Natalie Niemi @nieminm Twitter profile | Pikagi

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Natalie Niemi

@nieminm

4,139

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2,543

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Assistant professor @WUSTLmed @WUSM_BMB Biochemistry & Molecular Biophysics. Mitochondria, metabolism & cell signaling. Mom of 2. Advocate for women in science.

St. Louis, MO

https://t.co/bTHTlBDEq8

Joined March 2012

Don't wanna be here? Send us removal request.

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@nieminm

Natalie Niemi

3 months

Excited to share our latest work, “PPTC7 limits mitophagy through proximal and dynamic interactions with BNIP3 and NIX”, led by the extra talented @jerrylianjiewei and representing our first independent Niemi lab manuscript. 🧵1/14

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PPTC7 limits mitophagy through proximal and dynamic interactions with BNIP3 and NIX

PPTC7 is a mitochondrial-localized PP2C phosphatase that maintains mitochondrial protein content and metabolic homeostasis. We previously demonstrated that knockout of Pptc7 elevates mitophagy in a...

www.biorxiv.org

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@nieminm

Natalie Niemi

3 years

First grant funded today. Merry Christmas indeed! 🎉🥂🍻🎄

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@nieminm

Natalie Niemi

3 years

I am reviewing a paper in which the authors use 6 (!!!!) independent mouse models to test their hypothesis. Is this what it takes to publish now? If so, we will publish our first paper in 10 years or so. 😂😭

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@nieminm

Natalie Niemi

4 years

First day in the Niemi Lab. We are recruiting - come help us fill all of this newly renovated lab space! More details on who we are and what we do at . #mitochondria #WashU

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@nieminm

Natalie Niemi

4 years

A bit of good news in these strange times: I’m thrilled to announce that I’ll be starting my lab in the department of Biochemistry and Molecular Biophysics @WUSTL this summer. 1/n

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@nieminm

Natalie Niemi

10 months

Can’t tell you how many agarose gels I’ve overrun bc I’ve been distracted by reapplying mascara

@Prokaryota

Elisa Granato

10 months

Someone I know met a woman who's a Nobel-prize winning biologist and she said "I see you are wearing make-up, that already tells me that you're not focussed and committed enough to make it in science".

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@nieminm

Natalie Niemi

1 year

Science friends - what is the minimum concentration of ATP required to maintain cellular viability?

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@nieminm

Natalie Niemi

2 years

2 years later: 7 lab members, 1 alumna, 6 rotations —> 4 grad students, 1 passed QE, 6 grants submitted, 1 grant funded, 2 publications, 2 preprints, 1 lab flood, 2 -80 failures, too many tweets, lots of laughs, loads of supportive colleagues, tons of excitement for the future 🎉

@nieminm

Natalie Niemi

4 years

First day in the Niemi Lab. We are recruiting - come help us fill all of this newly renovated lab space! More details on who we are and what we do at . #mitochondria #WashU

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@nieminm

Natalie Niemi

10 months

More good news for our lab! 🎉🥳🍾

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@nieminm

Natalie Niemi

3 years

A while back, I brought my son into lab with me. His biggest concern: “Mom, why don’t you guys let penguins in here?”

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@nieminm

Natalie Niemi

1 year

As a faculty at @WUSTLmed , I want to clarify that I condemn sexual harassment and discrimination and know most of my colleagues strongly align with this sentiment. I have and will continue to advocate for trainees however I can. If you need a safe space here, my door is open.

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@nieminm

Natalie Niemi

10 months

One day shy of the 3 year anniversary of first stepping into my lab space, we got our first NoA. 🥳🎉🍻🍾

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@nieminm

Natalie Niemi

5 years

A group of postdocs organized via @FuturePI_Slack have collected data from >300 people who applied for STEM faculty positions this year, and want to analyze the data to help future applicants. What types of questions would you want answered with these data?

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@nieminm

Natalie Niemi

1 year

Happy Mother’s Day, especially to the science moms! 🫶🏻

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@nieminm

Natalie Niemi

9 months

STILL GOT IT and tied for 1st in the Niemi Lab BCA standard curve challenge

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@nieminm

Natalie Niemi

3 years

Survived the first year on the tenure track. Cheers to year 2! 🥂

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@nieminm

Natalie Niemi

7 months

Very (very!!) happy to share our latest publication, "PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy", out today in @NatureComms . 1/n

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PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy

Nature Communications - The mitochondrial phosphatase PPTC7 has previously been linked to the maintenance of mitochondrial content, but the mechanisms underlying this phenotype remain unclear....

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@nieminm

Natalie Niemi

1 year

About a month ago, I reached out to @GarciaLabMS about something I was struggling with as a junior PI. He responded quickly with sage advice. It was great. Today, I received an unprompted follow up email to see how I was doing regarding that situation. This is leadership.

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Natalie Niemi

1 year

Are you interested in how mentorship of graduate students and postdocs can be improved? Our survey-based analysis of trainee mentorship practices and perceptions is now online! A 🧵1/9

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Insights from a survey of mentorship experiences by graduate and postdoctoral researchers

Mentorship is vital for early career researchers in training positions, allowing them to navigate the challenges of work and life in research environments. However, the quality of mentorship received...

www.biorxiv.org

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@nieminm

Natalie Niemi

3 years

To celebrate #InternationalWomensDay , I wanted to profile one of my all time favorite scientists, Gerty Cori - an incredible icon in metabolic biochemistry and physiology. (1/n)

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@nieminm

Natalie Niemi

3 years

Excited to see that our new review, published with @Pagliarini_Lab , is online at JBC! (Link: ). A Tweetorial on "The extensive and functionally uncharacterized mitochondrial phosphoproteome": (1/10)

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The extensive and functionally uncharacterized mitochondrial phosphoproteome

More than half a century ago, reversible protein phosphorylation was linked to mitochondrial metabolism through the regulation of pyruvate dehydrogenase. Since this discovery, the number of identif...

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@nieminm

Natalie Niemi

2 years

Hi friends, I found a place for us all to retire.

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@nieminm

Natalie Niemi

4 years

I made this bottle of media in. my. own. lab. !!!! Bonus: I didn’t blow up the autoclave.

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@nieminm

Natalie Niemi

2 years

What is the landscape of mentorship for junior faculty? Is the mentoring of junior faculty valued and beneficial? Are junior academics generally satisfied with the level of mentorship received? We gathered survey data on over 450 faculty worldwide. 🧵 1/n

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The faculty-to-faculty mentorship experience: a survey on challenges and recommendations for...

Faculty at research institutions play a central role in advancing knowledge and careers, as well as promoting the well-being of students and colleagues in research environments. Faculty members must...

www.biorxiv.org

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@nieminm

Natalie Niemi

2 years

Frightochondria?! Haunted house of the cell?! Come visit the Niemi Lab @WUSM_BMB . There is also candy by the door for your early trick or treating needs. 🎃👻

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@nieminm

Natalie Niemi

1 year

Excited to share our new work on the mitochondrial phosphatase Pptc7 and its role in suppressing receptor-mediated mitophagy! A 🧵1/n

@biorxivpreprint

bioRxiv

@biorxivpreprint

1 year

Pptc7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy #bioRxiv

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@nieminm

Natalie Niemi

2 years

This past year, I started sending my lab one paper per day on a lab Slack channel called #365_papers . We covered lots of topics ranging from the structural biology of the mitochondrial protein import machinery to the physiology of disrupting fatty acid oxidation. 1/4

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@nieminm

Natalie Niemi

10 months

3 years ago. The department halls were as empty as these benches, with most WFH. I knew most colleagues only over Zoom. I made friends with the maintenance guys, who were amongst the only people I saw in person for 2 months. How far we have come. Cheers to year 4.

@nieminm

Natalie Niemi

4 years

First day in the Niemi Lab. We are recruiting - come help us fill all of this newly renovated lab space! More details on who we are and what we do at . #mitochondria #WashU

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@nieminm

Natalie Niemi

5 years

Incredibly happy to see our paper on Pptc7, a mitochondrial phosphatase, out @NatureComms . We found that loss of Pptc7 disrupts metabolism, diminishes mitochondrial content, and causes perinatal lethality. Many thanks to our co-authors and collaborators!

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Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis

Nature Communications - The mitochondria houses several phosphatases, but their function is not well characterized. Here, the authors show that mitochondrial phosphatase Pptc7 is important during...

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@nieminm

Natalie Niemi

3 years

Finally getting rid of my first car. Bought it the month I started grad school. It has seen a marriage, two degrees, one puppy, two kiddos, three states, four job changes, and 194,117 miles. Cheers and best wishes, Honda Civic. You have served our family well.

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Natalie Niemi

2 years

Today we got a delivery of gel loading tips that we ordered on January 28th... of 2021. 😱 #375dayslater

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@nieminm

Natalie Niemi

4 years

Biochemistry Christmas. #alltheaminoacids

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@nieminm

Natalie Niemi

2 years

We have doubled in lab size this past month, with the addition of 3 (!) @WUSTLdbbs graduate students to our lab. Welcome to Tessa Lochetto, @tloch_ first year MCB student, Youmian Yan, first year @BBSBwustl , and Hannah Pletcher @hpletch , first year @BBSBwustl ! 🎉🥂

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Natalie Niemi

2 years

Hi metabolism friends - if I wanted to place mice on a high fat diet to study diet induced obesity in our mouse model, which chow/diet should I use? There are lots of options and I'm not sure if labs have specific preferences on this. Thanks!

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Natalie Niemi

2 years

Two Niemi lab firsts today - first mito prep from yeast (Figure 1) and first escaped mouse (data not shown… I eventually caught him). 🎢 #PIinthelab

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@nieminm

Natalie Niemi

2 years

I get asked which PI I work for far more often now that I am actually a PI. 🤷🏼‍♀️

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@nieminm

Natalie Niemi

2 years

Make that two years. Happy 2nd birthday to the Niemi lab! 🥂

@nieminm

Natalie Niemi

3 years

Survived the first year on the tenure track. Cheers to year 2! 🥂

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Natalie Niemi

2 years

Super proud of the lab’s first graduate student, @jerrylianjiewei , for passing his @BBSBwustl qualifying exam!! Congratulations, Jerry!!! #ProudestPI 🎉🎉🎉🎉

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@nieminm

Natalie Niemi

3 years

Ran my gel backwards yesterday. #PIinthelab

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@nieminm

Natalie Niemi

2 years

Cheers and Happy Thursday to all of my fellow over-educated women. 🥂

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@nieminm

Natalie Niemi

3 years

Me, at the whiteboard in my office, trying to interpret my first 13C flux metabolomics experiment.

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Natalie Niemi

1 year

IACUC RENEWAL APPROVED this is probably a top 5 most proud moment of being a PI so far 😂😭

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@nieminm

Natalie Niemi

2 months

Powerful last page @TheRealDoctorT

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Natalie Niemi

1 year

Really excited that the lab has been awarded a new P&F grant from the Digestive Diseases Research Cores Center (DDRCC) here @WUSTLmed . This project will help us to transition some of our work on mitochondrial phosphorylation into the context of liver disease. 🎉

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Natalie Niemi

3 years

Contacted our FACS core to get trained on their instruments. Admitted that I haven’t done FACS since grad school but back then I was a pro on the BD FACSCalibur. Was told they actually *have* a FACSCalibur that no one uses… except, of course, ME now. 🎉 #FlashbackFACS

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Natalie Niemi

1 year

The Niemi lab is off to @ASBMB #DiscoverBMB 2023 in Seattle! Come check out our work on Monday ( @hpletch ) and Tuesday ( @jerrylianjiewei ) of next week. Excited to see old friends and meet new ones.

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Natalie Niemi

1 year

Today I had the pleasure of returning to my hometown, Grand Rapids, MI, to give a talk at @VAInstitute . My parents still live in town and came to see me present. Proud to report that my dad “even understood some of it” 😂🥹

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@nieminm

Natalie Niemi

1 year

Grant rejection and game changing data all within one hour. This job.

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@nieminm

Natalie Niemi

1 year

All the mito decor for my office, this one compliments of ⁦ @tloch_ ⁩ 🤩 #bestlabever

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@nieminm

Natalie Niemi

4 years

A week of firsts for the Niemi Lab - today was the first day for our new members (welcome Michaela and Emily!). Tomorrow, the first Niemi Lab journal club covering the classic MitoCarta paper by @Pagliarini_Lab and @VamsiMootha . Will be fun to reread it with a new crowd!

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Natalie Niemi

2 years

Merry Cristae-mas from the Niemi Lab. A tale from our @WUSM_BMB door decorating contest:

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@nieminm

Natalie Niemi

6 months

@DrPorman There is always more to do, so for me, it has been helpful to keep a mindset that whatever gets done today has to be good enough. Some days are more productive than others, and that’s okay. Also, knowing 1. this is just a job, 2. you are not your job, and 3. you are enough.

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Natalie Niemi

1 year

Our lab has had a great couple of weeks! First, @BBSBwustl student Emily Harrelson started her rotation with us. Second, we had two @BBSBwustl students pass their QEs this week - congratulations to newly minted PhD candidates Hannah @hpletch and Youmian Yan! 🎉🎉🎉

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Natalie Niemi

2 years

The first rule of mitochondrial protein import is that we don’t talk about mitochondrial protein import. #googlescholar

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Natalie Niemi

1 year

Third (!!) annual state of the lab address today. It’s fun to look at the past documents and realize that we actually have come a long way since July 2020, despite progress feeing slow at times. Cheers to the coming year! 🥂

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@nieminm

Natalie Niemi

2 years

So excited to have @BBSBwustl Hannah Pletcher @hpletch join our lab @WUSM_BMB for her thesis work! Hannah is broadly interested in mitochondrial metabolism, and I can't wait to see all of the amazing discoveries that she will make during her time in graduate school. 🎉🎉

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Natalie Niemi

2 years

Looking forward to the @ASBMB 2022 meeting! Stop by the Mitochondria Interest Group on Saturday (3-5 p.m.) or our poster ( #A317 ) in the Protein kinases & phosphatases session on Sunday (12:45-2 p.m.) to hear about our work. So excited to see colleagues in person! #ASBMB2022

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@nieminm

Natalie Niemi

1 year

Our hood has a fun (depressing?) feature of tracking hours spent doing tissue culture. I guess it’s only fitting for me to pass the 1000th hr (=41.67 days) of TC in the first Niemi lab hood. #PIinthelab

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@nieminm

Natalie Niemi

1 year

VERY proud of Tessa @tloch_ and Hannah @hpletch for being awarded Honorable Mentions on their @NSF GRFP applications. 🎉

@WUSM_BMB

WUSM Biochemistry and Molecular Biophysics

1 year

Congratulations to two graduate students in our department, Hannah Pletcher @hpletch and Tessa Lochetto @tloch_ (both in the @nieminm lab), for being awarded Honorable Mentions for the NSF GRFP! This is a great achievement! #proudBMBnation

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Natalie Niemi

2 years

Today we said goodbye to Niemi lab technician Michaela Morhaus, the lab's first hire. She is off to pursue her MD/PhD @UWMSTP @UWMadison . Congratulations and best of luck, Michaela!

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@nieminm

Natalie Niemi

2 years

K2 is ‘star of the week’ in his kindergarten class starting tomorrow. He gets to bring in his favorite book to be read to the class. This is the one he chose. 🤣

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@nieminm

Natalie Niemi

2 months

NYT games does not employ biochemists.

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@nieminm

Natalie Niemi

5 months

Our publication on faculty mentorship is out @royalsociety ! Check it out here: . See thread below if interested in some of our findings, which we expanded with further analyses during revision. #mentorship

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The faculty-to-faculty mentorship experience: a survey on challenges and recommendations for...

Faculty at research institutions play a central role in advancing knowledge and careers, as well as promoting the well-being of students and colleagues in research environments. Mentorship from...

royalsocietypublishing.org

@nieminm

Natalie Niemi

2 years

What is the landscape of mentorship for junior faculty? Is the mentoring of junior faculty valued and beneficial? Are junior academics generally satisfied with the level of mentorship received? We gathered survey data on over 450 faculty worldwide. 🧵 1/n

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Natalie Niemi

6 months

Congratulations to @BBSBwustl and Niemi lab graduate student Emily Harrelson on passing her qualifying exam! An excellent way to start the weekend. 🥳 🎉 #ProudPI

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@nieminm

Natalie Niemi

1 year

@PSBROOKES Will now forever use the proper “crapped-out” terminology 😂

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@nieminm

Natalie Niemi

1 year

Congratulations to Jerry Wei @jerrylianjiewei for winning the 2022 MilliporeSigma Award! This award, given to an outstanding student in biochemistry and molecular biophysics, was established @WUSM_BMB in memory of Gerty Cori in 1958. Well deserved, Jerry! 🎉 #ProudPI

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@nieminm

Natalie Niemi

1 year

Lab also bought me birthday gifts and wrote me cards 🥹😭 #bestlabever

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@nieminm

Natalie Niemi

7 months

It was truly a pleasure to highlight this fantastic study from @guha_sukanya , @AsifaAkhtar1 , and colleagues in @NatMetabolism . Their work finds MOF, a histone acetyltransferase, localizes to mitochondria to acetylate COX17 and promote Complex IV activity.

@NatMetabolism

Nature Metabolism

7 months

Online now! MOF moves into mitochondria

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@nieminm

Natalie Niemi

9 months

My parents found my Twitter account today and relayed all of their favorite tweets, some going back years. I guess they read my entire feed in one sitting. 😂 (If you’re reading this, hi Mom and Dad.)

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@nieminm

Natalie Niemi

2 years

Congratulations to Hannah Pletcher @hpletch for winning the inaugural BMB Science Communication Award! The award recognizes a first year @WUSM_BMB student for their clarity in scientific reasoning and their contributions to science communication. Well deserved, Hannah!🎉 #ProudPI

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@nieminm

Natalie Niemi

1 year

Congratulations to Tessa Lochetto @tloch_ for passing her qualifying exam today!!! Excited and VERY proud to have three graduate students advance to Ph.D. candidacy this year! 🥹🤩🎉

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@nieminm

Natalie Niemi

2 years

My husband, a banker, had to move offices today. Overhearing our discussion about this, Kid #2 exclaimed, “Dad?! You moved?! When can we go see your new lab!?!” 😂😂😂

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Natalie Niemi

1 year

K2 demanded photographic evidence that I went to DC, specifically that I saw the White House. #futureReviewer2

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@nieminm

Natalie Niemi

1 year

Wait are you saying there is a tornado warning

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@nieminm

Natalie Niemi

3 years

Exciting day - a new @WUSTLdbbs @BBSBwustl graduate student started her rotation in our lab! Welcome @hpletch - we are so happy to have you join us! 🎉

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@nieminm

Natalie Niemi

2 years

K1 was googling our last name tonight and found my lab website and was like WAIT THIS HAS MITOCHONDRIA IS THIS YOURS?! 😂😂😂

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@nieminm

Natalie Niemi

3 years

Recruiting and working with amazingly talented and smart people is 💯 the best part of being a PI. What a privilege.

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@nieminm

Natalie Niemi

2 years

By far my favorite part of today has been seeing all of the incredible celebrations and stories about @CarolynBertozzi . A Nobel is an incredible honor, but I think being so highly regarded by the collective scientific community is the truest measure of achievement in science.

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Natalie Niemi

1 year

K2 got this as an early Christmas gift. “See mom, it says super lab. You just have a regular lab.” 😂😂

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@nieminm

Natalie Niemi

2 years

Oh no. Not my Micrasoft account.

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Natalie Niemi

5 months

Lab exceeded expectations with their idea of the “mitopha-tree” for the @WUSM_BMB door decorating contest this year. Ornaments include proteins and organelles in autophagosomes. #powerhomefortheholidays

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Natalie Niemi

3 years

We need more messages like this. I also defended my thesis while pregnant and had two kids during my postdoc. Academia and parenthood aren’t mutually exclusive.

@MaryEFoltz

Dr. Mary Foltz

3 years

Obtaining a PhD and having children are not mutually exclusive. Had my first son in the beginning of my PhD. Last week, I defended my PhD at 37 weeks pregnant. Despite folks telling me it wasn't possible, I am looking forward to being both a mom and assist prof this fall.

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Natalie Niemi

2 years

To so many of my friends and colleagues who now find themselves in a state that no longer supports or values their rights: I hope you will not heed to call to flee. I hope you will heed the call to fight. We are stronger together. #Resist

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Natalie Niemi

2 years

Study section ended yesterday with no score posted today = death by refresh ☠️☠️☠️

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@nieminm

Natalie Niemi

11 months

Friendly reminder that @WUSM_BMB has an open faculty position available! I have found our department to be incredibly supportive. Excellent start up package, top notch students @WUSTLdbbs , fantastic collaborators and core facilities. Deadline 9/1/23.

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Natalie Niemi

3 years

Spring in St. Louis 😍

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@nieminm

Natalie Niemi

26 days

🥳

@WUSM_BMB

WUSM Biochemistry and Molecular Biophysics

26 days

@WUSM_BMB at the 1st annual Graduate Student, Staff, & Faculty Awards! -- @AndreaSoranno & @nieminm awarded Outstanding Faculty Member along with @tloch_ & @aflynn031 winning Outstanding Service and Commitment to St. Louis awards. Congratulations! We are lucky to have you in BMB!

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Natalie Niemi

2 years

Look what showed up outside of my office last night!! Does this mean I can add 2 years to my ESI/tenure clock bc I wasn’t really here until today? 😂

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@nieminm

Natalie Niemi

2 years

There was a time, seemingly not too long ago, where my best friend could convince me to sign up for a 10K and, even though I hadn’t trained for it, I could roll out of bed mildly hungover and crush it out. Friends, TIL those times are solidly in my past. 🫠😬🥵

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Natalie Niemi

5 months

Looking forward to seeing everyone at #cellbio2023 ! Stop by and chat after the Integration of signaling and metabolism in cell physiology minisymposium (Sunday, 12/3/2023, talk at 5:50 PM) or at my poster Monday, 12/42023 12:15 PM - 3:15 PM). #mitochondria

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Natalie Niemi

3 years

Yesterday, Dr. George Vande Woude, a prominent cancer researcher and Founding Research Director of the @VAInstitute , passed away. A thread on his contributions to cancer research, @VAInstitute , and more. 1/12

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Natalie Niemi

3 years

Sharing the home office with a 4 year old, part I

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Natalie Niemi

2 years

K2 embracing the STL lifestyle by insisting on ordering a 9 oz burger topped with 2 jumbo fried ravioli.

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Natalie Niemi

1 year

Cloning we have been trying since October worked. You only need one. Happy Friday, friends. 🍻

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Natalie Niemi

1 year

Congratulations to Niemi lab grad student @jerrylianjiewei for winning an ASBMB travel award!! Excited to join Jerry and Hannah @hpletch in Seattle and have some Niemi lab representation (beyond Niemi) at a national meeting! 🎉

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Natalie Niemi

4 years

Lots of proteins have been shown to localize within mitochondria to mediate metabolism. This study is an important reminder that thorough biochemical characterization of such events is needed, as many proteins localize TO mitochondria (i.e. outside) and not IN mitochondria.

@biorxivpreprint

bioRxiv

@biorxivpreprint

4 years

STAT3 localizes in mitochondria-associated ER membranes instead of in mitochondria #bioRxiv

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Natalie Niemi

3 years

Finally did something today that I have been procrastinating for months. It was worse than I expected, reenforcing my procrastination habits for the future. 😂😭

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Natalie Niemi

1 year

Greetings. Please read my newest preprint, "title..." which I have been invited to submit to a peer reviewed journal.

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Natalie Niemi

3 years

Too soon

@OdedRechavi

Oded Rechavi

3 years

Young PI learning how to run a lab

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Natalie Niemi

2 years

A couple of days late, but excited to welcome @WUSTLdbbs student Tessa Lochetto to a rotation in our lab! Tessa is a first year MCB student interested in mitochondria and cardiovascular disease. Welcome, Tessa!

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