Peter Fedichev📍Hong Kong @fedichev Twitter profile

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Peter Fedichev📍Hong Kong

7 months

Let's sink into the rabbit hole, ladies and gents - first step to digital immortality, perhaps - fedichevGPT absorbed my (yet to be published book) and all interviews over the last two years. Talk to me, AMA, follow, like and repost - it feels lonely over

ChatGPT - fedichevGPT

AMA about aging, latest news on longevity biotech, science-based hints on longer life from P. Fedichev, geroscientist and founder of gero.ai

chatgpt.com

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Peter Fedichev📍Hong Kong

@fedichev

6 months

What should we remember about the future as we head into the New Year? Especially given that in recent years, we've narrowly avoided a global, possibly even man-made, epidemic? The world teeters on the brink, engaged in a war with nuclear-armed participants, all under the shadow

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Peter Fedichev📍Hong Kong

@fedichev

10 months

Okay, let me run a provocation. In our information bubble related to the research and development of anti-aging drugs, it is customary to discuss the concept of longevity escape velocity (LEV). The discussion is often framed as if LEV is almost achieved. What could possibly go

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Peter Fedichev📍Hong Kong

@fedichev

7 months

Aging is so obviously bad, yet most (but not all) living creatures age. To make significant progress against aging, it’s crucial to understand why aging might be evolutionarily advantageous.The first glimpse of the answer I've got a while ago from Professor Robert Schmukler Rice,

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Peter Fedichev📍Hong Kong

@fedichev

9 months

Most doctors are taught and believe that the brain dies after about five or 10 minutes of oxygen deprivation. That is actually not true. The evidence comes from an expansive multi-year study led by Sam Parnia, an intensive care doctor and an associate professor in the department

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Peter Fedichev📍Hong Kong

@fedichev

4 months

It's been a while since I've posted here (there will be a new quite provocative preprint online in a few days). In the meanwhile, let's dive into something light. As you know, I have a fondness for history, especially where it intersects with science and the study of longevity.

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Peter Fedichev📍Hong Kong

@fedichev

8 months

Magic

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Peter Fedichev📍Hong Kong

@fedichev

8 months

It may sound strange, but beyond our "longevity" bubble people often ask: what are the reasons, scientifically, culturally, etc. for the reasons why people want to stop aging? My guess is that consciousness, once emerged, faced the vastness of universe and shortness of life.

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Peter Fedichev📍Hong Kong

@fedichev

10 months

Friends, let me show what is probably the most horrific visuals in the world. While there are questions regarding the origin of the data and the curves, the key takeaway remains consistent across different datasets. It becomes painfully obvious that many traits we associate with

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Peter Fedichev📍Hong Kong

@fedichev

3 months

The extinction of the dinosaurs, believed by many to have been caused by the Chicxulub asteroid impact around 66 million years ago, has long perplexed me. How could such a singular and yet what seems to be a pretty local event lead to the demise of so many species? This question

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Peter Fedichev📍Hong Kong

@fedichev

9 months

Okay, as promised, let me finish the provocation and review of anti-aging tech. The bad news is that despite all the hype and the remarkable advances in biology and medicine in understanding aging and treating age-related diseases, most of the anti-aging interventions under

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Peter Fedichev📍Hong Kong

@fedichev

9 months

Lately, we have been delving into how factors related to social status and mental health might influence longevity. The deeper we dive, the more curious the waters become. There are genetic variants, that appear to be linked to how often folks attend church. And in other,

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Peter Fedichev📍Hong Kong

@fedichev

2 months

The complexity of fields such as biology, ecology, and economics often prompts skepticism towards the use of analytical tools. However, the study of complex systems in physics provides compelling examples where understanding the large-scale behavior requires surprisingly few

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Peter Fedichev📍Hong Kong

@fedichev

1 month

You might have noticed that I often ask for likes and reposts on my tweets, referring to the struggle between kind and wicked memes in our longevity community. In the field of anti-aging medicine, there are at least three particularly detrimental narratives: * Aging is solved:

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Peter Fedichev📍Hong Kong

@fedichev

4 months

Ladies and gentlemen, I have exciting updates for you! Two years ago, we theorized that aging results from a mix of "wear and tear" - an entropic, seemingly irreversible process, and a dynamic instability of the organism state. We suggested human aging is mostly entropic,

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Peter Fedichev📍Hong Kong

@fedichev

1 month

Last time, I cited a study analyzing the exponential increase in the size of the "useful" (or, God forbid, non-redundant) genome from the inception of life to the present day. The graph suggests that life's origin might have preceded the formation of our planet's solid crust.

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Peter Fedichev📍Hong Kong

@fedichev

7 months

I totally admire Isaac Asimov's "Foundation" series, which unfolds around a cadre of scholars led by the mathematician Hari Seldon, who forge a new academic field dubbed psychohistory. The narrative is a crowning achievement that secured Asimov's induction into the pantheon of

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Peter Fedichev📍Hong Kong

@fedichev

30 days

As I noted before, no significant scientific problem in the 21st century can be discussed without relation to the Fermi Paradox, paraphrasing Dobzhansky's statement about Darwinian evolution and biology. While it may be difficult to find civilizations of our size, there should

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Peter Fedichev📍Hong Kong

@fedichev

20 days

Friends! I’m debating with @aubreydegrey tomorrow. Please write in comments if you think something is important and must be covered.

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Peter Fedichev📍Hong Kong

@fedichev

8 months

We are moving forward! Thank you for being with us @ymelnichek @vita_dao , @alxdobrin , and @DToddWhite Physics-Powered GenAI Biotech Gero Raises $6M to Find Root Causes of Aging and Age-Related Diseases Funding by Melnichek Investments fuels Gero’s strategy to apply AI in

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Peter Fedichev📍Hong Kong

@fedichev

6 months

I had the privilege of attending and speaking at the first-ever biomarkers of aging event #BoAS2023 the Buck Institute. It was an excellent experience, yet I want to share my concerns about the concept of biomarkers of aging. Biomarkers are essentially numerical indicators used

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Peter Fedichev📍Hong Kong

@fedichev

2 months

I've become involved in several fascinating discussions here on X and in other places regarding whether a comprehensive theory of aging is necessary to fundamentally solve aging. What has caught my attention is the distinct perspective on what constitutes a "theory" across

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Peter Fedichev📍Hong Kong

@fedichev

5 months

What do these have in common: the ongoing struggle to address global warming, the conflict in Ukraine, and the development of anti-aging drugs? Isn't it disheartening to see time squandered, not because the right solutions are unknown, but because the right decisions are not made

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Peter Fedichev📍Hong Kong

@fedichev

8 months

''Everyone has a limited number of heartbeats in their life, and I'm not going to waste mine on exercise'' is often attributed to Neil Armstrong, the first man on the Moon. He probably never said that, but the saying has taken on a life of its own. Surprisingly, this seemingly

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Peter Fedichev📍Hong Kong

@fedichev

1 month

🎉Celebrating 2,500 Followers! 🚀 Thank you! It might be a good time to discuss why I post detailed long-reads covering the science and biology of aging. 🛑Let me state first who I Am Not: I am not a creator or influencer in the traditional sense. I’m not here to monetize or

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Peter Fedichev📍Hong Kong

@fedichev

2 years

Meet our "Aging clocks, entropy, and the limits of age-reversal" manuscript (version simplified and improved). Hayflick was right - aging in humans is entropic (that is hardly reversible but stoppable)

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Peter Fedichev📍Hong Kong

@fedichev

10 months

Most of tricks we use to extend lifespan in mice are probably already included in our genome that is to say for free. We need to be far more aggressive if we want meaningful effects in humans.

Maxim Kholin

@GeroMaxim

10 months

HOW TO DOUBLE HUMAN LIFESPAN? Peter @fedichev opened his speech with a question to the audience, 'Raise your hand if you genuinely believe that drugs capable of doubling our lifespan are currently undergoing clinical trials?' Not a single hand was raised. The resounding absence

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Peter Fedichev📍Hong Kong

@fedichev

1 month

I will be exploring these questions and more with @aubreydegrey on May 27th in San Francisco. Join our discussion online or in person at the Foresight Institute

Peter Fedichev📍Hong Kong

@fedichev

1 month

You might have noticed that I often ask for likes and reposts on my tweets, referring to the struggle between kind and wicked memes in our longevity community. In the field of anti-aging medicine, there are at least three particularly detrimental narratives: * Aging is solved:

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Peter Fedichev📍Hong Kong

@fedichev

1 month

From the inside, the situation is way “more interesting” Aging is solved?: If you're a mouse, we might delay your death, but not for long, even with combinations of all we know. Companies targeting single aging hallmarks pivot to drug discovery against specific diseases. As you

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Peter Fedichev📍Hong Kong

@fedichev

9 months

What many probably don't appreciate is how ancient the idea of indefinite life-extension is. Truly said, if you desire immortality, go to the church. What it's more intriguing, is that some influential precursors to modern transhumanism emerged from the church. I'm referring to

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Peter Fedichev📍Hong Kong

@fedichev

9 days

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Peter Fedichev📍Hong Kong

@fedichev

10 months

I've got the "blue badge" and may post long texts. Here we go: We don't hear often that life extension isn't a matter of moral choice but part of the already ongoing demographic transition. The decrease in birth rate and simultaneous increase in life expectancy occur in all

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Peter Fedichev📍Hong Kong

@fedichev

5 months

Let me briefly explain why drug design is extremely challenging and may not be the wisest approach when done conventionally. To support this argument, I'll reference Philip Anderson's 1972 paper "More is Different," a groundbreaking work that posits the need for new languages and

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Peter Fedichev📍Hong Kong

@fedichev

8 months

I've got into unlocking immortality with our friends from Open Longevity (the link in the followup tweet).

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Peter Fedichev📍Hong Kong

@fedichev

4 months

Thank God they managed to invent the steam engine when they didn't know that matter consists of molecules. If they had been given the means to measure, with the same quality as they measure single cell methylation, the coordinates and positions of all molecules and even numbered

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Peter Fedichev📍Hong Kong

@fedichev

2 months

Friends, colleagues! Today, after extensive considerations, I announce that I am giving up and will no longer work on slowing down aging. Why, you might ask? Consider this—there are plenty of compelling arguments for not trying to slow down the aging process: * Evolution

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Peter Fedichev📍Hong Kong

@fedichev

2 years

Principia of aging by @hacking_aging team

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Peter Fedichev📍Hong Kong

@fedichev

5 months

Let me revisit this unsettling chart I shared a year ago. It's certainly alarming to see how our cognitive abilities decline with age, especially as we're living longer. Combine this with a falling birth rate, and what do you get? Just look at the chart and see what this trend

Peter Fedichev📍Hong Kong

@fedichev

10 months

Friends, let me show what is probably the most horrific visuals in the world. While there are questions regarding the origin of the data and the curves, the key takeaway remains consistent across different datasets. It becomes painfully obvious that many traits we associate with

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Peter Fedichev📍Hong Kong

@fedichev

18 days

Thank you, @nikhilyadala ! Good and probably the first summary of the debates and one of the best questions from the audience.

Nikhil Yadala

@nikhilyadala

18 days

Attended one of the most important debates in the Longevity space between Peter @fedichev , and Aubrey @aubreydegrey . The debate had two major questions - 1) what should we do to extend human lifespan asap? 2) Is it possible to rejuvenate the human body? You can watch the full

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Peter Fedichev📍Hong Kong

@fedichev

2 years

@davidasinclair thank you for noting, @davidasinclair ! the results are not exactly those we wanted to find; that's the reason why we are the last people on Earth writing a paper on epigenetic age :) I would be happy to discuss Shannon's observer

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Peter Fedichev📍Hong Kong

@fedichev

4 months

Everything you wanted to ask but didn’t dare to regarding biomarkers of aging is here

Agingdoc⭐David Barzilai🔔MD PhD MS MBA DipABLM🩺

@agingdoc1

4 months

Validation of biomarkers of aging @mahdi_moqri , @chiara_herzog , @jpoganik , @j_n_justice , @Danbelsky , @drbrianchen , @kpfortney , @fedichev , @biogerontology , @NirBarzilaiMD , @lasky_su , @BKennedy_aging , @EricVerdin , @AndreaBMaier , @SnyderShot , @gladyshev_lab , @prof_horvath , Luigi

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Peter Fedichev📍Hong Kong

@fedichev

10 months

The saying goes, "There's nothing more permanent than the temporary." Interestingly, it possible to estimate chances whether what we observe at any given point will persist in the future. This can be done by simply assuming that you're witnessing events at an arbitrary moment in

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Peter Fedichev📍Hong Kong

@fedichev

6 months

End of year is a good time to reflect on keep yourself focus on truly big problems. There are science issues that do not want to die no matter how hard you try. Aging is one of them. Life on Mars and astrobiology/Fermi paradox is another one. Let me share the story that lingers

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Peter Fedichev📍Hong Kong

@fedichev

1 month

We've just survived another OpenAI update. As the dust settles, my "copium" observations are: *The folks are pivoting to new features, like speech synthesis, etc. It's super-cool, but... * This probably happens for a reason: if they had a mind-blowing AGI like GPT-5, they would

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Peter Fedichev📍Hong Kong

@fedichev

9 days

When I started writing long-reads on X, my idea was to a bunch of interesting people discussing interesting science together. Last week I ran a provocation explaining my position on strong rejuvenation in humans and got comments from @DrMorganLevine , @drmichaellevin , @DerekU02 ,

Peter Fedichev📍Hong Kong

@fedichev

9 days

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Peter Fedichev📍Hong Kong

@fedichev

7 months

It will take more than eliminate major age-related diseases (+2–3 years of life each with quickly diminishing returns) to increase human lifespan by a large margin. also, tackling diseases without reducing the rate of aging = miserable life. Do not let your thinking about life

Maxim Kholin

@GeroMaxim

7 months

The last words were just perfect CEO of @fedichev @ the opening panel of Hevolution Healthspan Summit #Hevolution

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Peter Fedichev📍Hong Kong

@fedichev

10 months

When I was a student at a physics school, many students who considered applying their minds to biology were told with disdain: "It has happened that physicists became biologists, but for biologists or medics to become physicists — never. So, young man, take a physics textbook and

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Peter Fedichev📍Hong Kong

@fedichev

9 months

Last time, I told you that if we deem the current moment in our civilization's life as no special (applying the Copernican principle in time), then ahead of our species lies anywhere from thousands to millions of years. However, there's no particular reason to believe this is

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Peter Fedichev📍Hong Kong

@fedichev

1 month

Here we go

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Peter Fedichev📍Hong Kong

@fedichev

10 months

(📕review inside ) Recent research, this time by Swedish scientists, has revealed an interesting discrepancy: while income does correlate with cognitive test results to some degree, the highest earners are not necessarily those who score best on mental ability tests (see the

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Peter Fedichev📍Hong Kong

@fedichev

10 months

Tomorrow I am presenting at @ARDD_Meeting .

Alexey Kadet

@Alexey_Kadet

10 months

GERO is delighted to be the sponsor of the 2023 Conference on Aging Research & Drug Discovery Meeting in Copenhagen 🇩🇰 As the 10th event in a series, ARDD 2023 has evolved into an existing international symposium for the longevity biotech sector, as well as for our partners in

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Peter Fedichev📍Hong Kong

@fedichev

9 months

Last time we discussed the promising implications of our technological and demographic transitions, particularly their tie-ins with longevity and what's often referred to as 'singularity'. The overall conclusion was as if nothing bad is happening. Here's a catch (this is an

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Peter Fedichev📍Hong Kong

@fedichev

5 months

Polishing up a manuscript involving entropy and aging. Reflecting on the fact, that "Ludwig Boltzmann, who spent much of his life studying statistical mechanics, died in 1906, by his own hand. Paul Ehrenfest, carrying on the work, died similarly in 1933. Now it is our turn to

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Peter Fedichev📍Hong Kong

@fedichev

2 months

(4/4) Let’s compare the stories and summarize: We anticipate the development of multiple microscopic theories, each valid to explain the aging dynamics and related factors in various animals (such as mice, humans, and NMRs). Currently, we're making more progress with mice, but

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Peter Fedichev📍Hong Kong

@fedichev

1 year

Much to our surprise, our latest highly technical and still unpublished preprint () made it into "Popular Mechanics" (), "Independent," "USA Today," and other media outlets.

Humans Can Stop—But Not Fully Reverse—Aging, Study Suggests

It’s a lesson in thermodynamics.

www.popularmechanics.com

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Peter Fedichev📍Hong Kong

@fedichev

9 months

Here's the latest update on our quest to understand aging from large datasets of biomes data and to develop genuinely strong anti-aging drugs (the link is in the followup tweet, #longevitysummitdublin )

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Peter Fedichev📍Hong Kong

@fedichev

2 months

Let’s run an experiment: if you suggest a reference to an interesting paper concerning aging in the comment to this post, i will try to write up how aging phenomenology explains its results.

Peter Fedichev📍Hong Kong

@fedichev

2 months

I've become involved in several fascinating discussions here on X and in other places regarding whether a comprehensive theory of aging is necessary to fundamentally solve aging. What has caught my attention is the distinct perspective on what constitutes a "theory" across

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Peter Fedichev📍Hong Kong

@fedichev

9 months

Thank you, @vita_dao ! (Decentralized) science can beat aging and ageless world will be beautiful!

VitaDAO 💛

@vita_dao

9 months

📣 VDP-118 [Assessment]: GERO ( @hacking_aging ) - Machine Learning Platform for Age-Related Disease Targeting & Drug Discovery has successfully passed!✅ Creating therapeutics to slow down human aging and eliminate root causes of age-related diseases Read the proposal 👇

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Peter Fedichev📍Hong Kong

@fedichev

6 months

The mystery of biogenesis, closely linked to the development of biological chirality, remains an unresolved issue. Stuart Kauffman's autocatalytic cycle model offers a plausible explanation for biogenesis, yet the enigma of chirality remains unsolved. We have lived to see the

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Peter Fedichev📍Hong Kong

@fedichev

8 days

Thank you, @LifespanIO , @aubreydegrey and the organizers + jury. Progress will likely come from where we disagree and I wish more such discussions in the future!

Lifespan.IO

@LifespanIO

8 days

In a much-anticipated debate, prominent aging researchers Aubrey de Grey @aubreydegrey and Peter Fedichev @fedichev discussed what parts of aging are feasible to reverse. by @ArkadyMazin @foresightinst @OpenLongevity @SayForeverOrg @LongevityEVF

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Peter Fedichev📍Hong Kong

@fedichev

6 months

ladies and gents, what the funny story we have today in Scientific American! "Science fiction (SF) influences everything in this day and age, from the design of everyday artifacts to how we—including the current crop of 50-something Silicon Valley billionaires—work. And that’s a

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Peter Fedichev📍Hong Kong

@fedichev

24 days

A bad theory is better than no theory since a bad theory may still provide you with interesting edge cases—possible experiments leading to its own invalidation and hence to a better theory with even more challenging edge cases. People often say aging needs its Manhattan or

Mikhail Batin

@MikhailBatin

24 days

@joshuamcclure @LongevityTech @economy @aubreydegrey @fedichev @hacking_aging @OpenLongevity @foresightinst @LongevityEVF Let's say you have 70 intervention options and you want to test a combination of 5 of them. This results in 1,452,361,680 possible drug combinations. How much time and money do you think it would take to conduct such a vast number of clinical studies? Additionally, we would need

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Peter Fedichev📍Hong Kong

@fedichev

10 months

Recently, while preparing for a panel on Al-Jazeera (), I was posed with several intriguing questions, including, "Have there been any unforeseen outcomes in experiments aimed at halting aging?" Time constraints during the show prevented me from diving into

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Peter Fedichev📍Hong Kong

@fedichev

2 months

As @LidskyPeter taught me during our debates, nothing in biology makes sense except in the light of evolution. Perhaps, a hundred years from now, the same will be said about solving the Fermi paradox. This issue, if thoroughly investigated, should inform us about the "Great

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Peter Fedichev📍Hong Kong

@fedichev

2 months

"If you can't measure it, you can't improve it." Let's see what actually works - please follow, like and repost!

Aleksandr Sviridov

@_sviridov_

2 months

🧵 Do you agree that life is good and death is bad? Do you want to contribute to aging research? If yes, help us spread this message. Today, we are starting a new non-profit initiative called GeroSense Studies, which you can join to help accelerate aging science. Details ⬇️

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Peter Fedichev📍Hong Kong

@fedichev

1 month

🚀No action is required, since:🚀 Problem is solved: “Enough companies have been created, the problem is essentially solved—no need for further action, neither research or investments, as you can't achieve much more or make substantial money: antioxidants, telomere activators,

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Peter Fedichev📍Hong Kong

@fedichev

15 days

A little bit of Gero ( @hacking_aging )’s work on the intersection of AI,quantum computing and biotechnology in mini-review from @ScienceMagazine . Thank you, @RobertFService !

Quantum computers could soon speed the development of novel materials, catalysts, and drugs

Advances show quantum computing is nearing real-world payoffs

www.science.org

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Peter Fedichev📍Hong Kong

@fedichev

12 days

"Two Leading Scientists Debate Human Lifespan: A debate titled “How to Defeat Aging” featured two distinguished scientists, Peter Fedichev and Aubrey de Grey, both proponents of radical life extension with biotechnology, with opposing views. Fedichev believes aging is

Lifespan.IO

@LifespanIO

12 days

What has been happening in the aging and rejuvenation sphere last month? Check out the Rejuvenation Roundup May 2024 to find out! #aging #longevity #lifespan #healthspan #rejuvenation @OraBiomedical @MIT_AgeLab @fedichev @aubreydegrey @turn_bio

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Peter Fedichev📍Hong Kong

@fedichev

12 days

Amen! Here's the argument I usually use in response —imagine you're managing a server. You install and uninstall packages, manage users, having fun. Despite your efforts, things become increasingly cluttered, and eventually, you ask all users to back up their data (and back off

Nunzio Cuzzucoli

@NunzioCuzzucoli

12 days

@fedichev when the first mammal was cloned from a reprogrammed old cell, and this mammal lived its life as healthy as anyone else. We have had 100% certain proof that in our old cells there is everything necessary to rejuvenate. you can't stop time but you can restore youth!!

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Peter Fedichev📍Hong Kong

@fedichev

5 months

Train your models responsibly and have a good weekend!

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Peter Fedichev📍Hong Kong

@fedichev

18 days

Thank you, @KarlPfleger , for coming and summarizing. It’s already second your post I’d love to find time to comment at length - I’ll surely do!

Karl Pfleger

@KarlPfleger

18 days

@aubreydegrey & @fedichev debated whether rejuvenation (reversal of biological age) is possible or not on 2024/5/27. Below is my summary, personal take, & 3 suggested topics for further discussion, plus a few more detailed notes. Full 3hr video:

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Peter Fedichev📍Hong Kong

@fedichev

11 months

paying homage to @aubreydegrey at @LongevityDublin , a top event for the longevity scene. See you there, august 17–20!

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Peter Fedichev📍Hong Kong

@fedichev

9 months

Ladies and gents, it’s all I want to tell you this time

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Peter Fedichev📍Hong Kong

@fedichev

6 months

The best explanation of our theory of aging!

floguo

@floguo

6 months

Day 2 of @BuckInstitute ’s Longevity Summit 🧬 Yesterday’s highlights: 🚺 @OvivaTx @DaisyRobinton Ovaries are the key to female longevity 👯‍♀️ @jenngarrison Reframing women’s health & aging ⏳ @fedichev Aging clocks & entropy 💛 @vita_dao @MaxUnfried dinner! More updates to come

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Peter Fedichev📍Hong Kong

@fedichev

9 months

see you 12/5-6

Agingdoc⭐David Barzilai🔔MD PhD MS MBA DipABLM🩺

@agingdoc1

1 year

LONGEVITY SUMMIT 2023 @BuckInstitute 12/5 - 6 Speakers: @geochurch @kpfortney @prof_horvath N Lauc, @EricVerdin @DaisyRobinton @bryan_johnson O Amirov-Drory @AleZonari @kapahi_pankaj @RobinMansukhani @fedichev @janiceschen @CoCo_Headley 🔗 @LongevityGL

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Peter Fedichev📍Hong Kong

@fedichev

9 months

I'm speaking at in a few days. Anyone on Cyprus these days?

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Peter Fedichev📍Hong Kong

@fedichev

7 months

#hevolution #XPRIZEHealthspan

Maxim Kholin

@GeroMaxim

7 months

CEO of @fedichev @ the opening panel #Hevolution @hacking_aging

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Peter Fedichev📍Hong Kong

@fedichev

2 years

thank you, @vitadao , for covering our recent works + me talking about the state of longevity research and biotech

November Longevity Research Newsletter

A multitude of discoveries and inventions throughout history have been made by people who were initially trained in one domain, but were able to make a significant contribution to a different field...

www.vitadao.com

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Peter Fedichev📍Hong Kong

@fedichev

2 months

(1/4) In physics, experiments usually challenge the existing paradigm, often providing a set of empirical facts or fundamental observations about new phenomena. For instance, the discovery of superconductivity led to observations of zero electrical resistance below a certain

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Peter Fedichev📍Hong Kong

@fedichev

16 days

“To those who do not know mathematics it is difficult to get across a real feeling as to the beauty, the deepest beauty, of nature ... If you want to learn about nature, to appreciate nature, it is necessary to understand the language that she speaks in.” Richard Feynman Thank

Andrew Steele

@statto

16 days

I enjoyed this debate, and Karl’s summary here is great too. @fedichev did a great job laying out his stand (which like Karl and with apologies to Peter I’d not fully grasped due to not having time to go through the maths in the papers, but I feel like I get much more now)

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Peter Fedichev📍Hong Kong

@fedichev

2 months

Last week, while discussing with @statto and @AlexanderMWolf7 , we brought up the issue of correlations between hallmarks of aging. I argued that age-dependent features in aging organisms are dynamically locked—strongly correlated beyond mere dependence on chronological age. This

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Peter Fedichev📍Hong Kong

@fedichev

8 months

A few years ago, while listening to Dan Carlin's podcast, I learnt that our children might be the last generation on Earth to taste large fish. The raise of humans has been an ecological disaster for the rest of the planet since the natural selection forces can't keep pace with

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Peter Fedichev📍Hong Kong

@fedichev

8 months

I have a confession to make: I do not like the concept of biological age and believe it is a wrong target for longevity interventions. Watch my hands - we are all fascinated by aging clocks. Take any good paper on biological clocks and see that the risk ration at the std level of

Kamil Pabis

@Aging_Scientist

8 months

Here my controversial opinion piece. Briefly put, exercise and diet are important, but real geroscience is orders of magnitude better. The former are overrated due to biased data. @fedichev @DocLarus agree? @mkaeberlein @MaxUnfried @NirBarzilaiMD ?

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Peter Fedichev📍Hong Kong

@fedichev

2 months

In Dubai for another week. Let’s meet - I know many are here

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Peter Fedichev📍Hong Kong

@fedichev

2 months

(2/4) Let's get into cosmology. After Einstein's general theory of relativity (now seen as an effective theory without a solid microscopic foundation) was established, it became a tool for cosmology—the study of the universe. In the following decades, astronomical experiments

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Peter Fedichev📍Hong Kong

@fedichev

2 months

had a great time at Akshay Summit! 😍 #AkshaySummit thank you @nasdaily @akshaybd !

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Peter Fedichev📍Hong Kong

@fedichev

5 months

Gero @hacking_aging with @Alexey_Kadet inside Thank you, @omri_drory

omri_drory

@omri_drory

5 months

Our NFX documentary on longevity goes live today. Excited to share our vision on this major transition from sick care to healthcare, as well as the work of so many great founders, scientists and investors in the space. Why we made this now:

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Peter Fedichev📍Hong Kong

@fedichev

6 months

Here’s the discussion of what’s probably the most important topic in aging science and longevity tech. A lot more of this is coming

Lifespan.IO

@LifespanIO

6 months

⁉️Is Aging Truly Reversible? Watch Dr. Aubrey de Grey, Dr. Peter Fedichev, Dr. Hanadie Yousef, Reason, and Dr. Hans Keirstead debate and discuss at EARD 2023. Available now on YouTube! @aubreydegrey , @fedichev #longevity #lifespandesci #biotech

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Peter Fedichev📍Hong Kong

@fedichev

6 months

Every Christmas Eve, I find myself reflecting on the same date in 1968. On that day, Apollo 8's crew, the first humans to orbit the Moon, read from Genesis during a live TV broadcast. In their ninth lunar orbit, Anders, Lovell, and Borman shared the creation narrative, verses

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Peter Fedichev📍Hong Kong

@fedichev

2 months

(3/4) Let's explore how these "rules of engagement" might benefit the science of aging. The initial step is to identify a minimum set of crucial observations—let's term these the fundamental aging truths (FATs). To me, these encompass the exponential acceleration of mortality

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Peter Fedichev📍Hong Kong

@fedichev

12 days

This is a good one - thank you, @DerekU02 , for commenting. I noted many times that replacing piece by piece is the boldest attempt to beat back the thermodynamic irreversibility. I would argue it relies on technology that we do not have and may not have very soon: (1) in

Derek Underwood

@DerekU02

12 days

@fedichev The ship of theseus argument could improve the case against your example. If you replace things piece by piece, it will be hard to argue the resulting human is a different individual than the one who started the therapies. Of course this happens naturally at the molecular level.

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Peter Fedichev📍Hong Kong

@fedichev

8 months

thanks to everybody involved!

Gero

@hacking_aging

8 months

We're excited to announce our recent financing round's closure! This will drive Gero's drug development, strengthen our scientific team, and expand our US presence. Thank you @vita_dao & @ymelnichek for your support." Link for the full press release:

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Peter Fedichev📍Hong Kong

@fedichev

2 years

Hi, folks. I am in Singapore for 2 weeks. Let me know if there's anybody I must talk to (aging researchers, AI/ML experts interested in helping to solve aging, publishers, journalists (we are about to start a PR action), investors, you name it)

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Peter Fedichev📍Hong Kong

@fedichev

6 months

Discussing aging science and art in Buffalo

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Peter Fedichev📍Hong Kong

@fedichev

3 months

Next week I’m @hacking_aging in Singapore. Whom should I meet? DM/reach out

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Peter Fedichev📍Hong Kong

@fedichev

3 months

For anyone concerned - happy holiday!

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Peter Fedichev📍Hong Kong

@fedichev

7 months

see you around

Biomarkers of Aging Consortium

@agingbiomarkers

7 months

The Consortium is thrilled to host our inaugural 2023 Biomarkers of Aging Symposium, a full-day event focused on sharing the latest research on biomarkers of aging, discussing key issues we face moving forward, and defining Consortium priorities for 2024 & beyond, in less than a

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Peter Fedichev📍Hong Kong

@fedichev

3 months

Science at work - more findings on intermittent fasting

Agingdoc⭐David Barzilai🔔MD PhD MS MBA DipABLM🩺

@agingdoc1

3 months

Intermittent fasting and health outcomes: an umbrella review of systematic reviews and meta-analyses of randomised controlled trials Intermittent fasting "may decreased WC, fat mass, LDL-C, TG, TC, fasting insulin, and SBP, while increasing HDL-C & FFM"

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Peter Fedichev📍Hong Kong

@fedichev

4 months

@surmenok Focus on interventions that can stop the entropic component. This is “allowed” with less effort than any attempt of age reversal. We’re working on experimental demo

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Peter Fedichev📍Hong Kong

@fedichev

4 months

Notions of chaos and unpredictability, traditionally seen as synonymous, are well-established areas of study. Early on, in good schools, they teach as about the Lyapunov time scale, beyond which prediction becomes practically impossible. This principle explains why investing ten

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