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Hans Clevers Profile
Hans Clevers

@HansClevers

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Professor at Utrecht University, advisor at Hubrecht Institute and Princess Máxima Center. Head of Pharma Research and Early Development at Roche from 18-3-22

Utrecht, The Netherlands
Joined June 2013
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@HansClevers
Hans Clevers
2 years
Entered my first academic lab in 1978. Fond memories of >40 years in science with great colleagues at public institutions in Kenya, the US and in my country, the Netherlands. Excited to step into the pharma world as head of research/early development at Roche, Basel in March
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@HansClevers
Hans Clevers
2 years
Today I start my new role @Roche as Head of pRED. Excited to take on this new challenge and work alongside brilliant people to translate #science into revolutionary medicines that can change patients’ lives. #Innovation #Research
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@HansClevers
Hans Clevers
2 years
A bispecific #antibody which distinguishes #cancer cells from healthy cells, doesn't care about #KRAS mutations & was developed entirely on human cancer #organoids . In 3 years from drawing board to clinic. Congrats to all collaborators. Read:
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@HansClevers
Hans Clevers
3 years
Growing human tear gland #organoids and making them cry... 😢 Done by PhD students Marie Bannier and Yorick Post in collaboration with Saskia Imhoff and ophthalmology colleagues at #UMCutrecht . See:
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@HansClevers
Hans Clevers
4 years
Reptilian tissues can be grown as #organoids . See paper by Yorick Post et al in #Cell today. Snake #venom gland #organoids produce a full complement of toxins. Step towards improved treatment of #snakebite , known to kill 100,000 people yearly?
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@HansClevers
Hans Clevers
3 years
First-in-man clinical trial in post-radiation cancer patients with dry mouth and consequent severe damage to the oral cavity. Transplantation with salivary gland #organoids , developed by Rob Coppes c.s. at UMCG Groningen, Netherlands. Starts this summer!
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@HansClevers
Hans Clevers
1 year
Today we announce Roche's Institute of Human Biology in Basel, a bridge between academia and industry. #TeamIHB will develop and validate #organoid technology for every step of drug development at pRED & beyond to improve patient outcomes. @IHB_Research
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@HansClevers
Hans Clevers
4 years
great imaging of #snakevenom gland #organoids by Ravian van Ineveld and Anne Rios at the Princess Maxima Center in Utrecht, NL
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@HansClevers
Hans Clevers
4 years
Patient-derived #cancer #organoids hold great promise for personalized medicine. Here, Else Driehuis and Kai Kretzschmar describe how to establish (cancer) organoids and how to test their in vitro sensitivity to anti-cancer therapy
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@HansClevers
Hans Clevers
3 years
A must-read for anyone interested in stem cells. And this includes myself, because Christine, Anja and Bernard did all the hard work
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@HansClevers
Hans Clevers
4 years
#ibiology recorded three lectures of 20 minutes each covering 30 years or research in my lab. They can be viewed at: #stemcells #organoids @coloncancer
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@HansClevers
Hans Clevers
4 years
Better late than never. Bell tied around neck, and -after a long winter- finally outside! Morgins, CH. 6-6-20
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@HansClevers
Hans Clevers
2 years
Today's hike in the Swiss Alps.
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@HansClevers
Hans Clevers
5 years
Brief animation of gut stem cells at work. In the center is a villus. 6-8 crypts surround its base. Stem cells reside at the bottom of the crypts of Lieberkuehn. It only take 4-5 days for stem cell daughters to complete their journey to villus tip, after which they sadly die
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@HansClevers
Hans Clevers
4 years
Deletion of the two alleles of only a single gene (APC) in #Lgr5 gut #stemcells unleashes the #Wnt pathway and results in the formation of an adenoma. Also known as polyps, these can evolve into colon cancer. Shown by Nick Barker et al in #Nature doi: 10.1038/nature07602.
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@HansClevers
Hans Clevers
4 years
Nick Barker discovered Lgr5 as a marker of small cells that hide between the stem cells at the crypt base. Using a genetic trick called linage tracing, he turned one of these little cells blue in a live mouse. Watch what he noted next:
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@HansClevers
Hans Clevers
4 years
In case you have too much time on your hands in these strange weeks...
@HansClevers
Hans Clevers
4 years
#ibiology recorded three lectures of 20 minutes each covering 30 years or research in my lab. They can be viewed at: #stemcells #organoids @coloncancer
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@HansClevers
Hans Clevers
3 years
Honored to receive the Pezcoller-AACR Award this year
@pezcoller
Fondazione Pezcoller
3 years
Delighted to announce the Winner of 2021 @pezcoller - @AACR International Award for Extraordinary Achievement in #Cancer #Research : 🏆 Dr Hans Clevers, from @_Hubrecht , @prinsesmaximac , @UtrechtUni 🔎 More details:
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@HansClevers
Hans Clevers
4 years
COVID-19: Organoids go viral. A brief overview of the use of organoids in virology research: Image: SARS-CoV2 in gut organoids taken bij Joep Beumer (Lamers, Beumer, van der Vaart et al, Cell 2020).
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@HansClevers
Hans Clevers
4 years
Mamoru Watanabe's lab developed ways to transplant colon organoids to diseased intestines. Toshi Sato expanded a single RFP+ colon stem cell into many organoids. These were infused by Mamoru's people into the colons of mice with experimental colitis. Look what happened
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@HansClevers
Hans Clevers
5 years
This beautiful animation supports Inha Heo, DJ Dutta et al in Nature microbiology (PMID: 29946163). Made by Luis at Nymus3D, it depicts the life cycle of Cryptosporidium, a pathogen in immunodeficient patients
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@HansClevers
Hans Clevers
5 years
an image providing the various cell types of the small intestinal epithelium. Note that enteroendocrine cells come in many flavours. The crypt base columnar cell was first described -and proposed to be the stem cell- by Hazel Chang and J.P. Leblond. More about the latter later
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@HansClevers
Hans Clevers
4 years
A view in a cleanroom at Juntendo University Hospital Tokyo. Prof Watanabe's people are growing autologous colon #organoids for @RegenerativeMedicine : transplantation of IBD patients. First-in-man trial will happen soon!
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@HansClevers
Hans Clevers
4 years
Very impressive PhD thesis defense this morning by Joep Beumer. Title: "Constructing roadmaps towards functional cell types using organoids". The diploma is handed over under strict Corona-distancing rules in the historic Utrecht University building.
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@HansClevers
Hans Clevers
3 years
Got my first AZ #COVID #vaccine shot today. I posted this elated cow from 'our' village Morgins (CH) during the first lockdown in the spring of 2020. Appears much more appropriate at this moment.
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@HansClevers
Hans Clevers
6 months
💡New Insights! Proud to share our @ScienceMagazine research: High-throughput screening in human #organoids illuminates ZNF800 as a key factor in differentiation of the gut cells that make hormones like #GLP1 . Learn more about it here: 🔍 #ScienceDiscovery
@_Hubrecht
Hubrecht Institute
6 months
How do stem cells form enteroendocrine cells of the gut? @TheCleversLab , @prinsesmaximac and @MaastrichtU used human gut organoids to answer that question and identified ZNF800 as a key regulator. The results were published in Science today! Read more:
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@HansClevers
Hans Clevers
2 years
Two of my favourite writers, Michel Houellebecq (photo) and Paul Auster, got the Taobuk Literature Prize at Teatro Antico, Taormina, yesterday. I received the Taobuk DaVinci Prize today. A true case of feeling humbled. I read many of their books. I doubt that they read our papers
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@HansClevers
Hans Clevers
1 month
Sangho Lim and collaborators report mouse #thymus #organoid lines that can be expanded for years, represent cortex and medulla and sustain T cell development in vitro and in vivo. @TheCleversLab
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@HansClevers
Hans Clevers
4 years
Last week’s PhD defense photo of Joep evoked remarks about gender equality at our university given the portraits of 18th century scientists. Kim Boonekamp just defended her PhD proudly. Her picture taken in another university room. Well done, Kim!
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@HansClevers
Hans Clevers
5 years
Nothing beats real biology. This is a 3D confocal reconstruction of the inner surface of the small intestine. Courtesy of our collaborators at the #prinsesmaximamac in Utrecht
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@HansClevers
Hans Clevers
4 years
Great collaborative project with the labs of @bart_haagmans , Edwin Cuppen and Peter Peters.
@_Hubrecht
Hubrecht Institute
4 years
Coronavirus SARS-CoV-2 can infect cells of the intestine. @HansClevers , @bart_haagmans @ErasmusMC and Peter Peters @MaastrichtU show that intestinal organoids, tiny cultured intestines, can be infected by the coronavirus SARS-CoV-2, in @ScienceMagazine .
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@HansClevers
Hans Clevers
4 years
Beautiful @_Hubrecht Institute has gone into lockdown yesterday, at least until the end of March. We will work from home..
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@HansClevers
Hans Clevers
4 months
Thrilled about our @CellStemCell review on adult stem cells (ASCs) with #TeamIHB 's @BeumerJoep . 6 biological hallmarks define their regenerative capabilities and provide insights into tissue-specific strategies for tissue maintenance. Paper👉🏻
@BeumerJoep
Joep Beumer
4 months
1. Adult stem cells (ASCs) compensate for cell loss during daily wear and tear. Evolution has created a variety of stem cell designs. In this review, @HansClevers and I define six hallmarks that are key enabling features of the basic function of ASCs, replacing lost tissue.
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@HansClevers
Hans Clevers
3 years
Who would have thought? Not believed by many when Nick Barker published his paper on #Lgr5 #stemcells in 2007, . And now an entire book devoted to these critters...
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@HansClevers
Hans Clevers
3 years
Left: my little joke on the lab App group, where my colleagues report when lab reagents are running out. Right: my birthday present from the lab #peanutbutter #pindakaas #maximac
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@HansClevers
Hans Clevers
2 years
First public PhD defense in two years. Margit did very well and is now Dr Bleijs!
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@HansClevers
Hans Clevers
5 months
⚕️Major Step Forward: A new organoid model offers hope for patients with pulmonary neuroendocrine tumors. Researchers from @_Hubrecht and @IHB_Research suggest EGF inhibitors as a potential game-changer. Learn more: #CancerResearch #Organoids @BeumerJoep
@_Hubrecht
Hubrecht Institute
5 months
@TheCleversLab and the @CancersRare Team (IARC/WHO) developed the first organoid model for neuroendocrine tumors. During the development of this new model, they already discovered a potential new treatment for pulmonary NETs: . @TalyaDayton @nl_alcala
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@HansClevers
Hans Clevers
1 year
Great thesis defense by Marie Banner: Tear gland organoids that can cry, conjunctival organoids that can be transplanted.
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@HansClevers
Hans Clevers
3 years
Great study from Yi Miao in Chris Garcia's lab describes a potent engineered protein that engages #Wnt receptors and replaces Wnt in #organoid medium. It can be used at subnanomolar concentration and is superior to anything we have used previously
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@HansClevers
Hans Clevers
1 year
Very nice paper by @HendriksDelilah , @BArtegiani and collaborators using human hepatocyte @organoids and @Crispr to model @fatty_liver disease. Movie shows endogenous lipid-loaded organoids cleared by addition of an Acc inhibitor in 3 days.
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Hans Clevers
4 years
Benedetta Artegiani, Delilah Hendriks et al report a highly efficient gene insertion technique for human @organoids . The movie gives the example of a tubulin-GFP fusion in hepatocyte organoids. For the complete paper:
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@HansClevers
Hans Clevers
1 year
Academic researchers from around the world with experience in human in vitro model systems / #organoids : If interested to join us, please reach out @IHB_Research
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@HansClevers
Hans Clevers
4 years
An artist's impression of the first 3D mini-guts, grown by Toshi Sato in our lab #organoids #stemcells
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@HansClevers
Hans Clevers
4 months
🧠Scientists @prinsesmaximac & @_Hubrecht unlocked a new method to study brain development with brain #organoids from fetal tissue. This could revolutionize our understanding of brain development & diseases. @HendriksDelilah @BArtegiani Read more:
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@HansClevers
Hans Clevers
4 years
Last year we opened the Princess Maxima Center, where alle Dutch kids with cancer are treated. Our 300 scientists (growing to ~500) are all working with the doctors towards improved cures for the children. This is the Maxima building in progress, in Utrecht, The Netherlands
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@HansClevers
Hans Clevers
4 years
And the real images Snippert et al Cell. 2010 Oct 1;143(1):134-44. doi: 10.1016
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@HansClevers
Hans Clevers
2 years
Join us in #LosAngeles this December to discuss the latest advances in #stemcellresearch and to champion new ideas to overcome the current challenges in the field @CellSymposia #CSStemCells22 @CedarsSinaiMed
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@HansClevers
Hans Clevers
4 years
Our phD students Cayetano, Jens and Axel explain how a common E coli variant secretes a mutagen and induces a unique mutational signature upon chronic exposure inside gut #organoids . This signature also occurs in some colon cancers.
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@HansClevers
Hans Clevers
4 years
3 Days of 3D, a virtual event on 3D models for academia and industry Nov 10-12. Rob Vries and me give keynotes (pro bono, just so you know). Register at
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@HansClevers
Hans Clevers
5 years
As a young scientist from Germany, Lieberkuehn defended his discovery of crypts in 1745 at Leiden University in the Netherlands. I discovered his thesis in Museum Boerhaave. Of special note to current PhD students, it covers just 32 pages. It was, however, written in English.
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@HansClevers
Hans Clevers
1 month
What a win for @Roche and a warm welcome to Juergen. With his efforts and leadership of IHB, more bridges will form between academia and pharma to enable better and faster drug development. @Knoblich_lab
@IHB_Research
Institute of Human Biology
1 month
🎇Big news! Prof Juergen Knoblich @IMBA_Vienna @oeaw @MedUni_Wien joins #TeamIHB as its new Head. Bringing extensive leadership experience, he is also a pioneer in #organoids biology. His lab was 1st to develop an organoid model for a human brain disorder. Welcome @Knoblich_lab !
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@HansClevers
Hans Clevers
3 years
Today from 3-4pm ET, I'll present a number of examples as to how to use #organoids for modeling human disease @gvnlab @columbiabme #TissueTalk RSVP:
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@HansClevers
Hans Clevers
2 months
🔍Understanding genetic mutations & signaling pathways is key to advancing personalized therapies for #ColorectalCancer . This study is a crucial step toward more effective treatments. Learn more: #CancerResearch #FBXW7 #EGFRSignaling
@_Hubrecht
Hubrecht Institute
2 months
Researchers from the Organoid group have found a new link between a commonly mutated gene in colon cancer, FBXW7, and EGFR signaling. Read more here: @geurts_maarten @HansClevers @sha_gandhi @TheCleversLab
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Hans Clevers
4 years
The European budget of the highly successful ERC program is under threat. Please sign a petition in support of the ERC at
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Hans Clevers
2 years
Retreat with the Hubrecht PIs in Noordwijk. Storm Corrie comes in from the North Sea..
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@HansClevers
Hans Clevers
4 years
Vijf jaar geleden al uitgelegd waarom biomassa niet werkt, door @martijnkatan @LEMVet @_knaw
@FD_Nieuws
FD Nieuws
4 years
Biomassasector stort in
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@HansClevers
Hans Clevers
5 months
🧠Shape matters! Breakthrough in pediatric brain organoids! Discover in this cutting-edge research from @prinsesmaximac and @_Hubrecht how these mini-brains are paving the way for targeted treatments of childhood brain tumors. #Organoids
@prinsesmaximac
PrinsesMáximaCentrum
5 months
Essential features of the cortex, like cell organization, stem cell expansion and cell identity, are more accurately captured in organoids. The mini-organs were generated by researchers of the Máxima Center and the @_Hubrecht  Institute. @NatureComms
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@HansClevers
Hans Clevers
4 years
Gorgeous movie by Prisca Liberali
@FMIscience
FMI science
4 years
This video of intestinal #organoids from the lab of @priscaliberali is featured by @sciam in this week’s #BestScienceGIFs ! Read more about her work here: and see the @sciam article here:
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@HansClevers
Hans Clevers
3 years
PhD defence of @JensPuschhof today. Summa cum laude! Not the traditional ceremony though, all online
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@HansClevers
Hans Clevers
2 years
Updating #VaticanCity on the latest in #stemcell science through a workshop organised by Helen Blau and Elaine Fuchs for the Pontifical Academia Scientiarum -the pope's scientific academia-, located behind the #StPeterBasilica last week
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@HansClevers
Hans Clevers
3 years
Next Monday (16-11), I speak at this virtual symposium bringing together artists, academics, biologists and creative technologists to examine the confluence of art and science. Part of Mutating Story-exhibition by @jacobvanderbeugel in museum Beelden aan Zee
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@HansClevers
Hans Clevers
4 years
Yorick Post defended his thesis this morning (his midnight) from San Francisco. #snakevenom #cardiacstemcells #teargland . Entirely virtual, which was at moments a bit awkward, but it went very well. Cum laude!
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@HansClevers
Hans Clevers
3 years
Interested in watching a traditional Dutch thesis defense in COVID times? No 16th century senate hall, but some great science: @JensPuschhof on genotoxic E coli in #ColonCancer , #snakevenom gland #organoids , gut hormones and more. Tue 9-3 at 10:30 CET.
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@HansClevers
Hans Clevers
4 years
Great paper from Jennifer Rosenbluth and Joan Brugge. Must-read
@organoidscience
Organoid News
4 years
#Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages. @NatureComms @HansClevers
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Hans Clevers
3 years
Great thesis defense by Kadi Lohmussaar today! @Organoids of female genital tract and gynecological cancers. Picture taken in front of the @UtrechtUni female professors wall (Note the 'Make Estonia Great Again'-flag on Kadi's jacket.)
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@HansClevers
Hans Clevers
3 months
Many adult stem cells remain to be identified.Together with #TeamIHB ’s @BeumerJoep , we review the current state of knowledge, highlight their complexity and potential to make new models and approaches for drug discovery. 👉🏻Read more:
@Roche
Roche
3 months
🌟Adult stem cells: a biological universe still to be fully explored🌟 @BeumerJoep & @HansClevers review how we biologically define these cells and chart new research avenues that could lead to new medical innovation. More at #RocheInnovation @IHB_Research
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Hans Clevers
4 years
Great first day!
@emboreports
EMBO Reports
4 years
The virtual EMBO/EMBL Symposium ' #Organoids : Modelling #Organ #Development and #Disease in 3D' #EESOrgan is starting today. -> Looking for a home for your paper? Have an online chat with our editor Esther Schnapp and tell her about your work.
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Hans Clevers
4 years
Strategy used by Toshi Sato to grow the first cancer #organoids , aka #tumoroids . Gastroenterology 2011. doi: 10.1053/j.gastro.2011.07.050.
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Hans Clevers
4 years
Image of attempt to grow neuronal #organoids by Marc vd Wetering. Taken on March 24th 2016, when Johan Cruijff passed away
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@HansClevers
Hans Clevers
4 months
Despite the rise of drug resistance, there has not been a single novel class of antibiotics effective against gram-negative bacteria on the market since 1968. Proud of this research done in #pRED . Check it out: and .
@Roche
Roche
4 months
Scientific progress is key to solving major global health challenges. Resistant bacteria today present a major threat. To outsmart them, our very dedicated scientists have now found a promising and surprising new path. 📷 Check out our latest discoveries in this field to address…
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Hans Clevers
2 months
British science giants, laid to rest in the north aisle of the nave of Westminster Abbey (also includes my feet...)
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Hans Clevers
3 years
Very simple and efficient way to create any knock-in organoid with CRISPR
@TheCleversLab
The Clevers Lab
3 years
A great ''behind the paper'' by @HendriksDelilah : the most recent progress on CRISPR-engineering human liver organoids. CRISPRing mini human livers #method #protocol
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Hans Clevers
1 year
Just before the start of Camilla Calandrini's thesis defense at Utrecht University. It went very well #jarnodrostlab #prinsesmaximac
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Hans Clevers
2 months
Tour and dinner at Westminster Abbey at the occasion of the annual scientific advisory board of @TheCrick Institute
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Hans Clevers
4 years
And these are the PhD students who -with some fantastic collaborators- conceived and executed the #snake #venom gland #organoid project: Yorick Post, Joep Beumer and Jens Puschhof. Post et al #Cell doi 10.1016/j.cell.2019.11.038
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Hans Clevers
4 years
Our mutagenic pks-E coli paper is directly accessible at
@HansClevers
Hans Clevers
4 years
Our phD students Cayetano, Jens and Axel explain how a common E coli variant secretes a mutagen and induces a unique mutational signature upon chronic exposure inside gut #organoids . This signature also occurs in some colon cancers.
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Hans Clevers
4 years
Benedetta Artegiani, Delilah Hendriks and collaborators made the cover of Nature Cell Biology reporting a highly efficient gene insertion technique for human @organoids For the complete paper:
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@HansClevers
Hans Clevers
4 years
Bonne annee de Morgins
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Hans Clevers
4 years
Talya wrote the NETRF grant and also got a personal fellowship. She has been leading our NET organoid project. The award is so well deserved
@CureNETs
NET Research Foundation
4 years
@TalyaDayton 's presentation of @CureNETs funded research from @HansClevers lab at @_Hubrecht won Presidential Award for Basic Science at #ENETS20 for their work on #NETCancer #organoids #tumoroids . Learn about this promising cell line.
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Hans Clevers
4 years
View from the #Organoids2019 meeting at the New York Academy of Sciences
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@HansClevers
Hans Clevers
4 years
Discover #OPTIMISTICC : the Opportunity To Investigate the Microbiome’s Impact on Science and Treatment In Colorectal Cancer, an international team of scientists/physicians & advocates. Proud to participate! #microbiome #crcsm #crc #colorectalcancer #cruk
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Hans Clevers
4 years
Final day of the 2020 Organoids meeting at EMBL #EESOrgan
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Hans Clevers
5 years
Next generation scientists at Festival del Scienza in Genova, Italy
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@HansClevers
Hans Clevers
4 years
Comprehensive and up-to-date overview of the liver organoid field
@organoidscience
Organoid News
4 years
Organoid models offer new perspectives in #PersonalizedMedicine and drug discovery. 📖 In this review, the authors discuss the current liver #organoid models for the study of liver disease. 🔓 Open access
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@HansClevers
Hans Clevers
5 years
In 1887, the Viennese pathologist Josef Paneth gives the first describtion of Paneth cells, residing at the crypt base (the whitish cells at the top). Of note, he indicates tiny cells nestled between the Paneth cells with an 's'. Of note also, this is Figure 29 of his paper..
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@HansClevers
Hans Clevers
6 months
🚀 Exciting news! We are honoured to be recognised as an innovative leader in the world's top 20 BioPharma employers @ScienceCareers 2023 Top Employers! 🏆 Find out more here:
@Roche
Roche
6 months
🚀 Excited to see three of our innovation engines make it to the prestigious list @ScienceCareers 2023 Top Employers! 🔝 Our recipe for success? A wealth of passion, a good deal of autonomy, and the strength of our collective experience.
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@HansClevers
Hans Clevers
4 years
Empty streets in @Amsterdam at noon this Sunday. Few walk or cycle. No tourists.
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@HansClevers
Hans Clevers
2 years
Visited the Science Dome @Roche in Basel this weekend, where I was immersed into a virtual reality experience through the brain. Upon until June 3rd #CelebrateScience #Roche125
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