Eric Lim Profile
Eric Lim

@ekslim

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Thoracic surgeon, statistician, clinical trialist. 🇬🇧 Into research, post grad education and patient advocacy.

London
Joined October 2011
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@ekslim
Eric Lim
1 year
Delighted to announce MARS 2 data is now mature and we aim to report this year! Thank you to our patients, UK investigators, @BrsTrialsCentre , @NIHRresearch @CRUKresearch for 7 years of hard work!!
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@ekslim
Eric Lim
5 years
UK thoracic surgery research collaborative have reached target accrual for NIHR funded VIOLET trial of keyhole versus open surgery for lung cancer! With over 500+ patients randomised two months ahead of schedule! Results will be released in major conferences later this year.
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@ekslim
Eric Lim
2 years
At long last with over 5 years of work and 2 years of collation of results and reporting I am over the moon with delight to see the results of VIOLET in print!
@NEJMEvidence
NEJM Evidence
2 years
“Video-Assisted Thoracoscopic or Open Lobectomy in Early-Stage #LungCancer (VIOLET trial),” an Original Article by @ekslim et al., now available. #VATS #OncoAlert
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@ekslim
Eric Lim
2 years
Congratulations Dr Valerie Rush on a richly deserved acknowledgment of your years of dedication to advancing our understanding and management of lung cancer! #WCLC2022
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@ekslim
Eric Lim
2 years
An amazing #WCLC22 , incredibly proud of my co-chairs, @IASLC , lCS, speakers, sponsors, patient groups and attendees to make this such a success! See you in Singapore for #WCLC2023 !
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@ekslim
Eric Lim
2 years
Chemo-IO is the new standard of care for resectable IIIA non-small cell lung cancer.
@DrSanjayPopat
Sanjay Popat
2 years
Yvonne Summers places neoadjuvant chemo-IO in context. Highlighting NADIM1-2 & CM816. “Major pathway change” for neoadjuvant chemo-IO. That’s an understatement! #BTOGsummerMeeting @BTOGORG
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@ekslim
Eric Lim
2 years
Congratulations Isabelle Opitz for your IASLC lectureship award for surgery!
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@ekslim
Eric Lim
1 year
Today we made a small piece of UK thoracic surgical history operating on two stage IV nsclc patients with radical intent after initial sact as part of a surgical RCT! #RAMON
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@ekslim
Eric Lim
3 years
Working hard in planning what we hope will be a face to face #wclc2022 conference. Increasing number of surgical sessions with better integration within neoadjuvant and adjuvant therapies as well surgical representation in stage III and IV NSCLC!
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@ekslim
Eric Lim
5 years
MARS 2 training and update session at #BTOG2019 ! Discussing nuts and bolts of a randomised trial on data quality, recording and submissions. The backbone of what makes a good RCT!
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@ekslim
Eric Lim
8 months
@IsaOpitz @paugalde20 @IASLC operations for mars 2 were done in 4 national centers of excellence for mesothelioma surgery, and one none expert centre (no statistical evidence for worse outcomes)
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@ekslim
Eric Lim
2 years
I am so stoked about the Presidential Session at WCLC 2022, featuring mostly early stage multi-modality trials, but perhaps MOST exciting for surgeons is the results of CALGB 140503 to be presented by Dr Nasser Altorki and discussed by Dr Hisashi Saji [of JCOG 0802]. 1/2
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@ekslim
Eric Lim
5 years
It's a misconception that chemotherapy is safer than surgery for lung cancer, the UK 30 day mortality rate for systemic anti-cancer treatment was reported as 3%, compared with 2% for surgery (UK National Lung Cancer Audit 2016).
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@ekslim
Eric Lim
6 years
MARS 2 reaches 100 participants randomized!!!!
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@ekslim
Eric Lim
1 year
Proud of the @RBandH thoracic surgery department’s contribution to the @SCTSUK lectures at this years 2023 annual meeting!
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@ekslim
Eric Lim
2 years
No difference in lung function loss, twice higher recurrence, complex segments had twice higher complications. OS driven by other non-lung cancers, yet authors conclude in favour of segment? 🤷🏻‍♂️
@BrendonStilesMD
Brendon Stiles
2 years
Great to see the results of JCOG0802 published in @TheLancet . This is a practice changing trial (for at least some parts of the world) of lobectomy vs. segmentectomy for peripheral stage I lung cancer </=2cm. #lcsm #tssmn
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@ekslim
Eric Lim
1 year
This is a game changer - we need to start working out the pathways to get this place now! @SCTSUK @BTOGORG @BTSlearning
@NICEComms
NICE
1 year
Thousands of people could benefit from a further treatment option for resectable non-small-cell lung cancer. Our draft guidance has recommended nivolumab with chemotherapy before surgery. Learn more: #NICENews
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@ekslim
Eric Lim
4 years
Despite two waves of COVID, UK mesothelioma research community - you rock!!!
@_johnedwards
John Edwards PhD FRCS(C/Th)
4 years
N=328 Final accrual reached for #MARS2 @ekslim #Mesothelioma An absolute triumph for collaborative work with wonderful @BTOGORG and @BrsTrialsCentre @RoyalPapRes colleagues
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@ekslim
Eric Lim
1 year
Fantastic talk by Kelvin Lau on the future of navigation bronchoscopy and surgery! Incredible amount of work to set up, define and confirm accuracy for lesion targeting that I didn’t appreciate. #scts2023
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@ekslim
Eric Lim
3 years
Humbled to have been awarded the 2020 IASLC Robert J Ginsberg Award in recognition of my work in thoracic surgery. It's a huge honour for me, and my sincere gratitude to the nominating committee.
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@ekslim
Eric Lim
8 months
@BrendonStilesMD @IsaOpitz @paugalde20 @IASLC There was no statistically significant differences in outcomes (data will be provided in the manuscript).
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@ekslim
Eric Lim
5 years
At the 99th @AATSED (AATS) meeting talking about N2, off to @thoracic (ESTS) to talk about (guess what?) yes more N2! What we need is to come to one place to settle this issue once and for all (click here ) @IASLC @tssmn @myESMO @ERSTalk @BTOGORG
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@ekslim
Eric Lim
11 months
Do you have Spotify on your phone? Now you can watch and listen to grand rounds wherever you are! Waiting for a case to start, at a bus stop… possibilities are endless!
@BGrandRounds
Brompton Grand Rounds in Thoracic Surgery
11 months
Brompton Grand Rounds webinars from 2021, 2022, and 2023 are now available on Spotify! Tap into a wealth of medical knowledge, featuring renowned experts and leaders in the field of thoracic surgery. @ekslim
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@ekslim
Eric Lim
8 months
@DrewMoghanaki @SBRT_CR @SalmaJabbour1 @sueyom 😂 I think the correct interpretation is patients with stage IA NSCLC deemed inoperable or refuse surgery will soon have a choice of SBRT+ICI?
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@ekslim
Eric Lim
6 years
Lung resection rates for cancer continue to rise in the UK! #SCTSUK @duggiewest
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@ekslim
Eric Lim
5 years
Presentation day for VIOLET...
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@ekslim
Eric Lim
3 years
ESTS! Get ready for some mind blowing data on improving disease free survival after surgery in 30mins! AstraZeneca Industry Symposium #ests21 #AstraZeneca #ests
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@ekslim
Eric Lim
5 years
Delighted to announce that Thoracic Oncology 2019 a conference I am organising on the future of integrated management of non-small cell lung cancer (throughout all lung stages) has been endorsed by the IASLC! #iaslc
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@ekslim
Eric Lim
2 years
What happens when two national guidelines give contradictory recommendations to operate (BTS 2010) and not to operate (NICE 2011) on patients with clinical N2 disease. How did clinicians respond?
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@ekslim
Eric Lim
1 year
London is one the very few cities you see this passing your hosptial on the way into work! #RoyalBromptonHospital
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@ekslim
Eric Lim
2 years
Thank you West of Scotland Research Ethics Service for the review meeting for @ramon_study yesterday! We are looking forward to opening UK sites shortly!
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@ekslim
Eric Lim
1 year
Let’s get UK sites open people! We can do this (say it back)!
@ramon_study
RAMON Study
1 year
📢📢 Site number 2⃣ have just been given the green light to begin recruitment! Good luck to @nizarasadi and the Harefield team!! 🏥🫁 @RBandH #lungcancer #research #clinicaltrials
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@ekslim
Eric Lim
8 months
@DrewMoghanaki @SBRT_CR @SalmaJabbour1 @sueyom Does VALOR have a SBRT+ICI arm? If not imo your revised statement would need qualification in a fair SABR+ICI versus surgery+ICI head to head RCT. 👍🏼
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@ekslim
Eric Lim
1 year
@BrendonStilesMD @StephenVLiu @AltorkiNasser @NEJM @biniamkidaneMD @DavidCookeMD @TomVargheseJr @JackWestMD @DrSteveMartin @IASLC @AATSHQ @jdoningtonmd @DrYolondaColson It’s ironic but the best case scenario is no difference in lung function, overall survival or recurrence with whatever extent of resection is offered. 😊
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@ekslim
Eric Lim
5 years
Dr Popat updating European surgeons @thoracic on immunotherapies! @IASLC @BTOGORG @ERSTalk @myESMO
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@ekslim
Eric Lim
4 years
@DrLou83 Way to go! I don’t understand why the UK ARCP members are so anti-family and continue to have such antiquated views.
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@ekslim
Eric Lim
6 years
Difficult to use registry data to compare vats versus open outcomes due to selection bias - needs to be evaluated in a RCT like VIOLET #26ests
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@ekslim
Eric Lim
2 years
Two titan trials in 2022 for surgery, one focusing on wedge and the other on segmentectomy - together representing over 17 years of follow up with >2,000 patients randomised! This will be THE most exciting plenary in thoracic surgical history! 2/2
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@ekslim
Eric Lim
8 months
P(A|B) = ePD surgical series whereas P(A| do (B)) = MARS 2, read on…
@kareem_carr
🔥Kareem Carr | Statistician 🔥
8 months
Every Data Scientist needs to know these ideas. They will blow your mind. 1. Correlation vs Causation P(A | B) is the probability of A given B. It is the probability that we will observe A given that we have already observed B. P(A | do(B)) is the probability of A given
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@ekslim
Eric Lim
5 years
@DrHugoA @DrHughHarvey @lungdiagnosis @ChestConsultant @veggielungdoc @LungConsultant @lungsforliving @MatthewEvison1 Silicon valley is all about hype to raise their company value. Show us some randomised trial data?!
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@ekslim
Eric Lim
5 years
Congratulations Andrew on the Mary J Matthews Award at the #WCLC19 ! Can’t imagine anyone more deserving! Lots more frozen sections to come!! 😂
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@ekslim
Eric Lim
5 years
We don’t need to stage the mediastinum to exclude cN2 disease. Patients should be offered surgical multimodality management!
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@ekslim
Eric Lim
2 years
Dr Saji himself presenting on JCOG0802! #ESTS2022
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@ekslim
Eric Lim
1 year
@FarhoodFarjah segment 6 aside why is everyone choosing segment? a technical single segment (7-10) or combo in hours versus a 15 min wedge with no difference in outcomes (disease free survival)?!
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@ekslim
Eric Lim
8 months
OMG this make so much sense!
@DrewMoghanaki
Drew Moghanaki 🐕
8 months
Move over FDG-PET/CT and say hello to Duvalumab-PET/CT. @CzerninJohannes @bensolomon1
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@ekslim
Eric Lim
8 months
@_ShankarSiva @tssmn @BrendonStilesMD @biniamkidaneMD @DoctorJSpicer @TomVargheseJr @maraantonoff @RajaFlores @ElliotServaisMD @Clavikul @JoeChangMD It’s about perfect evidence, it’s about the best available evidence. I quote this study (and limitations) to my patients and allow them to choose. Approximately 20% decline surgery based on this. #SharedDecisionMaking
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@ekslim
Eric Lim
7 years
@Helmy_L2K Helmy, I am a surgeon in the UK trying to contact you about a collaborative trial, may I have your email?
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@ekslim
Eric Lim
3 years
I’ve checked - it’s really him. Proud picture coming out off a huge jet from London to Cornwall to talk about climate change! 🤦🏻‍♂️
@BorisJohnson
Boris Johnson
3 years
I’ve arrived in Cornwall for this year’s @G7 where I’ll be asking my fellow leaders to rise to the challenge of beating the pandemic and building back better, fairer and greener. It will be a busy and important Summit, and I can’t wait to get started. #G7UK
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@ekslim
Eric Lim
2 years
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@ekslim
Eric Lim
9 months
@biniamkidaneMD @ElliotServaisMD @DrewMoghanaki @JackWestMD @IASLC @JTOonline @DoctorJSpicer @FordePatrick @finn_corinne @shalinivinod13 @n8pennell @CharuAggarwalMD @StevenLin_MDPhD @StephenVLiu @NitinOhri3 @LindaMThoracic @BrendonStilesMD @FarhoodFarjah @NateEvansMD @BorisSepesi @TomVargheseJr @jdoningtonmd Traditionally the British has separated resectable (can it be removed completely) and operable (can the patient tolerate it). It can never be “defined” or standardised because the former varies on surgeons expertise and the latter is patients acceptability of risk.
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@ekslim
Eric Lim
5 years
@BrendonStilesMD @DrSanjayPopat @STS_CTsurgery cN0 to pN1 was 6.2% VATS versus 5.2% open.
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@ekslim
Eric Lim
6 years
Great article on neoadjuvant immunotherapy for early stage lung cancer! Revealing objective response in the majority but not all tumours - to me, suggesting that the role of surgery (due to tumoural heterogeneity) will be preserved…
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@ekslim
Eric Lim
8 months
@RajaFlores @BrendonStilesMD @IASLC @DrSanjayPopat @StephenVLiu @NarjustFlorezMD @_johnedwards @IsaOpitz @DrJNaidoo @OncBrothers @JackWestMD @BTOGORG you raise some good points - i would love to have an open discussion with meso surgeons from around the world ideally in a non-confrontational / safe space. i’ll have a think about what i can organise
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@ekslim
Eric Lim
5 years
ESTS @thoracic first conference running session in Dublin!
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@ekslim
Eric Lim
1 year
Super important question that the UK seeks to answer!
@ramon_study
RAMON Study
1 year
@ekslim 's RAMON study is looking at multi-modality LCT for stage IV lung cancer patients with induced oligometastatic disease 🫁 If your hospital is interested in taking part, we would love to hear from you at ramon-study @bristol .ac.uk #lungcancer #research #clinicaltrials
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@ekslim
Eric Lim
2 years
Full text link to VIOLET as published in NEJM Evidence 2022:
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@ekslim
Eric Lim
8 months
@DrJNaidoo @BrendonStilesMD @IASLC @DrSanjayPopat @StephenVLiu @NarjustFlorezMD @_johnedwards @IsaOpitz @OncBrothers @JackWestMD @BTOGORG Important to state we didn’t withhold IO, more likely reason is because of poor health status (as evident in our qol measures) that led to less pt in surgery arm completing chemo and receiving IO.
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@ekslim
Eric Lim
6 years
@ekslim
Eric Lim
6 years
@benjamin_smood Personal drive, knowing the steps, wanting to do the operation, practicing on their own. Those traits signal the trainee that will whizz though the system.
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@ekslim
Eric Lim
6 years
@DrewMoghanaki @tssmn We are looking at this question the U.K. multicentre RCT - VIOLET, results are due in 2019. Get ready!
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@ekslim
Eric Lim
2 years
@LindaMThoracic @FarhoodFarjah @JVelottaMD @biniamkidaneMD @SBroderickMD @LisaBrownMD @ElliotServaisMD @SethBKrantz @leahbackhusmd @DavidCookeMD @BTongMD @ShandaBlackmon 2 “big” differences include a 26% reduction of in-hospital complications and massive cost savings up to one year (formal health economic outcomes to be published soon)!
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@ekslim
Eric Lim
8 months
@esinghimd @paugalde20 @OncoAlert @IASLC @LungCancerRx The operation was done in 4 national high volume surgical centres of excellence
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@ekslim
Eric Lim
10 months
Thank you @DrewMoghanaki , waking up at 3am and still delivering such a fantastic grand round!
@BGrandRounds
Brompton Grand Rounds in Thoracic Surgery
10 months
Thank you Dr @DrewMoghanaki for delivering a highly engaging session on Surgery or SABR for Early Lung Cancer (update on VALOR) this morning! If you missed it, you can watch here ⬇️ You can also catch it on Spotify: @ekslim @AstraZeneca @Medtronic
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@ekslim
Eric Lim
5 years
What's the future of CT screening and early detection in lung cancer? What the role of AI in image processing and detection? How is best to confirm the diagnosis? What is the role of hybrid theatres for a joint approach?
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@ekslim
Eric Lim
2 years
@_ShankarSiva @BrendonStilesMD @DrewMoghanaki @StokedStokes @PeterMacCC @PeterMacRadOnc I Chaired the 2010 British Guidelines in it we explain “operability” is a statement of a continuum of risk, it’s not binary, it’s the threshold patients (and surgeons) are willing to accept.
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@ekslim
Eric Lim
6 years
T1Q2 For general thoracic surgery independent lobectomy / pneumonectomy needs to be acquired prior to graduation. UK training is 6 years and trainees can achieve this somewhere between years 2 to 6 depending on their abilities #TSSMN
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@ekslim
Eric Lim
2 years
Such an important paradigm, moving towards greater multi-disciplinary integrations to improve survival in lung cancer!
@IASLC
IASLC
2 years
#WCLC22 is less than a month away. The Sunday Plenary: Multidisciplinary Approach to the Oligo Paradigm features novel research from world-renowned experts! Join us in person or virtually and learn more about #oligometastatic disease. Register now at #LCSM
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@ekslim
Eric Lim
6 years
@biniamkidaneMD @gianlucasali Problem is that most thoracic surgeons are not evidence based. Publicity is often rated higher than demonstration of value #26ests
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@ekslim
Eric Lim
8 months
@DrJNaidoo @BrendonStilesMD @IASLC @DrSanjayPopat @StephenVLiu @NarjustFlorezMD @_johnedwards @IsaOpitz @OncBrothers @JackWestMD @BTOGORG Thank you, in fact we already anticipated this question addressed it in the trial design phase (4 high volume national centre’s and intentionally 1 that is not). Results in the manuscript (currently under review).
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@ekslim
Eric Lim
8 months
@IsaOpitz @BrendonStilesMD @Alfdoc2 @StephenVLiu @paugalde20 @HwakeleeMD @karenkellymd @DrSanjayPopat @IASLC @_johnedwards @BTOGORG @DrJNaidoo i think everyone is missing the point - nobody denied chemo to the surgery cohort - more like they were too unwell to complete. Good luck in your next trial try to achieve it!
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@ekslim
Eric Lim
2 years
@BrendonStilesMD @TheLancet @IASLC @PercyLeeMD @SBRT_CR @DrewMoghanaki @drdavidpalma @ElliotServaisMD @rweichselbaum @BobTimmermanMD @FredFgrannis @samsonpp I have proposed that the only item in favour of segmentectomy for jcog 0802 is likely to be chance finding (type 1 error, smaller than that expected for what was defined as non inferiority, driven by secondary cancers and not consistent with previous RCTs, not expected a priori)
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@ekslim
Eric Lim
8 months
@RajaFlores @BrendonStilesMD @IASLC @DrSanjayPopat @StephenVLiu @NarjustFlorezMD @_johnedwards @IsaOpitz @DrJNaidoo @OncBrothers @JackWestMD @BTOGORG no a weakness - it’s reality, clinicians tend to struggle with real data that don’t fit conventional processes. maybe we should have used restricted mean survival or parametric modeling for one P value to alleviate the mental gymnastics required
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@ekslim
Eric Lim
1 year
@ElliotServaisMD @BrendonStilesMD @ammara_a @DavidCookeMD @ShandaBlackmon @LindaMThoracic @TomVargheseJr @LisaBrownMD @FarhoodFarjah Yes IIIB can be considered resectable (extended resection), this is such a great design! So much progress in thoracic surgical ontology! 👏🏻
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@ekslim
Eric Lim
5 years
@DrRiyazShah It should be the SAME day. That’s what we offer at the Brompton with real time reporting. Patients should not need to wait.
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@ekslim
Eric Lim
1 year
@biniamkidaneMD Wow! Linguistic masterpiece of a statement! I don’t think we should be too caught up about the definition of resectabilty further than the expectation of R0 outcome - cancer is microscopic.
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@ekslim
Eric Lim
5 years
@biniamkidaneMD @maraantonoff @NHSuk @ThoracicsCanada @CAGS_ACCG If there was not difference then surgeons can do what they want. If there is a diffenece then there is incentive to change.
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@ekslim
Eric Lim
2 years
@AbdoPainHotline I think you are missing the point, the role of a junior doctor is to train to be a consultant. Admin and other routine tasks are better handled by allied healthcare professionals to allow you to concentrate on being a leader when you finish your training.
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@ekslim
Eric Lim
6 years
@gianlucasali @MaxiRebecca @thoracic @SCTSUK @tamaranihici @duggiewest @Mikeshackcloth I can say that how I practice now is ENTIRELY different to how it was when I trained.
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@ekslim
Eric Lim
6 years
In the UK, we usually let trainees progress in components for each part of the operation. Once this is achieved, the procedure is done with the surgeon in theatre but not scrubbed to assist when required #TSSMN
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@ekslim
Eric Lim
2 years
@StephenVLiu @HwakeleeMD @IASLC Promise I wasn’t sleeping! 😂
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@ekslim
Eric Lim
2 years
So good to have patient advocates support!
@LUNGevity
LUNGevity Foundation
2 years
@ekslim @RBandH ’s great discussion on the role of multidisciplinary care in the tx of oligomets. We need more clinical trials and let’s not confine ourselves to definitions based on size when deciding treatment. #WCLC22 #LCSM @IASLC
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@ekslim
Eric Lim
7 years
Our research from @RBHHPrivateCare on the rising frequency of non smoking lung cancer
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@ekslim
Eric Lim
2 years
Are you still a slave to fluid levels before considering when to pull your chest drains?
@Drainology1
Drainology
2 years
#SCTS2022 : Outcomes of Chest Drain Management Using Only Air Leak (Without Fluid) Criteria for Removal After General Thoracic Surgery - A #Drainology Study
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@ekslim
Eric Lim
5 years
All violet (in colour)...
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@ekslim
Eric Lim
2 years
@BrendonStilesMD 26% reduction in hospital complications, 19% reduction in readmissions and £46,000+ savings (not expenditure) per QALY gained not big enough reasons? 😂
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@ekslim
Eric Lim
2 years
@SeverinSchmid Finally the “benefit” was 3.2% improvement in survival - is that meaningful? Given they declared 5% worse survival to be non-inferior? If so why should be accept less than 5% benefit as “superior”?!
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@ekslim
Eric Lim
1 year
The reason is because in the majority air leak is small or stopped, that’s why small drains work. But the same cannot be applied to big air leak situations (tension pneumothorax, traumatic lung lacerations etc)
@Drainology1
Drainology
1 year
Does size matter? @ekslim ⁩ at #SCTS2023 suggests a thoughtful approach. ⁦Patients with malignant pleural effusions, pneumothorax & pleural infection may be successfully managed with small-bore drains, guidelines say. However good quality data is lacking ⁦ @naj_rahman
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@ekslim
Eric Lim
6 years
Eric Lim, General Thoracic Surgeon, Royal Brompton Hospital, London, UK #TSSMN
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@ekslim
Eric Lim
2 years
@FarhoodFarjah @JVelottaMD @biniamkidaneMD @SBroderickMD @LisaBrownMD @ElliotServaisMD @SethBKrantz @leahbackhusmd @DavidCookeMD @BTongMD @ShandaBlackmon Transparency is key to all doctor patient communications and also need to inform on the benefits. FYI the 2 listed complications were not statistically significantly higher, and important to also quite the absolute difference which in my opinion was very small.
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@ekslim
Eric Lim
2 years
@BrendonStilesMD Physical function is a time dependant variable. It’s not that vats is 5 points better, but rather 5 points at 5 weeks. In the first 2 weeks it was 13 points better, and if we measured at 1 week 🤷🏻‍♂️?
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@ekslim
Eric Lim
5 years
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@ekslim
Eric Lim
5 years
@DrRiyazShah Agree it won’t be, but it can and should be. Radiologist’s are reporting during the sessions anyway and we should not make patient travel twice just because the set up is not optimised.
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@ekslim
Eric Lim
6 years
@duggiewest @maheshramanan @gianlucasali @thoracic @SCTSUK @tamaranihici @TomVargheseJr @drnikkistamp @Mikeshackcloth It makes discharge easier cos u don’t need a gp visit, more comfortable for patients, less work for nurses, less travel for patients, maybe less pneumothorax, better cosmesis?
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