The first catalytic intermolecular 1,2-alkylborylation reaction via a radical-relay mechanism between unactivated olefins, bis(pinacolato)diboron, and an alkyl electrophile is reported. Successful...

Conventional organic synthesis generally relies on the use of liquid organic solvents to dissolve the reactants. Therefore, reactions of sparingly soluble or insoluble substrates are challenging and...

A new C2-symmetrical P-chirogenic bisphosphine ligand with silyl substituents on the ligand backbone, (R,R)-5,8-TMS-QuinoxP*, has been developed. This ligand showed higher reactivity and enantiosel...

Nature Nanotechnology - The ammonia was synthesized under ambient conditions via a mechanochemical method, reaching a final concentration of 82.5 vol%.

Carbon–nitrogen (C–N) bond-forming cross-coupling reactions catalyzed by palladium-based catalysts, the so-called Buchwald–Hartwig aminations, have been widely employed for the synthesis of pharmac...

The oxyboration of arynes was achieved for the first time. A series of 2-aryl-1,3,2-dioxaborolane derivatives were reacted with aryne precursors in the presence of CsF to give the corresponding...

A library of 12 dibenzo- and naphtho-fluoranthene polycyclic aromatic hydrocarbons (PAHs) with MW = 302 (C24H14) was synthesized via a Pd-catalyzed fluoranthene ring-closing reaction. By understand...

Ball milling method avoids problems surrounding solution-based chemistry when synthesising arylmanganese nucleophiles

Organic compounds bearing both silyl and boryl groups are important building blocks in organic synthesis because of the adequate reactivity of the silyl and boryl groups and high stereospecificity in...

The Ultimate Birch Reduction?

The direct synthesis of organomanganese reagents from organic halides and manganese metal remains a challenge. Current solution-based approaches require the preparation of activated manganese (Rieke...

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Nature Chemistry - The distortion of an amide group away from a planar conformation typically enhances its reactivity and such activation is usually achieved through the chemical synthesis of...

Protocol solves 'malleability problem' of activating alkali metals like sodium

The catalytic enantioselective nucleophilic borylation of ketimines is reported. A series of acyclic dialkyl ketimines reacted efficiently with bis(pinacolato)diboron in the presence of a copper(I)...

The first examples of single crystals exhibiting salient effects by different structure change mechanisms are reported. The crystals of newly prepared aryl(9-isocyanoanthracene)gold(I) complexes jump...

Visualization of mechanochemical damages, especially for those in the molecular-scale (e.g., bond scission in polymeric materials), is of great industrial and academic significance. Herein, we report...

Synthetic polymer chemistry endeavors to imitate the spatial and temporal control exhibited within biological systems to obtain well-defined polymeric materials with unique structures, properties,...