Howard Crawford @HCCvPDAC Twitter profile

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Howard Crawford

5 years

Is the NIH grant system broken? Shockingly, I have thoughts. Thoughts from both sides of the process, grantee and reviewer. Thoughts from a mid-career scientist. Thoughts as an employer. Thoughts as a mentor. These are MY thoughts, attributable to no one else. Still with me?/1

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Howard Crawford

@HCCvPDAC

3 years

Henceforth, in person talks will be termed "in vivo" and Zoom talks "in vitro".

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Howard Crawford

@HCCvPDAC

3 years

Yes, we ordered carrots from Imperfect Foods...why do you ask?

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Howard Crawford

@HCCvPDAC

4 years

In a moment of clarity, I’ve realized that underfunding science to save a buck has destroyed the US economy.

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Howard Crawford

@HCCvPDAC

6 years

For the record, my goal isn't to publish 50 papers a year. My goal is to never have someone listening to a journal club on one of my papers say "How the Hell did this get published?" or "Why can't WE publish crap like this?" or "Who the heck reviewed this? His mother?"

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Howard Crawford

@HCCvPDAC

4 years

It's time! December 4th will be my last day at the University of Michigan. On Dec 7th, I will become the Scientific Director of the Henry Ford Pancreas Cancer Center in Detroit. So as to not bury the lede, I will be hiring 2 junior & 2 senior faculty, postdocs, techs & more.

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Howard Crawford

@HCCvPDAC

2 years

Random musings. When you’re a young PI, you really want to break into the “elite” journals, but those long term studies are not compatible with tenure most of the time. So publish wherever you can to establish productivity. Check.

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Howard Crawford

@HCCvPDAC

2 years

Study Section Eve. There’s one phrase I know I’ll hear at least 3 times: “best one in my pile”. It’s an important 🏆 to win, believe it or not. But how do you do it? 2 simple rules:

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Howard Crawford

@HCCvPDAC

1 year

@SmithImmunology That’s when you whip off your glasses and spin around in your chair and say “you asked to see me?”

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Howard Crawford

@HCCvPDAC

5 years

My lab celebrates every trainee’s paper. The richer we are scientifically, the poorer I become financially. Fair trade, IMO.

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Howard Crawford

@HCCvPDAC

3 years

In an infinitely recurring grant pro-tip: Use definitive verbs. No “may be, might be, could be.” Instead- “We hypothesize X *IS* true.” Let the word “hypothesize” carry the doubt. Putting it on the modal verb only emphasizes the doubt unnecessarily

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Howard Crawford

@HCCvPDAC

6 years

@joshtpm Anybody else hear Gilbert and Sullivan when you read this? “I am the very model of a modern stable gen-I-us”

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Howard Crawford

@HCCvPDAC

7 months

I don’t usually do hot takes, but… Researchers should work the days of the week and the number of hours a day that they want. They’re capable of understanding the consequences of their choices without your input, outrage, or ridicule. One size does not fit all.

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Howard Crawford

@HCCvPDAC

12 days

Glad to finally see this (it almost didn't happen even with a 9%ile. Don't ask.)! And it's a big boi, $$$-wise!

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Howard Crawford

@HCCvPDAC

3 years

Hey! I’m interested in hiring postdocs who sincerely want to make a difference for pancreatic cancer patients. We have lots of defined projects but also an enormous amount of freedom to branch out on your own. Team players only need apply.

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Howard Crawford

@HCCvPDAC

3 years

I got a sign, so I guess it’s official...

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Howard Crawford

@HCCvPDAC

5 years

The lab is worried. I’m very “water off a duck’s back” with them because I don’t want them to worry about their jobs. It’s got to be the most stressful part of being a PI. Worrying not just about your trainees, but their families, if you don’t get your funding./20

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Howard Crawford

@HCCvPDAC

1 year

I do think it’s time, before the death of Twitter, that we have an honest discussion about the pressures to fake data. I’ve had postdocs crying on my shoulder (literally) about their PIs demanding data that fits their hypotheses NO MATTER WHAT.

Drug Monkey

@drugmonkeyblog

1 year

It’s even worse. It is saying that earning a PhD is based on the positive outcome bias of publication. And not on learning to do science, regardless of the direction of the outcome. This incentivizes data faking.

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Howard Crawford

@HCCvPDAC

4 years

So, is there a university in New Zealand interested in hiring me or am I going to have to start my own?

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Howard Crawford

@HCCvPDAC

4 months

The most diabolical tactic of scientific institutions is to put a clock on the use of start up funds. No clocks. Get it in writing in your offer letter. If it’s not mentioned at all, don’t assume that there isn’t one. Assume the opposite.

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Howard Crawford

@HCCvPDAC

3 years

I got a chance to watch #PictureAScientist . An excellent documentary depicting how much institutional sexism and individual assholes have cost us scientifically. More subtly, it depicts how changing the existing power structure is essential and requires white males to step up.

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Howard Crawford

@HCCvPDAC

5 months

PSA: Please understand the biology of your model system BEFORE you single cell seq the hell out of it.

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Howard Crawford

@HCCvPDAC

1 year

For scientists yucking it up about the House debacle- it won’t be so funny next Fall when the NIH puts a freeze on your grants because of the ongoing shutdown or you have to wait on your NOA because they can’t pass a budget. #askmehowIknow

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Howard Crawford

@HCCvPDAC

3 years

@jflier “…a billionaire…academic scientist”

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Howard Crawford

@HCCvPDAC

3 years

It’s been a trip, UM. Proud of what I helped to build here. Onto the next challenge!

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Howard Crawford

@HCCvPDAC

5 years

And therein lies the problem. With an 8% pay line, all it takes is one reviewer. One reviewer who doesn’t have the right knowledge base. One reviewer who simply isn’t excited about your proposal. One reviewer who says “it’s not translational enough”. /36

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Howard Crawford

@HCCvPDAC

3 years

Lab renos are also complete! The process of filling them up continues!

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Howard Crawford

@HCCvPDAC

4 years

There has been a real benefit of shelter in place for a month: each of my trainees has had amazing revelations about their projects simply because they’ve had time to think...and daydream. Everyone is learning how to work smart. And how important time away is...always.

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Howard Crawford

@HCCvPDAC

2 years

Taking my own advice for a change and having Word read this grant to me like a bedtime story. So far- riveting! And I found at least 5 critical edits that my eyes just did not see. #GrantProTips

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Howard Crawford

@HCCvPDAC

6 months

Challenge accepted CSR! Study section on Halloween? Say hello to your chair!

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Howard Crawford

@HCCvPDAC

5 years

Should there be a special award system for those who spend time and money to correct the incredibly flawed dogmatic data of sloppy influential labs? I think so. It should be the “Reallocating funding to the unfunded PI who turned out to be right all along” award. The R🖕.

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Howard Crawford

@HCCvPDAC

2 years

He shuttered his lab after 5 years. You hear a lot of us in this app preaching about “white space”, which is a huge deal. Tired eyes lead to grumpy reviews. The simplest words, sentence and paragraph structure. It might feel “dumbed down” to you, but it’s not. It’s just clear.

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Howard Crawford

@HCCvPDAC

3 years

Turns out I'm infinitely more comfortable with being called "well-seasoned" than I am with "world-renowned", but nonetheless here's the press release for my latest career move.

Henry Ford Health System Receives $16 Million Gift to Benefit Henry Ford Pancreatic Cancer Center

/PRNewswire/ -- Henry Ford Health System today announced a $16 million gift to its Henry Ford Pancreatic Cancer Center (HFPCC), which was launched in 2018 by...

www.prnewswire.com

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Howard Crawford

@HCCvPDAC

10 days

A little personal news. When I went dry Jan-Mar, I was a little bored at night, so I started doing pushups before I went to bed. Meh, a minimal amount of exercise. I could do maybe 30-35 when I started. For my age, not bad. Last night I finally hit 100. First time in my life.

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Howard Crawford

@HCCvPDAC

6 months

I’d be happy, but for the doom and gloom stories I’m hearing from POs

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Howard Crawford

@HCCvPDAC

1 year

Tomorrow is my lab’s 20th b-day, so this is how I’m greeted this morning. I wanted to take everyone out tomorrow, but thought it was bad form for the boss to plan an event on a Friday evening (that also happens to be Cinco de Mayo). But next year, my lab can drink legally, so…

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Howard Crawford

@HCCvPDAC

3 years

@SaelicesL It’s a one carrot diamond

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Howard Crawford

@HCCvPDAC

1 year

Reminder: When I turn around your administrative task with lightning speed, it's not because I prioritize those responsibilities. It's because I'm procrastinating about doing something that actually requires thought.

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Howard Crawford

@HCCvPDAC

4 years

I didn't want to steal my former trainee @CJHPhD 's thunder yesterday, but just in case you thought the travails of my long-fought grant might conclude with me being one of two people with a 4%ile who still didn't get the money, let me put your mind at ease....

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Howard Crawford

@HCCvPDAC

7 months

I don’t care how weird or awkward it might seem, but get *everything* that’s important to you in a new position *in writing* in the offer letter/contract. If they say “but of course that’s true” then it’s no skin off their nose to WRITE IT DOWN.

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Howard Crawford

@HCCvPDAC

2 years

Reflecting this morning on the asst prof who, years ago, worked through a burst appendix and died in his sleep…and another who hung himself in his lab after getting scooped. Don’t know why this morn, but next time there’s a work/life balance in academia debate, I’ll remind you.

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Howard Crawford

@HCCvPDAC

2 years

@cterminiPHD With a good startup, you have more liquid money than any of your more senior colleagues/competitors. Use some of that money to build a tool everyone in the field wants but can’t afford and let the collaborations come to you. Don’t hoard those $$…it’s not a rainy day fund.

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Howard Crawford

@HCCvPDAC

5 years

Reviewers? Don’t do this. Don’t tell someone to change their project focus entirely. If you don’t like the current project, that’s fine. Say that. Advice to refine it? Cool! So helpful! But “do this think I like better instead”? Just no. /7

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Howard Crawford

@HCCvPDAC

6 months

We got the band together for World Pancreatic Cancer Day #WPCD #HFPCC .

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Howard Crawford

@HCCvPDAC

2 months

An awesome off-kilter (appropriate for me) matcha birthday cake, courtesy of Dr. Hui Ju Wen! Thanks for the well-wishes my #HFPCC family!

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Howard Crawford

@HCCvPDAC

1 year

I spent my lunch yesterday trying to convince grad students and postdocs that their mental health and well-being is more important than their work. Underfunded labs having to compete with overfunded labs results in some very, very stressed out lab members.

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Howard Crawford

@HCCvPDAC

2 years

Off season grant pro tip: “Rigor of prior research” translates to “the gap in the literature” NOT a detailed ripping apart of every paper in the field.

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Howard Crawford

@HCCvPDAC

5 years

Another reviewer clearly thought that reviewer was insane and had nothing but nice things to say. These reviewers ARE out there, people! Marry them if you have to. No wait, then they’d be COI. Don’t marry them./28

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Howard Crawford

@HCCvPDAC

6 months

@mike_feigin Spend the first half hour scheduling future faculty meetings.

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Howard Crawford

@HCCvPDAC

6 months

Got my purple on for World Pancreatic Cancer Day. But also the day after losing one of our brightest rising stars in the field. So forgive my lack of smile. See you Cullen. Purple hair in your honor next year.

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Howard Crawford

@HCCvPDAC

3 years

Ok…time has passed Grant reviewer pet peeve: if an A0 gets criticism questioning PI productivity and, in response, they publish a high profile paper that includes a good amount of the preliminary data… DO NOT be the reviewer who says “it’s no longer innovative”, as a result.

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Howard Crawford

@HCCvPDAC

3 years

@ClementYChow Even if you strip it of the blatant racism doesn’t this translate to “Don’t impinge on my right to eavesdrop on your private conversations”? Going out on a limb to say, that’s not awesome either.

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Howard Crawford

@HCCvPDAC

4 years

Tomorrow will be bittersweet. I graduate my 11th PhD student by freakin’ Zoom. She’s been with me for a long time, not because she’s slow, but because she’s *curious*. And the idea of not being there with her, to support her, is going to be hard. @UMICHpancreas @UMRogelCancer

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Howard Crawford

@HCCvPDAC

2 years

Hearing tonight of an old friend’s suicide and reading his very long, smart, insightful suicide note… All I can say is…don’t assume that someone you haven’t talked to in a long time doesn’t care about you…but also don’t assume that they’re OK. Talk to each other, FFS. RIP EP

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Howard Crawford

@HCCvPDAC

5 months

@MarkELindsay This scores high on the “this can’t possibly be real” scale?

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Howard Crawford

@HCCvPDAC

2 years

Twitter over the last two days has been devastatingly sad. I hope you all can find the briefest of moments to tell your loved ones how much they mean to you. It will only take a second, I promise. (And if it takes longer…good.) Peace everybody. Take care.

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Howard Crawford

@HCCvPDAC

9 months

NIH funding for the next few years is going to be rough(er). Find ways to support each other. It’s the only way we don’t lose great scientists.

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Howard Crawford

@HCCvPDAC

4 years

My backyard trees have distinctly different opinions about this whole “Fall” thing

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Howard Crawford

@HCCvPDAC

2 years

#2 is “easy to read”. I knew a brilliant guy who wrote his great science proposals in dense, inscrutable language. When I suggested he make it more easily accessible, he refused, saying that “study section members are supposed to be experts. It’s up to them to take the time.”

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Howard Crawford

@HCCvPDAC

4 months

Since I haven’t seen it on here- I’m sad to report the passing of Dr. Bonnie Sloane, pioneering researcher on the role of proteases in breast cancer progression, and former Chair of Pharmacology @waynestate . She passed on Christmas Eve, after her own battle with cancer.

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Howard Crawford

@HCCvPDAC

6 years

Ok, this tweet blew up a bit. I have the feeling that journal clubs across the country will be presenting my papers this week followed by an equal number of “Bro, sorry to tell you this, but...” tweets.

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Howard Crawford

@HCCvPDAC

4 years

Who can say enough great things about @Pasca_Lab and her promotion to full Professor? Amazing scientist, prolific mentor, DE&I champion! Raise a glass 🥂 in these difficult times (she’s a mother of 3, so....) to let her know that she is a valued colleague, collaborator and friend

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Howard Crawford

@HCCvPDAC

4 years

Seeing as it’s my birthday, I expect you all to acknowledge this momentous occasion every time you wash your hands today. Twice.

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Howard Crawford

@HCCvPDAC

2 years

Soooo… my wife takes our visiting niece to a bread baking class at Zingerman’s while I’m at work and now here’s our kitchen:

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Howard Crawford

@HCCvPDAC

4 months

Does anyone else want to start a journal that exclusively publishes all of the unpublished stuff from labs where the PI is about to retire? The Journal of Crap that No One Cared About But Me?

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Howard Crawford

@HCCvPDAC

6 months

Mentoring young faculty and your own postdocs at the same time is hard. But the advice (with intense questioning) is ultimately the same: “What’s the narrative?” If some of your data don’t fit your story, you can’t change the data. So change the story.

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Howard Crawford

@HCCvPDAC

3 years

Moving into the new lab over the next couple of days!

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Howard Crawford

@HCCvPDAC

6 months

I’ll admit, the new hallway is pretty cool.

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Howard Crawford

@HCCvPDAC

2 years

What covers it all is to ask colleagues to read your grant. Someone with only OK knowledge of your science. The feedback you’re looking for is not scientific, but literally a “1st impression”, because that’s what’s going to determine your status in “my pile” of good science apps.

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Howard Crawford

@HCCvPDAC

2 months

Authors of a new Nature paper breathlessly reporting that “cancer is bad”, but now with single cell sequencing.

Science girl

@gunsnrosesgirl3

2 months

Making a delicious glass of water 😜 📹 foodkagechris

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Howard Crawford

@HCCvPDAC

4 years

Oh hey! Welcome to my 2000th follower! Amazing what bitching about NCI funding and the occasional snark will do! Big news coming, especially if you work in pancreatic cancer research and you want a job...

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Howard Crawford

@HCCvPDAC

5 months

Ok, time to work on that Tweetorial for our new preprint: 1st off, this was a massive project driven entirely by a talented senior research scientist in my lab, Dr. Simone Benitz. She's on the TT job market, and you'll see why you'll be lucky to get her.

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Howard Crawford

@HCCvPDAC

3 years

I know this is a weird thing to say on Twitter, but you aren’t actually *required* to say your every stupid thought out loud. But even if you do, you don’t need to submit it to Nature Communications or EMBO Journal. You can just keep it to yourself and no one will be the wiser.

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Howard Crawford

@HCCvPDAC

7 months

I was stumped about the keynote for the UTSW cancer bio grad students. Tell them about all the BS I had to deal with? Boooring. Typical science talk? Meh. Then it dawned on me- it’s not about me, it’s about them. So here we go…my past GSs and the story they told the world:

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Howard Crawford

@HCCvPDAC

1 year

How sick am I of senior investigators getting a bye for proposing budget period-impossible experiments in their grants, and getting a pass, while junior investigators have to have all tools in place with preliminary data? Very.

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Howard Crawford

@HCCvPDAC

7 months

Quite possibly my favorite talk. Finally, someone mentions the biological effects of reporter proteins! They ain’t biologically neutral folks!

Anirban Maitra

@Aiims1742

7 months

Next up at #AACRPan23 is @dow_lab @WeillCornell who has used CRISPR to develop a cache of KRAS mutant strains on B6 background that can be used to study #PancreaticCancer and other KRAS mutant cancers. Incredible service to the community making them available for research.…

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Howard Crawford

@HCCvPDAC

3 years

I am mystified by all the academics trying to get a “blue check”. I’m guessing that going up for tenure gave you a taste for meaningless hurdles to leap?

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Howard Crawford

@HCCvPDAC

2 years

My wife and I are childless, by choice. Yesterday, after a day's work, all we wanted was some quiet time. But the neighborhood kids were playing next door, screaming and yelling. SO annoying! Then we saw the news. We watched them quietly from the window until it got dark.

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Howard Crawford

@HCCvPDAC

4 years

Now that the cats are out of the bags, I want to shout out a BIG congratulations to two of my former grad student trainees, @DelgiornoKathy and @CJHPhD , joining the faculty of @VanderbiltU and @UCIrvine , respectively. Huge accomplishment, both of you!

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Howard Crawford

@HCCvPDAC

2 years

So you may have heard that I’ve hired more than a few young pancreatic cancer superstars ( @DebVendramini , @RAFrancescone , @NinaSteele17 , @linghuangbiores ) for the @HenryFordHealth Pancreatic Cancer Center. Now I’m looking for a mid-career superstar to join our team! Is it you?

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Howard Crawford

@HCCvPDAC

4 years

4th percentile!

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Howard Crawford

@HCCvPDAC

3 years

Welcome to the beginning of the next phase of my career. #CancerHealthDisparitiesSymposium

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Howard Crawford

@HCCvPDAC

3 years

I was infatuated before, but now I’m in love.

CBS News

@CBSNews

3 years

Kamala Harris says she feels a “certain kinship” with the new science team, as her mom was a scientist: “Science has a way of shaping how you think and way of life, and she instilled in me a fundamental belief in the importance of collecting and analyzing data. Facts.”

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Howard Crawford

@HCCvPDAC

6 months

Up til now, I was not allowed to pay people what they're worth. I fought it every step of the way and found work arounds over and over. Now I'm happy to say we are allowed to pay people competitively. Come join us at the Henry Ford Pancreatic Cancer Center, we're always hiring!

Gilp

@The_Gilp

6 months

Among the many frustrations inherent to running a lab, not being allowed to pay people what they’re worth is probably number one on the list. How do we fix this retention problem? Uh, pay people. It’s not rocket surgery.

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Howard Crawford

@HCCvPDAC

4 years

Life’s a fucking roller coaster. Good grant score one day, very close relative put on hospice care the next. Thinking of those for whom the holidays aren’t that awesome. Love and peace.

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Howard Crawford

@HCCvPDAC

3 years

Ahem...manuscript accepted! Details to come! @sam_kemp20 @Pasca_Lab @CR_AACR

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Howard Crawford

@HCCvPDAC

2 years

Why is "our protein is overexpressed 2-fold in cancer" evidence of aberrant function, but "we will overexpress the our protein a billion fold" is a legit method to define normal function? (Psst... rhetorical question)

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Howard Crawford

@HCCvPDAC

2 years

These were a couple of years apart, same place (one floor separated them). Funding rate was around 20% at the time. Take care of yourself, people. It might be your passion, but it’s still just a job. Sorry to be morbid…

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Howard Crawford

@HCCvPDAC

4 years

@thoughtsofaphd Old mentor here- I always tell my trainees that my job is to help them reach *their* goals. I’ve been disappointed by trainees who wanted to leave academia when I know how good they would be at it. And relieved when others decided the same. But it’s not *my* life. So you do you.

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Howard Crawford

@HCCvPDAC

10 months

Oh shit, I just submitted a very positive review of a first submission. Like "just accept this already" level. Who am I?

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Howard Crawford

@HCCvPDAC

7 months

I’ll be damned if at least 40% of my overall stress isn’t caused by trying to meet deadlines that nobody else really gives a shit about.

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Howard Crawford

@HCCvPDAC

5 months

@mike_feigin Counterpoint: naming your lab anything else is pretentious.

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Howard Crawford

@HCCvPDAC

2 years

I used to say “If the paper that reports the cure for pancreatic cancer cites a paper that cites one of my papers, I’ll feel like I did something good”. If I keep having weeks like this week, it just might turn out a little better that.

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Howard Crawford

@HCCvPDAC

3 years

Now we know where the island shopped

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Howard Crawford

@HCCvPDAC

9 months

Ignore the common imposter syndrome phrase “If *I* thought of it, surely someone else must have thought of it and is already doing it”. Eureka moments are not just your knowledge at work, but your knowledge mixed with your unique, eclectic personal experiences. Do it!

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Howard Crawford

@HCCvPDAC

3 years

I’ll be honest…when you work on cancer and with patients, you always wonder how you’d respond if you were ever diagnosed with an *especially* deadly form. Accept your fate or do whatever it takes? Nadia answered that question for me. And I will always be grateful. #NeverQuit

Dr. Krista Byers-Heinlein

@Krista_BH

3 years

@DrNadiaChaudhri passed away yesterday evening, having reached the end of her road with ovarian cancer. She leaves behind her Sun and Moon, a loving extended family, colleagues and students, friends around the world, and so many others who have been touched by her & her story 1/n

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Howard Crawford

@HCCvPDAC

3 years

@12BadgerInASuit I’ll let you know when I’m done peeling it next week

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Howard Crawford

@HCCvPDAC

3 years

@DrBenNeel @LeonidasPlatan1 I don’t want to make a comment that might seem to apply to any specific real grant in question, but I can say that I’ve reviewed mediocre grants from my scientific heroes. I score what’s in front of me, as I’m asked to. Sorry, not sorry.

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Howard Crawford

@HCCvPDAC

8 months

Squeeeee! The Xenium has landed!

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Howard Crawford

@HCCvPDAC

5 years

Critiques come back. *Clearly* not the same reviewers. Reviewer 1 - “not translational enough”. What happened to the SRO speech at start of the meeting reminding reviewers that the NCI also funds *basic science*? “Not translational enough” is supposed to be a verboten criticism.

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