Delighted to announce MARS 2 data is now mature and we aim to report this year! Thank you to our patients, UK investigators,
@BrsTrialsCentre
,
@NIHRresearch
@CRUKresearch
for 7 years of hard work!!
UK thoracic surgery research collaborative have reached target accrual for NIHR funded VIOLET trial of keyhole versus open surgery for lung cancer! With over 500+ patients randomised two months ahead of schedule! Results will be released in major conferences later this year.
At long last with over 5 years of work and 2 years of collation of results and reporting I am over the moon with delight to see the results of VIOLET in print!
Congratulations Dr Valerie Rush on a richly deserved acknowledgment of your years of dedication to advancing our understanding and management of lung cancer!
#WCLC2022
An amazing
#WCLC22
, incredibly proud of my co-chairs,
@IASLC
, lCS, speakers, sponsors, patient groups and attendees to make this such a success! See you in Singapore for
#WCLC2023
!
Today we made a small piece of UK thoracic surgical history operating on two stage IV nsclc patients with radical intent after initial sact as part of a surgical RCT!
#RAMON
Working hard in planning what we hope will be a face to face
#wclc2022
conference. Increasing number of surgical sessions with better integration within neoadjuvant and adjuvant therapies as well surgical representation in stage III and IV NSCLC!
MARS 2 training and update session at
#BTOG2019
! Discussing nuts and bolts of a randomised trial on data quality, recording and submissions. The backbone of what makes a good RCT!
@IsaOpitz
@paugalde20
@IASLC
operations for mars 2 were done in 4 national centers of excellence for mesothelioma surgery, and one none expert centre (no statistical evidence for worse outcomes)
I am so stoked about the Presidential Session at WCLC 2022, featuring mostly early stage multi-modality trials, but perhaps MOST exciting for surgeons is the results of CALGB 140503 to be presented by Dr Nasser Altorki and discussed by Dr Hisashi Saji [of JCOG 0802]. 1/2
It's a misconception that chemotherapy is safer than surgery for lung cancer, the UK 30 day mortality rate for systemic anti-cancer treatment was reported as 3%, compared with 2% for surgery (UK National Lung Cancer Audit 2016).
No difference in lung function loss, twice higher recurrence, complex segments had twice higher complications. OS driven by other non-lung cancers, yet authors conclude in favour of segment? 🤷🏻♂️
Great to see the results of JCOG0802 published in
@TheLancet
. This is a practice changing trial (for at least some parts of the world) of lobectomy vs. segmentectomy for peripheral stage I lung cancer </=2cm.
#lcsm
#tssmn
Thousands of people could benefit from a further treatment option for resectable non-small-cell lung cancer.
Our draft guidance has recommended nivolumab with chemotherapy before surgery.
Learn more:
#NICENews
Fantastic talk by Kelvin Lau on the future of navigation bronchoscopy and surgery! Incredible amount of work to set up, define and confirm accuracy for lesion targeting that I didn’t appreciate.
#scts2023
Humbled to have been awarded the 2020 IASLC Robert J Ginsberg Award in recognition of my work in thoracic surgery. It's a huge honour for me, and my sincere gratitude to the nominating committee.
Do you have Spotify on your phone? Now you can watch and listen to grand rounds wherever you are! Waiting for a case to start, at a bus stop… possibilities are endless!
Brompton Grand Rounds webinars from 2021, 2022, and 2023 are now available on Spotify!
Tap into a wealth of medical knowledge, featuring renowned experts and leaders in the field of thoracic surgery.
@ekslim
ESTS! Get ready for some mind blowing data on improving disease free survival after surgery in 30mins! AstraZeneca Industry Symposium
#ests21
#AstraZeneca
#ests
Delighted to announce that Thoracic Oncology 2019 a conference I am organising on the future of integrated management of non-small cell lung cancer (throughout all lung stages) has been endorsed by the IASLC!
#iaslc
What happens when two national guidelines give contradictory recommendations to operate (BTS 2010) and not to operate (NICE 2011) on patients with clinical N2 disease. How did clinicians respond?
Thank you West of Scotland Research Ethics Service for the review meeting for
@ramon_study
yesterday! We are looking forward to opening UK sites shortly!
Two titan trials in 2022 for surgery, one focusing on wedge and the other on segmentectomy - together representing over 17 years of follow up with >2,000 patients randomised! This will be THE most exciting plenary in thoracic surgical history! 2/2
Every Data Scientist needs to know these ideas.
They will blow your mind.
1. Correlation vs Causation
P(A | B) is the probability of A given B. It is the probability that we will observe A given that we have already observed B.
P(A | do(B)) is the probability of A given
@FarhoodFarjah
segment 6 aside why is everyone choosing segment? a technical single segment (7-10) or combo in hours versus a 15 min wedge with no difference in outcomes (disease free survival)?!
I’ve arrived in Cornwall for this year’s
@G7
where I’ll be asking my fellow leaders to rise to the challenge of beating the pandemic and building back better, fairer and greener.
It will be a busy and important Summit, and I can’t wait to get started.
#G7UK
Great article on neoadjuvant immunotherapy for early stage lung cancer! Revealing objective response in the majority but not all tumours - to me, suggesting that the role of surgery (due to tumoural heterogeneity) will be preserved…
@ekslim
's RAMON study is looking at multi-modality LCT for stage IV lung cancer patients with induced oligometastatic disease 🫁
If your hospital is interested in taking part, we would love to hear from you at ramon-study
@bristol
.ac.uk
#lungcancer
#research
#clinicaltrials
@benjamin_smood
Personal drive, knowing the steps, wanting to do the operation, practicing on their own. Those traits signal the trainee that will whizz though the system.
Thank you Dr
@DrewMoghanaki
for delivering a highly engaging session on Surgery or SABR for Early Lung Cancer (update on VALOR) this morning!
If you missed it, you can watch here ⬇️
You can also catch it on Spotify:
@ekslim
@AstraZeneca
@Medtronic
What's the future of CT screening and early detection in lung cancer? What the role of AI in image processing and detection? How is best to confirm the diagnosis? What is the role of hybrid theatres for a joint approach?
T1Q2 For general thoracic surgery independent lobectomy / pneumonectomy needs to be acquired prior to graduation. UK training is 6 years and trainees can achieve this somewhere between years 2 to 6 depending on their abilities
#TSSMN
#WCLC22
is less than a month away. The Sunday Plenary: Multidisciplinary Approach to the Oligo Paradigm features novel research from world-renowned experts! Join us in person or virtually and learn more about
#oligometastatic
disease. Register now at
#LCSM
@biniamkidaneMD
Wow! Linguistic masterpiece of a statement! I don’t think we should be too caught up about the definition of resectabilty further than the expectation of R0 outcome - cancer is microscopic.
@AbdoPainHotline
I think you are missing the point, the role of a junior doctor is to train to be a consultant. Admin and other routine tasks are better handled by allied healthcare professionals to allow you to concentrate on being a leader when you finish your training.
In the UK, we usually let trainees progress in components for each part of the operation. Once this is achieved, the procedure is done with the surgeon in theatre but not scrubbed to assist when required
#TSSMN
@ekslim
@RBandH
’s great discussion on the role of multidisciplinary care in the tx of oligomets. We need more clinical trials and let’s not confine ourselves to definitions based on size when deciding treatment.
#WCLC22
#LCSM
@IASLC
#SCTS2022
: Outcomes of Chest Drain Management Using Only Air Leak (Without Fluid) Criteria for Removal After General Thoracic Surgery - A
#Drainology
Study
@BrendonStilesMD
26% reduction in hospital complications, 19% reduction in readmissions and £46,000+ savings (not expenditure) per QALY gained not big enough reasons? 😂
@SeverinSchmid
Finally the “benefit” was 3.2% improvement in survival - is that meaningful? Given they declared 5% worse survival to be non-inferior? If so why should be accept less than 5% benefit as “superior”?!
The reason is because in the majority air leak is small or stopped, that’s why small drains work. But the same cannot be applied to big air leak situations (tension pneumothorax, traumatic lung lacerations etc)
Does size matter?
@ekslim
at
#SCTS2023
suggests a thoughtful approach. Patients with malignant pleural effusions, pneumothorax & pleural infection may be successfully managed with small-bore drains, guidelines say. However good quality data is lacking
@naj_rahman
@BrendonStilesMD
Physical function is a time dependant variable. It’s not that vats is 5 points better, but rather 5 points at 5 weeks. In the first 2 weeks it was 13 points better, and if we measured at 1 week 🤷🏻♂️?
@DrRiyazShah
Agree it won’t be, but it can and should be. Radiologist’s are reporting during the sessions anyway and we should not make patient travel twice just because the set up is not optimised.