A 31-year-old Asian man with hepatitis C cirrhosis complicated by variceal hemorrhage and ascites underwent an inpatient evaluation for orthotopic liver transplantation. He was a graduate student who...

This study suggests that implementing a protocol for peripheral administration of norepinephrine safely can avoid 1 CVC day in the average patient, with 51.6% of patients not requiring CVC insertion....

POCUS has good sensitivity and specificity for the diagnosis of NF. POCUS should be considered as an adjunct to the initial clinical decision making for the diagnosis of NF.

The SPEED protocol has an overall sensitivity of 93.2% for AoD.

Plasma D-dimer levels can provide useful diagnostic information about whether an aVCF is present.

Cardiac arrest is common and deadly, affecting up to 700 000 people in the United States annually. Advanced cardiac life support measures are commonly used to improve outcomes. This “2023 American He

Background Current guidelines suggest the introduction of early nutrition support within the first 48 h of admission to the intensive care unit (ICU) for patients who cannot eat. In that context, we...

lation. This review explores systematic post-cardiac arrest management strategies, associated complications, and prognostication in ECPR patients. DATA SOURCES: A PubMed search from inception to 2023...

身近なところで、「SIMVはダメだ」話が出た。うー、と思った。返事しようかと思ったが、一晩考えていたら長くなったので、ここに書いておく。白状しますが、1997年に専門をICUにしてから2020年に臨床から引退するまで、「ファーストチョイスはSIMV」という施設以外で働いたことがない（バリバリの呼吸不全は除く）。ある時期から非同調という言葉を耳にするようになったが、完全に無視していた。理由は、...

Background Although patients with interstitial pneumonia pattern (ILD-UIP) and acute exacerbation (AE) leading to severe acute respiratory failure may require invasive mechanical ventilation (MV),...

日本集中治療医学会雑誌, 2022 年 29 巻 6 号 p. 606-607

Background There is very limited evidence identifying factors that increase respiratory drive in hypoxemic intubated patients. Most physiological determinants of respiratory drive cannot be directly...

Background Vasopressin is a second-line vasoactive agent for refractory septic shock. Vasopressin loading is not generally performed because of the lack of evidence for its effects and safety....

Objective The aim of this prospective longitudinal study was to compare driving pressure and absolute PaO2/FiO2 ratio in determining the best positive end-expiratory pressure (PEEP) level. Patients...

Respiratory drive is defined as the intensity of respiratory centers output during the breath and is primarily affected by cortical and chemical feedback mechanisms. During the involuntary act of...

Intensive Care Medicine - This study aimed to determine the best strategy to achieve fast and safe extubation. This multicenter trial randomized patients with primary respiratory failure and...

With the advent of new therapies and improvements in supportive care, survivorship in patients with interstitial lung disease (ILD) is increasing. However, this increase in number of patients living...

Intensive Care Medicine -

Most of the patients who die after cardiac arrest do so because of hypoxic-ischemic brain injury (HIBI). Experimental evidence shows that temperature control targeted at hypothermia mitigates HIBI....

Background Rapidly improving acute respiratory distress syndrome (RIARDS) is an increasingly appreciated subgroup of ARDS in which hypoxemia improves within 24 h after initiation of mechanical...

Background In patients on mechanical ventilation, positive end-expiratory pressure (PEEP) can decrease cardiac output through a decrease in cardiac preload and/or an increase in right ventricular...

Background Assessment of the patient’s respiratory effort is essential during assisted ventilation. We aimed to evaluate the accuracy of airway pressure (Paw)-based indices to detect potential...

この件ですが、なんと、知らぬ間に発表されてました。製造・販売会社（IDORSIA、IDORSIAJapan、そーせい）のウェブサイトにも書いてないし、ピヴラッツのサイトにもないし、Googleと旧twitterで日本語と英語で検索しても出てこない。ほぼ誰も知らないのではないか？？発表されたのは文献ではなくClinicalTrials.govの中。PubMed検索していてリンクに飛んで気がつい...

We proposed a novel formula using deceleration time to estimate ideal heart rate that achieves a zero overlap between E-wave and A-wave in patients with systolic heart failure. Prognostic impact of...

Background Outcomes following aortic occlusion for trauma and hemorrhagic shock are poor, leading some to question the clinical utility of aortic occlusion in this setting. This study evaluates...

Although the stretch that generates ventilator-induced lung injury (VILI) occurs within the peripheral tissue that encloses the alveolar space, airway pressures and volumes monitor the gas within the...

Among patients subjected to lung resection under one-lung ventilation, iOLA was associated with a reduced risk of severe postoperative pulmonary complications when compared with conventional lung-p...