimonRobinson13 @SamraTurajlic @AnnaKirby17 @PETImagingICR @PoulogiannisLab Thank you @ICR_London for this recognition, all credit for our achievements goes to the extremely talented and dedicated teams @TurajlicLab and @royalmarsdenNHS
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
3 years
We are looking for a senior laboratory scientist to join our multidisciplinary group @TheCrick @TurajlicLab to study cancer evolution using unique patient cohorts and cutting-edge technologies. Please re-tweet/share
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
3 years
Amazed by our lab team who have just finished processing today's samples from CAPTURE study as we increase capacity to recruit vaccinated participants. Fantastic support @TheCrick and on the ground @royalmarsdenNHS @royalmarsden - thank you so much
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
What underlies indolent behaviour of small renal masses? Could molecular profiling aid decision making in active surveillance of RCC? Thrilled our proposal to tackle these questions funded @USDOD in a collaborative research partnership w/ @ICR_London
Scientists to develop tools to identify killer cancers

Researchers at the Crick and The Institute of Cancer Research have been awarded a $900,000 grant to develop tools to predict whether a kidney cancer will grow slowly or spread aggressively. 

www.crick.ac.uk
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
Such a proud day for @TurajlicLab #ICRGrad ceremony in the stunning @LondonGuildhall . Chairman prizes for outstanding students @lewisjwau and @SpainLavinia , and for our post-doc @feng_geoffrey for his work in @TheDownsLab @ICR_London .
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
1 year
🔥new paper: Sotrovimab restores neutralisation against current Omicron subvariants in patients with blood cancer🔥 Now published @Cancer_Cell @MaryYiWeiWu @cancerBRC @fendler_annika @stcshepherd @EdjCarr @dremmacbw @TheCrick @royalmarsdenNHS 👇 🧵1/9
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
3 years
we are hiring! clinical fellow in translational research to work on the Skin&Renal unit at @royalmarsdenNHS and collaborate with @TurajlicLab . Would suit a CMT considering oncology or oncology trainee interested in translational research PLEASE RE-TWEET
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
3 years
We are looking for an enthusiastic research scientist to join our lab and work on next generation sequencing methods including single cell sequencing and spatial transcriptomics across unique clinical cohorts. Background in NGS desirable- please DM us! @TheCrick
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
3 years
Team CAPTURE - early morning shift!! 🔬🧪🧫 @fendler_annika @lewisjwau @stcshepherd @TheCrick
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
We are hiring a postdoc in tumour immunology! What makes kidney cancer immunogenic is one of the greatest mysteries in #Immunotherapy #oncology . Be the one to solve it using patient cohorts and models and cutting edge technologies in @TurajlicLab @TheCrick .
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 months
Our report from a clinical trial which started 15 years ago! #melanoma #rarecancers #mucosal #acral . Nilotinib in KIT-driven advanced melanoma: phase II single-arm NICAM trial: Cell Reports Medicine. ⁦ @royalmarsdenNHS ⁩ ⁦ @ICR_London ⁩
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Nilotinib in KIT-driven advanced melanoma: Results from the phase II single-arm NICAM trial

Larkin et al. found that 6/26 patients with a rare melanoma had not progressed after ≥6 months of treatment with nilotinib. These rare melanomas have a mutation in a gene called KIT, and this gene...

www.cell.com
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
9 months
All of us in @TurajlicLab are very proud of Charlotte Spencer and her trail-blazing work in #AI #histology #Rcc and this fantastic collaboration with @OwkinScience - watch this space!
@OwkinScience
Owkin
@OwkinScience
9 months
Hear Dr. Charlotte Spencer, CRUK Clinical Research Fellow at the @TheCrick , discuss how Owkin's #multimodal patient #data approach and collaborations are essential to drive #cancer research projects forward. Are you an early career researcher interested in incorporating…
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
20 days
Sometimes you have to go all the way to California to catch up with your @TheCrick colleagues #AACR24 . Great to see the future of melanoma research @BeckiLee !
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
We are recruiting! talented & creative bioinformaticians to work on unique datasets generated in our lab @TheCrick using cutting edge technologies. DM to find out more or apply here .plsRT @CharlesSwanton @kevlitchfield @landau_lab @NickyMcGranahan
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
3 years
Merry Christmas everyone🎄!! Also wanted to say WELCOME to Husayn and Will who just joined & a BIG THANK YOU to our collaborators and funders for the support through this challenging year. Sending out well wishes to @royalmarsden @TheCrick esp Crick-COVID19 consortium (1/2)
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
4 years
And equally proud of or lab team who are supporting CAPTURE: Covid-19 antiviral response pan-tumour immune monitoring study. We aim to rapidly generate the data required to inform the care of cancer patients in the context of COVID19 @TurajlicLab
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
4 years
How does cancer type & anti-cancer therapy impact anti-viral response in the context of COVID-19? What are the risks in the wider cancer population? CAPTURE is a prospective, longitudinal study set up to address these questions: @royalmarsden @TheCrick 1/6
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Cancer, COVID-19, and Antiviral Immunity: The CAPTURE Study

The SARS-CoV-2 pandemic has posed a significant challenge for risk evaluation and mitigation among cancer patients. Susceptibility to and severity of COVID-19 in cancer patients has not been studied...

www.cell.com
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
4 years
Two opportunities for doctoral fellows in our lab @TheCrick 1. to study non-coding drivers of Renal Cancer Evolution with @HoulstonLab_ICR and 2. to study Renal Cancer Metastases and Treatment Resistance - get in touch!
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Clinical PhD Fellowships - The Institute of Cancer Research, London
www.icr.ac.uk
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
4 years
New tumour sampling method significantly improves genetic testing for cancer treatment @TheCrick
New tumour sampling method significantly improves genetic testing for cancer treatment

A  new tumour sampling method that more accurately detects genetic alterations in tumours, has been developed by researchers at the Crick, Roche and The Royal Marsden. Identifying these alternation...

www.crick.ac.uk
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
Given incremental benefit of 3rd dose esp in blood cancer patients – these data support further vaccine doses in this group High community viral prevalence/transmission will disproportionately impact vulnerable patients 😷
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
13 days
#ThinkTank on Kidney Cancer #EIKCS2024 ⁦ @JBrugarolas ⁩ showing his meeting stamina- always standing up! ⁦ @KidneyCancer ⁩
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
6 months
With ⁦ @ArozarenaImanol ⁩ at the SMR Congress 2023 - congrats to Imanol’s team and collaborators including Sanchez-Laorden lab on their findings on improving immunotherapy efficacy in #melanoma . Watch this space!
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
4 years
Prognostic and predictive impact of circulating tumor DNA in patients with advanced cancers treated with immune checkpoint blockade v cool- congrats to Matt Hellmann and colleagues @sloan_kettering and @AstraZeneca
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
4 years
Not Covid-19 or science related. Today marks 25 years since the worst war crime committed in Europe since the 2WW. 8000 Bosnians were mass murdered over just a few days, after UN failed to protect them. Please join the Memorial online featuring survivors, @BillClinton and others
@SrebrenicaUK
Remembering Srebrenica
@SrebrenicaUK
4 years
On July 11th at 7 pm (UK Time) we will gather together with genocide survivors, UK leaders as well as other notable figures to commemorate the 25th anniversary of the Bosnian genocide. In the lead up, we will be announcing our guests for the evening and invite you to join us:
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
🎉Thank you @AACR @CR_AACR for highlighting our ADAPTeR Study @Cancer_Cell 🎉 #BreakingInsights Determinants of Anti-PD-1 Response in ccRCC: Multiomic profiling of multiregion, longitudinal tumour samples 👉 feat. in the Jan issue!
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
4 years
First melanoma patient dosed with a clonal neoantigen T cell (cNeT) therapy in the THETIS study! @TheCrick
Immunotherapy spin-out tests new personalised therapy for melanoma

Achilles Therapeutics, a company built on the research of Crick group leader Charles Swanton and Sergio Quezada and Karl Peggs at the UCL Cancer Institute, has started a clinical trial for a new...

www.crick.ac.uk
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
4 years
Socially distanced Tuesday lab meetings, and WELCOME to our new lab members!! @TheCrick
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
Calling all motivated and creative post-doctoral bioinformaticians! Join our growing group at the @TheCrick and work on exciting interdisciplinary projects to decipher cancer evolution. Apply here and/or contact us for further information please RT!
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
1/3📢out NOW @CellRepMed Immune responses after 4 vaccine doses in patients with blood cancer Neutralising Ab (NAb) to omicron BA.1 💉💉💉 After 3 doses, 62% detectable 💉💉💉💉After 4 doses, 79% detectable #CAPTUREstudy @royalmarsdenNHS @TheCrick
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
4 years
Thank you @MelanomaReAlli and @RosetreesT for supporting our work on melanoma evolution. We are very excited to be taking this project forward collaborating with the @royalmarsdenNHS and the PEACE consortium @MariamJHanjani @CharlesSwanton
@TheCrick
The Crick
@TheCrick
4 years
We're delighted that Samra has also recently received two new grants from @NIH , @MelanomaReAlli and @RosetreesT . They'll be to used to continue her work understanding how cancers grow and spread, and identifying possible weaknesses in these processes.
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
3 years
Clinical PhD opportunity in our lab . The project would suit a cancer evolution and cancer immunotherapy enthusiast from any background- surgery, oncology, pathology... Applications close on 18th October. please RT.
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Clinical PhD Fellowships - The Institute of Cancer Research, London
www.icr.ac.uk
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
3 years
We are so proud of Annika and all that she has achieved in the last 18 months- she's a super-star! Huge congratulations also to all the members of the #CAPTURE team in @TurajlicLab and @royalmarsdenNHS for their dedication and success.
@stcshepherd
Scott Shepherd
@stcshepherd
3 years
@fendler_annika receiving @TheCrick scientific achievement award for her incredible work on #CAPTURE study
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
3 years
💐A WONDERFUL and TOUCHING surprise from the talented Niamh/Andrea/Taja 🎨👩‍🎨of team #CAPTUREstudy to the trio @stcshepherd @fendler_annika @lewisjwau 👩‍👧‍👦!! Q: who wore it best? 🤣
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
4 years
nonsense mediated decay and anti-tumour immune response. @SwantonLab @kevlitchfield
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Escape from nonsense mediated decay associates with anti-tumor immunogenicity

Frameshift insertion/deletions (fs-indels) are an infrequent but potentially highly immunogenic mutation subtype. Although fs-indel transcripts are susceptible to degradation through the non-sense...

www.biorxiv.org
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
Our paper is online! Predicting cancer evolution for patient benefit: Renal cell carcinoma paradigm Thanks Biochimica et Biophysica Acta ( BBA ) - Reviews on #Cancer
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Predicting cancer evolution for patient benefit: Renal cell carcinoma paradigm - PubMed

Evolutionary features of cancer have important clinical implications, but their evaluation in the clinic is currently limited. Here, we review current approaches to reconstruct tumour subclonal...

pubmed.ncbi.nlm.nih.gov
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
3 months
#WorldCancerDay . Thinking of all the patients with #cancer and their families everywhere, especially those unable to access #cancercare . Celebrating all the clinicians, scientists, advocates and funders for their commitment to improving the lives of our patients.
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
3 years
2nd paper 📰📰 Vaccine Cohort 💉 We analysed vaccine responses in 585 patients with cancer after COVID-19 vaccination, measuring neutralising responses against the original SARS-CoV-2 and variants of concern (incl. Delta) and T cell responses (1/11)
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
Out now @NatureEcoEvo 🎉 We used computational modeling to show how tumour growth patterns impact clonal evolution in ccRCC 🧬📊🔍 A wonderful collab w @PaulBatesBMM @eriksahailab @kevlitchfield led by @XiaoFu90 - check it out!! #TracerxRenal @TheCrick @royalmarsdenNHS
@XiaoFu90
Xiao Fu
@XiaoFu90
2 years
Super excited to share our latest paper in @NatureEcoEvo - Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study.
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
We are recruiting! Bioinformaticians interested in cancer genomics, cancer evolution, and cutting-edge methods to advance the outcomes of patients with cancer, please apply here. Please RT
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
3 months
Thank you @CRUKresearch @RosetreesT for supporting a dynamic meeting with diverse perspectives. Thanks to @Alexis_Barr @claus_jorgensen @trevoragraham Susan Short, Peter Weightman. Loved hearing @VickySanzMoreno @ara_anderson @FlorentMouliere @RossCagan Tim Eisen @XiaoFu90 ⭐️
@CRUKresearch
Science and Innovation at Cancer Research UK
@CRUKresearch
3 months
First up at the Tackling Drug Resistance workshop is the Mechanisms of resistance session chaired by Samra Turajlic, teaching us about tumour microenvironments and #DrugResistance . @TurajlicLab
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
11 days
It’s such a privilege to know Bernard Escudier- one of a kind Human
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@DrYukselUrun
Yüksel Ürün
@DrYukselUrun
12 days
Congratulations to Dr. Bernard Escudier on receiving the Nicholas J. Vogelzang Humanitarian Award at the 2024 International Kidney Cancer Symposium. His dedication to medical oncology and humanitarian efforts,patient advocacy are truly inspirational and deserving of this…
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
25 days
Today is the anniversary of the start of the Siege of Sarajevo. Electricity and water were cut off.~ 329 shells fell on the city daily & snipers shot at civilians waiting for aid. 1600 children were killed in Sarajevo. 13,000 children have been killed in Gaza. @savechildrenuk
@savechildrenuk
Save the Children UK
@savechildrenuk
27 days
233 aid workers have been killed in #Gaza between October 7th - March 24th. How many more children, civilians, aid workers – humans – must be killed before we get a #CeasefireNOW ? #StopTheWarOnChildren
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
14 days
Landed in Barcelona for the #EIKCS2024 . @KidneyCancer Thank you #Brexit for the Q. Can’t wait to hear from these amazing women all working to improve the lives of patients with kidney cancer @lisapic @crisuarez08 @AlbigesL @schmidingerRCC SylvieNegrier @CSpencer_path @RCCadvocate
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
3 years
Our methods for representative tumour sampling developed in collaboration between @royalmarsdenNHS and @nelsonralexand1 and team.
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@nelsonralexand1
Nelson Alexander
@nelsonralexand1
3 years
So pleased to share our latest work on representative sampling of solid tumors. For better NGS results, you need better sampling. Props to @LisaLeonGal , @SamraTurajlic & @royalmarsdenNHS .
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
And here it is - exciting news for patients with melanoma! Amazing effort from ⁦ @HaanenJohn ⁩ and team- academic study, started recruitment in 2014
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
5 months
Only in Barcelona could you have such an amazing venue. Enjoyed the science #tapas offering from @LabJacks on the determinants of epigenetic states through cancer progression; the role of complement in pancreatic ca rejection; and modelling of different KRAS variants in NSCLC.
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@FJCarmonas
Javier Carmona 🇪🇺
@FJCarmonas
5 months
“ #Cancer In Context: cellular, tissue, and organismal determinants of malignant fates” #BioMed conference by @IRBBarcelona . Superb lineup of speakers & program at a beautiful venue. Co-organisers @DirenaAC & @TuomasTammela welcome participants to 3 days of top-notch science.
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
23 days
Very proud of @DrJonLim ! Congratulations! We can’t take much credit for his success (that is @ReiseSousaLab ) but excited to have him as a colleague in @TurajlicLab and a collaborator in the future when he takes up his role at @TheChristieNHS
@CSpencer_path
Charlotte Spencer
@CSpencer_path
23 days
Thrilled to be at #AACR24 with @DrJonLim presenting his poster on how dendritic cells shape cancer immunity winning the scholar in training award. @AACR @TurajlicLab @TheCrick
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
5 months
So grateful to these two wonderful people @DirenaAC @TuomasTammela for a very special meeting- fantastic science, great atmosphere, so much learning. @IRBBarcelona #Biomed23
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
HUGE thanks to patients, funders, and Team CAPTURE 🎉🎉 Also check out @TheLANCET : Neutralising antibody responses to 3 vaccine doses in the general population & haemodialysis patients ‼️ Legacy: NAOMI:
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Three-dose vaccination elicits neutralising antibodies against omicron

Omicron, the SARS-CoV-2 B.1.1.529 variant of concern (VOC), was first detected in southern Africa in November, 2021, and its BA.1 sub-lineage is now dominant in the UK. Omicron BA.1 contains 32...

www.thelancet.com
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
26 days
@TurajlicLab at the #AACR24 @AACR very proud to have @CSpencer_path and @Sanroman_Fern presenting their work from #TracerX_Renal and @DrJonLim presenting his work from @ReiseSousaLab . Check them out- details 👇
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
Thank you @CCR_AACR for the opportunity to write on this topic with @AljosjaRogiers @IreneLobon @SpainLavinia
@CR_AACR
Cancer Research
@CR_AACR
2 years
Molecular studies have identified genomic features associated with the development of metastases. The #ReviewArticle by Rogiers et al, discusses how these insights can inform clinical decisions and treatment strategies. @TurajlicLab
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
@myESMO #ESMO22 Presidential Symposium @CharlesSwanton @SwantonLab - incredible data on #lungcancer #pollution
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@CharlesSwanton
Charles Swanton
@CharlesSwanton
2 years
LBA1 #esmo22 today I will be discussing three lines of evidence supporting causative link between air pollution and lung cancer in the context of a Tumour promoting role independent of DNA mutagenesis pioneered by Allan Balmain @UCSF and Isaac Berenblum @CRUKresearch
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
4 years
We are recruiting! Please see below for an exciting opportunity to study cancer evolution @TheCrick
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
26 days
While we are at the #AACR24 our own Chloe Belland won the best poster award at the #EADO24 Congress in Paris #Uveal_melanoma @DrHMShaw @pdnpdnpdn @Ben_Shum_ @AnneCattin @husaynahmed @CamilleGrard6 #PEACE consortium @MariamJHanjani
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
3 years
We are looking for a post-doc Bioinformatics fellow to work on exciting questions in cancer evolution, with unique datasets and cutting edge technologies. Please share @CharlesSwanton @HoulstonLab_ICR @VanLooLab @kevlitchfield @NickyMcGranahan
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
10 months
Beautiful new work on metabolic heterogeneity in RCC from ⁦ @arihakimi ⁩ check it out in #CellMetabolism #AACRKidney2023
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
1 year
Link to paper:
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Late-Stage Metastatic Melanoma Emerges through a Diversity of Evolutionary Pathways

Metastatic melanoma evolution was illustrated through research autopsy and extensive multiomic profiling and revealed the diverse routes to treatment resistance, including extensive copy-number...

aacrjournals.org
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
4 years
We are looking for a Senior Bioinformatician to join our lab and work with some unique cancer genomic datasets. For more information see the link below and/or email me (Samra.turajlic @crick .ac.uk). PLEASE RE-TWEET!
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
10 months
⁦ @BraunMDPhD ⁩ presenting a vaccine study in RCC at #AACRKidney2023 - so exciting- watch this space!
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
1 year
📢📢Come and work with us @TheCrick !! 👀 👀Computational biologist to establish image analysis pipelines to deconvolve cancer evolution within complex micro-environments 🔬 👩‍🔬👨‍🔬Apply to be part of a MDT of scientists in a leading academic setting
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
It was fantastic to visit the absolutely wonderful @NKI_nl institute and hospital - thank you @HaanenJohn for hosting. #doubletreat @ProfCUBlankNKI incredible inauguration at @UniLeidenNews @MedemaRene Ton Schumacher in their fancy robes! Congratulations Christian!
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
4 years
@TheCrick @LabGandhi @CR_UK @The_MRC The foundations for this award were laid over years of effort in the lab and clinic. Thank you Andrew Rowan, Tim Chambers, @GoodayXu , stu horswell, @kevlitchfield , @MariamJHanjani , @CharlesSwanton , @tsoburol , @royalmarsdenNHS . We are excited to continue making discoveries in RCC
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
5 months
So proud and delighted to have our amazing #kidneycancer physician and scientist take on this role @KimrynRathmell
@KimrynRathmell
Kimryn Rathmell
@KimrynRathmell
5 months
#Cancer impacts every family and community, and it is time to #EndCancerAsWeKnowIt . My family and I have been overwhelmed by the support in the wake of this announcement – thank you! I was at a loss for words, but I decided to share a 🧵: 1/
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
4 years
Thank you @trendscancer and @CellPressNews
@CellPressNews
Cell Press
@CellPressNews
4 years
The Future of Cancer Research @LeilaAkkari1 @Samuel_Bakhoum @KrishnaswamyLab @sidichen @stefanispranger @Tanner_Lab @lyssiotis @SamraTurajlic @trendscancer
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
4 years
Really honoured to be welcoming our #ESMO20 @myESMO Keynote Speaker Lieping Chen to discuss the present and future of cancer immunotherapy; this Sat at 13.45 cet
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
Martin’s legacy lives on in all we do (as do his jokes- we recycle them frequently!)
@CharlesSwanton
Charles Swanton
@CharlesSwanton
2 years
⁦ @SamraTurajlic ⁩ giving her amazing #ESMO2022 prize lecture standing room only - dedicating her talk to the wonderful late Professor Gore a close friend and mentor to so many oncologists ⁦ @royalmarsdenNHS ⁩ ⁦⁦⁦ @TheCrick ⁩
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
4 years
Thinking of everyone in Beirut. Hope you are all ok @dmukherji . @DrChoueiri - hope family and friends are safe
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
6 months
Congratulations @DrJonLim and colleagues on this initiative for budding #clinicianscientists
@myESMO
ESMO - Eur. Oncology
@myESMO
6 months
@ESMO_Open @DrJonLim @BenWestphalen @quimmateo @matteolambe @TeresaSAmaral According to @SamraTurajlic_ , 3 factors are key for #ClinicianScientists : to cultivate a genuine desire to pursue lab-based #OncologyResearch & continue to treat patients, receive first-class scientific training, and benefit from #mentorship & sponsorship opportunities.
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
3 years
#EIKCS2021 has started! Latest in #Kidneycancer @DrChoueiri @brian_rini @HHammersMD @tsoburol @DrDabestani @g_develasco @AlbigesL @tompowles1 @foxal72 and many others
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
The COVID-19 pandemic showed what can be achieved with clear goals, less bureaucracy and enough funding — important lessons for cancer research.
Why I pivoted from COVID-19 back to cancer research

Nature Medicine - The COVID-19 pandemic showed what can be achieved with clear goals, less bureaucracy and enough funding — important lessons for cancer research.

www.nature.com
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
1 month
#KnowTheirNames Dr Ahmad Al Maqadmeh, Plastic Surgeon; Royal College of Surgeons Humanitarian Innovation Fellow @RCSnews Helped 1000s of patients. Ahmad was missing from #AlShifa_Hospital for 10 days. Today Ahmed and his mother were confirmed dead. HCW #NotATarget
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
4 years
Please see here and re-tweet for an exciting opportunity to do your MBPhD in our lab
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
10 months
Beautiful data from ⁦ @LisaHenske ⁩ on signalling pathways in TS #AACRKidney2023
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
2 years
Another fantastic #MAP meeting!congratulations @HaanenJohn @CharlesSwanton @FAndreMD for continuing to bring energy, top-notch science and much fun to these meetings. amazing execution by @myESMO staff, as ever!
@CharlesSwanton
Charles Swanton
@CharlesSwanton
2 years
MAP2022 in Amsterdam ⁦ @CRUKresearch ⁩ ⁦ @GroupeUnicancer ⁩ ⁦ @myESMO ⁩ fantastic talks on Clonal evolution ⁦ @MariamJHanjani ⁩ ⁦ @naxerova ⁩ @SamraTurajlic , ⁩ TME and adoptive cell therapies with friends ⁦ @FAndreMD ⁩ ⁦ @c_sotiriou ⁩ John Haanen
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@TurajlicLab
Turajlic Lab @ The Crick
@TurajlicLab
1 year
Very grateful to @VHLAlliance for supporting our work @feng_geoffrey @stcshepherd
@VHLAlliance
VHL Alliance
@VHLAlliance
1 year
We are thrilled to announce that three new research projects for 2023 have been granted to Dr. Samra Turajlic, Dr. Mei Yee Koh, and Dr. Reut Halperin. Read more about the grant program here: Read more about our 2023 recipients in our newsletter!
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