Andy Vaughan also on bluesky @vaughandy Twitter profile

Last Seen Profiles

@Hijabbacol2883

@robastha

@Promediator

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@manjiiro

@TiaMarieDoesArt

@kalhonaho07

@Arlene235085166

@bnt50588

@okamotoorimono

@psjbautista1929

@cleexyz

@Fat9T

@matt_dud

@fcgia__

@musukogauhouho

@kcsfa

@kebabby_mae

@chihaya0425

@AlexanderSoros

@Emma_S59

@ppieeri

@kotaraya

@sgrueziel

@BAR_UNKNOWN

@OlteanVld

@KEMS972

@denicewesterb

@ODOT_Statewide

@HannahSeide

@SihaamMumin

@skylerblue400

@bokeplokalmalam

@ODEN_BB

@wesca_

@mikomikomikochi

Andy Vaughan also on bluesky

@vaughandy

4 months

For the love of God people just do some experiments, enough with the single cell seq atlases

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@vaughandy

2 years

Biggest tells for a PI’s age: >40, double spaces after periods in manuscripts. >60, comic sans font in keynote lectures.

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Andy Vaughan also on bluesky

@vaughandy

1 year

I just received notification of my promotion to Associate Professor with Tenure. I am beyond grateful to stay on here at Penn and keep working with such wonderful colleagues. Most importantly, this would not have happened without my wonderful lab members. They are the best!

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Andy Vaughan also on bluesky

@vaughandy

2 years

This one took a lot of work and patience on the backend, but very happy to confirm our second R01 for the Vaughan lab. Thanks to everyone in my lab (especially @zhao_gan who is the primary driver of this arm of our work)!

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@vaughandy

4 years

Very happy to share our new paper in @ScienceAdvances in which we explore repair of the lung's blood vessels after influenza injury. Extremely proud of first author @zhao_gan for his incredible work. Happy Thanksgiving!

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@vaughandy

2 years

Absolutely thrilled to share @aaiweiner 's thesis work from my lab, out now in @CellReports ! In short, loss of the transcription factor p63 increases the ability of basal cells to transdifferentiate into alveolar cells. (1/2)

ΔNp63 drives dysplastic alveolar remodeling and restricts epithelial plasticity upon severe lung...

Weiner et al. find that ΔNp63 is required for dysplastic remodeling of the distal lung after severe pulmonary injuries. Without ΔNp63, the basal-like cells responsible for this remodeling either...

www.cell.com

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Andy Vaughan also on bluesky

@vaughandy

4 years

Truly honored to be featured in Cell Stem Cell with this amazing group of early career scientists.

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Andy Vaughan also on bluesky

@vaughandy

2 years

Excited to share that our paper on injury-induced lung tuft cells is out now in @eLife ! This is the fruit of an awesome collaboration with @lab_xin . Congratulations to the all authors, especially co-first authors @barrjamie and Marilena Gentile! (1/2)

Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines,...

Influenza-induced pulmonary tuft cells are a heterogenous population and emerge independently of Type 2 and interferon signaling, and do not impact dysplastic epithelial regeneration.

elifesciences.org

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Andy Vaughan also on bluesky

@vaughandy

2 years

A very heart congratulations to Joanna Wong, my second PhD student, for receiving an excellent score on her F31! On the first try!! Co-mentored by @MorriseyLab . Look for great things from her in the near future! Unfortunately her dog Athena’s grant was not discussed.

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Andy Vaughan also on bluesky

@vaughandy

4 months

New study from our lab finally out, led by the amazing @zhao_gan ! We discovered that injured lung endothelial cells secrete SPARCL1, a protein which makes macrophages very angry. And @nualameyer showed this tracks with mortality in COVID-19!

Vascular endothelial-derived SPARCL1 exacerbates viral pneumonia through pro-inflammatory macroph...

Nature Communications - The molecular basis underlying infection infection-mediated lung pathology is not fully revealed. Here the authors report that SPARCL1 expressed in pulmonary capillary...

www.nature.com

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Andy Vaughan also on bluesky

@vaughandy

4 years

DO NOT TRY TO MAIL YOUR BALLOTS. Take to a designated drop box.

The Philadelphia Inquirer

@PhillyInquirer

4 years

USPS says Pennsylvania mail ballots may not be delivered on time, and state warns of ‘overwhelming’ risk to voters

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Andy Vaughan also on bluesky

@vaughandy

2 years

Wow, big day for the Vaughan lab. @aaiweiner successfully defended his thesis! Honestly he killed it. All of the lab’s successes are due exclusively to the hard work and perseverance of the lab members, and Aaron exemplified that today!

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@vaughandy

8 months

Excited to share @zhao_gan and @Lulu_Xuee 's amazing work out today in Science Translational Medicine! This was a highly collaborative project with @MJMitchell_Lab and also great assists from @MorriseyLab , @MariaCBasil , and many others. Hope you enjoy!

TGF-βR2 signaling coordinates pulmonary vascular repair after viral injury in mice and human tissue

TGF-βR2 signaling drives regeneration of lung blood vessels.

www.science.org

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Andy Vaughan also on bluesky

@vaughandy

2 years

Very happy to share what were, for me anyway, some quite surprising findings about X inactivation and sex differences in gene expression in the alveolar epithelium. A really fun collaboration with @montserrat 's lab!!

Unusual X chromosome inactivation maintenance in female alveolar type 2 cells is correlated with...

Anguera, Vaughan, and colleagues show that lung alveolar type 2 (AT2s) cells maintain X chromosome inactivation with fewer epigenetic modifications on the inactive X, with very high numbers of...

www.cell.com

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Andy Vaughan also on bluesky

@vaughandy

2 years

Vaughan Lab representing at the Penn Lung Biology Institute symposium today! Many thanks to @MariaCBasil and Twitterless Jeremy Katzen for organizing. @aaiweiner @zhao_gan

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Andy Vaughan also on bluesky

@vaughandy

8 months

Happy to share our latest paper from @zhao_gan and @Lulu_Xuee , this time out in PNAS. Another great collab with @MJMitchell_Lab ! Precision treatment of viral pneumonia through macrophage-targeted lipid nanoparticle delivery | PNAS

Precision treatment of viral pneumonia through macrophage-targeted lipid nanoparticle delivery |...

Macrophages are integral components of the innate immune system, playing a dual role in host defense during infection and pathophysiological states...

www.pnas.org

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@vaughandy

3 years

Holy crap I should say yes to this review request right?!?

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Andy Vaughan also on bluesky

@vaughandy

3 years

Beyond thrilled to be a small part of this study, currently featured on the STM front page ! Congrats to Nilam Mangalmurti and Metthew Lam, and the rest of the cool co-author crew including @SunnyShinLab @KingOfPathogens @aaiweiner and many others

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@vaughandy

3 years

Just noting that the acronym “APC” refers to way too many totally different entities in biology…

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Andy Vaughan also on bluesky

@vaughandy

3 years

Congratulations to Joanna Wong, who just unanimously, unconditionally passed her prelim exam! Very happy to have her in @lab_vaughan as an official PhD Candidate. Look forward to awesome things from her!

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Andy Vaughan also on bluesky

@vaughandy

1 year

Very happy to share some exciting work from my lab led by the amazing @zhao_gan . We really got out of our comfort zone on this one! Lots of great collaborators including @nualameyer , @MariaCBasil , @Lulu_Xuee , too many to fit here!

Vascular Endothelial-derived SPARCL1 Exacerbates Viral Pneumonia Through Pro-Inflammatory Macroph...

Inflammation upon infectious lung injury is a double-edged sword: while tissue-infiltrating immune cells and cytokines are necessary to control infection, these same factors often aggravate injury....

www.biorxiv.org

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Andy Vaughan also on bluesky

@vaughandy

9 months

An important statement from the Penn AAUP chapter's executive committee on the ongoing disaster happening with Penn's leadership.

Statement of the AAUP-Penn Executive Committee on Marc Rowan’s Questions to Penn Trustees |...

December 12, 2023 Today, unelected trustees with no academic expertise are evidently attempting a hostile takeover of the core academic functions of the University of Pennsylvania—functions related...

aaup-penn.org

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@vaughandy

2 years

Pretty gosh darned jazzed to find this sweet 70s Japanese tele clone in a free pile in West Philly. It sounds shockingly great without any work at all!

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@vaughandy

3 years

Thrilled to share our collaborative story with @lab_xin , led by the incredible @barrjamie and Marilena Gentile. Lung tuft cells are enigmatic little guys, and many of the rules they follow in the intestine don't seem to matter much in the lung! And a big assist from @KotasMaya

bioRxiv

@biorxivpreprint

3 years

Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair #bioRxiv

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@vaughandy

1 year

If this doesn't convince academic institutions to revamp the ideas of tenure track and research track, I don't know what will.

The Nobel Prize

@NobelPrize

1 year

“Ten years ago I was kicked out and forced to retire.” Our new medicine laureate Katalin Karikó ( @kkariko ) told us how much it means to be awarded the Nobel Prize after a scientific career that has been full of challenges. Ten years ago, Karikó was still doing all her

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Andy Vaughan also on bluesky

@vaughandy

1 year

The best department retreat co-chairs a guy could ask for ⁦ @montserrat ⁩ ⁦ @TheModzLab ⁩

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Andy Vaughan also on bluesky

@vaughandy

8 months

Vaughan lab out celebrating TWO accepted papers from @zhao_gan !

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Andy Vaughan also on bluesky

@vaughandy

5 months

Inspiring words in support of @GETUPgrads from @SunnyShinLab !! Thrilled that grad students are about to solidify their collective bargaining power and insure the grad school experience is better for future classes! With an umbrella assist from @SaraKGMD

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Andy Vaughan also on bluesky

@vaughandy

2 years

Lab photo while celebrating @aaiweiner ‘s birthday!

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Andy Vaughan also on bluesky

@vaughandy

1 year

I wasn’t allowed to attend (trainee only session) but word on the street is that @zhao_gan just gave a stellar talk for the NHLBI Progenitor Cell Research and Translation meeting! Way to represent the Vaughan lab Dr. Zhao!

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@vaughandy

2 years

I'm very, very sick of unending single cell transcriptome atlases being published at top tier journals. I'm equally flabbergasted by people who claim single cell seq is a useless technique / hasn't enabled any fundamentally new discoveries.

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@vaughandy

3 years

Come be my new colleague! Our sister department (Pathobiology) is hiring a new tenure-track professor to study pathogens (your choice!) and immune responses to them. Applications are only accepted until Dec 1 so hurry!

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@vaughandy

1 year

Iceland is an incredible place

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@vaughandy

2 years

Great lab hang last night! @aaiweiner @SaraKGMD @zhao_gan and the others not on Twitter

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@vaughandy

2 years

Great dinner with our invited speaker and new Mt. Sinai assistant professor Jaymin Kathiriya, along with the cool kids ⁦ @MariaCBasil ⁩ ⁦ @WestPhillyTough ⁩ and Shaon Sengupta

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@vaughandy

4 years

Made a new lab web site!

The Vaughan Lab @ The University of Pennsylvania

www.vaughanlab.com

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@vaughandy

4 years

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@vaughandy

1 year

Hey out there, I'm still looking for a postdoc interested in figuring out what the hell tuft cells are doing in the lung after respiratory viral injury... Shoot me a DM if interested! Some immunology background would be very helpful.

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@vaughandy

4 years

Thrilled that the second @lab_vaughan grad student Joanna was just awarded the Cell and Molecular Biology T32 training grant!

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Andy Vaughan also on bluesky

@vaughandy

11 months

Unfortunately I had the same reaction to Dr. Magill’s message. I’m puzzled why the university can’t forcefully condemn Hamas terrorism and antisemitism while simultaneously expressing concern for innocent Palestinian people.

Will Bunch

@Will_Bunch

11 months

What is happening at the University of Pennsylvania right now is deeply disturbing -- a complete erasure of the Palestinian community and backpedaling away from academic freedom to satisfy billionaire donors

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@vaughandy

4 years

Congrats to @aaiweiner of @lab_vaughan for receiving his official Notice of Award for an F31 Fellowship!!

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@vaughandy

3 years

Most PIs worth their salt would LOVE to pay trainees more, and of course it’s also true that R01 budgets are limited. The solution here seems really obvious but it’s going to require a big shift in how the public values federal funding for the NIH / NSF.

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@vaughandy

3 years

My department is hiring a new assistant professor! "Candidates with interests in stem cell biology, regenerative medicine and cancer biology in particular, are encouraged to apply"

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@vaughandy

9 months

"Trustees who neither understand nor respect the purpose of the university and who threaten its educational and research mission should not govern these institutions." 👏👏👏

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@vaughandy

4 years

Is there some kind of an award for saving democracy? Give it to Stacey Abrams.

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Andy Vaughan also on bluesky

@vaughandy

2 years

Super proud of my Twitter-less wife Dr. Kastner for matching into her #1 fellowship choice @CooperADMF !!

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@vaughandy

2 years

Way to make me feel real old CAMB graduate group! I feel like I just defended my own thesis yesterday 😭. But I am SUPER EXCITED for everyone to hear about Aaron's amazing thesis work on Monday, plus beer and fallafel afterwards!

CAMB Graduate Group

@CAMBUpenn

2 years

Aaron Weiner @aaiweiner from the Vaughan lab @vaughandy defends on Monday!

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@vaughandy

4 years

My three favorite grad students: Tenley, Athena, and Pachi. Unfortunately I’m pretty sure they’re on track to fail prelims

Penn Epigenetics

@PennEpiInst

4 years

What’s the best way to boost morale when you work at @pennvet ? Get a puppy! @montserrat got a puppy, and now there’s 5 dogs on the 3rd floor office areas. Stay tuned for pet photos all day today!

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@vaughandy

2 years

Congrats to two of my third floor @pennvet neighbors, @BrodskyIgor and @DeBroski1 , on their promotions to full professor!

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@vaughandy

2 years

Yesterday’s @CAMBUpenn DSRB retreat was an absolute blast. Hard to imagine a better group of grad students and faculty than these weirdos!

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@vaughandy

11 months

I am very excited to share that my department at Penn is recruiting new tenure-track faculty! We are especially interested in those working in embryonic and adult stem cell biology as well as tissue regeneration and repair.

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@vaughandy

2 years

Days like today really reinforce how lucky I am to have such amazing faculty colleagues in Biomedical Sciences at Penn Vet!

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Andy Vaughan also on bluesky

@vaughandy

2 years

Beautiful spring day in Philly

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@vaughandy

2 years

We are hiring! Looking for the next great research technician to help push forward our work in lung repair. Folks at various experience levels considered if they're the right person for the job!

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@vaughandy

1 year

Congrats to rock star Vaughan Lab and @CAMBUpenn PhD student Nick Holcomb for passing his prelim with flying colors!! Super excited for the science this guy is doing!

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@vaughandy

4 months

Super proud of my incredibly talented wife Dr. Kastner for finishing her addiction medicine fellowship, recognized at the ACAAM ceremony tonight!

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@vaughandy

6 months

@HaoYin20 We showed this to be the case in other cells types a few years ago too, see fig 2 here I totally agree that’s this is really important to take into account!

Local lung hypoxia determines epithelial fate decisions during alveolar regeneration

Nature Cell Biology - Xi et al. show that after influenza infection, hypoxia drives Notch signalling to expand Krt5+ basal-like cells in the lung. On HIF1α loss, epithelial progenitors...

www.nature.com

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@vaughandy

3 years

Lab lunch @renatas_kitchen . Delicious as always and >50% chicken and waffles.

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@vaughandy

1 year

Hao is such a terrific science communicator. Thanks for highlighting @zhao_gan ’s recent preprint!

Hao Yin

@HaoYin20

1 year

#Angiocrine in acute viral lung injury+regeneration🤠 🫁General capillary #EndothelialCell SPARCL1, ⏫by influenza inflection, favors macrophage M1 over M2 polarization to exacerbate viral pneumonia Dr. Andrew Vaughan lab bioRxiv 2023 @vaughandy

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@vaughandy

3 years

Hike up Snow’s mountain at @GRClung2021

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@vaughandy

4 years

Thank you soooo much for everyone who worked so hard to get this fascist out of the White House!!!! Lots of work to do but THANK GOD for this CRITICAL first step!!!!!

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@vaughandy

3 years

Holy crap! A colleague just told me my face is on the cover of the current issue of Cell Stem Cell. Turns out here's right, middle right edge here: . Thanks a ton to @j_saxe for including me with all these amazing junior investigators!

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@vaughandy

3 years

My lab is way too nice to me! Twin Peaks socks and a pooping dogs calendar!

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@vaughandy

5 months

Beautiful morning at the Penn encampment. Great place to get some grant work done and show solidarity for students’ right to protest

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@vaughandy

5 years

@PhillyMayor Why isn’t it being outright cancelled?

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Andy Vaughan also on bluesky

@vaughandy

3 years

Fantastic lab outing floating down the Brandywine today with @lab_vaughan @aaiweiner @zhao_gan and the other not on Twitter. Highly recommend!

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@vaughandy

2 years

@CterminiPhD I will push back a tiny bit on this and say that many new / newish PIs I know continue to have a hard time recruiting postdocs in spite of extensive outreach, paying for ads, recruiting at meetings, etc. Maybe not your intent but no reason to minimize the difficulty.

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@vaughandy

4 years

Very happy to have been a contributor to this manuscript, in which Dr. Nilam Mangalmurti and her team identify an entirely novel, and super important, function of red blood cells! with @KingOfPathogens @SunnyShinLab

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@vaughandy

2 years

Celebrating fellowship match at Via Locusta!

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@vaughandy

4 years

Phone banking again, talked to a young guy planning to vote for Biden who DIDNT KNOW TUESDAY IS ELECTION DAY🤯.

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@vaughandy

4 years

#WalterWallace was murdered by police blocks from my house. Had this been a white man going through a mental health crisis in the suburbs, does anyone doubt he would be alive today?

Heather Klusaritz

@HKlusaritz

4 years

To all my @PennMedicine and @Penn colleagues, do not go about your days without acknowledging the killing of #WalterWallaceJr . Our students, colleagues, patients, friends, and families are hurting #SayHisName . Talk about how we can fight for racial justice.

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@vaughandy

1 year

Had a fantastic time at the Celebration of NHLBI Progenitor Cell Research and Translation. Really proud of the great work presented by the amazing Vaughan lab members @SaraKGMD , Joanna, Marilena, and Gan (who already got his own tweet).

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@vaughandy

4 years

VACCINATED BABY!! Joanna and Gargi of ⁦ @lab_vaughan ⁩ plus myself (not pictured). That’s about half the lab!

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@vaughandy

4 years

Officially signed up to work the polls on Election Day! Beginning my second career as a voting machine inspector

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@vaughandy

4 years

Official ballot drop off achieved! Heartened to see it relatively bustling >1 month out from Election Day.

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@vaughandy

4 years

Can we please come together as a nation and agree to take a week off zoom meetings?

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@vaughandy

2 years

Honestly humbled to attend this meeting with many of the true pioneers in tuft cell biology. Come join us in Germany in August!

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@vaughandy

4 years

Tata @Tatalab_Duke kicking ass as usual. Human lung stem cell-based alveolospheres provide insights into SARS-CoV-2 mediated interferon responses and…

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@vaughandy

1 year

@MariaCBasil from @MorriseyLab presenting her fantastic work at the NHLBI Celebration of Progenitor Cell Research

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@vaughandy

2 years

Had a great time in Oakland at #IVBM2022 , and was able to carve out time to bike around and check in on some of the ol’ stomping grounds. Lots of changes but lots of classics holding steady!

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@vaughandy

2 years

Back in Seattle, doing this tomorrow morning

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@vaughandy

2 years

This beautiful paper nicely complements work from @Ian_Stancil , providing further evidence that dysplastic “basal-like” cells can directly drive fibrosis in vitro… AND orthotopic xenografts of human basal cells into mildly injured immunocompromised mice results in fibrosis!

Naftali Kaminski

@KaminskiMed

2 years

1/n FINALLY OUT! "Airway basal cells show a dedifferentiated KRT17⬆️ Phenotype & promote fibrosis in idiopathic pulmonary fibrosis" In the following 🧵I explain some of the key findings of this Herculean work and why I'm so excited #CureIPF #IPFABC

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@vaughandy

4 years

Stressful work day negated by this totally unprompted, amazing gift from my wife!!

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@vaughandy

4 years

This is not a very nice thing to say, but I’m compelled: even if Biden wins, there is something profoundly broken in many, many Americans’ brains and it’s hard to fully comprehend what this portends for the future.

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@vaughandy

1 year

Patiently awaiting Molly’s fav band Queens of the Stone Age @orangefeeling

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@vaughandy

3 years

@cterminiPHD Buy 10x more tips / tubes / etc than you think you need with the startup discount. It will seem insane when you receive it and then you’ll go through it all in 6 months

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@vaughandy

4 years

FWIW, I was briefly on local news today talking a little about COVID-19 and some of the work we're starting... very glitchy but anyway

Dr. Andy Vaughan on COVID-19 for 6ABC Action News

Dr. Vaughan of the University of Pennsylvania describes the potential for long term pulmonary consequences and suggests a possible reason for sex differences...

www.youtube.com

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@vaughandy

2 years

Man alive, sometimes it really hits ya how absolutely nuts it is that luck of the draw for reviewer assignments is the major determinant of what papers end up in what journals… A really unfair scenario for trainees 😕

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@vaughandy

2 years

Single cell seq is very useful. It is also obviously not applicable to every biological question. And I don't love that journals seem to be requiring single cell as a new gatekeeping strategy 🤷‍♂️

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@vaughandy

2 years

This is an excellent primer from my colleagues Nilam Mangalmurti and @KingOfPathogens . A great read that's totally accessible even for immunology dummies like me, highly recommend!

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@vaughandy

3 years

Happy Halloween with @montserrat

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@vaughandy

4 years

OMG I FIGURED IT OUT. If anyone else wants to avoid my 3 hours of frustration this afternoon:

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@vaughandy

6 years

@mulaney @nickkroll @BigMouthNetflix @nickkroll looks like a young Gil Faison

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@vaughandy

4 years

New ⁦ @lab_vaughan ⁩ member Tenley!!

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@vaughandy

5 years

New one from the Vaughan lab! @aaiweiner

Mesenchyme-free expansion and transplantation of adult alveolar progenitor cells: steps toward...

npj Regenerative Medicine - Mesenchyme-free expansion and transplantation of adult alveolar progenitor cells: steps toward cell-based regenerative therapies

www.nature.com

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@vaughandy

4 years

Won’t be getting a vaccine myself anytime soon so I guess I’ll live vicariously through my wife Molly, who just received her first dose!

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@vaughandy

3 years

Absolutely wild to be at a screening of Eraserhead in an old tunnel a block away from where David Lynch lived during his art school years. Thanks @PhilaMOCA !!

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@vaughandy

3 years

Beautiful new work from the Morrisey lab. Was great to have had a front row seat watching this paper develop. I don't think any of these authors are on Twitter for me to tag them...

@PennMedBenchmarks

@PennMedBench

3 years

New @PennMedicine research shows, mechanistically, how the infant lung regenerates cells after injury differently than the adult lung. Findings open a new level of understanding regarding two very different kinds of lung alveolar epithelial cells.

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Andy Vaughan also on bluesky

@vaughandy

1 year

Beautiful talk at the Celebration of NHLBI Progenitor Cell Research and Translation from @JayminKathiriya

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Andy Vaughan also on bluesky

@vaughandy

4 years

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