Deeply humbled by the confidence given by the nominating committee,
@EACTS
council and members to take on the role of secretary general.
Excellent to continue learning from
@rafasadaba
during this transition year (and dare I say relieved 😉?)
#EACTS2021
The election of new Officers & Councillors just took place at the EACTS General Assembly. Voting was unanimous. We're pleased to announce that
@pomyers
has been selected as the new Secretary General Elect.
@rafasadaba
continues as Secretary General until October 2022 (🧵1/4)
Last week, 37 yo aortic dissection walked in to the ED, collapses from tamponnade. Awake cannulation for bypass, full repair. Now out of the hospital & great.
When I learned his daughter had just blown the candle on her 1st birthday cake 10 days before:
After almost 1 year, the wait is over - the
#EXCEL
investigators finally release the UDMI data in
@NEJM
🧵 in a nutshell:
- the EXCEL investigators had the UDMI data, although they said they didn’t
- It shows higher MI risk for PCI
We have lost a dear friend, mentor and outstanding member of our surgical community. Domenico Pagano
@dompagano
passed away yesterday. All my thoughts go out to his partner Rossana and his two daughters.
After listening to/reading
@drjohnm
,
@VPrasadMDMPH
and others, my first impression on reading this
@nytimes
opinion: why don't we have RCTs, comparing masking - no-maksing - school closure and look at hard outcomes? This would provide helpful data...
David Taggart - update on EXCEL
#EACTS2019
“In over 300 pubmed publications, I have never withdrawn from authorship. I withdrew from EXCEL manuscript submitted to
@NEJM
”. Wow!
EXCEL:
• Selected LM disease
After a few days to go over the
#EXCEL
5 year results published in
@NEJM
and thinking hard about
@DrMoritzWvB
tweet on IC and cardiac surgery seeing things quite differently, here are a few thoughts. Glad to hear your thoughts
@tssmn
@ctsnetorg
@EACTS
1/30
Leaving sunny San Diego, after an outstanding
#STS2023
meeting. Great to see everyone in person again, and an amazing program.
Looking forward to serving
@STS_CTsurgery
as international director, a privilege to learn and advance cardio-thoracic surgery world-wide!
PCI vs. CABG in diabetics: excellent commentary from
@VictorDayan1
and
@tomcnguyen
in
@AATSJournals
Whether "in the movies or the history books", the message is clear: CABG has better outcomes
80 YO M new onset HFrEF (30%), diagnostic cath shows 100% CTO of RCA & LCx, last remaining conduit is LAD. Surgical turn down, shared decision made for high risk PCI - how would you approach this?
CTO first or LAD first? Protected PCI? Plaque modification? Will share what I did
Aortic root and ascending aortic aneurysms: are our current guidelines too lenient (>5.5 cm)?
This updated series from Yale (whose data underpins most of our aortic recommendations) with >1'100 pts shows interesting new data
Real world
#TVT
data on low risk TAVI patients from
@BavariaMd
: 5% mortality at 1 year. Compare that to the
#COMMENCE
trial, a recent prospective follow-up of SAVR valve: 2.4% at 1 yr (1.8% isolated AVR), 10.8% at 5 years.
#EACTS2022
With
#COVID19
, we are cancelling all elective surgical cases to avoid contaminating patients at risk and keeping resources focused on handling COVID. Any cases that can be deferred 3 months will get cancelled. The issue: how to define these?
(thread)
First coronary session
#EACTS2022
: impressed by trials (recent / ongoing / starting / funding):
• AF (PALACS and EPIC)
• CABG vs OMT
• ROMA:Women
• STICH 3.0
• ACS with cardiogenic shock
• Anticoag for CABG POAF
Surgeons working on improving evidence in our practice! 🤩
#PROACT
Mitral RCT: low-dose warfarin (INR 2-2.5) + aspirin did not meet PEP non-inferiority compared to standard (INR 2.5-3.5): 11.9%/patient-year low-dose vs 12%/patient-year standard-dose (95% CI -3.40, 3.26, NI margin 1.5%)
1/ Oh no… another tweetorial on
#EXCEL
Very interesting to see so many IC colleagues underscore the importance of periprocedure MI in
#EXCEL
(to the benefit of PCI) and reverse 180° after
#ISCHEMIA
(as it didn’t benefit PCI)
An update on
#EXCEL
: following our open letter to
@EACTS
president and council signed by 52 surgeons and cardiologists, and supported by 727 more on , most surgical associations have officially written to
@NEJM
...
Great commentary on the Michigan statewide experience in repeat AVR (SAVR or TAVI-in-TAVI) after TAVI:
• 40% required TAVI explant
• these had 15% mortality
After EXPLANT-TAVR, makes me wonder more about TAVI-first “lifelong management of aortic valve” being pushed
Mark Hazekamp - 35th president of
@EACTS
#EACTS2021
“We all make mistakes - the onus is on us to recognize them, even late after a procedure, own it and correct”
Fantastic news this morning:
@escardio
is joining
@EACTS
in revising the LM chapter of the myocardial revascularisation guidelines.
Good news for our patients &
#HeartTeams
!
Glad to work with our colleagues for the benefit of our patients
@Nicole_Lee_Sch
Wow, sounds like you would be an amazing patient to take care of: engaged, interested, and with clear questions & documentation!
We often misunderstand while taking a history, and this generates errors in notes. I give a copy of notes to patients, asking them to correct mistakes
#STS2024
@VinodThourani
presenting
#PARTNER3
SAVR outcomes: isolated SAVR show outcomes similar to benchmark
#STS
-database outcomes, better than SAVR-concomitant
Root enlargement just 5%, yet higher mortality than isolated SAVR
How can an editor in chief who received $100s of thousands per year from industry be trusted to give impartial editorial decisions on manuscripts? Eye-opening public data showing the
#cancerwithin
On my way (in a more eco-friendly means of transportation) to
#Milan
and
#EACTS2022
. Look forward to catching up with everyone, listening to experts in their field give us keen insights, and discussions with leaders from all around the globe and all sides of the Heart Team
We’re so excited that
@pomyers
is our new Secretary General! 👏 Patrick plans to explore new ways to deliver value to our members whilst continuing to equip the cardiothoracic community with everything we need to improve patient outcomes.
#EACTS
Updated analysis on use of multi-arterial CABG in
@STS_CTsurgery
database:
- MAG still underutilized (5.6% BITA, 8.5% LIMA-RA)
- Highest in the North East
- Appearance of volume-outcome relationship
Patrick Perier’s
#EACTS2023
presidential address
The Death of Dogma is the birth of Reality
Three lessons for success:
• continuous improvement
• curiosity
• partnerships
Lively and informative discussion on multiple arterial
#CABG
My 2 cents:
- The main survival advantage of CABG is LIMA-LAD
- All other variations (no touch SVG, BIMA, RA) other than optimizing OMT are flat of the curve and likely don’t have a huge survival advantage over LIMA-LAD
@EulertJ
@ctsnetorg
@pomyers
The evidence for a second arterial graft is pretty weak— especially BIMA. I’m always amazed at hearing some surgeons be such strong proponents of a technique in the absence of meaningful evidence.
Last week, almost 5000 delegates from 99 countries came together at
#EACTS2023
- the home for the global cardiothoracic surgical community. Let’s recap on the final day! 🎥
⭐ Guidelines updates
⭐ Fascinating abstracts
⭐ EACTS Awards
⭐ Learning Labs
Enjoy the highlights and
Continuous monitoring after discharge after cardiac surgery - interesting RCT in
@JAMANetworkOpen
Congratulations on a highly relevant, well designed and executed RCT. Raising the bar for evidence in cardiac surgery!
@BobbyYanagawa
@DLBHATTMD
Concerning early results of
#Inspiris
in pulmonary position, for those not in a graft: 48% developed PR, 22% moderate and 11% severe.
@annalsthorsurg
@samsaid75
#EACTS2020
is going all out - choose your avatar and explore the virtual conference like a video game
If English isn’t you primary language, it will be available live in your language!
Really looking forward to
#EACTS2020
Leveraging technology to enable the next level conference
#Corrected
: dear residents and fellows, my apologies if I didn’t show you well enough, then supervised you, and gave you enough autonomy to perform skin closure to the highest standards, while keeping an eye on the final result. Let’s go through this from the start
#meded
#EXCEL
An interesting opinion published in 12.2018 (last year!), suggesting how PCI vs. CABG trials may be gamed against CABG
The list of authors is an impressive and international group of expert surgeons
Main points in thread (1/9)
Outstanding evidence review of surgical mitral valve repair by
@BadhwarVinay
at
#LatAm2022
reviewing
@STS_CTsurgery
DB:
• surgeons have improved - mitral valve repair now 93,6% successful
• mortality is exceptional - now a low risk op
• MV repair PROM to come soon
Extremely grateful to
@EACTS
and Drs.
@pomyers
&
@rafasadaba
for putting 1st dedicated
#GlobalCardiacSurgery
session on
#EACTS2021
agenda, allowing me to moderate.
Big thank you to new EACTS President, Dr. Beyersdorf, for co-moderating & supporting efforts through EACTS & CSIA.
Very nice summary of SWEDEHEART registry data presented at
#EACTS2022
, on the utility of FFR-guidance for CABG.
Admittedly observational and likely confounded, fu short for CABG (3.2y), but 17k pts …
This CT scan is definitely the most traumatic during lockdown I've been shown. Archery accident.
Arrow through the heart.
Miraculously and thankfully the patient survived.
Let's look at all the ways they were lucky:
Great joint
@EACTS
@STS_CTsurgery
@AATSHQ
session on transcatheter mitral and tricuspid valve interventions - a space surgeons need to get involved in and collaborate more
#EACTS2023
I hear that there are efforts to attack and discredit Prof. Taggart, who had the courage to say what happened.
I just want to say:
#LeaveTaggartAlone
The authors of
#EXCEL
5yr were invited in due time to trial update session but declined 🧐
#EXCEL
#EACTS2019
@GreggWStone
@DKarmpaliotis
@GreggWStone
“But he has nothing on!” a little child cried out at last.
- H.C. Andersen, The Emperor’s New Clothes
It's not because only one disagrees against all others that they are wrong.
I'm not taking sides, but please don't attack the messenger, only the message
@dr_benoy_n_shah
It’s not about the possibility of conversion to surgery - it’s the heart valve clinic / heart team discussions leading to choice of treatment (OMT / TEER / surgery). If you can’t discuss with a full heart team, indication creep for what you can offer is a real risk.
I hope to see you in Vienna for
#EACTS2023
!
The program committee, domains and taskforces of
@EACTS
are working hard to deliver top-notch presentations, lots of time for discussion, and raising the bar for the best science. Don't miss it!
🌟Registration for the 37th EACTS Annual Meeting is now OPEN! 🌟
Attend
#EACTS2023
and raise the bar to improve standards through education, research and innovation💡
Register today 👉
Since the last myocardial revascularisation guidelines were published, we have had:
• EXCEL gate and support to LM chapter withdrawn
• ISCHEMIA & I-CKD
• SYNTAXES
• EXCEL UDMI data
And so many outstanding studies published. When do you think the next guidelines should come?
Update from the ROMA trial:
- including patients faster than expected
- avoids the pitfalls of ART trial (excessive cross-over)
- largest RCT on
#CABG
- highly selective on sites, to ensure modern-day CABG w/ multiple arterial grafts
filmed at
#EACTS2019
A new Francis Fontan Fellowship from
@EACTS
in collaboration with
@UCL_CCTU
: apply today to this Master in Clinical Trials and Statistics.
A 2 year part-time program to train future surgical leaders in understanding clinical trials.
Saturday morning run with my running buddy - just back from China pitching his femtech startup. Made it to the top of the highest point in GVA (Signal de Bernex, 510 m 🤣) and through the vineyards.
And yes, there are vineyards in Switzerland and Geneva!
Break before an early flight to
#Vienna
. I look forward to catching up in person with our
@EACTS
family and friends, the program our amazing taskforces & domains have prepared, and how small changes to the format impact the meeting. See you shortly for
#EACTS2023
Interesting initial experience from
@EACTS
vascular domain chair Konstantinos Tsagakis et al., using a 3 zone graft to achieve FET in type I
#aorticdissection
with
#ACP
and Zone 0 (ascending) anastomosis
Promising technology
When are editors going to call out these design switches to get the result the authors want ? Primary endpoint (1yr results) was a non-inferiority of all-cause mortality, MI, stroke or repeat revasc. These 3 year results are now superiority of all-cause death, MI, stroke. 🙀
More pearls from
#EACTS2019
roundtable on
#TAVI
vs.
#SAVR
trials
At 7:10 of full video below: "10% loss to follow up not found in supplement, many more data points difficult to find"
Thank you for your honnesty Michael Reardon! This is the kind of open discussion we need
Very moving tribute to
@dompagano
by
@drjohnm
in
#TWICpodcast
Domenico was extremely well read, and an avid follower of Bernard Lown’s teachings. I am sure he would be pleased beyond measure to be called a modern Bernard Lawn.
A group of surgeons, cardiologists and physicians co-signed this open letter to the
@EACTS
president, secretary general and council, following the publication of the
#EXCEL
UDMI data in
@NEJM
.
Please join in by adding your signature to this petition!
#EXCEL
: It is mandatory to publish all results, outcomes and statistical analyses of clinical trials under FDAAA 801 and “Final rule”.
Including secondary outcomes.
Failure to do so carries consequences for future government funding, as well as civil and penal liability
Aortic surgery is one of the 4 core fields of acquired/adult cardiac surgery. Data to back that up, and a call to improve data and research in this area
#EACTS2023
"[Aortic surgery] is not just a niche area .. In the United States, aortic cases make up 8% of all cardiac surgery cases."
Dr.
@NimeshDesaiMD
@pennsurgery
discusses the growing role of
#BigData
in thoracic aortic surgery through the
@STS_CTsurgery
Aortic Database.
#EACTS2023
#PALACS
trial presented at
#AHA2021
- congratulations to Irbaz, Gaudino et al. for a straightforward RCT for preventing post-op AF
• 17% vs 32% pAF, OR 0.44, P=0.0005)
• less pericardial effusion (RR 0.58)
• no safety issues
Simple design, clear results - practice changing?
👇 this - I am biased as a surgeon, but this wins
#cardiotwitter
for today. Practically unlimited ressources for a trial, but the surgical dressing is mightier
Long term patency of IMA, RA and SVG from Melbourne group.
Interesting retrospective data on 900 patients followed for 10 y with angiographic imaging
#AATS2022
#AATSBackTogether
@ctsnetorg
The future of the aortic root by
@EricRoselliMD
: endovascular interventions
• Ascending endoprosthesis for acute type A dissection
#ARISE
trial
• Endo-Bentall: just one use so far from
#LATAM
#LatAmCardiac2022
So to summarize, if the data had been available to the guideline committee:
1. EXCEL (CABG superior)
2. NOBLE (CABG superior)
3. Lancet meta-analysis: underpowered, possible slight advantage for CABG
The
#HeartTeam
needs to sit down and revise the guidelines
@escardio
@EACTS
Meet
@EACTS
response to the death of meetings: a hybrid!
- in person if possible
- virtual for who prefers
- all virtual if necessary
Virtual doesn’t have to mean a Zoom webinar: create your avatar, chat with other avatars or attendees, and watch & discuss presentations
Introducing the EACTS Barcelona Portal | Suddenly Zoom is obsolete-Visit the 34th Annual Meeting in person and also amazingly, through a revolutionary new online experience, the EACTS Portal. Register now-
#EACTS
34th Annual EACTS Meeting 8-10 October, 2020
#EXCEL
results if UD rather than SCAI definition of MI was used. Eye-opening that these all point to clear absence of non-inferiority.
The
#EXCEL
investigators have said this is fake. Where is the lawsuit for libel against
@BBCNewsnight
? And where is the
#opendata
?
@NEJM
Using data received by
@EACTS
and
@escardio
, through “right to reply” in November 2019 from
@bbcnewsnight
of the unpublished UDMI,
#EXCEL
would look like this. When do the EXCEL group publish it? We are all waiting for
#opendata
and
@NEJM
:
A very balanced and comprehensive view of the
#EXCEL
trial.
@drjohnm
makes a very good case for a rewrite of the
@NEJM
manuscript.
It's just short of my
#RetractEXCEL
, but based on the same worry: impact on interpretation and guidelines.
Time to review latest
@escardio
@eacts
?