Virologist | Principal Scientist | Adjunct Professor | Co-Lead, One Health
@USask
. My team investigates highly pathogenic zoonotic viruses
#LZCI
| My views
Some personal news. Today I became a citizen of Canada 🇨🇦. An amazing country that gave me a second family, education and the opportunity to train the next generation of scientists. Thank you friends, mentors and family❤️. I shall go buy poutine now! 🍁
The mutation in the spike protein of circulating
#SARSCoV2
has been the focus of many stories over the last couple of days. We and others have shown that coronaviruses exist as mixed populations (quasispecies) in a host.. here’s what we know.
A THREAD..
#mutantcovid
🚨BREAKING
Just 0.04% of Israelis caught
#COVID19
after two shots of
#Pfizer
#vaccine
.
More IMPORTANT - all those infected experienced only a mild form of the disease, and NONE were hospitalized.
So, get the
#covidvaccine
. It may save your life.
If you feel the need to shame
#India
on its policies, blame the people for rising
#COVID19
cases and deaths, DON’T. You aren’t helping. Living in India is complex and not everyone can just shut down and wait it out. For most, no work = no food. So if you can’t help, get lost.
Hello prospective
#students
! Applying to a laboratory for graduate studies? Don’t make these common mistakes. I often notice these in emails and they instantly dampen my enthusiasm. A 🧵 on tips for your first contact email with potential thesis supervisors.
#AcademicTwitter
The Laboratory of Zoonotic Viruses and Comparative Immunology () will be opening its doors on April 1, 2021 at the Vaccine and Infectious Disease Organization (
@VIDOInterVac
)
@usask
. Come work with us. We will be looking for trainees at all levels.
Thus, the existence of
#SARSCoV2
as quasispecies is not surprising. Mutations within spike are concerning because current vaccines induce antibodies against spike. But as noted by other experts, one or two amino acid changes within spike ‘May not’ affect antibody binding.
I work with viruses (
#SARSCoV2
too) and I study how cells interact with viruses. My parents received two doses of the
#AstraZenaca
vaccine and I am not worried at all. If you received this vaccine, you have nothing to worry about. You made the right choice!
#COVID19Vaccination
We've updated our preprint on the transmissibility of SARS-CoV-2 VOC 202012/01, aka B.1.1.7, with new statistical and modelling methods. Headline: we estimate VOC is 43–82% more transmissible than preexisting variants. UNDER PEER REVIEW (1/6)
🚨Canadian academics/trainees, your advocacy paid off. Finally a welcome increase in scholarships and fellowship amounts.
MSc ($27k), PhD ($40k), and PDF ($70k). Today feels like a small win, tomorrow we continue to build a resilient future for our young scientists.
#Budget2024
Just another day. Filling up at a gas station.
Dude: get the fuck out of this country.
Me: talking to me?
Dude: yes. Look at you.
Me: ah, what? 😂 😂
Shouldn’t have burst out laughing. Enraged him further? Eventually dude just took off. 😂🤦🏽♂️🤷🏽♂️
He was my best friend through grades 11 and 12. He inspired me to become a microbiologist and then a virologist.
#COVID19
stole him from me. He is my hero, my no. 1 cheerleader.
RIP Dr. Gramps. 💔
🚨Findings represent the FIRST evidence of a highly divergent lineage of
#SARSCoV2
in white-tailed deer and of deer-to-human transmission. Work by excellent colleagues.
Obesity has been a risk factor for high pathogenic coronaviruses since before
#COVID19
, but we didn’t really fully understand the mechanism. Now, a recent study highlights that
#SARSCoV2
can infect some ‘fat cells’ and induce inflammation. We have much to learn about CoVs.
An important study from
@blish_lab
and Tracey McLaughlin groups showing that mature adipocytes and adipose tissue macrophages become infected with SARS-CoV-2. Another potential viral reservoir?
By
@RoniNYTimes
with comments from
@VishwaDeepDixi1
My ribosomes are working at the rate of up to 6–9 amino acid residues per second. You got this little guys. Pump out that spike protein.
#COVID19Vaccination
Made it to Saskatoon after 4 days of driving (>3000 kms). Drove through rain, sunshine and a snow storm. 😆
This view - totally worth it! 😍
On to the next chapter of my life.
#Zoonotic
viruses, antiviral
#immunity
,
#bats
and more. 🤩
🚨 New article from the lab. Bats 🦇 play a critical role in our environment. Here
@toriagraison
summarizes factors that enable bats to carry viruses. She put this together to consolidate information for current and new researchers in the field.
#LZCI
No more sweaty hands after wearing gloves in the lab for long hours.
@toriagraison
’s first paper from the lab now comes in a towel format.
#LZCI
@iScience_CP
👏🏾 👇🏾
Link to Victoria’s article:
Fellow reviewers, please be aware of the 3x amount of work/time it takes to complete studies in a
#BSL3
/
#CL3
facility. What may seem simple to you, requires arduous paperwork, risk assessment and SOP approval prior to validation and execution. 🙏🏾
#SARSCoV2
#PeerReview
A number of you have followed me over the last few weeks. Thank you. I am a virologist and I study how bats coexist with their viruses, including coronaviruses. Currently working on
#SARS_COV_2
and it’s pathogenesis.
Stay safe, stay strong and stay grateful. Love to all. :)
Fellow
#CL3
/
#BSL3
workers, please be gentle on yourself and take adequate rest. Long hours in a biosafety cabinet inside a high-containment lab is rough on your back, neck & shoulders. Let me share my personal story since we started work on
#COVID19
last year. 🧵
We will be hiring a PhD student. Please contact us if you’d like to work on
#coronaviruses
and immune adaptations in humans and bats. You can find out more about our work and contact us using the link below 👇🏾. More details soon. Please RT 🙏🏾.
#LZCI
#Postdocs
are not students. Our title is not ‘PDF’. We have earned our PhD just as much as anybody else. Our proper title is Dr. If you are using titles in your institution, please use the correct title for all. As for me, I’m Arinjay or Jay. :)
@AcademicChatter
#AcademicTwitter
My partner just printed out some pictures and I realized how intricately
@usask
is connected to our lives. I did my doctoral studies here, we got married on campus and now my laboratory is back at
@VIDOInterVac
@usask
! ❤️
Makes perfect sense and hence
#SARSCOV2
replicates to higher levels in the nasal epithelia, where temperatures are lower and antiviral response less potent.
@EllenFoxman
and
@VirusesImmunity
have laid the premise for this with rhinoviruses (common cold virus). Study link in 🧵 👇🏾
#SARSCoV2
doesn't like it hot.
#COVID19
involves onset of fever, raising body temp to 38-41°C; study shows that raising temp to 40°C limits replication of
#SARSCoV2
in respiratory airway cultures, independently of interferon-mediated defences
#PLOSBiology
Our latest study to understand the dynamic regulation of
#interferon
(
#IFN
) and
#SARSCoV2
infection.
🧵summarizing what we found and what needs to be done to understand the dynamic interplay of infection and
#IFN
regulation.
@iScience_CP
#COVID19
One year since I lost my grandpa to
#COVID19
. It still hurts. This pandemic sucks! He was the biggest supporter of
#science
in my family and we always talked about
#microbes
. I am starting this
#tag
in his honour. We grieve for our loved ones together. ❤️
#FamilyLostToCovid19
Thank you everyone. My partner is recovering now. Thank you for all your caring notes. I read through them as I sat in the ER. You are all good people. ❤️. I will tell her about all the love here too.
If you are worried that the
#CovidVaccine
will integrate in your genome or become part of your DNA, there is now scientific evidence that
#sarscov2
RNA does not enter your DNA. So, the mRNA in the vaccine will not become part of your DNA either. Go get the shot. 💉
Online now: "No evidence of human genome integration of SARS-CoV-2 found by long-read DNA sequencing" - Read the Report from
@Faulkner_Lab
and colleagues in
@CellReports
Excellent
#CovidVaccine
news 👏
BNT162b2 (Pfizer vaccine) can neutralize three
#VariantsOfConcern
- UK (B.1.1.7 lineage), South Africa (B.1.351 lineage), and Brazil (P.1 lineage).
#COVID
Two vaccine hesitant friends had multiple chats with me to make up their minds. Today they sent me a picture of their smiling faces after the second shot. I count this as a win. I am so proud of them.
#CovidVaccine
#covid19
💉
So, what we realized is that the virus itself doesn’t actively change, but the major represented population does, based on selection pressure. So what does that mean?...
Let’s say a coronavirus exists as different variants - A+B+C.
The variants exist in different quantities - 4A + 2B + 1C. Now when you sequence a patient sample, your sequencing is likely to pick up the most represented variant - in this case: 4A.
🚨 We are looking for a driven PhD student to lead our studies on coronavirus-host interactions. CL3 work and cutting edge techniques to dissect how coronaviruses (SARS-CoV-2, MERS-CoV) drive disease symptoms.
#LZCI
Please RT🙏🏾
Check out our lab website:
I just learnt that as a new Canadian, I get 365 days of free access to museums, parks, science centres, historic sites and art galleries! WHAT! I can't wait to hit these up in the new year! Thank you
@inclusion_ca
. Very inclusive indeed. <3
Some personal news. Today I became a citizen of Canada 🇨🇦. An amazing country that gave me a second family, education and the opportunity to train the next generation of scientists. Thank you friends, mentors and family❤️. I shall go buy poutine now! 🍁
As the virus circulates, due to multiple factors, this ‘represented’ population may evolve and change to become 2A + 4B +2C. Thus, if you sequence this sample from a patient - your sequence will likely represent identify 4B as the circulation strain.
In all the labs that I have trained in Canada, we had regular-ish coffee breaks and brainstormed several ideas. Now I see why this may matter. | Why scientists should take more coffee breaks
@AcademicChatter
Just got an email with the subject line: Best blot ever!
PhD student finally optimized the immunoblot to probe for the impression of a bat wing! Never a boring day in our lab.
#LZCI
😆
Getting our
#COVID19Vaccination
today and I am thinking about: 🧵
1. The physician (Dr. Li) who got infected and eventually lost his life, but warned the world of an ‘unknown pneumonia’ outbreak.
#COVID19
2. Researchers that shared the sequence of
#SARSCoV2
with the world
I'll honor him by commiting to fight viruses. I was infecting cells with
#SARSCoV2
this morning and I told the virus that this was personal (for many). I'm sure my grandpa is watching over my shoulders. He knew plenty about viruses. 😔 💔
He was my best friend through grades 11 and 12. He inspired me to become a microbiologist and then a virologist.
#COVID19
stole him from me. He is my hero, my no. 1 cheerleader.
RIP Dr. Gramps. 💔
And here it is. The cover of this month's
@TrendsImmuno
issue features our favourite mammal, bats! Thanks to Brock and Sherri Fenton for sharing their fabulous photograph. Our first time on a cover. We are very pleased.
#LZCI
Thanks to an
@NSERC_CRSNG
Discovery Grant, we can continue to investigate immune mechanisms that allow bats to tolerate virus infections. The funding will also support the training of highly qualified personnel to prevent the next
#pandemic
. 🙏🏾
#LZCI
@VIDOInterVac
@usask
A shoutout to members of my lab and collaborators who have been working meticulously and tirelessly to understand
#omicron
. Preprint coming soon. To summarize - get your shots! 💉.
@VIDOInterVac
#LZCI
Delighted to be here
@VIDOInterVac
. The Laboratory is now officially open. We shall introduce our trainees over the next few weeks.
Now to begin work to understand and 🛑 emerging
#zoonotic
#viruses
.
As a new
#PI
, my first week has been slow. I am learning to multitask - permits, grants, ordering, hiring... and these are just work stuff. We are still settling down in our house, which is far from over. I have so much respect for others that are in the same boat.
#NewPI
I am so stoked for my friend
@Thilina_B
who is starting as an Assistant Prof. at the School of Public Health
@usask
. We did our PhDs together and did some fascinating interdisciplinary
#OneHealth
work. Now we can develop collaborative programs. 👏🏾
#NewPI
#ECR
#ScienceMeetsPolicy
🚨 Victoria (
@toriagraison
), doctoral fellow in the lab just had her *first* *first* author paper accepted. Such a privilege to work alongside talented trainees and watch them grow👏🏾. Details about the article will follow soon.
#LoveVirology
#LZCI
@NSERC_CRSNG
Our latest on
#interferon
and
#SARSCoV2
. Still lots to learn about the nuances of modulation of immune responses by this virus during the course of
#COVID19
.
"Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses" - Read the article by Arinjay Banerjee (
@sci_questions
) and colleagues now in
@iScience_CP
We are now looking for a MSc student to lead studies on virology and comparative innate immunology. If you are up for a challenge, please contact us. Link to lab website below👇🏾. Selected candidates will be contacted with further details. Please RT. 🙏🏾
We will be hiring a PhD student. Please contact us if you’d like to work on
#coronaviruses
and immune adaptations in humans and bats. You can find out more about our work and contact us using the link below 👇🏾. More details soon. Please RT 🙏🏾.
#LZCI
Structural basis of mismatch recognition by a
#SARSCoV2
proofreading enzyme.
We all knew about the proof-reading activity of
#coronaviruses
, but now we have structural data! So cool.
#COVID19
has changed us forever.
> 3.2 million deaths and one of them is my grandpa💔. He is now a star in a sky full of million stars. Millions of moms, dads, brothers, sisters, lovers... Their memories will live with us forever.
❤️
#SARSCoV2
is set to become endemic. The key is to reduce disease severity so that we can coexist with this virus. As vaccines role out, statistics/diagnosis may need to evolve and report severe disease or hospitalizations with
#COVID19
. Simply ‘reports’ will not mean much.
For future graduate students, I cannot insist the importance of picking a lab that has a supportive environment and supervisor 🧵. Your Masters/PhD is more than just publishing. You will develop interpersonal skills which often happen organically in a supportive environment.
A bat protein that suppresses inflammasome and inflammatory disease in a mouse model. Talk about learning from natural evolution to design therapies. Just out in
@CellCellPress
. 🦇
@BatResearch
How do you deal with your emotions when folks are dying by the hundreds:
A spark from an air conditioner set an ICU ablaze. The oxygen supply in the room aided the fire and instantly killed the patients.
#CovidIndia
Families are begging for help.😭
Viruses can jump between species. How do
#bats
co-exist with
#viruses
? Did you know that microbes also kill bats?
I recently collaborated with
@TED_ED
to make this educational video on
#bats
, their
#microbes
and bat
#immunity
.
A THREAD to highlight some of the
#scientists
.
🚨New article from the lab
#LZCI
.
The typeset version of
@toriagraison
's mammoth review is now out (39 pages!). Hopefully this'll help you as you navigate your way through studies on bat-virus interactions. Lots to do, and lots to learn..🦇
@iScience_CP
We only know of
#variants
that have been detected by countries with intense genomic surveillance. Countries with low to no genomic surveillance have not ‘detected’ variants. There are other variants. They just haven’t been found yet.
#COVID
#SARS_CoV_2
There is some confusion about the data that exists for 1-dose vs. 2-dose of the
#COVID19
vaccines. In this infographic, I have summarized the three major vaccines and publicly available data for them, including efficacy, dosage and time between the doses.
#CovidVaccine
More
#coronaviruses
, especially Sarbecoviruses in bats that can likely emerge in humans that have antibodies to SARS-CoV-2. COVID-19 is unlikely to be the last. Very timely and important study by
@FViromics
,
@seifert_steph
and colleagues.
@PLOSPathogens
Some thoughts about
#SARSCoV2
persistence in humans. 🧵
1/n This recent study identified SARSCoV2 proteins in tissues other than lungs, including colon, appendix and liver up to 6 months after a negative
#COVID19
test :