Institute of Human Biology @IHB_Research Twitter profile

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Institute of Human Biology

3 months

🎇Big news! Prof Juergen Knoblich @IMBA_Vienna @oeaw @MedUni_Wien joins #TeamIHB as its new Head. Bringing extensive leadership experience, he is also a pioneer in #organoids biology. His lab was 1st to develop an organoid model for a human brain disorder. Welcome @Knoblich_lab !

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Institute of Human Biology

@IHB_Research

1 year

We’re seeking Early Career Scientists to establish their own independent #research program, with competitive funding, across three key focal areas. Open to mature #scientists with PhD or Postdoctoral training in #HumanModelSystems . Apply to #TeamIHB here:

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Institute of Human Biology

@IHB_Research

1 year

Welcome to the #IHBResearch Twitter channel 👋 We’re excited to be sharing news of the latest research into #Organoids and connecting with all those interested in this scientific field 🧫 Find out more about our work here ➡️ #Science #HumanModelSystems

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Institute of Human Biology

@IHB_Research

6 months

Patient-derived intestinal organoids predict immunotherapy toxicities of T-cell-engaging bispecific antibodies, which may guide safer cancer treatments in future. 👏to authors at #TeamIHB @Roche #pRED @UnivParisSaclay & @DepBiomedicine for the @natBME 📰!

Analysis of off-tumour toxicities of T-cell-engaging bispecific antibodies via donor-matched...

Nature Biomedical Engineering - Patient-derived intestinal organoids and tumouroids supplemented with immune cells can be used to predict and study the on-target off-tumour toxicities of...

www.nature.com

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Institute of Human Biology

@IHB_Research

1 year

We have a big announcement! You may have heard of the ITB (Institute for Translational Bioengineering) and our exciting research into #Organoids . Well, the ITB is now the IHB (Institute of Human Biology)—and our research has suddenly got a lot more exciting 🧵⬇️

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Institute of Human Biology

@IHB_Research

1 year

Could #organoids be used to unlock the secrets of human evolution? In a review for @NatureRevGenet , #TeamIHB describes how the sequencing of genomes from modern and archaic hominins, great apes and other primates is revealing human-specific genetic changes. ⬇️

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Institute of Human Biology

@IHB_Research

1 year

Allow us to introduce the Multi-tissue Systems Engineering team 📣 These scientists explore novel approaches to increase tissue-tissue complexity in #Organoids 🧫 Learn more about their pioneering work: #MeetTeamIHB #MultiTissueEngineering

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Institute of Human Biology

@IHB_Research

1 year

We’re proud to introduce you to #TeamIHB , a group of highly talented and curious scientists! 📣 We’ll be taking you through each IHB department in turn, starting this week with the Developmental Systems and Computational Biology ⬇️

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Institute of Human Biology

@IHB_Research

9 months

Bioengineered models of the immune system like #organoids & organs-on-chips may help us 1) understand human (patho)physiology & 2) design better therapies for immune-related pathologies.👏 @natrevbioeng review by #TeamIHB 's Nikolche Gjorevski & colleagues

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Institute of Human Biology

@IHB_Research

8 months

Join us in giving a warm welcome to our newest team member, Prof Michael N Hall! He augments #TeamIHB 's basic biology expertise via his new lab on adipose tissue biology while he leads his @biozentrum lab in parallel. A true bridge between academia and industry. @UniBasel_en

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Institute of Human Biology

@IHB_Research

9 months

#TeamIHB went on a deep dive with Professor @JenniferALewis1 into biomanufacturing vascularized kidney tissues for drug testing, disease modeling & therapeutic use! Fascinating to see her lab's latest work to vascularize and scale #HumanModelSystems @Harvard @hseas @wyssinstitute

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Institute of Human Biology

@IHB_Research

1 year

Today, we’re praising the Organoid Gene Editing team! This group focuses on overcoming technical challenges in implementing CRISPR-mediated gene engineering in adult stem cell-derived #organoids . It applies these learnings to study adult stem cells in homeostasis and disease ⬇️

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Institute of Human Biology

@IHB_Research

1 year

#TeamIHB had the honour of welcoming Prof. Melissa Little ( @MCRI_for_kids , @reNEW_Global , @UCPH_Research ) to share groundbreaking insights on #kidney development, stem cells and the game-changing impact of #organoid technologies. 🌟 A true pioneer in #MedicalResearch

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Institute of Human Biology

@IHB_Research

1 year

The potential for #Organoids to revolutionise human understanding and healthcare can’t be underestimated. For example, generating brain-like tissue from human stem cells could help shed light on our brain development ⬇️

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Institute of Human Biology

@IHB_Research

1 month

🥳Happy Birthday IHB! 🎂 One year ago, @Roche launched our Institute of Human Biology. To mark the occasion, we’re celebrating our incredible team and the milestones we have collectively achieved. #TeamIHB #organoids #humanmodelsystems

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Institute of Human Biology

@IHB_Research

1 year

What are the ethical questions around #Organoids research? And could we use them as human grafts in the future? Nikolce Gjorevski of #TeamIHB says this is “not science fiction,” despite many obstacles. 🎧 Listen to @ngjorevski in this Impulse #podcast :

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Institute of Human Biology

@IHB_Research

1 year

#TeamIHB is all about sharing and learning from the best scientific minds. And one of the stars of our team is @RyoOkuda5 , a postdoctoral researcher who is collaborating on a project that has huge potential for #cancer therapy. Check out his team ⬇️

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Institute of Human Biology

@IHB_Research

10 months

#TeamIHB is #hiring ! Want to be an innovative team lead, driving tech development for automated, large-scale #organoid production and enabling increased reproducibility and physiological relevance of organoid model systems? apply now 👉 Pls RT!

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Institute of Human Biology

@IHB_Research

1 year

Very excited to share that we have just launched a joint doctoral programme for Translational Engineering of Biological Systems together with @ETH_BSSE

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Institute of Human Biology

@IHB_Research

10 months

#TeamIHB is in awe of this live imaging of #organoids . Big applause to researchers @Jain_Akanksha_ , @GillesGut , @TreutleinLab , @GrayCampLab on your preprint! @ETH_BSSE #HumanModelSystems

Gray Camp

@GrayCampLab

10 months

Mosaic organoids + Multi-protein labeling + Longest-term organoid LSM + Morphometric demultiplexing + SCG + Biological insight into self-organization of loosely constrained human developmental systems 😍 Super! @Jain_Akanksha_ @GillesGut @TreutleinLab

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Institute of Human Biology

@IHB_Research

1 year

Today we’re introducing you to Anna Bremser, another fab #TeamIHB scientist who works within the Phenotyping team on establishing automation protocols for #organoids . Her focus is on translating organoid cultures, assays, stainings and screening projects into robotic platforms ⬇️

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Institute of Human Biology

@IHB_Research

9 months

Thanks @erturklab for bringing wildDISCO to #TeamIHB !🕺Had a blast discussing how to harness #AI & cell-level #imaging to speed up drug development. This weekend we're reading their @NatureBiotech paper on whole-body immunolabeling and imaging in mice.

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Institute of Human Biology

@IHB_Research

1 year

@GrayCampLab at #TeamIHB , @TreutleinLab & @lucaspelkmans have unveiled #CuttingEdgeResearch : a detailed image of the human retina. Unlocking new possibilities in eye disease diagnosis and treatment. Witness the marvels of science 👁️

Detailed image of the human retina

ethz.ch

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Institute of Human Biology

@IHB_Research

1 year

Another brilliant #TeamIHB scientist collaborating on ground-breaking work, @mike_nikolaev is part of the Organoid Engineering team. His laser focus is on creating lab-grown organs that mimic real life with remarkable accuracy and could lead to personalized medicine. ⬇️

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Institute of Human Biology

@IHB_Research

10 months

🤜💥🤛Feeling motivated by @HansClever 's vision! #TeamIHB , together with fellow scientists from @Roche pRED and academia, will revolutionize disease modeling, enhance drug development and unravel the mysteries of human biology. #humanmodelsystems #organoids #bioengineering

Roche

@Roche

10 months

"The Institute of Human Biology will be one of the world's research centers where revolutionary innovations will emerge and where we will get closer to the biology of human organs and diseases." - @HansClevers looks ahead to @IHB_Research in 10 years. 👇 #TeamIHB

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Institute of Human Biology

@IHB_Research

1 year

Drum roll please, for the Microtechnologies team! 📣 These scientists develop microfluidics, optics & mechatronics to analyse biological systems, including #Organoids . Their aim is to create a suite of microtechnologies #Science #MicroEngineering #TeamITB

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Institute of Human Biology

@IHB_Research

7 months

#TeamIHB 's inaugural IHB Science Days 2023 brought together our #HumanModelSystem scientists for 2 days of deep dive talks, science slams, workshops and fun! Congrats to our presentation winners @NinoukAkkerman @Giuliana_Rossi_ @_RubenL_ @CamachoRufino , Adrian, Marius & Lukas!

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Institute of Human Biology

@IHB_Research

1 year

Fun times at the #IHB internal #launch event on the #Roche campus! Our teams were able to showcase all their cool science on large digital posters, while our speakers included @HansClevers , @TheLutolfLab and CEO Thomas Schinecker, among many others. ⬇️

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Institute of Human Biology

@IHB_Research

9 months

Who will help #TeamIHB establish a tissue & #organoids #biobank ? We're looking for a collaborative and resourceful Sr Assoc to work with multidisciplinary organoid experts to advance more predictive #HumanModelSystems . More & Pls RT! #sciencejob #organoids

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Institute of Human Biology

@IHB_Research

2 months

🤩stunning footage! Congrats to the whole @EPFL_en team on the great @Nature publication! Excited to see the work continue at #TeamIHB using human #organoids ! #humanmodelsystems

Matthias Lutolf

@TheLutolfLab

2 months

Have you ever seen real-time footage of a tumor developing outside a living organism? We are thrilled to announce a new paradigm in ex vivo cancer modelling . Let’s have a quick look!

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Institute of Human Biology

@IHB_Research

11 months

The success of #IHB is entirely due to the wonderful and #inspiring people who work in its labs. This week, we’re singling out senior #scientist @JyotiRao_ , who is part of the Multi-Tissue Systems Engineering team.

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Institute of Human Biology

@IHB_Research

1 year

Science is about discovery and evolution. #Organoids may be used for applications such as drug development in the future, but the technology is “far from perfect” and not quite there yet 🧵⬇️

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Institute of Human Biology

@IHB_Research

6 months

Great afternoon today with @Biozentrum @UniBasel #MolecularBiology bachelor students! #TeamIHB had fun showing our research and potential career pathways. #Basel is a strong hub for the life sciences and we are glad to meet and encourage the young talent in our community.

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Institute of Human Biology

@IHB_Research

4 months

🙌Dr🙌Umut Kilik is in the house! Huge round of applause for @KlkUmut for successfully defending his thesis on human intestinal #EvoDevo using single-cell genomics, #organoids & comparative genomics.🤗 #TeamIHB wishes you all the best in your next step of your hitchhiking journey!

Umut Kılık

@KlkUmut

4 months

🎓 Excited to share my PhD journey with you all! 🚀 From @MPI_EVA_Leipzig to @UniBasel_en and @IHB_Research and short visits at @ETH_BSSE @TreutleinLab , @UMich @TheSpenceLab , it's been a hitchhiking adventure, meeting incredible minds along the way!

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Institute of Human Biology

@IHB_Research

9 months

#TeamIHB ’s success is due to the fabulous and inspiring people who work here. This week, we’re spotlighting @NinoukAkkerman , who joined the #Organoid Gene Editing team in April. Her past work on #organoid models fueled her desire to further explore their untapped potential.

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Institute of Human Biology

@IHB_Research

1 year

Good news! #TeamIHB has just opened new #laboratories at Roche Glycart AG in Schlieren, near Zurich. To celebrate, we held an event with our Schlieren #colleagues , including Pablo Umaña, Christian Klein and Priska Rüegg (plus #organoid cake), to share what we’ll be working on ⬇️

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Institute of Human Biology

@IHB_Research

6 months

🎓Huge congrats to🌟DR🌟Bruno Gjeta, @GrayCampLab , #TeamIHB 's FIRST PhD graduate, on your impressive thesis tracking cellular dynamics using #organoid models & #SingleCell tech! We're immensely proud of your achievement— a perfect close to 2023. Cheers to a successful future!🥳

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Institute of Human Biology

@IHB_Research

10 months

Calling all explorers to map🗺️the cell phenoscape! Pack your bag with #PredictiveModeling & #Organoids tech & join @josch_f & @GrayCampLab , #TeamIHB and @TreutleinLab , @ETH_en on the #HumanCellAtlas frontier. Read their @ScienceMagazine perspective or🧵👇

Jonas Simon

@josch_f

10 months

What’s next for cell atlases? In our new perspective in @sciencemagazine , we envision that perturbing #humanmodelsystems at scale will help better understand cell types by charting human cell phenoscapes 🧵

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Institute of Human Biology

@IHB_Research

1 year

The Organoid Phenotyping team is in the spotlight this week! 📣 These scientists develop high throughput methods for studying complex biological systems, such as #Organoids and patient-derived tissues. #MeetTeamIHB #OrganoidPhenotyping

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Institute of Human Biology

@IHB_Research

1 year

In this interview from 2021, the father of #Organoid research @HansClevers talks about spotting the potential of #Organoids and why, for cystic fibrosis, they are now “integral” to the Dutch health system:

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Institute of Human Biology

@IHB_Research

27 days

Perfect way to relax after work! We had a great time attending the recent science talk by #pRED leaders @HansClevers & Gijs van den Brink and #TeamIHB 's lead @BeumerJoep ! 💡They explored how incretins are secreted by the gut and their role in metabolic health and disease.

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Institute of Human Biology

@IHB_Research

1 year

A couple of weeks ago, we shared a collaborative paper on retinal #organoid development. Today, we’re putting two of the #TeamIHB scientists involved, @brangiov and @HarmelChristoph from the Developmental Systems and Computational Biology team, in the spotlight ⬇️

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Institute of Human Biology

@IHB_Research

6 months

As 2023 closes, we're feeling very grateful and we wish all our #TeamIHB family, colleagues and friends a joyous and restful holiday. This year has been filled with growth, hard work, collaboration and new ways of thinking. Excited for 2024- we're ready to tackle new challenges!

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Institute of Human Biology

@IHB_Research

1 year

Some intriguing #Organoid research we're revisiting: mapping prohormone processing by proteases in human enteroendocrine cells (EECs) 🦠 EECs control physiological processes like appetite and insulin secretion. But their relative rarity makes these processes hard to assess ⬇️

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Institute of Human Biology

@IHB_Research

5 months

#TeamIHB 's start to 2024 continues strong with a great talk by @priscaliberali on the design principles of tissue organization and the determinants of pattern formation in multicellular systems. @FMIscience @UniBasel @NovartisScience

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Institute of Human Biology

@IHB_Research

11 months

💡 @HansClevers sheds light on the potential of #organoid #biobanks for the future of drug development & precision medicine. Yet significant work remains to validate this technology. #TeamIHB is thrilled to be part of this effort to advance this field. More

Translation & Technologies - IHB

Translation & Technologies Our Translation & Technologies core covers projects executed in close collaboration with pRED and Roche teams to solve portfolio-relevant challenges. Supported by technol...

institutehumanbiology.com

BioCentury

@BioCentury

11 months

Roche’s Hans Clevers sees the organoid biobank the pharma's new institute is building as source of patient avatars for building diverse preclinical study populations, and generating data based on human tissue rather than animal models.

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Institute of Human Biology

@IHB_Research

5 months

Thanks @VallierLab for visiting #TeamIHB ! Super to learn from you all about liver regeneration in chronic liver diseases! @berlinnovation

ludovic vallier

@VallierLab

5 months

Great visit yesterday @IHB_Research yesterday and exciting discussion with @TheLutolfLab , @AnnieMoisan_wl and @HansClevers about strategic vision of pharmas on organoids and their use in drug discovery. Now on my way to Cambridge to pack my long last remaining office.

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Institute of Human Biology

@IHB_Research

8 months

Thanks Peter Loskill @pe_losk for showing #TeamIHB the latest work by your @MicroOrganoLab on recapitulating complex immunocompetent tissues using #Organ_on_Chip and #organoids technologies, especially intriguing to see the translation applications. @3RCenter @uni_tue @NMI_De

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Institute of Human Biology

@IHB_Research

1 year

Let's look back at some work carried out last year ——specifically, formulating a system for naming human multicellular models, including #organoids , assembloids and transplants. Such as system could help with research and improve communication with #scientists and the public. ⬇️

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Institute of Human Biology

@IHB_Research

2 months

Thank you @MadelonMaurice @UMCUtrecht @oncodeinstitute for visiting #TeamIHB and sharing insights into your lab's research on E3 ligase biology in colorectal cancer #organoids !

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Institute of Human Biology

@IHB_Research

7 months

#TeamIHB is so honoured to welcome Prof @JenniferALewis1 onto our Scientific Advisory Board (SAB). Her #bioengineering pioneering work to vascularise and scale #HumanModelSystems will greatly benefit the IHB. More on our SAB: @Harvard @hseas @wyssinstitute

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Institute of Human Biology

@IHB_Research

10 months

#TeamIHB is pleased to introduce you to our newest members! They are joining our rapidly growing effort to push the boundaries of #humanmodelsystems , #bioengineering , #microtechnology & #organoids . More on our efforts👉

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Institute of Human Biology

@IHB_Research

8 months

Exciting opportunity to become #TeamIHB 's Scientific Operations Director! Help us drive IHB’s positioning in the scientific community and ensure the operational efficiency of the institute and its integration within the Roche ecosystem. Pls RT & details at

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Institute of Human Biology

@IHB_Research

7 months

The success of the #TeamIHB owes much to the wonderful and inspiring people who work in its labs. This week, we’re shining a spotlight on Research Fellow Mar Cervera Negueruela, who is part of a team focusing on #microtechnology

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Institute of Human Biology

@IHB_Research

1 year

Today, we’re tipping our hats to the Roche Cell and Organoid Banking team! This group expands and cryo-preserves patient-derived #organoids in order to study #disease mechanisms, identify potential #drug targets and evaluate drug efficacy. #TeamIHB

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Institute of Human Biology

@IHB_Research

2 months

💬🧫🔬🗨️ #TeamIHB had a blast participating in last week's @_industrienacht and chatting with citizens of #Basel about #humanmodelsystems and #organoids . We were honored to help represent #RocheInnovation . Learn more about what we do at . #scicomm @Roche

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Institute of Human Biology

@IHB_Research

5 months

Full house at #TeamIHB for Prof Paola Arlotta's talk on human brain chimeroids as avatars to understand human interindividual variation in response to neurotoxic triggers! @ArlottaLab @harvardstemcell

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Institute of Human Biology

@IHB_Research

9 months

The academic year is off to a great start with the addition of our new colleagues to #TeamIHB ! We're grateful to have their fresh energy, innovative ideas and complementary expertise in #HumanModelSystems , #bioengineering , #microtechnology , #organoids and #DataAnalytics .

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Institute of Human Biology

@IHB_Research

3 months

#sciencejob 🚨Exciting opportunity to join the Roche Cell and #Organoids Biorepository group at #TeamIHB . We're searching for a stellar intern to work with us on implementing the adipocyte organoid model in our #biobank . More at & Pls RT! #HumanModelSystems

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Institute of Human Biology

@IHB_Research

4 months

Packed room for #TeamIHB 's @CabonLauriane 's talk at @Roche 's & @ETH_en 's #NextGenBioeng programme, Lunch & Learn event. She showed efforts in refining organoid models to closely mimic human diseases for drug development. Future events👉. #pRED @ETH_BSSE

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Institute of Human Biology

@IHB_Research

1 year

This is the goal of a number of scientists in the neural #organoid field, especially @Sergiu_P_Pasca and @TreutleinLab , with involvement from @GrayCampLab of #TeamIHB . Read more in @Nature here ➡️ #Research #HumanModelSystems

A nomenclature consensus for nervous system organoids and assembloids

Nature - The nomenclature for human multicellular models of nervous system development and disease, including organoids, assembloids and transplants, is discussed and a consensus framework is...

www.nature.com

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Institute of Human Biology

@IHB_Research

1 year

ITB to IHB is more than just a name change. Bringing biology, data analysis, computation, engineering and translation under one roof allows IHB to redefine research into human model systems such as #organoids . Find out more about #TeamIHB here ➡️

About the IHB - IHB

About the IHB With close ties to academia and Roche’s Pharma Research & Early Development (pRED) – led by Hans Clevers – the IHB takes an end-to-end approach to advancing human model systems, from...

institutehumanbiology.com

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Institute of Human Biology

@IHB_Research

1 year

This week, it’s the turn of the Applied Organoid Technologies team to hog the limelight! This group is focused on advancing #organoid -based models for use in preclinical and #clinical assays, with the aim of enabling their adoption in #drug development ⬇️

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Institute of Human Biology

@IHB_Research

1 year

It’s amazing what #BioEngineering can do! 🤓 Fun Fact: researchers have grown ‘sentient’ brain cells that have learned to play the 1970s video game, Pong. This marks the first time these cells have interacted with an external environment ➡️

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Institute of Human Biology

@IHB_Research

9 months

☀️ #TeamIHB has your next weekend read! Check out this recent @Dev_Cell paper by @JyotiRao_ , @PourquieOlivier & colleagues from @HarvardMed . They demo'd that signaling cues identified in mice can lead to efficient differentiation of brown adipose tissue in vitro from human PSCs.

Jyoti Rao

@JyotiRao_

9 months

Excited to share our paper in @Dev_Cell on tracking brown fat adipogenesis in mouse and using human pluripotent stem cells to recapitulate the development in vitro! Big thanks to all the contributors and collaborators in and out of the twitterverse

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Institute of Human Biology

@IHB_Research

3 months

Congrats @KlkUmut for your poster prize on "Charting human-specific intestine development using great-ape #organoids ." Thanks for representing #TeamIHB and @UniBasel_en so well at @IMBA_Vienna !

IMBA

@IMBA_Vienna

3 months

Jethro Lundie-Brown, Cambridge Stem Cell Institute, and runner up Umut Kilik, University of Basel and IHB took home awards for Best Poster. Daniel Klimmeck, Senior Editor at EMBO, presented the prize, which was sponsored by EMBO.

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Institute of Human Biology

@IHB_Research

5 months

🔥New @CellStemCell review by @BeumerJoep & @HansClevers describes 6 stem cell hallmarks that collectively enable long-term maintenance of adult tissues and highlights the diversity and complexity of #ASC strategies across tissues and species. OA 🔗 or 🧵👇

Hallmarks of stemness in mammalian tissues

Stem cell function is defined by their capacity to replace lost tissue through division. Beumer and Clevers put forth a set of six complementary hallmarks that are key enabling features of this...

www.cell.com

Joep Beumer

@BeumerJoep

5 months

1. Adult stem cells (ASCs) compensate for cell loss during daily wear and tear. Evolution has created a variety of stem cell designs. In this review, @HansClevers and I define six hallmarks that are key enabling features of the basic function of ASCs, replacing lost tissue.

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Institute of Human Biology

@IHB_Research

4 months

Great article covering what we currently know about adult stem cells. #teamIHB 's @BeumerJoep and #pRED 's @HansClevers reviewed their universal features that enable long-term tissue maintenance strategies and identified aspects yet to be understood. More at

Roche | Defining hallmarks of stem cells

A new review from Roche scientists describe stem cells’ unique and shared features, laying the foundation of what is known about them and mapping new approaches in drug discovery

www.roche.com

Roche

@Roche

4 months

🌟Adult stem cells: a biological universe still to be fully explored🌟 @BeumerJoep & @HansClevers review how we biologically define these cells and chart new research avenues that could lead to new medical innovation. More at #RocheInnovation @IHB_Research

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Institute of Human Biology

@IHB_Research

1 year

Great collaboration between @TreutleinLab @ETH_BSSE and @GrayCampLab which is published in @Nature . Read all about it here ➡️ #Research #Science

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Institute of Human Biology

@IHB_Research

11 months

Say 👋 to our new #TeamIHB members! Want to see yourself here? If you're passionate about #humanmodelsystems , #bioengineering & #organoids , we’re looking for you! More about our EC Group Leaders👉 & PhD Programme w/ @ETH_BSSE 👉 .🙏RT!

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Institute of Human Biology

@IHB_Research

5 months

Thanks Jim @JimWellsLab for sharing with #TeamIHB about your next gen work on engineering human gastrointestinal tissues from pluripotent stem cells for disease modelling and therapeutic discovery! @CincyChildrens @CuSTOMOrganoids

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Institute of Human Biology

@IHB_Research

1 year

@mike_nikolaev 's ambitious goal is to elevate the complexity and accuracy of bioengineered tissues by incorporating essential cell types specific to each organ, replicating intricate processes of the tissue development and engineering complex organ physiology. ⬇️

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Institute of Human Biology

@IHB_Research

1 year

Credits to: Alex Pollen @brainevodevo , Craig Low and Umut Kilik @KlkUmut 🙌 Read the full review here: ➡️ #Evolution #Genetics #Sapiens

Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution

Nature Reviews Genetics - In this Review, the authors discuss our latest understanding of evolutionary genetic changes that are specific to humans, which might endow uniquely human traits and...

www.nature.com

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Institute of Human Biology

@IHB_Research

8 months

Prof Schier @schierlab visited #TeamIHB and told us about his lab’s efforts in reconstructing cellular biographies during differentiation. We were intrigued by killifish's unusual embryogenesis! @Biozentrum @UniBasel_en

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Institute of Human Biology

@IHB_Research

21 days

Spring is in full swing and #TeamIHB is flourishing with all our fresh new talent! 🪻🌷🌱Big welcome to Elena, Silvia, Manuel, Nadine, Yannick, Noella and Klara! Thrilled to have your expertise.

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Institute of Human Biology

@IHB_Research

5 months

🙌Gorgeous front cover @BeumerJoep and @HansClevers showing hallmarks of adult stem cells! Great way to kick off 2024! #TeamIHB , @Roche , #pRED

Cell Stem Cell

@CellStemCell

5 months

Happy New Year! We're ringing in 2024 with lots of great papers and an exciting Reviews series on the Hallmarks of Stem Cells! Check out the flagship Review from @HansClevers & Joep Beumer on Hallmarks of stemness in mammalian tissues. More to come!

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Institute of Human Biology

@IHB_Research

10 months

#TeamIHB is #hiring ! We are looking for a talented #postdoc to establish patient-derived preclinical ex vivo #HumanModelSystems of multiple myeloma to inform the drug discovery process. Apply now & Pls RT! #postdocjobs #postdocposition #organoids

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Institute of Human Biology

@IHB_Research

1 year

What makes us human? Could the use of #organoids to create 3D “mini-brains” provide an answer to this? Madeline Lancaster, a member of the IHB Scientific Advisory Board, pondered this and other tricky questions in a @TEDx Talk in 2015. Check it out 👉

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Institute of Human Biology

@IHB_Research

5 months

New year, new teammates! 🥳Welcome to #TeamIHB Laura, Carola, Luigi, Thomas, Namitha @r_nayy_ and Philip! Glad to have your expertise with us!

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Institute of Human Biology

@IHB_Research

1 year

Overall, it was a great opportunity to share what we’ve been up to and celebrate everyone’s hard work over a few drinks (and cupcakes!). It demonstrated how far #IHB has already travelled, and all the exciting #research that’s coming down the pipeline.⬇️

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Institute of Human Biology

@IHB_Research

10 months

What's it like doing cutting-edge research on #bioengineering , #humanmodelsystems & #organoids every day? To find out, we're peeling back the covers on #TeamIHB with our series, the #ABCsofIHB - from the extraordinary to the absurd! 🙃Next up: E through H

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Institute of Human Biology

@IHB_Research

1 year

The Organoid Engineering team is paving the way for a world where we can accurately predict how organs will respond to treatments, medicine tailored to individuals and better drug testing. Read more about Mike and the team here:

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Institute of Human Biology

@IHB_Research

7 months

#sciencejob 🚨Great chance to join #TeamIHB and work with the incredible @mike_nikolaev and the #bioengineering group!

Mike Nikolaev

@mike_nikolaev

7 months

We are looking for an intern to join our team at @IHB_Research ! This is not your average internship – it's an opportunity to immerse yourself in the bioengineering the most complex human organs-on-a-chip systems. Check more details here:

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Institute of Human Biology

@IHB_Research

11 months

It’s time to introduce the Operations team! 📣 These are the people who make it happen in the background, supporting the operational set-up, strategic development and shared vision of #TeamIHB . #MeetTeamIHB #Organoids

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Institute of Human Biology

@IHB_Research

3 months

#TeamIHB has your next read for the long weekend! 😎See 👇for an insightful article by @metricausa for @naturemethods on the application of #organoids to unravel tumor complexity. Great input by our @TheLutolfLab on how #bioengineering contributes to these efforts.

Nature Methods

@naturemethods

3 months

And @metricausa asked cancer researchers about what they find most useful about using cancer organoids in their research.

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Institute of Human Biology

@IHB_Research

17 days

#postdoc #sciencejob alert! 🚨Come work with amazing scientists in this unique @Roche position between #pRED 's #immunology unit and #TeamIHB 's #bioengineering group

Mike Nikolaev

@mike_nikolaev

19 days

Join our team and contribute to the development of engineered models of intestinal inflammation to study #IBD and derive novel therapeutic approaches. This is a unique postdoc position hosted by the Immunology department within Roche pRED, in collaboration with the

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Institute of Human Biology

@IHB_Research

9 months

👏 @MaireneCoto ! Thanks for representing #TeamIHB at @LabOfTheFuture congress and showcasing our ambitions for a @Roche #biobank of #organoids . We're grateful for your hard work and expertise to make this a reality!

Mairene Coto

@MaireneCoto

9 months

At the Lab of the Future Congress, I had the pleasure of sharing the experience, opportunities, and challenges of establishing the organoid biobank at Roche's IHB. It was an excellent opportunity to learn more about digital innovation and automation. #InstituteofHumanBiology #IHB

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Institute of Human Biology

@IHB_Research

8 months

Thank YOU @biozentrum for hosting #TeamIHB ! Indeed it was a pleasure to exchange and share ideas.

Biozentrum, University of Basel

@biozentrum

8 months

Thank you, @IHB_Research , for sharing your latest research and the interesting discussions. It was a pleasure to have you at the @biozentrum , and we are looking forward to a fruitful collaboration.

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Institute of Human Biology

@IHB_Research

1 month

💪 @mike_nikolaev ! Big 👏from #TeamIHB

Olga Mitrofanova

@olga_mitrofan

1 month

Congratulations to @mike_nikolaev for winning the best poster prize! @IHB_Research #stemgastro24

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Institute of Human Biology

@IHB_Research

1 year

#Organoids have already been used to model disorders such as microcephaly and autism, and now scientists are using them to study gene regulatory networks ⬇️

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Institute of Human Biology

@IHB_Research

7 months

🎂Happy half-iversary #TeamIHB !🥳6 months ago we launched and our activities sky rocketed- all thanks to the energy and talent of our members. Where will we be at our 10 anniversary? IHB director Matthias Lütolf @TheLutolfLab shares his vision👇and more at

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Institute of Human Biology

@IHB_Research

11 months

The success of IHB is dependent on the high-quality #scientists involved in its work. This week, we’re putting the spotlight on Manuela Jaklin, who supports #TeamIHB in establishing optimal workflows for the cell and #organoid biobank (RoCOB) ⬇️

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Institute of Human Biology

@IHB_Research

8 months

#TeamIHB had front row seats to @Genentech 's Michelle Chen's talk on leveraging #single_cell omics to build and apply to in vitro human models. Fascinating to see her team's collaborative research in neurodegeneration and inflammatory bowel disease. Thanks @Mbchen3 !

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Institute of Human Biology

@IHB_Research

1 year

@BeumerJoep and his team are currently focusing on the development of next-generation #CRISPR tools in #organoids , to engineer model systems that can be used to study healthy and diseased stem cells. Learn more about the team here:

Exploratory Research - IHB

Exploratory Research Our Exploratory Research core includes academic-style basic science projects addressing open questions, and hypothesis- or discovery-driven. Expected outcomes are new biological...

institutehumanbiology.com

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Institute of Human Biology

@IHB_Research

3 months

🚨open #postdocs #sciencejob in #TeamIHB 's newest group: Metabolic Homeostasis! Who will drive the development of multicellular in vitro systems for modeling interactions between adipose tissue and sensory neurons? More .🙏 RT! #HumanModelSystems #organoids

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Institute of Human Biology

@IHB_Research

10 months

Fab collaboration among researchers at @ETH_BSSE , @ETH_en , @IOB_ch , @UniBasel_en , @UZH_en & #TeamIHB exploring multimodal spatiotemporal phenotyping of human retinal #organoid development. @NatureBiotech OA paper🔗 or get insights from @GrayCampLab 's🧵👇

Gray Camp

@GrayCampLab

1 year

Our strategy to understand heterogeneous human neural organoids through spatiotemporal integration of scSeq and multiplexed protein maps! Thank you @cziscience for supporting our project! @lucaspelkmans @TreutleinLab @IHB_Research 👉🧵

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Institute of Human Biology

@IHB_Research

1 year

In addition, new molecular and cellular approaches, including organoid research, enable explorations of the factors that underlie human-specific traits. ⬇️

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Institute of Human Biology

@IHB_Research

1 year

@HarmelChristoph brings imaging and genomics data together to create multimodal digital representations of organoids. For his research, he designed a browsable app to visualise the development of retinal organoids through such representations: ⬇️

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Institute of Human Biology

@IHB_Research

6 months

Thank you Lorenz Studer @Studerl for entrancing #TeamIHB with your talk on your lab's current work in directing neural fate, maturation and age in human pluripotent stem cells. @MSKCancerCenter

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6

Institute of Human Biology

@IHB_Research

11 months

Experts alert! 🚨 and make sure to get your insights on intestinal #organoids from #TeamIHB 's #Basel colleague @priscaliberali @FMIscience

Organoid News

@organoidscience

11 months

What do leaders in their fields think about the present and future of #organoids ? Read key insights and watch presentations by Drs. Hans Clevers, Madeline Lancaster, Meritxell Huch, and more from this “Advances in Organoid Applications” Round Table.

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