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Kow Akaa Essuman MD PhD Profile
Kow Akaa Essuman MD PhD

@kmaessuman

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PGY-4 Neurosurgery Resident Physician | Neurosurgeon | Scientist | @MGHNeurosurg @BostonChildrens @WUSTLmed @WashUGenetics @TempleUniv

Boston, MA
Joined March 2019
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
4 years
“The lines are fallen unto me in pleasant places; yea, I have a goodly heritage. I will bless the Lord, who hath given me counsel...” Psalms 16:6-7.. I matched into neurosurgery at the Mass General Hospital!! #WashUMed #Match2020 . Thanks to my family, friends, @WashUNeurosurg
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
2 years
Today, 3 first release papers published in Science, including our review article continue to elucidate TIR enzyme function. Thankful for this contribution! Cheers to PGY3! @WashUGenetics @WUSTLmstp @MGHNeurosurg @HHMINEWS
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Shared TIR enzymatic functions regulate cell death and immunity across the tree of life

A review explains that shared enzymatic functions in innate immunity build diverse immune systems from archaea to bacteria to plants to humans.

www.science.org
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
4 years
“When you are with family, you are yourself. And when you are yourself, you are at your very best.” Mike Krzyzewski. The new members of my family. Nathan Sisterson, Bobby Gramer @MGHNeurosurg .
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
9 months
Very thankful for this opportunity, trust, and huge investment by the HHMI. In the words of a dept chairman, “We’re going to use every available technology, method, and procedure to improve the lives of patients all over the world.” @MGHNeurosurg @ChrisAWalsh1 @BostonChildrens
@HHMINEWS
HHMI NEWS
@HHMINEWS
9 months
🎉 Today we're thrilled to announce our 2023 #HannaGrayFellows ! Please join us in welcoming and celebrating these outstanding early career scientists! Learn more:
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
3 years
Neurosurgery North team commemorating the end of my role as North intern. Re: cake - “Kow, stay orthogonal to the surface!” @AtharNMalik @IDavidConnolly @MGHNeurosurg
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
3 years
And the new interns arrived… and I became a PGY-2!! @MGHNeurosurg @DrTariqParker @HsuehBrian @ndsisterson #futureleadersinneurosurgery
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
4 years
In 2017, we reported SARM1 as the founding member of a new family of enzymes. New work from others shares insights on how this neuronal enzyme is turned on and activated. Hoping to study the role of SARM1 in neurosurgical conditions.
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
3 months
Amazing clinical response in this phase I clinical trial using CART-cell in GBM. Congrats to @BryanDChoi @BobCarterMD @WTCNeuroscience and the entire team, @MGHCancerCenter !
@BryanDChoi
Bryan D. Choi MD PhD
@BryanDChoi
3 months
Today, @NEJM published our clinical study of a novel #CARTCell in patients with #Glioblastoma . Early results with CARv3-TEAM-E suggest safety and bioactivity. Special thanks to all collaborators @MGHNeurosurg and @MGHCancerCenter !
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
3 months
Excellent work from the Walsh and Park labs published today highlighting the rates and patterns of somatic mutations in single neurons and oligodendrocytes during aging, w/ implications for age related brain conditions including brain tumors. @CellCellPress @ChrisAWalsh1
@Javier_Ganz
Javier Ganz
@Javier_Ganz
3 months
Our work about contrasting patterns of somatic mutation accumulation between oligodendrocytes and neurons in the aging human brain, is now online in @CellCellPress ! Huge thanks to @sarabiz86 @JoeLuquette @peter_j_park @ChrisAWalsh1 . See tweetorial (1/10).
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
1 year
Important work from the Mass General Cancer Center and @MGHNeurosurg team!
@NEJM
NEJM
@NEJM
1 year
Read "BRAF–MEK Inhibition in Newly Diagnosed Papillary Craniopharyngiomas," the NEJM Original Article referenced in this  @statnews article:
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
4 years
Great that our work in the lab is reaching such heights! The SARM1 journey continues...
@EliLillyandCo
Eli Lilly and Company
@EliLillyandCo
4 years
Today we’re announcing an agreement to acquire biotech company Disarm Therapeutics, expanding our R&D efforts in pain and neurodegeneration. Learn more:
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
6 months
The power of surgery in advancing science! Congrats to neurosurgery residency applicant @emauryg , and @KahleKristopher @ChrisAWalsh1 for this perspective article.
@emauryg
Eduardo Maury, MD, PhD
@emauryg
6 months
Excited to share our perspective article in @ScienceMagazine ! We explore how neurosurgery can help illuminate fundamental research on brain somatic mutations @ChrisAWalsh1 @KahleKristopher 1/5
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
6 months
Amazing program for early career scientists! Encouraging all my fellow post-docs, physician-scientists, surgeon-scientists that are eligible to apply! #HannaGrayFellows
@HHMINEWS
HHMI NEWS
@HHMINEWS
6 months
Applications for the 2024 #HannaGrayFellows Program are now open! At HHMI, we believe in 'People, not projects.' Join the Hanna Gray Fellows Program and be part of a community where every scientist's journey and contribution matters.
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
9 months
That’s my brother @nyessuman @CondeNast . Congrats!!
@databricks
Databricks
@databricks
9 months
Media moves fast — but an effective data + AI platform moves faster✨ @CondeNast uses Unity Catalog and Databricks SQL to speed up their analytics + decision-making and keep up with ever-changing trends, all while reducing infrastructure costs by $6M ⬇️
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
4 years
When we found that the TIR domain of neuronal SARM1 was an NADase, we had something special. We quickly defined this new enzyme family in bacteria and plants. Great to see TIR NADase play a role in prokaryotic STING biology. The beauty of basic research. From nerves to bacteria!
@NaturePortfolio
Nature Portfolio
@NaturePortfolio
4 years
A study in Nature reports the discovery of prokaryotic STING and shows that the mechanism of activation is conserved between prokaryotes and eukaryotes.
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
5 years
Today, we place #TIR domains, #NAD , and #SARM1 on the public map again. The TIR domain is indeed an emerging family of NAD consuming enzymes. We and others publish back to back papers in Science today. Enjoy! Check our Horsefield et al in the same issue.
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
19 days
@yasminaghajan @BWHNeuroICU @MGHNeuroICU @DanHarrisonMD @Takanshooka @PriyaSrikanth9 @DrUsaamahKhan Def an outstanding class right here!! Fond memories.. thanks for bearing with us and best wishes in your future endeavors!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
3 years
@DrTariqParker Congratulations Tariq! Welcome to MGH.
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
3 years
New and exciting work from my WashU thesis lab group. #ALS
Tweet card media
Constitutively active SARM1 variants found in ALS patients induce neuropathy

In response to injury, neurons activate a program of organized axon self-destruction initiated by the NAD+ hydrolase SARM1. In healthy neurons SARM1 is autoinhibited, but single amino acid changes...

www.biorxiv.org
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
9 months
The elucidation of TIR NADase function in biological systems continues….
Nucleic-acid-triggered NADase activation of a short prokaryotic Argonaute

Nature - Cryo-electron microscopy structures of a short prokaryotic Argonaute (pAgo) and the associated TIR-APAZ proteins bound by guide RNA and target DNA shed light on the mechanisms of assembly...

www.nature.com
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
2 years
@Smith_WilliamJ @MGHNeurosurg @acglaser9 Welcome to MGH William!! Looking forward to working with you!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
4 years
Thanks @jkosarchukmd for the nomination. Day 1/7 in the life of a neurosurgery resident. No words, no people. Nominated by @jkosarchukmd . Next up - @jkhalifeh_md
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
5 years
Congrats Jawad
@jkhalifeh_md
Jawad Khalifeh, MD
@jkhalifeh_md
5 years
Two-part article published in November issue of @TheJNS . On using peripheral #nerve surgery to reanimate paralyzed upper extremity muscles after cervical spinal cord injury. #SCI @WashUNeurosurg Part 1: Part 2:
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
3 years
Amazing work.. truly a landmark study...Congrats!
@LehtinenLab
Lehtinen Lab
@LehtinenLab
3 years
The choroid plexus blood-CSF barrier has remained a mystery for far too long! Our study led by @NeilCDani1 and Rebecca Herbst, w/ Aviv Regev & @naomi_habib , is out today in @CellCellPress showcasing a cell atlas & exciting new findings. 1/11 Read it here
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
4 years
@GregoryZipfel @strahleMD @WUSTLmed @WashUNeurosurg Congratulations Dr. Strahle!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
3 years
Hyperactive SARM1 NADase discovered in ALS patients!
Tweet card media
Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients...

Rare SARM1 alleles encoding SARM1 variants that have constitutively high NADase activity and sensitise cultured neurons to mild stress are risk alleles for ALS and other, related motor disorders.

elifesciences.org
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
11 months
Another nice example of TIR enzymatic function in nature…. RNA/DNA binding activated TIR NADase activity.
@Nature
nature
@Nature
11 months
Nature research paper: Oligomerization-mediated activation of a short prokaryotic Argonaute
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
2 years
Great to see new discoveries of TIR NADase activity in immune systems, and its repurposing to detect DNA.
@CellCellPress
Cell
@CellCellPress
2 years
Online now! Short prokaryotic Argonaute systems trigger cell death upon detection of invading DNA #microbiology #sciencetwitter
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
5 months
Congrats to @MGHNeurosurg team for this beautiful study on speech production in the human brain.
@zivwilliamslab
ZivLab
@zivwilliamslab
5 months
Our new study is out today in @Nature ! We employed Neuropixels recordings to understand how speech is produced by single neurons in the human brain.
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
9 months
@Cpt_Gin @MGHNeurosurg @ChrisAWalsh1 @BostonChildrens Thanks Eugene!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
2 years
@francisdeng @drjengillespie @CMGlastonbury @DrAndrewDixon @JennyKHoang @Radiopaedia interesting… now I’ll think about this Dx when I think of dAVF for pulsatile tinnitus.. But I wonder how many of IIH patients w/ tinnitus have elevated venous sinus pressures and can benefit from sinus stenting.
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
9 months
@AbbyLChengMD @STLRHC @STL_IHN Congrats!!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
2 years
@HeraKamdar @HannawiYousef @MGHNeuroICU @OhioStateNeuro @OSUWexMed Woot! Woot!! Congrats Hera
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
4 months
@IDavidConnolly @ShankarLabMGH @spinesection @JohnHShinMD @MGHNeurosurg @MGHNSResidency Congrats Ian!!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
3 years
Congrats to all! Shout out to my co-resident @ndsisterson
@RMarkRichardson
Mark Richardson MD PhD
@RMarkRichardson
3 years
Love to the brain on Valentine's Day: 367-case study from @NINDSnews #BRAINInitiative Research Opportunities in Humans consortium shows safety of research ECoG during DBS @USBrainAlliance Thanks @drpouratian @UeliRutishauser @PittNeurosurg @MGHNeurosurg
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
5 years
SARM1 is the founding member of a new family of enzymes. Efforts are underway to block neurodegeneration via SARM1 inhibition. Thankful to have made the seminal discovery of Toll/Interleukin-1 Receptor (TIR) domain enzymes.
Extending human life

Two new centers focus on chronic diseases of aging

outlook.wustl.edu
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
4 years
@_TheEsquire @WashUNeurosurg The ish!!! Thanks OP!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
2 years
@jgrajalesreyes @WUSTLmed @YAnesthesiology @WashUPain @WUSTLmstp @WUSTL_AnesRsrch Congrats man!!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
9 months
@SigFigs87 @MGHNeurosurg @ChrisAWalsh1 @BostonChildrens Thanks Matt.
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
1 year
@Julia_A_Wagner Nice. Neurosurgery life is hard… lol., gets a bit manageable with the years… but the cases are cool!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
3 months
@kedousmekbib @MayoClinicNeuro @RobSpinnerMD @JamieVanGompel Congrats Kedous!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
9 months
@EkowJadenAdams @MGHNeurosurg @ChrisAWalsh1 @BostonChildrens Thanks Seth!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
4 years
@jkhalifeh1 @NeurosurgeryCNS @WashUNeurosurg Congrats Jawad!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
5 years
The Blues have made STL proud!! Stanley Cup Champs!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
4 years
@jonatlin @WustlDOVS @WUSTLmstp @WUSTLdbbs Congratulations Jon
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
1 year
@nyessuman Charley, he silence us koraaa… clutch!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
4 years
@arnavm1 @CellCellPress Congratulations Arnav!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
4 years
@McKnightLab_UO I’m sorry you had to go through this. May your family find strength in this time, and may you see Christ in this hour.
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
5 years
New paper from a fellow WashU MD/PhD student - Mitsu from Shin-ichiro Imai’s lab. #NAD #aging
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
1 year
@eewicks Congrats Lizzy.
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
2 years
@francisdeng Nsgy not on the list?
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
4 years
@jonatlin @HMSeye @MassEyeAndEar @Schultz_SA @WustlDOVS @WUSTLmstp Congratulations Jon!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
2 years
@jonatlin @ApteLab @WUSTLmstp Congrats Jon!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
4 years
@JimBrinkMD @francisdeng @RSNA Congrats Francis!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
4 years
@DrEmilyT @WashUNeurosurg Thank you!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
4 years
@jkhalifeh1 @WashUNeurosurg Thanks Jawad!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
5 months
@NRCDP_K12 @BWHNeurosurgery @UCLANsgy @StanfordNsurg @UHCLENeurosurg @PittNeurosurg Last I knew, Fred Barker is at MGH not BWH, so might want to above correct post.
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
4 years
@WashUGenetics @WashUNeurosurg Thanks!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
9 months
@ErikHerzog Thanks Dr. Herzog… thanks to the WashU training and experience.
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
3 years
@NaifMA1 @MassGeneralNews @harvardmed @AmanBPatel @rwregen Congrats Naif.
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
4 years
@jonatlin @WashUNeurosurg Thanks Jon! Congratulations to you as well.
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
3 years
@WashUNeurosurg Congrats Ananth!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
3 years
@Sarah_E_Smith @AzadBonni @drbhooma Congrats Sarah!! Nice!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
4 years
@SumedhSShah @umiamimedicine @UMiamiHealth @umneurosurgery Congratulations Sumedh!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
4 years
@jkhalifeh1 @WUSTLmed Thanks Jawad!
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
2 years
New study characterizing TIR NADase activity in human gut microbiome. Congrats to the Gordon, Milbrandt, and DiAntonio labs.
Products of gut microbial Toll/interleukin-1 receptor domain NADase activities in gnotobiotic mice...

Weagley et al. characterize NAD metabolic activities of TIR domains in human gut bacterial proteins in vitro and in gnotobiotic mice. They show that TIR representation and activities differ in the...

www.cell.com
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@kmaessuman
Kow Akaa Essuman MD PhD
@kmaessuman
7 months
@yasminaghajan Your ride never disappoints too!! :)
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