Science Signaling @scisignal Twitter profile | Pikagi

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Science Signaling

@scisignal

16,724

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448

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4,434

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Uncovering mechanisms in biology, gaining insights into physiology and disease.

Washington, DC

https://t.co/gaazr3uYCl

Joined April 2010

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@scisignal

Science Signaling

2 days

Don’t miss this week’s issue of #ScienceSignaling ! Experiments in mice suggest that a neuron-supporting factor could be a promising target in depression, scientists discover a new approach that boosts memory in models of Alzheimer’s disease, and more.

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@scisignal

Science Signaling

5 years

This animation highlights the complex interactions between the various channels, pumps, transporters, and binding proteins that help to move Ca2+ ions between various locations within cells. @KU_Leuven @ScienceVisuals

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Science Signaling

1 year

Scientists have traced the heart toxicity of the cancer drug #doxorubicin to disruptions in iron utilization in #mitochondria —and find that the amino acid 5-ALA can prevent ferroptosis and cell death in vitro and in mice. @KyushuUniv_EN

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@scisignal

Science Signaling

1 year

A vicious cycle in pulmonary arterial hypertension may present a new treatment target, protein palmitoylation supports synaptic plasticity in fear-conditioned mice, and more in this week’s new issue of Science Signaling.

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@scisignal

Science Signaling

1 year

A computational framework designs new protein-protein interactions through sequence analysis, offering a powerful tool to dissect cell processes or to engineer cells to perform new functions. @m_madan_babu @MRC_LMB #ComputationalBiology

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@scisignal

Science Signaling

10 months

The commensal bacteria #Fusobacterium can promote the migration of #PancreaticCancer cells, according to a 2022 study highlighting the growing importance of the #TumorMicrobiome in cancer progression and therapeutic research. #WorldMicrobiomeDay

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@scisignal

Science Signaling

3 years

Cells generate distinct responses – such as proliferation or migration – to the growth factors #EGF and #heregulin depending on receptor trafficking patterns to different pools of the kinase Erk. @maxplanckpress

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@scisignal

Science Signaling

1 year

This week’s new issue of #ScienceSignaling has arrived! Research decodes a mechanism in the nuclei of neurons that supports memory consolidation, scientists discover a promising precision medicine strategy for a subtype of leukemia, and more.

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@scisignal

Science Signaling

1 year

Experiments show that neutrophils can release #NeutrophilExtracellularTraps through a mechanism that doesn’t rely on #CellDeath or gasdermin D—contrasting with previous findings and adding nuance to how researchers understand NET formation. @unibern

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@scisignal

Science Signaling

4 months

The first #ScienceSignaling issue of 2024 has arrived! Researchers dissect how seedlings respond to light and spread their leaves, a study probes the TAO(K3) of T cells, an Editorial discusses the bright future of basic biology research in India, and more.

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@scisignal

Science Signaling

1 year

This week’s new issue of Science Signaling has arrived! Researchers leverage a 3D human skin model to probe the role of TGF-beta in skin biology and invasive tissue spread, a study shows how neutrophils manage to squeeze through tight spaces, and more.

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@scisignal

Science Signaling

1 year

This week’s issue of #ScienceSignaling is here! Researchers uncover a tumor-suppressive role for intracellular IL-33 in liver cancer and explore how stress granules trigger cell death. Plus, a Review details insights from a model of the NF-kB system.

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@scisignal

Science Signaling

2 years

A new study demystifies how extracellular vesicles drive pancreatic cell aggressiveness, our weekly Editors’ Choice piece examines recent research on host-microbe interactions and inflammation, and more in this week’s new issue of Science Signaling.

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@scisignal

Science Signaling

4 months

In a new Editorial, @arshukla shares his experiences and opinions on the state of #BasicBiology research in India and discusses promising opportunities, advances in research infrastructure, and remaining obstacles to progress. @BSBEIITK1

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@scisignal

Science Signaling

2 years

The new issue of Science Signaling is out now! Macrophages depend on calcium signaling to support skeletal muscle repair, and scientists link an ion channel to harmful responses to rigid medical implants.

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@scisignal

Science Signaling

2 years

Mutations in congenital pain insensitivity led scientists to a new therapeutic target in pain, a new Editors’ Choice piece explores research on how neuropeptides promote respiratory stress, and more in this week’s new issue of Science Signaling.

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@scisignal

Science Signaling

11 months

An RNA supports the migration and invasiveness of breast and lung cancer cells, scientists discover a “sticking point” mechanism that helps activate T cells, and more in this week’s new issue of #ScienceSignaling .

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@scisignal

Science Signaling

4 years

In rat megakaryocytes, patterns in calcium ion waves activate and polarize integrins in a manner dependent on two purinergic receptors. @uniofleicester #CellBiology

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@scisignal

Science Signaling

2 years

Don’t miss this week’s new issue of Science Signaling! Neuronal studies yield clues about how omega-3 DHA supports the brain, a Review explores how connections between mitochondria and the ER balance energy and protein regulation, and more.

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@scisignal

Science Signaling

2 years

Don’t miss this week’s issue of Science Signaling! Researchers find that excessive zinc in immune cells may exacerbate rheumatoid arthritis, and mouse studies reveal how internalization of a GPCR protects against inflammation of the colon.

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@scisignal

Science Signaling

4 years

The common chemotherapy #doxorubicin can promote the migration of cancer cells through phosphorylation of a translation factor, shows the Willis lab at @Cambridge_Uni .

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@scisignal

Science Signaling

11 months

This week’s issue of #ScienceSignaling has arrived! Research in rodents suggests that the lungs help protect other organs from #SARSCoV2 infections, scientists explore how the conformation of a kinase shapes its substrate specificity, and more.

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@scisignal

Science Signaling

4 months

An alcohol-processing enzyme also helps the immune system to suppress invading viruses, a new Review spotlights the emerging role of NF-kappaB in inflammatory bowel disease, and more in this week’s new issue of #ScienceSignaling .

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@scisignal

Science Signaling

1 year

Surprising discoveries about neutrophils and how they release sticky “NETs,” a mechanism enforces forward information flow in bacterial signaling systems, and more in this week’s issue of #ScienceSignaling .

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@scisignal

Science Signaling

7 years

All review articles published in 2016 are now free! Peruse the #SciSig archives:

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@scisignal

Science Signaling

10 months

Researchers decipher how a protein from Helicobacter pylori may promote stomach cancer, a kinase tether helps regulate the transcription of a common cancer-linked gene, and more in this week’s issue of Science #Signaling .

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@scisignal

Science Signaling

3 years

Don’t miss this week’s new issue of Science Signaling! Scientists explore how cancer cells extend telomeres to avoid cellular aging, and a SARS-CoV-2 structural study reveals a potential new drug target.

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@scisignal

Science Signaling

4 years

These animations demonstrate how adjacent amino acid sequences (1-2) and posttranslational modifications in proteins (3-4) can affect or impair how two research monoclonal #antibodies recognize their targets in a protein. @ScienceVisuals #Biochemistry

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@scisignal

Science Signaling

2 years

The new issue of Science Signaling is out! This week, scientists discover how enzyme mutations can endow cancerous B cells with drug resistance. Plus, a Review explores how T cells follow two basic laws of physiology while adjusting to their environment.

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@scisignal

Science Signaling

3 years

Don’t miss this week’s issue of Science Signaling! A molecular “trap” may lead to more precise treatments for inflammation and autoimmunity, and studies reveal a new binding partner for an important chemokine.

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@scisignal

Science Signaling

1 year

Don’t miss this week’s issue of #ScienceSignaling ! A pair of papers reveals how SARS-CoV-2 and other coronaviruses use proteases to evade innate immunity, scientists discuss strides in the study of injury-sensing proteins in innate immune cells, and more.

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@scisignal

Science Signaling

2 years

This week’s new issue of Science Signaling is here! Researchers show how thyroid hormone may both increase and decrease liver fat, and identify an enzyme duo that underpins calcium signaling and the early activation of T cells.

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@scisignal

Science Signaling

1 year

A computational framework designs new protein-protein interactions through sequence analysis, offering a powerful tool to dissect cell processes or to engineer cells to perform new functions. @m_madan_babu @MRC_LMB #ComputationalBiology

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@scisignal

Science Signaling

4 years

Don’t miss this week’s issue of Science Signaling! Featuring how Salmonella senses fatty acids to colonize and invade the gut, and a rheostat for mitochondrial calcium flux during nutrient stress.

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@scisignal

Science Signaling

3 years

This week’s new issue of Science Signaling is here! Researchers link poorer outcomes in men with COVID-19 to a metabolic molecule, and show that long-chain polyphosphates can inhibit the SARS-CoV-2 virus in cells.

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@scisignal

Science Signaling

1 year

A study ties an inflammatory protein complex’s activity to “traffic jams” in cell cargo transport, research in cells reveals how a kinase helps insulin regulate cell metabolism, and more in this week’s new issue of #ScienceSignaling .

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@scisignal

Science Signaling

6 months

New research sheds light on how an anion channel’s flexibly regulates blood pressure, a study connects a cerebral blood vessel disease to disrupted calcium signaling, and more in this week’s issue of #ScienceSignaling .

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@scisignal

Science Signaling

1 year

The new issue of #ScienceSignaling is here! Preclinical work shows how dangerous E. coli colonize the gut, a study demystifies stress-protecting kinases, and an Editorial argues for the enduring importance of basic research in the era of “Big Data.”

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@scisignal

Science Signaling

9 months

This week’s issue of #ScienceSignaling has arrived! Scientists discover a macrophage-tuning mechanism that may worsen sepsis, a structural analysis of a cardiovascular receptor could inform drug development, and more.

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@scisignal

Science Signaling

1 year

Scientists tie chronic pain in #LongCovid to disruptions in sensory neurons in a hamster model, a study illustrates how the T cell protein THEMIS shapes the development of thymocytes, and more in this week’s issue of #ScienceSignaling .

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@scisignal

Science Signaling

3 years

This week’s new issue of Science Signaling is here! Experiments in mice reveal how pressure overload leads to heart inflammation, and scientists explore the origins of inflammation in some patients with lupus.

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@scisignal

Science Signaling

1 year

The first issue of #ScienceSignaling in 2023 has arrived! Don’t miss research on how Staphylococcus aureus bacteria tolerate antibiotics, a study explores how mutations in the kinase TAOK1 are linked to neurodevelopmental disorders, and more.

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@scisignal

Science Signaling

4 years

Tumor-associated macrophages boost #glycolysis and growth in breast cancer cells by secreting #TGFbeta and suppressing oxidative phosphorylation, according to findings from Ng and Gómez. @uclcancer

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Science Signaling

1 year

How do #neutrophils squeeze through tight spaces? @Lab_AViola & @vargas_lab find that the chemokine #CXCL12 increases the deformability of the nuclei in mouse neutrophils and compacts chromatin, enabling them to navigate narrow microchannels. @UniPadova

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@scisignal

Science Signaling

3 years

This week’s new issue of Science Signaling has arrived! Two approved drugs flip astrocyte brain cells to fight Alzheimer’s disease in mice, and a new study identifies a key brake on excessive and harmful inflammation.

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@scisignal

Science Signaling

3 years

In this week’s new issue of Science Signaling, researchers dive into the mechanisms of healing tendons and discover why some breast cancers often resist a well-known chemotherapy drug.

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Science Signaling

2 years

CRISPR techniques reveal an important release factor in the migration and adhesion of T cells, our weekly Editors’ Choice piece discusses research on the neurological effects of social isolation, and more in the new issue of Science Signaling.

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@scisignal

Science Signaling

3 years

Cancer-associated mutations in PTEN and P-Rex2 combine to enhance the activation of #Rac1 and potentially promote metastasis, according to new #MassSpectometry and functional studies from @Dr_Ellisdon , @Dr_MLHalls and co. @MonashBDI #Biochemistry

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@scisignal

Science Signaling

2 years

The new issue of Science Signaling has arrived! This week, scientists probe a prominent family of cancer-linked proteins, and discover that one such protein may contribute to lung cancers even when it is not mutated.

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@scisignal

Science Signaling

3 years

Don’t miss this week’s new issue of Science Signaling! A coordinated pause in protein synthesis supports synaptic plasticity, and how a protein limits the immune system’s inflammatory responses to flu.

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@scisignal

Science Signaling

7 years

The new issue of Science Signaling is out now! #SciSig

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Science Signaling

4 years

The @PeredaLab discovers that disruptions in the autoinhibitory structure of the C3G protein may support the progression of #nonHodgkinsLymphoma by activating the GTPase Rap1. @usal @ArturoCarabias #autoinhibition Credit: Carabias and de Pereda

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@scisignal

Science Signaling

10 months

This week’s new issue of #ScienceSignaling is here! Scientists target a mechanism in dendritic cells that exacerbates allergic airway responses, a new study shows how naïve T cells develop survival skills, and more.

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@scisignal

Science Signaling

5 years

The Kaelin Lab discovers that the CDK4/6 inhibitor #palbociclib broadly inhibits tumor growth in VHL-mutant clear cell renal cell carcinoma. @DanaFarber @kaelin_lab

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@scisignal

Science Signaling

1 year

Researchers answer the mystery of how SARS-CoV-2 enters macrophages, a calcium-regulating protein also maintains the architecture of mitochondria, a kinase gets activated by a helicase, and more in this week’s issue of #ScienceSignaling .

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@scisignal

Science Signaling

4 years

Aspirin sensitizes breast cancer cells to chemotherapy, how dimerization of a mitotic enzyme prevents its degradation, and GPCR heteromers go intracellular together in this week’s issue of Science Signaling.

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@scisignal

Science Signaling

5 years

Fat cells secrete molecules that promote invasion of melanoma cells, and how two p38 pathways balance inflammatory activity in T cells in this week’s issue of Science Signaling.

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@scisignal

Science Signaling

2 years

Don’t miss this week’s new issue of Science Signaling! Research yields surprising results about biased signaling by GPCRs and probes a receptor that restrains cancer cell growth. Plus, a Focus explores a new mechanism in GPCR signaling.

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@scisignal

Science Signaling

1 year

New discoveries about inflammatory cell death during chemotherapy could inform cancer treatment, how the degradation of an enzyme unleashes the innate immune system, and more in this week’s issue of Science Signaling.

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@scisignal

Science Signaling

3 years

Don’t miss this week’s new issue of Science Signaling! Research teams identify sequences in receptors that SARS-CoV-2 exploits to enter and replicate in cells, and a study shows how BMP signaling causes abnormal cartilage formation in the face and skull.

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@scisignal

Science Signaling

4 years

3D cell cultures shine a light on oxidative stress in breast cancer, and how an enzyme supports proper B cell responses in this week’s new issue of Science Signaling.

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@scisignal

Science Signaling

3 years

Small molecules exploit a metabolic weakness in triple-negative breast cancer, and how migrating immune cells coordinate inside-out and outside-in integrin signaling in this week’s new issue of Science Signaling.

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@scisignal

Science Signaling

3 years

A branch of opioid signaling dampens anxious and fearful behavior in mice, how a mitochondrial enzyme coordinates a checkpoint for inflammasomes, and a review on a phospholipase’s role in endothelial biology in this week’s issue of Science Signaling.

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@scisignal

Science Signaling

5 years

Why do cancer cells become resistant to 2-deoxyglucose? A yeast model shows that an evolutionarily conserved phosphatase enables resistance to the glucose analog’s metabolic effects. @CNRS #Metabolism

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@scisignal

Science Signaling

6 months

The new issue of #ScienceSignaling has arrived! Research in fruit flies suggests that the loss of Notch signaling may exacerbate advanced prostate cancer, scientists explore how chemokines selectively recruit immune cells, and more.

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@scisignal

Science Signaling

4 years

How calcium sparks within cells control blood pressure, and insights into a protein that supports cancer growth and metastasis in this week’s new issue of Science Signaling.

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@scisignal

Science Signaling

2 years

Studying fat cells and mice, the @ghotamis and @apsarruda labs discover that calcium-releasing IP3 receptors underpin harmful metabolic complications of #obesity , including inflammatory signaling and insulin resistance. #CalciumSignaling @sabriulkerctr

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@scisignal

Science Signaling

3 years

The spleen doesn’t act alone in systemic inflammation, and how a bioactive lipid controls the movement and adhesion of endothelial cells in this week’s new issue of Science Signaling.

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@scisignal

Science Signaling

4 years

How a high-salt diet changes kidney metabolism, and diving into protein-protein interactions in this week’s new issue of Science Signaling.

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@scisignal

Science Signaling

9 months

A rapid “refocusing” strategy refashions antiviral antibodies into potential therapies for SARS-CoV-2, researchers discover how a protein from the virus HCMV can trigger the growth of brain cancer, and more in this week’s issue of #ScienceSignaling .

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@scisignal

Science Signaling

1 year

This week’s new issue of Science Signaling has arrived! Research demystifies how an enzyme coordinates nutrient retention in the kidneys, a recent scientific meeting celebrates a pioneer in calcium signaling, and more.

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@scisignal

Science Signaling

7 months

This week’s issue of #ScienceSignaling has arrived! Scientists employ smart cytokine design to tackle an immunotherapy’s tradeoff between selectivity and potency, a study reveals how a lipid fine-tunes hedgehog signaling during development, and more.

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@scisignal

Science Signaling

5 years

How tumors defend themselves from T cells, reviewing how pathogens infiltrate cells, and insights into intracellular calcium pathways in this week’s new issue of Science Signaling.

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@scisignal

Science Signaling

1 year

Don’t miss this week’s new issue of Science Signaling! An oral compound lays the road for new inhibitors of inflammatory TNF signaling, how T cell populations maintain their size, and a new Review explores the role of the metabolome in cancer progression.

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@scisignal

Science Signaling

2 years

A self-sustaining molecular loop that drives Parkinson’s disease can be targeted in mice, new research answers a longstanding question about Wnt signaling, and more in this week’s new issue of Science Signaling.

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@scisignal

Science Signaling

2 years

Don’t miss this week’s new issue of Science Signaling! Scientists explore how temperature can influence cholesterol’s stabilizing effects on GPCRs, an Editors’ Choice piece discusses how memories are linked in neurons, and more.

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@scisignal

Science Signaling

8 years

Methylation of #dopamine receptors affects behavior #SciSig #neuroscience

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Science Signaling

7 months

Fluorescent reporter T cells decipher an enigmatic target in cancer immunotherapy, cell experiments reveal how neutrophils “triage” chemical calls for help, and more in this week’s issue of #ScienceSignaling .

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Science Signaling

1 year

New research illuminates a connection between two proteins that may raise the risk of Parkinson’s disease, how a conserved amino acid residue shapes the active states of G protein alpha-subunits, and more in this week’s issue of #ScienceSignaling .

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Science Signaling

10 months

This week’s new issue of #ScienceSignaling has arrived! A subset of lipid molecules can foster wound healing and protect mice from sepsis, research decodes how an ion channel clears out toxic amyloid proteins in a model of Alzheimer’s disease, and more.

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Science Signaling

3 months

This week’s new issue of #ScienceSignaling has arrived! Discoveries about the nature of inflammasomes could inform research into inflammatory conditions, a study illustrates how protein competition enables the growth of cellular “antennae,” and more.

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Science Signaling

11 months

This week’s new issue of #ScienceSignaling has arrived! Experiments in mice show how hepatic stellate cells help maintain normal liver mass, how the suppression of cholesterol synthesis by UHRF2 could be important for liver regeneration, and more.

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Science Signaling

1 month

Don’t miss this week’s new issue of Science Signaling! Preclinical experiments decipher how a genetic risk factor for Parkinson’s disease drives neuroinflammation, our new Editors’ Choice piece examines how microglia destroy amyloid aggregates, and more.

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Science Signaling

3 years

The new issue of Science Signaling is out now! Live, isolated tumor cells damaged by chemotherapy strengthen antitumor immunity, two G protein pathways enable a receptor to protect neurons, and new insights into stress granule protein assembly.

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Science Signaling

3 years

The new issue of Science Signaling has arrived! Researchers show that nerve cell signaling may contribute to pain sensitivity from morphine, and present new biosensors that can detect the disease-related activity of GPCR proteins.

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Science Signaling

3 years

This week’s new issue of Science Signaling has arrived! Experiments illustrate how protein patterns trigger a “checkpoint” in natural killer cells, and reveal a component of an mRNA-splicing mechanism in cells responding to stress.

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Science Signaling

10 months

Enzyme clusters agitate disease-linked synovial fibroblasts in inflammatory arthritis, an exchange factor “piggybacks” on motor proteins to drive cell division, and more in this week’s new issue of #ScienceSignaling .

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Science Signaling

11 months

Don’t miss this week’s new issue of #ScienceSignaling ! Researchers show how a biochemical modification enables macrophages to neutralize tuberculosis, a mouse study demystifies the mechanisms behind brain swelling in stroke, and more.

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Science Signaling

3 years

This week’s issue of Science Signaling has arrived! New studies highlight the research applications of a rapamycin derivative and link a transcription factor to age-related osteoarthritis in mice.

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Science Signaling

2 years

Don’t miss the latest issue of Science Signaling! Researchers investigate enzyme mutations in spinocerebellar ataxia and connect an adaptor protein to T cell activation. A Review also explores the link between extracellular vesicles and tumor angiogenesis.

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Science Signaling

1 year

ICYMI: A Focus in our November 29 issue highlighted discussions from a scientific meeting celebrating the career of Colin W. Taylor, a researcher at Cambridge University and a leading pioneer in #CalciumSignaling research. @uclcdb

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Science Signaling

3 years

This week’s new issue of Science Signaling has arrived! Studies identify a “division of labor” in immune cells responding to a promising vaccine vector, present improvements for CAR T cells, and discuss new discoveries and treatment frontiers in fibrosis.

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Science Signaling

4 years

How yeast cells deal with toxic arsenic, how DNA and RNA sensing in cells is linked, and a resource characterizing the human secretome in this week’s issue of Science Signaling.

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Science Signaling

2 years

The new year’s first issue of Science Signaling has arrived! A pathway that enables cancer cells to survive DNA-damaging therapies presents a treatment target, and research delineates how a transcription factor restrains antiviral immune responses.

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Science Signaling

5 years

How an epigenetic therapy inhibits small cell lung cancer, hypoxia alters cancer-associated fibroblasts, an adaptor restrains T cell activation, and the future of mantle cell lymphoma treatment in this week’s new issue of Science Signaling.

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Science Signaling

3 years

The new issue of Science Signaling has arrived! Studies suggest that the “satiety hormone” leptin may be critical for the brain’s development and explore how receptor-trafficking patterns influence how cells respond to growth factors.

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Science Signaling

3 years

The new weekly issue of Science Signaling is here! Cell studies may answer why the liver is vulnerable to chronic viral infections, and a suspected marker of T cell exhaustion can act as a costimulator.

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@scisignal

Science Signaling

1 year

How does #SARSCoV2 infect #macrophages ? A study from Schroder ( @inflammasomelab ), @LarisaLabzin , and co. shows the virus enters both ACE2-expressing and -deficient macrophages, but replicates and triggers antiviral responses only in ACE2-expressing cells.

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@scisignal

Science Signaling

2 years

This week’s issue of Science Signaling has arrived! Calcium-releasing channels may offer targets to prevent metabolic damage from obesity, and cell experiments probe the genetic roots of uveal melanoma.

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Science Signaling

1 year

Messy cell death in myeloid cells may explain the clinical variability of a common class of cancer drugs, a newly identified liver factor helps break down triglycerides in the blood, and more in this week’s new issue of #ScienceSignaling .

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Science Signaling

1 year

Researchers answer how the common foodborne bacterium Bacillus cereus “punches” holes in intestinal junctions, a new Editors’ Choice piece highlights a study of glioma cells, and more in this week’s new issue of #ScienceSignaling .

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