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Nature - Computational and machine-learning approaches that integrate genomic and transcriptomic variation from paired primary and metastatic non-small cell lung cancer samples from the TRACERx...

Nature - A robust, cost-effective technique based on whole-exome sequencing data can be used to characterize immune infiltrates, relate the extent of these infiltrates to somatic changes in...

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

Evolutionary Applications is an open access evolutionary biology journal, covering questions of health, social and economic significance.

Our lab focuses on using computational methods to explore the cancer genome and anti-tumour immunity within an evolutionary framework. We are based within the CRUK-UCL Lung Cancer Centre of

Our lab focuses on using computational methods to explore the cancer genome and anti-tumour immunity within an evolutionary framework. We are based within the CRUK-UCL Lung Cancer Centre of

High-grade serous ovarian cancer exhibits extensive intratumoral heterogeneity coupled with widespread intraperitoneal disease. Despite this, metastatic spread of tumor clones is non-random, implying...

The immune system is constantly on the lookout for diseased cells. Every cell in our body has signals on their surface that reach out to immune cells, lettin...

Nature Protocols - CONIPHER is a computational framework for accurately inferring subclonal structure and the phylogenetic tree from multisample tumor sequencing, accounting for both copy number...

Processed data and code to generate all main figures and extended data figures for the manuscript "Genomic–transcriptomic evolution in lung cancer and metastasis"

Cancer develops through a process of somatic evolution. Here, we reconstruct the evolutionary history of 2,778 tumour samples from 2,658 donors spanning 39 cancer types. Characteristic copy number...

A stop-motion animation presents a galloping horse which sculpts itself.

Our lives are increasingly dictated by the frantic pace of social media; it’s time to reclaim the space to slow down and think, says Guardian columnist John Harris

A key mutational process in cancer is structural variation, in which rearrangements delete, amplify or reorder genomic segments ranging in size from kilobases to whole chromosomes. We developed...

Recent reactions to racism are perhaps leading football somewhere new: isn’t it about time the game listened to its young black players such as Tottenham’s Danny Rose?

Author Summary Cancer is the consequence of an evolutionary process, which lasts several decades, is impossible to observe during most of its time, and only becomes apparent in late stages. We use...