Wojciech (Wojtek) Kopec @wojciechkopec3 Twitter profile

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Wojciech (Wojtek) Kopec

@wojciechkopec3

5 years

aaand the new movie, this time for the NaK2K channel

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Wojciech (Wojtek) Kopec

@wojciechkopec3

2 years

Got offered a lecturer position, now this is something to think about over Christmas

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Wojciech (Wojtek) Kopec

@wojciechkopec3

1 year

Starting my Lecturer in Computational Pharmaceutical Chemistry position at the Queen Mary University of London 🇬🇧🥳 @QMUL @QMULSPCS

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Wojciech (Wojtek) Kopec

@wojciechkopec3

3 years

German B2 exam passed 🎉🎉 that was a lot of work

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

3 years of work finally resulted in a paper! This time not potassium channels 😉 transport of small hydrophobic molecules through membranes via beta-barrel protein

A β-barrel for oil transport through lipid membranes: Dynamic NMR structures of AlkL | PNAS

The protein AlkL is known to increase permeability of the outer membrane of bacteria for hydrophobic molecules, yet the mechanism of transport has ...

www.pnas.org

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Wojciech (Wojtek) Kopec

@wojciechkopec3

2 years

After months of applying and many rejections, on my way to the interview for a junior professor position 🫣😇 98% nervous 2% excited or other way around

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Wojciech (Wojtek) Kopec

@wojciechkopec3

2 months

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Wojciech (Wojtek) Kopec

@wojciechkopec3

3 years

academia: thanks for your application. You will hear from us within a year (no joke, that was the actual email) industry: thanks for your application. can we talk next week?

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Wojciech (Wojtek) Kopec

@wojciechkopec3

10 months

🚨 I'm hiring a PhD student to join me in my new lab in London @QMUL Molecular Dynamics / Computational Electrophysiology of potassium K2P channels. Collaborations with top experimental groups. Please spread the word! Contact me at w.kopec @qmul .ac.uk

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

We got it!!!! 🥳🤩🤩🤩 Soon hiring my 1st PhD student!! Thanks so much to all my mentors and collaborators along the way, especially the one and only Bert de Groot @CompBioPhys

Wojciech (Wojtek) Kopec

@wojciechkopec3

5 years

Done! Waiting for the reviewers decision! All the groups did a wonderful job. Also the #ionman hashtag was born! #ionchannels #dynion 🎉🥳🤥🙏🙏😇🇩🇪

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Wojciech (Wojtek) Kopec

@wojciechkopec3

3 years

Thrilled to announce that our Human Frontier Science Program @HFSP joint proposal led by Andreas Hartel @AndreasHartel1 with Tiago Costa @tiagomlcosta and yours truly got funded! We will study mechanosensitive channels under ultrasounds with cutting edge el phys and MD sims!

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

Happy to get the 2nd prize from the German Society for Biophysics in the scientific photo competition. Two hydrophobic polycations are chilling on the membrane surface. Made exclusively in VMD, thanks all the devs for this great tool

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Wojciech (Wojtek) Kopec

@wojciechkopec3

2 years

Made it to the local newspaper, no impact factor though 🫣

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Wojciech (Wojtek) Kopec

@wojciechkopec3

1 year

If everything goes as planned I'll be starting my new position as a Lecturer in Computational Pharmaceutical Chemistry at @QMUL @QMULSPCS I'll be focusing on the computational development of molecules targeting potassium channels 🥳

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Wojciech (Wojtek) Kopec

@wojciechkopec3

3 years

it's not that "i don't wanna stay in academia" rather "academia doesn't want me to stay"

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Wojciech (Wojtek) Kopec

@wojciechkopec3

5 years

The most revealing 'scientific' story of 2019 for me: 1. A paper is published in @eLife , that claims an effect based on extremely low statistics [one measurement per condition, 4 conditions = 4 measurements in total] 2. Thanks to journal's visible reviewers comments.. 1/n

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

My #BPS2021 poster on current regulation in potassium channels studied with in silico electrophysiology simulations! 3 different mechanisms we have identified recently - i) filter widening ii) hydrophobic gating below the SF iii) direct knock-on formation efficiency...

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Wojciech (Wojtek) Kopec

@wojciechkopec3

5 years

Just potassium ions binding to the sodium-potassium pump

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Wojciech (Wojtek) Kopec

@wojciechkopec3

1 year

After 7.5 years it’s my last day at the Max Planck Institute for Multidisciplinary Sciences in Göttingen @mpi_nat @CompBioPhys thanks for the ride Max Planck Society and see you around @maxplanckpress

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

Trying to build a tutorial on simulating and analysing an ion channel with GROMACS.. wish me luck @GMX_TWEET

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Wojciech (Wojtek) Kopec

@wojciechkopec3

10 months

Feels unreal actually

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Wojciech (Wojtek) Kopec

@wojciechkopec3

2 years

🚨new preprint! We (with my partner in crime @VytasGapsys ) have discovered an unexpected artifact/effect in MD simulations at low salt concentration (or no salt at all)

Periodic boundaries in Molecular Dynamics simulations: why do we need salt?

Molecular dynamics (MD) simulations are usually performed by employing periodic boundary conditions (PBC). While this treatment of simulation system removes the necessity to treat the interactions...

www.biorxiv.org

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Wojciech (Wojtek) Kopec

@wojciechkopec3

2 years

I am reviewing a solid computational study on protein membrane interactions. Suddenly the second reviewer asks the authors if they can provide experimental evidence for their hypothesis. It is like trying to buy a car at a bakery. Please don't do it

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Wojciech (Wojtek) Kopec

@wojciechkopec3

5 months

@FromPhDtoLife Reminders from angry colleagues?

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

I have a MD joke but it needs more time to finish

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Wojciech (Wojtek) Kopec

@wojciechkopec3

6 months

Just got funding for an international candidate to join me as the first PhD student in my lab at @QMUL 🥳🥳 celebrating every small success

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Wojciech (Wojtek) Kopec

@wojciechkopec3

3 years

Last night my brain decided 3:45 am is a good time to think what might happen if I don't get any position I applied for. Managed to get some more sleep around 6 😴

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Wojciech (Wojtek) Kopec

@wojciechkopec3

2 years

Thanks to the HFSP grant I have, there are additional funds available to hire a PhD student/postdoc/senior scientist affected by the war in Ukraine. MD simulations of membrane proteins, ultrasounds, computational electrophysiology. Please DM and RT

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

@alexapetelina @AcademicChatter Things that happen in-between rejections ;)

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Wojciech (Wojtek) Kopec

@wojciechkopec3

1 year

- be a young PI - apply for a grant - reviewers dont like the fact that you dont have experience in being a PI - grant rejected - dont get the experience in being a PI Rinse and repeat 🫡

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Wojciech (Wojtek) Kopec

@wojciechkopec3

2 years

@prof_kozak Plus putting unnecessary pressure on the applicants with “letters have to arrive before xxx”, especially on younger folks. It’s like I did a msc with this prof. but now he’s travelling through australia but is supposed to write a letter within 3 weeks. Good luck with that

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

Today I start with some theory... #youngPI #halfPI

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Wojciech (Wojtek) Kopec

@wojciechkopec3

3 years

Dear research network - I just got contacted by a scientist from Ukraine, biology PhD, working on mucoadhesive dosage forms of biologically active substances, fleeing her country and looking for a position in the west. Anyone?

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Wojciech (Wojtek) Kopec

@wojciechkopec3

1 year

CHARMM, GROMOS, Amber

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

Cool senior people @mpi_bpc decided to promote me to a project group leader! whoop! 🥳🥳🥳

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Wojciech (Wojtek) Kopec

@wojciechkopec3

5 years

Isolation dance in the kitchen 🎵😇 stay positive and swing out! 🥳🥳🥳

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

This feeling when computational and experimental data fit so well (and they havent seen each other before) 🤯

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Wojciech (Wojtek) Kopec

@wojciechkopec3

1 year

Theres been some non scientific project going on 😊😉🥳

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

Side project's paper accepted! Thanks to all 4 Reviewers that helped a lot - we've learned so much in the process. Coming soon in @ACS_Langmuir @VytasGapsys @JagiellonskiUni

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

A potassium channel (NaK2K) at 1.20 A resolution!! Had a blast simulating these structures. Great collaboration with Leighton Coates team from the Oak Ridge National Lab

The structure of a potassium-selective ion channel reveals a hydrophobic gate regulating ion...

The atomic resolution structure of a potassium-selective ion channel reveals a hydrophobic gate that regulates ion permeation.

journals.iucr.org

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Wojciech (Wojtek) Kopec

@wojciechkopec3

3 years

Off for vacation! Van is full and we’re gonna camp, hike and discover some hidden gems, in both Germany and Poland 🇩🇪🇵🇱

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Wojciech (Wojtek) Kopec

@wojciechkopec3

11 days

Preparing my first teaching module from scratch (molecular modelling for drug discovery), probably more stressed than the students 🥵. Thanks to everyone for putting amazing resources out there and again big shout to @eriklindahl for amazing youtube videos on molecular biophysics

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Wojciech (Wojtek) Kopec

@wojciechkopec3

2 years

I had a wonderful visit at @scilifelab great scientific discussions with the members of @DelemotteLab and @eriklindahl labs! Thanks so much for the invitation 🙏🥳 @WillPPK

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

I applied exactly one year ago and no results yet (that I’m aware of). As my mom used to say - ‘the best time to look for a job is when you have a job’ 🙃

Wojciech (Wojtek) Kopec

@wojciechkopec3

5 years

just applied for the first time for a tenure track position 🤫🧐

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Wojciech (Wojtek) Kopec

@wojciechkopec3

10 months

3 months in the UK, trying to hire PhD students & postdocs

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

We've reviewed computational and experimental studies about ion permeation mechanisms in K+ channels. Article in revision, here's the preprint - feedback welcome!

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Wojciech (Wojtek) Kopec

@wojciechkopec3

6 months

When you have to work on a new machine where nothing works properly, gnuplot is there to rescue

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Wojciech (Wojtek) Kopec

@wojciechkopec3

3 months

A non-academic friend showed me some shady papers and saying “but they were peer reviewed!! 😭” so i made a meme for her

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Wojciech (Wojtek) Kopec

@wojciechkopec3

5 months

Very proud of my first final project (Bsc) students in the UK, Ivan and Sindi. We started in September and now they’re simulating those CFTR and Shaker channels like pros #proudpi @QMUL @QMULSPCS thank you @DERI_QMUL for all the flops 😋😋

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

I got invited for an interview after I've lost all hope 🙃

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Wojciech (Wojtek) Kopec

@wojciechkopec3

1 year

For my recent move between countries (🇩🇪->🇬🇧) I had to put aside ~20k £ (visas, moving company, few months rent paid in advance bc. no credit score). Ill be getting 90% of it back (or paid in advance) but it was super stressful and not easy, especially for an academic

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Wojciech (Wojtek) Kopec

@wojciechkopec3

2 years

also some unexpected good news for yours truly ;)

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

German exam today 😬 wish me luck

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Wojciech (Wojtek) Kopec

@wojciechkopec3

3 years

another day another rejection

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Wojciech (Wojtek) Kopec

@wojciechkopec3

5 years

just applied for the first time for a tenure track position 🤫🧐

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Wojciech (Wojtek) Kopec

@wojciechkopec3

3 years

interested in absolute free energies of ligand binding from MD? Don't miss this excellent new contribution outlining the state of the field: @VytasGapsys @davidlmobley @matteo_aldeghi @CompBioPhys

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

The new polish minister of education (and also a professor at the "catholic university" said 3 months ago "LGBT people are not equal to normal people" and I'm still being asked why I don't wanna move back to Poland

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Wojciech (Wojtek) Kopec

@wojciechkopec3

1 year

Global talent visa granted 🇬🇧🥳🎉

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Wojciech (Wojtek) Kopec

@wojciechkopec3

1 year

Arrived in the UK 🇬🇧🥳 first day at work tomorrow 😬

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Wojciech (Wojtek) Kopec

@wojciechkopec3

2 years

applying for academic positions in Germany, 2022 [in German]: "this questionnaire is to be sent to the Dean's Office via CD/floppy disk"

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Wojciech (Wojtek) Kopec

@wojciechkopec3

5 years

🥳🎉

Nature Communications

@NatureComms

5 years

Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling @RothbergLab @CompBioPhys @wojciechkopec3 @mpi_bpc

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

Join us🥳💅

Theoretical & Computational Biophysics Department

@CompBioPhys

4 years

➡️We have openings for PhD and Postdoc positions @CompBioPhys @mpi_bpc in @goettingen - Your application is most welcome! Please visit our website for more details on the announcments:

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Wojciech (Wojtek) Kopec

@wojciechkopec3

3 years

Not working this weekend, just studying few hours a day for the next language exam; sometimes the idea of trying to get a PI position in a foreign country just feels like too much

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Wojciech (Wojtek) Kopec

@wojciechkopec3

2 years

academic job announcements that ask you to prepare all your docs as pdfs and then in the actual application portal make you copy paste all this information again in some small boxes are another layer of evil

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Wojciech (Wojtek) Kopec

@wojciechkopec3

2 months

First graduation. Forgot my more formal hoodie 🤣 the students, Ivan and Sindi, did fantastic job in their final year projects

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Wojciech (Wojtek) Kopec

@wojciechkopec3

9 months

In 2023 I - got married ❤️ - moved countries 🇬🇧 - started an independent research career 😵‍💫 - got admitted to the hospital twice 🤕 - enjoyed climbing 🧗‍♂️ - suffered and recovered from a hamstring injury 🤕 - learned a bit a new dance (balboa)🕺🏿 - worked on my issues in therapy

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Wojciech (Wojtek) Kopec

@wojciechkopec3

3 years

Having a partner working over Christmas in a hospital meant that I was solely responsible for cooking this time. Tried several traditional polish recipes, with a vegan twist. Worked quite nicely!! 🎄🎅🤶

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Wojciech (Wojtek) Kopec

@wojciechkopec3

1 year

GROMACS reminds you: "I came up with the new convergence method, it's called a deadline driven convergence. My simulation is converged when it hits the deadline." (Tanadet Pipatpolkai) nice achievement @WillPPK @GMX_TWEET

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

just had a first session with my therapist since January 2019.. feel so much better already. Remember, if you keep feeling bad, they are there to help you! My mom calls them 'soul doctors' #mentalhealth @AcademicChatter

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

Grant proposal submitted. Few months of writing with twitterless Andreas Hartel and Tiago Costa - I never met them in real life! Many thanks to Gerhard Thiel from @TUDarmstadt who put us together 🙏🙏

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Wojciech (Wojtek) Kopec

@wojciechkopec3

5 years

Congratulations to my PI Bert de Groot @CompBioPhys (and the whole team) for this new paper on glycerol-selective aquaglyceroporins. Bert did all MD simulations on his own - amazing when PIs still manage to do research on their own!

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Wojciech (Wojtek) Kopec

@wojciechkopec3

3 years

starting a sentence with "our data clearly show..." and then being stuck for an hour is probably not a good sign

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Wojciech (Wojtek) Kopec

@wojciechkopec3

1 year

chloride ions (yellow) finding their way through the CFTR channel. Fun simulations with @isoteak

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Wojciech (Wojtek) Kopec

@wojciechkopec3

7 months

I had (still having) a great time in Oxford!! Lots of discussions, great science Thanks @ProfSyK @philbiggin ♥️

Syma Khalid

@ProfSyK

7 months

Really insightful seminar from @wojciechkopec3 on potassium ion permeation through K+ channels and also artefacts in molecular dynamics due to periodic boundaries. A pleasure to host Wojciech on behalf of SBCB: a UK membrane simulations powerhouse @philbiggin @BiochemOxford

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Wojciech (Wojtek) Kopec

@wojciechkopec3

1 year

Moving to the UK 🇬🇧 step 1

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Wojciech (Wojtek) Kopec

@wojciechkopec3

7 months

“Only cash” (nur Bargeld!) on an international Deutsche Bahn train was the first thing I heard when trying to get a bottle of water, coming from the UK. Hard to get more stereotypical @germany_iam

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Wojciech (Wojtek) Kopec

@wojciechkopec3

3 years

Lindy Hop ❤️

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Wojciech (Wojtek) Kopec

@wojciechkopec3

2 years

@patrickwintour @ecfr @jonhenley "In all European countries save Poland" vs. "Survey across 10 European countries and UK" seriously?

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

@careerconversa1 I was told the same when I became a PhD student and my english was not very good; i was told the same at my first posters that werent looking super fancy etc.. having these skills is great but it takes time to develop and often they are secondary to the main thing..

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Wojciech (Wojtek) Kopec

@wojciechkopec3

3 years

Breaks are important yo

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Wojciech (Wojtek) Kopec

@wojciechkopec3

5 years

New PhD and postdoc positions available in our group!! Please RT and feel free to DM me if you have any questions. #MDsimulations #Ionchannels #FreeEnergy #PotassiumChannels

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Wojciech (Wojtek) Kopec

@wojciechkopec3

2 years

this is kinda cool i have to say

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Wojciech (Wojtek) Kopec

@wojciechkopec3

2 years

Our new work with @RothbergLab is out! We looked at the selectivity filter gating and ion permeation in the MthK potassium channel and its KcsA-inspired V55E mutant

Driving Forces underlying Selectivity Filter Gating in the MthK Potassium Channel

K+ channel activity can be limited by C-type inactivation, which is likely initiated in part by dissociation of K+ ions from the selectivity filter, and modulated by side chains surrounding the...

www.biorxiv.org

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Wojciech (Wojtek) Kopec

@wojciechkopec3

5 years

I am a chemists who is using computational biophysical approaches to study ion channels and their inner workings Besides science, I like jazz music and especially dancing Lindy Hop #ThisIsWhatAScientistLooksLike #ILookLikeAScientist

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

A single simulation is enough

status annoyicus

@medburnbook

4 years

give me a horror story from your specialty in five words or less

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

Partner (nurse) got the first shot of the corona vaccine 💉🙏💪

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Wojciech (Wojtek) Kopec

@wojciechkopec3

2 years

Please do not organize conferences like this: "Please bring your PowerPoint Presentation on a USB flash drive. Please note that presentation from your own laptop will NOT be possible." - I don't use Powerpoint - I don't have a windows machine - I don't have a USB flash drive

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Wojciech (Wojtek) Kopec

@wojciechkopec3

1 year

even after 8 years after finishing my PhD I can randomly ask my PhD supervisor for academic and life advice. Truly a blessing

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

My PhD advisor Himanshu is looking for a postdoc in MD simulations of membranes, ion pumps and voltage sensing! Great place, great people, great science

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Wojciech (Wojtek) Kopec

@wojciechkopec3

3 years

Boostered 🚀

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

@SusannaLHarris Cholesterol (molecule) is the 2nd most abundant molecule in our bodies (after water)

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Wojciech (Wojtek) Kopec

@wojciechkopec3

3 years

I often work on weekends, especially since my partner does it too (she works in a hospital) but then i’d randomly go climbing at 2pm on Tuesday

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Wojciech (Wojtek) Kopec

@wojciechkopec3

3 years

found a fitting academic position, got rejected in the first round. Ouch 😨

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Wojciech (Wojtek) Kopec

@wojciechkopec3

9 months

11 years since I moved abroad, I tend to miss my hometown more and more, although living in London is pretty great. Probably signs of getting older. At least the connections are very good 😀 #Krakow

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Wojciech (Wojtek) Kopec

@wojciechkopec3

3 years

apparently i had a typo in the 3rd line of my CV for the last 5 years 🙃🥲

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Wojciech (Wojtek) Kopec

@wojciechkopec3

5 years

How K+ ions cross K+ channels? We still don't fully understand, but we were lucky enough to work with an amazing team of scientists led by Adam Lange and Han Sun, who showed, using ssNMR, that the ion conduction in K+ channels is water-free

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Wojciech (Wojtek) Kopec

@wojciechkopec3

4 years

Not going home for Christmas first time after I moved abroad 9 years ago - the situation in Poland is probably one of the worst in EU (don’t know for sure cause they gave up on testing). I’m grateful however that I managed to somewhat settle down in Germany 🥳

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Wojciech (Wojtek) Kopec

@wojciechkopec3

6 months

First time in LA on my way to GRC Ligand Recognition and Molecular Gating.. 11h flight and 2.5h in line to get in, but the views are stunning

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