🚩 Tranexamic Acid - it's complicated....
➡️It's widely used for treatment & prevention of haemorrhage
➡️It's in the WHO's List of Essential Medicines & recommended in the European Traumatic Haemorrhage guideline (2023)
➡️But is it as efficacious as we think?
🧵 1/17
One of the most outstanding questions in critical care is whether patients benefit from IV fluid resuscitation in septic shock.
A thread...
(image shutterstock)
1/16
Impact of Transfused Citrate on Pathophysiology in Massive Transfusion
CCR Journal Watch
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Today's Paper of the Day is by Mickael Lescroart on the medical treatment of cardiogenic shock
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Vasopressin in Sepsis and Other Shock States: State of the Art
CCR Journal Watch
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Albumin administration in internal medicine: A journey between effectiveness and futility
CCR Journal Watch
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➡️The history of resuscitation in cardiac arrest is long and fascinating
➡️Over time, four components have emerged to provide the central basis for saving an apnoeic, pulseless person just minutes from death
A thread.....
1/30
Acute dyspnea in the emergency department
CCR Journal Watch
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Review of Thromboelastography (TEG): Medical and Surgical Applications
CCR Journal Watch
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1/13
➡️ REBOA is an exciting "new" therapy for non-compressible torso haemorrhage
➡️ It's used across the world, but without robust evidence
➡️ Does it work? Is it beneficial?
➡️ A thread...
Today's paper of the day is on the physiological and pathophysiological consequences of mechanical ventilation
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Today's paper of the day is by Brigid Flynn on stepwise ventilator waveform assessment to diagnose pulmonary pathophysiology
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Today's Paper of the Day is on the fundamentals of arterial blood gas interpretation
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Today's Paper of the Day is by Michaela Anderson on the impact of obesity in critical illness
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Today's Paper of the Day is on the syndrome of inappropriate antidiuresis: from pathophysiology to management
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Today's paper of the day is on albumin administration in internal medicine: A journey between effectiveness and futility
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Fluids and Early Vasopressors in the Management of Septic Shock: Do We Have the Right Answers Yet?
CCR Journal Watch
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Today's paper of the day is on ten rules for optimizing ventilatory settings and targets in post-cardiac arrest patients
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Hydrocortisone in Severe Community-Acquired Pneumonia
➡️ 800 pts
➡️ IV hydrocortisone 200 mg daily for 4 or 8 days or placebo
➡️ D28 mortality: 6.2% vs 11.9% (difference, −5.6%; 95% CI, −9.6 to −1.7; P=0.006)
CCR Journal Watch
Today's paper of the day is by Rebecca Bruning on Beta-Adrenergic Blockade in Critical Illness
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A Systematic Approach to Understanding Acid-Base Disorders in the Critically Ill
CCR Journal Watch
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The Critical Care Reviews Book 2018 is now available as a free pdf download or as a print copy at minimum cost.
The best critical care trials of 2017 are summarised, critiqued & discussed.
Critical Care Reviews is a not-for-profit organisation
Use of Intravenous Albumin: A Guideline from the International Collaboration for Transfusion Medicine Guidelines
CCR Journal Watch
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The management of status epilepticus in neurointensive care: an update
CCR Journal Watch
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Corticosteroids in adults with acute respiratory distress syndrome and severe pneumonia (by
@D_Jayasimhan
)
CCR Journal Watch
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Management of Acute Life-Threatening Asthma Exacerbations in the Intensive Care Unit
CCR Journal Watch
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Today's Paper of the Day is by Patrick Wieruszewski on vasopressor choice and timing in vasodilatory shock
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Management of Sepsis and Septic Shock: What Have We Learned in the Last Two Decades?
CCR Journal Watch
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Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement
CCR Journal Watch
Guide to Lung Protective Ventilation in Cardiac Patients
CCR Journal Watch
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Today's paper of the day is on sodium bicarbonate use in different critically ill conditions: from physiology to clinical practice
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Fluid Therapy for Critically Ill Adults With Sepsis
CCR Journal Watch
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Today's paper of the day is by Domenico Luca Grieco on non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS
Today's Paper of the Day is on challenges in ARDS definition, management, and identification of effective personalized therapies
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Treatment of pediatric convulsive status epilepticus
CCR Journal Watch
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Glomerular injury after trauma, burn, and sepsis
CCR Journal Watch
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Contemporary Vasopressor and Inotrope Use in Cardiogenic Shock
CCR Journal Watch
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A review of intraoperative protective ventilation
CCR Journal Watch
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Hemodynamic and respiratory support in pulmonary embolism
@HectorMezaMD
CCR Journal Watch
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Today's paper of the day is by S. Frisvold on respiratory challenges and ventilatory management in different types of acute brain-injured patients
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Intracranial Pressure Monitoring and Management in Aneurysmal Subarachnoid Hemorrhage
CCR Journal Watch
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Our final Paper of the Day for 2023 is on the diagnosis and management of ventricular tachycardia
We start again tomorrow - can you read 1 paper per day in 2024 and stay up-to-date with the breadth of critical care?
Use of Inotropic Agents in Advanced Heart Failure: Pros and Cons
CCR Journal Watch
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Today's paper of the day is on new insights into diuretic use to treat congestion in the icu: beyond furosemide
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Interventional therapies for pulmonary embolism
CCR Journal Watch
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Diagnosis and management of ventricular tachycardia
CCR Journal Watch
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Viscoelastic testing: Critical appraisal of new methodologies and current literature
CCR Journal Watch
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Today's paper of the day is by Karim Kouz on Pulse Wave Analysis to Estimate Cardiac Output
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Practical Lessons on Antimicrobial Therapy for Critically Ill Patients
CCR Journal Watch
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2023 American Heart Association Update on the Management of Patients With Cardiac Arrest or Life-Threatening Toxicity Due to Poisoning
CCR Journal Watch
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Today's Paper of the Day is on chest wall loading in the ICU: pushes, weights, and positions
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Fluid management strategies & their interaction with mechanical ventilation: experimental studies to clinical practice
CCR Journal Watch
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Early Goal-Directed Hemostatic Therapy for Severe Acute Bleeding Management in the Intensive Care Unit
CCR Journal Watch
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Today's paper of the day is on acute dyspnea in the emergency department
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Diagnosis and management of subarachnoid haemorrhage
CCR Journal Watch
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Outstanding review of fluids in the critically ill by three of the most prominent fluid researchers of the past 20 years
@icuresearch
@JAMyburgh
@BellomoRinaldo
.
Is the definitive go-to review paper for this topic.
And published OA.
Highly recommended!
Today's Paper of the Day is on respiratory mechanics
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Today's paper of the day is on the ICU management of severe Guillain-Barré syndrome
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Today's Paper of the Day is by S Wallace on laryngeal complications after tracheal intubation and tracheostomy
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Management strategies for refractory status epilepticus
CCR Journal Watch
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JCS/JHRS 2022 Guideline on Diagnosis and Risk Assessment of Arrhythmia
CCR Journal Watch
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Evaluation and care of the critically ill patient with cirrhosis
CCR Journal Watch
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Respiratory challenges and ventilatory management in different types of acute brain-injured patients
CCR Journal Watch
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The Intra-Aortic Balloon Pump: A Focused Review of Physiology, Transport Logistics, Mechanics, and Complications
CCR Journal Watch
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Proximal versus distal diuretics in congestive heart failure
CCR Journal Watch
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Today's Paper of the Day is by Sami Safadi on Use of Ultrasound to Assess Hemodynamics in Acutely Ill Patients
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➡️ There are ~ 5.8 million trauma deaths per year globally
➡️ Trauma is the largest cause of death below the age of 50
➡️ One-third of severely injured trauma patients are coagulopathic at hospital arrival
➡️ Fibrinogen is often used, but is it effective?
a short 🧵
1/10