FireInABottle @fire_bottle Twitter profile

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FireInABottle

7 months

As promised. My weight loss results after 28 days on The Emergence Diet. TLDR: my scale says I’m down 14.5 lbs.

Scale Receipts: 28 days on The Emergence Diet - Fire In A Bottle

So I’ve been promising that I would share my weight progress after I had done The Emergence Diet for 28 days. My argument is that weight loss isn’t about calories, it’s about burning glucose effici...

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FireInABottle

@fire_bottle

3 years

All mammals share an ancestor who could switch their metabolism to a torpid state, as defined by low metabolic rate, low body temperature and elevated SCD1. The trigger? Dietary linoleic acid. The majority of Americans became torpid between 1962 and 1991.

Humans and Hibernating Mammals React to The Same Amount of Dietary Linoleic Acid in the Same Way....

Hibernating animals can't enter hibernation without eating enough linoleic acid to get into torpor. Humans can get into torpor by eating the same amount.

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FireInABottle

@fire_bottle

4 years

I think that vitamin K2 status explains why heart disease deaths in America rose and fell in the 20th century better than any other factor. @FatEmperor @siobhan_huggins @DaveKeto @KetoCarnivore @ChrisMasterjohn

An Alternative Hypothesis For The Rise And Fall of Heart Disease In The US In The 20th Century -...

How the fall and rise of vitamin K2 in the 20th century explain the rise and fall of heart disease rates.

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FireInABottle

@fire_bottle

1 year

Strange reality. Tomato sauce from a bottle has added seed oils. Tomato sauce from a can does not.

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FireInABottle

@fire_bottle

1 year

Something to think about as you drive past those fields of soybeans.

JB

@SimmonsBart

1 year

Think about it. I do all the time.

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FireInABottle

@fire_bottle

3 months

The more you look, the harder it is to deny the idea that specific amino acids have a huge effect on metabolic health. Cod: High in BCAAs. Makes mice fat. Scallops: High in glycine, arginine and taurine. Make mice lean.

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FireInABottle

@fire_bottle

7 months

I defer to Plato.

Pikachu

@pikalovebuster

7 months

@fire_bottle Still seems odd to me that such an ancient and traditional food could wreak so much havoc on the human body…

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FireInABottle

@fire_bottle

2 years

I haven’t talked much on here about my life as a pig farmer in rural America. More and more I think I can’t avoid it anymore. It’s a very real issue…. Do meat calories take more resources than plant calories?!?! I’m curious how much you all care about this issue.

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FireInABottle

@fire_bottle

7 months

I’m literally shocked at the effect on my Blood Glucose and weight. I won’t release the data from my scale until it’s been ~28 days (four weeks). I’m convinced that the majority of Americans are in a metabolic state analogous to torpor, if not exactly torpor.

Vero

@Vero_atLast

7 months

@fire_bottle I know a few people that would benefit from your work on the emergence diet. I’m excited to see it continue.

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FireInABottle

@fire_bottle

3 months

So I cold call the head of potato breeding at Cornell. He picks up immediately. I say: I’m looking for potato varieties with low protein content, the literature suggests there is a huge range. His response: “I have no idea. No one has ever asked that before!”

FireInABottle

@fire_bottle

3 months

Stopped by campus to get some potato varietals for BCAA testing. Where does one find potato breeders on campus? Tuber Drive

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FireInABottle

@fire_bottle

1 year

Thank you for having me on! Seed oils DO cause diabetes. The science is clear. It’s not even that complicated. More seed oils = more oxidized seed oils = diabetes. The culprit is an enzyme called D6D, but you, Twitter user, don’t care. Seed oils cause diabetes.

David Gornoski

@DavidGornoski

1 year

Thank you @fire_bottle for helping us see the truth of how seed oils cause diabetes.

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FireInABottle

@fire_bottle

7 months

I haven’t been in the 80s since… Well, New Year’s Eve, 1989.

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FireInABottle

@fire_bottle

7 months

It’s funny that fasting is a cool thing to do (0g protein) but if I say I’m restricting protein to 60g a day, some people think I’m crazy.

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FireInABottle

@fire_bottle

7 months

Pork rinds (skins) are routinely added to hot dogs and kielbasa in Germany. This is not only ecologically sound - don’t waste - it increases the collagen (glycine) content of the sausage. This is good for you! Adding skins to hot dogs is illegal in the US.

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FireInABottle

@fire_bottle

2 years

Hi all! I’ve been quite absent on this platform. I miss and love you all! (Even the detractors) I have low grade anxiety which makes it hard to deal with social media sometimes for months at a time, I hope you all understand. I’m going to try to be more present!

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FireInABottle

@fire_bottle

6 months

Oh, I’ve got this! Pork fat can be as high as 54% linoleic acid. That’s not a typo and I didn’t make it up.

L. Amber O'Hearn

@KetoCarnivore

6 months

@exfatloss @TuckerGoodrich @twitevit @firebottle The question was, if you did everything you could do to make pork have high PUFA content, how high could you get it? I don't know the answer to that.

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FireInABottle

@fire_bottle

8 months

Calorie restriction causes increased oxidation of PUFA, creating Oxylipins such as 20-HETE. These contribute to lowered metabolic rate, dysregulated appetite and fat gain once the Calorie Restriction ends.

The Dark Side Of Calorie Restriction. (Oxidized PUFA)

null

www.youtube.com

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FireInABottle

@fire_bottle

2 years

@dranthonygustin I can confirm. This is from a 7-yr old grass fed dairy cow I butchered this winter. Brown Swiss cross. Notice the color of the fat.

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FireInABottle

@fire_bottle

7 months

I did an oral glucose tolerance test to confirm that I have restored insulin sensitivity with the Emergence Diet (very high in starch and collagen). Verdict: confirmed, mostly. NAD+ matters.

How I Both Aced and Failed My Oral Glucose Tolerance Test (OGTT) - Fire In A Bottle

I’ve been consuming what I’m now calling the “induction phase” of the Emergence Diet. In short, this is a very high carbohydrate (>400g/day) diet that is low in fat and which the protein source is...

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FireInABottle

@fire_bottle

6 months

It even blows my mind. But I’m trying to get used to it. I mean, every morning I eat my pancakes with maple syrup and fruit preserves. It’s working pretty damn well…

exfatloss🥛

@exfatloss

6 months

@anabology "Sugar is good for you" is the donut-shaped meta-reveal at the end of the movie that's totally blowing everybody's mind🤣

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FireInABottle

@fire_bottle

7 months

I’ve been doing a very high carb, protein restricted diet for ten days now and I have lowered my fasting blood glucose by ~20 points, reversing years of pre-diabetic blood glucose levels.

From the SaturatedFat community on Reddit

Explore this post and more from the SaturatedFat community

www.reddit.com

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FireInABottle

@fire_bottle

7 months

What does snake venom do? It releases arachidonic acid from your cell membranes. Free arachidonic acid is prone to oxidation via our enzymes: cyclooxygenase and CYP450s. Result: death. What does aspirin do? It inhibits cyclooxygenase.

anabology

@anabology

7 months

@fire_bottle @exfatloss What happens to non-oxidized PUFAs once they’re in your body? Surely they don’t get oxidized… right? We would never use lipid peroxidation products as a measure of stress, surely.

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FireInABottle

@fire_bottle

2 years

This is Part I of my long delayed series: How seed oils cause reductive stress. This puts them at the root of oxidative stress and obesity. But how do they do it compared to saturated fat?

The Flooded Engine, An Analogy; How Seed Oils Cause Reductive Stress, Part I - Fire In A Bottle

I’ve been writing a lot about reductive stress and its role at the heart of both oxidative stress and obesity. I’m aware that the term reductive stress isn’t terribly intuitive. It’s a wonky,...

fireinabottle.net

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FireInABottle

@fire_bottle

7 months

Humans are not calorimeters! Thank you for coming to my TED talk.

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FireInABottle

@fire_bottle

5 months

Oleic acid restricted diet led to increased caloric consumption, lower body weight, lower adiposity, lower OEA at 15 weeks. LOAD = Low Oleic Acid Diet

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FireInABottle

@fire_bottle

8 months

This is enormously important. Lack of USDA slaughter availability is killing local farmers. This gives farmers other options if we ever want to have meat that is raised better. This provides opportunities to decentralize the agricultural system. Call your senator.

Thomas Massie

@RepThomasMassie

9 months

It's greener to buy meat locally, it's a lot more humane for the animals, and you can know the farmer who raises your food. Ask your congressional representative to support food freedom by cosponsoring the PRIME Act, HR 2814.

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FireInABottle

@fire_bottle

7 months

If someone can tell me an easy way to get lean without damaging the metabolism (ie caloric construction), I’m all ears. Until then I’m forging ahead with high-starch, low-fat, low-BCAA, high collagen/gelatin. Plus SEA.

exfatloss🥛

@exfatloss

7 months

@ChrisMasterjohn @macroarray @fire_bottle "Get lean" are you kidding? Not like people have been trying and failing to do so for 70 years dude.

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FireInABottle

@fire_bottle

2 years

This year’s solstice pie wheel.

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FireInABottle

@fire_bottle

7 months

I’m eating plenty of gelatin, broth and baked pork rinds. Also made a beef tripe and cassava stew the other. It really DOES seem to be the branched chain amino acids that are the key. I’m only restricting muscle meats.

exfatloss🥛

@exfatloss

7 months

Man reverses prediabetes by restricting protein.

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FireInABottle

@fire_bottle

6 months

The standard French Breakfast is Low-protein/BCAA. 1/4-1/2 baguette, butter, jam, fruit juice and coffee. Croissants on weekends.

From the SaturatedFat community on Reddit: The Low-BCAA French Breakfast

Explore this post and more from the SaturatedFat community

www.reddit.com

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FireInABottle

@fire_bottle

5 months

This morning my fasting blood glucose was 73. That’s down about 45 points from when I was consuming more BCAAs. I think there’s something to this BCAA restriction.

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FireInABottle

@fire_bottle

6 months

Probably the thing that destroyed metabolic health in America was the rise in soybean oil consumption. The obvious scapegoat is linoleic acid, omega 6. I’m still open to the idea that soybean oil ruined us due to its alpha-linolenic acid (omega 3) content.

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FireInABottle

@fire_bottle

3 years

I just got testing results back from the latest batch of Firebrand Meats pork. 6% linoleic! I sent some Smithfield bacon fat as a comparison. Firebrand Smithfield Stearic 13.4% 9.59% Linoleic 6.03% 15.6% Ratio 2.2 0.61 1/3

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FireInABottle

@fire_bottle

4 years

This is the big one! The ROS Theory of Obesity, Part 2. In this I argue that insulin and leptin are in a long term battle over stored body fat saturation levels by regulating the expression of SCD1, a desaturase strongly associated with obesity. 1/5

The SCD1 Theory of Obesity, Part 1 - Insulin, Leptin, SCD1 and Thermogenesis - Fire In A Bottle

Insulin and leptin are in a battle over SCD1 levels. Low SCD1 means saturated fat which leads to leanness. High SCD1 levels lead to unsaturation which leads to fatness.

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FireInABottle

@fire_bottle

6 months

I just edited the next Fire In A Bottle video. This is a perspective on PUFA you haven’t heard. Why does oxidized soybean oil make rats lean? Why does n3 ALA make pigs fat? Why do cholesterol lowering fibrates reduce PUFA? What can nematodes tell us? Tomorrow on YouTube!

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FireInABottle

@fire_bottle

4 years

@catdadaeternal Have you seen The Croissant Diet?

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FireInABottle

@fire_bottle

4 years

On this solemn day - the 30th anniversary of McDonald’s announcing their fries would be fried in vegetable oil instead of beef tallow, I give the world my Fat Bomb Fry recipe. Fries with TWICE the beef fat!

Fat Bomb Fries - Fire In A Bottle

It’s not by chance that I’m publishing this on July 23rd, 2020, 30 years to the day after McDonald’s announced they were switching from beef tallow to vegetable oil for their french fries. Here’s the...

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FireInABottle

@fire_bottle

8 months

This is a nothing burger. You repeat 4027, which conflates marine oils and plant oils into “PUFA”. 5402 is about altering total fat content and 0191 is an OVERFEEDING study comparing 2 plant oils. Where are the RCT results showing benefits of linoleic acid?

Layne Norton, PhD

@BioLayne

8 months

What about metabolic health? -Neutral or improved insulin sensitivity (PMID: 27434027 & 26615402) -PUFAs decrease visceral fat relative to saturated fat (PMID: 24550191) -PUFAs improve HbA1c, fasting glucose, C-peptide, & HOMA-IR compared to saturated fat (PMID: 27434027)

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FireInABottle

@fire_bottle

6 months

The real reason for the success of the Mediterranean diet is probably alcohol. If you feed mice pure oleic acid (IE olive oil) they go straight past obesity and straight to T2DM.

Paul Saladino, MD

@paulsaladinomd

6 months

Drinking alcohol is like borrowing tomorrow’s happiness today.

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FireInABottle

@fire_bottle

4 years

I need a word better than fasting that means "a day of mild caloric restriction where you choose macronutrients that don't raise insulin - mostly fat and alcohol."

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FireInABottle

@fire_bottle

28 days

I would have this debate in a box with a fox. Different fats have different roles. SFA: boring, just fuel, high oxygen requirement. MUFA: activate PPARa. Insulin resistance. Trigger D6D. PUFA: signaling molecules via D6D/CYP450s. Trigger MUFA. They’re not just calories.

Dave Feldman

@realDaveFeldman

30 days

FWIW, I think @tednaiman ’s statement on beef tallow, coconut oil, etc being effectively no different than seed oils would make a good debate proposition. (See video below for full context) Given a seed oil debate was intended for #CoSci this year (but couldn’t make scheduling),

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FireInABottle

@fire_bottle

7 months

BCAAs are not “bad”. The reason I’m currently restricting BCAAs is that I’m broken. At the moment I can’t metabolize them. I’ve already become insulin sensitive. Now I want to lose the weight and eat steak again. If you can regain BCAA catabolism, they are very thermogenic!

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FireInABottle

@fire_bottle

8 months

Linoleic acid doesn’t cause metabolic disease, oxylipins like 5-HETE do. The gating factor in converting linoleic acid to 5-HETE is delta-6-desaturase (D6D). D6D activity predicts diabetes and heart disease risk in Mendelian Randomization studies. DOI: 10.3390/nu12082261

Layne Norton, PhD

@BioLayne

8 months

What about metabolic health? -Neutral or improved insulin sensitivity (PMID: 27434027 & 26615402) -PUFAs decrease visceral fat relative to saturated fat (PMID: 24550191) -PUFAs improve HbA1c, fasting glucose, C-peptide, & HOMA-IR compared to saturated fat (PMID: 27434027)

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FireInABottle

@fire_bottle

9 months

Feeding trial: pure stearic acid Vs. pure oleic acid, WT mice. RESULT Stearic acid: 50% more calories consumed per g, 38% less white adipose tissue per gram. Oleic acid: liver fat accumulation and insulin resistance. 1/2

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FireInABottle

@fire_bottle

6 months

This is correct! Let’s look at the metabolic effects of ethanol: 1) higher metabolic rate 2) better insulin sensitivity 3) reduced obesity

Long-term low-dose ethanol intake improves healthspan and resists high-fat diet-induced obesity in...

Aging | doi:10.18632/aging.103401. Yan Diao, Junhui Nie, Peizhu Tan, Yuchen Zhao, Tingting Zhao, Jiajie Tu, Heng Ji, Yuwei Cao, Zhaojing Wu, Huan Liang, Hui Huang, Yanze Li, Xu Gao, Lingyun Zhou

www.aging-us.com

Poetic Outlaws

@OutlawsPoetic

6 months

@paulsaladinomd “Wine is one of the most civilized things in the world and one of the most natural things of the world that has been brought to the greatest perfection, and it offers a greater range for enjoyment and appreciation than, possibly, any other purely sensory thing.” —Hemingway

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FireInABottle

@fire_bottle

4 years

I follow keto/carnivore dieters, bakers and chefs. So my twitter feed is like: I ONlY EAT MEAT! Look at this CAKE I baked!! Insulin is the problem! #HFLC Here’s the CREAMIEST man-n-cheese. @OZmandia

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FireInABottle

@fire_bottle

3 months

This wasn’t true in 1943. MUFA above 55% in a human is metabolic dysregulation. Full stop. Hibernating animals have 60% MUFA when they’re fattening for winter. Hot blooded mammals should NEVER be at 60% MUFA. Disaster.

Benjamin Bikman

@BenBikmanPhD

3 months

One of the interesting things about adipose (fat) tissue in humans is the composition of the fat we store. Even though we only eat a modest amount of monounsaturated oleic acid (the primary fat in olive oil), almost 60% of the fat we store is oleic acid. Yes--your fat is mostly

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FireInABottle

@fire_bottle

8 months

I just finished this week’s video. I have to say I’m pretty proud of it. It explains both how/why ketogenic diets work as well as why/how very low fat diets work. Is it nerdy? It is. It comes out Sunday morning at 6AM Eastern on Fire In A Bottle YouTube.

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FireInABottle

@fire_bottle

7 months

Is a BCAA restricted diet thermogenic? It seems like it. This is ~20 minutes after (mostly) finishing the plate.

FireInABottle

@fire_bottle

7 months

Tonight’s Emergence Diet feast. Yuca in mojo sauce (sub sour cream for olive oil), head cheese cubes, imitation lobster with cocktail sauce and mixed greens. Could be worse!

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FireInABottle

@fire_bottle

6 months

My quick rundown of how to restrict BCAA in the real world. First off, protein from grain is high in BCAA. Better starch choices: cassava, glass noodles, certain gluten free products that have “starch” as ingredients rather than “flour”. I like Caputo Fioreglut flour. 1/3

Lamming Lab

@LammingLab

6 months

@real1kian @fire_bottle I think we need a diet guide for this

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FireInABottle

@fire_bottle

7 months

Did you know that a German sausage is VERY different than an American sausage?! More collagen in the German sausage! (Pork skin) The glycine (collagen) to branched amino acid ratio has a huge effect on metabolic health.

Is COLLAGEN the key to European Metabolic Health? The inside scoop.

KetOntrack: https://www.instagram.com/ketontrack/Low Carb Regenerator: https://www.youtube.com/channel/UCcWsJY4Yx6nlPxG5HltuSfQ

www.youtube.com

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FireInABottle

@fire_bottle

7 months

Switching from muscle meats to collagen based meats can have dramatic effects on your metabolism by lowering Branched Chain Amino Acids - associated with insulin resistance - and increasing glycine. Glycine reduces mitochondrial energy overload.

Emergence Diet Recipes: Tacos De Chicharron!

150g of water is a hair less than 2/3 cup.If you use an egg instead of gelatin in the tortillas, they are even better. Use less water. It pushes up BCAAs a...

www.youtube.com

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FireInABottle

@fire_bottle

8 months

So…. I’m going to release a new diet concept Sunday which is directly aimed at combatting insulin resistance. It is high in carbs, low in plant protein and high in gelatin. What should we call it? 🤔

Eric

@spirilis

8 months

Every time I see nutrition & metabolism discussions "in the wild" on places like reddit (say, recent r/Biohackers Q "How to address insulin resistance?") I keep thinking of how ahead-of-the-theory-game @fire_bottle is getting.

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FireInABottle

@fire_bottle

7 months

Tonight’s Emergence Diet dinner features cassava gnocchi in a pigs feet and beef tendon Sunday Gravy. Low fat, high starch, high collagen. The food is excellent here.

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FireInABottle

@fire_bottle

1 year

What are the only dietary fats that will actually displace unsaturated fats in your body tissues? Answer: Lauric Acid and Myristic acid, the 12 and 14 carbon saturated fats found in coconut oil and palm KERNEL oil.

The Pre-Emergence Diet: Low Protein, Tokelau and Coconuts

CORRECTION: At 32:00, I mean Rice Chex and Coconut MILK. Not coconut oil. That would be gross.List of foods by BCAA content: https://fireinabottle.net/l...

www.youtube.com

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FireInABottle

@fire_bottle

2 years

On the topic of PUFA free condiments. ⁦ @SeedOilDsrspctr ⁩ ⁦ @TuckerGoodrich ⁩

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FireInABottle

@fire_bottle

6 months

Drinking alcohol is like borrowing tomorrow’s happiness except I’ll be more insulin sensitive and have a higher metabolic rate tomorrow. I’ll leave the pushed off day of happiness to my children.

Long-term low-dose ethanol intake improves healthspan and resists high-fat diet-induced obesity in...

Numerous epidemiological studies have reported that moderate alcohol drinking has beneficial effects. However, few studies have focused on the beneficial effects of ethanol, the common component in...

www.ncbi.nlm.nih.gov

Paul Saladino, MD

@paulsaladinomd

6 months

Drinking alcohol is like borrowing tomorrow’s happiness today.

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FireInABottle

@fire_bottle

3 years

I’m roasting a Porchetta this weekend - a boneless whole hog stuffed with garlic, fennel, rosemary and black pepper - for a party my cousin is throwing. The pig was raised by a friend of mine. This is the finished roast. 1/N

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FireInABottle

@fire_bottle

1 year

Sometimes I am too quiet. I am flagging the forces pushing for pure oleic acid as an oil. Oleic acid causes diabetes. Full stop. 1/3

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FireInABottle

@fire_bottle

6 months

C8 MCT oil helps to break down BCAAs, which are elevated in obesity and evidence suggests contribute to insulin resistance. Recent events suggest that BCAA restriction aids weight loss. MCT oil aids weight loss. Is this where these two roads intersect?

Is BCAA-Catabolism The Mechanism Of MCT Oil? - Fire In A Bottle

MCT oil has long been associated with weight loss. This is especially true of the 8 carbon MCT, caprylic acid. I have yet to see any reasonably definitive reason for why this might be. I have...

fireinabottle.net

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FireInABottle

@fire_bottle

6 months

The metabolic health community on umm…. Twitter, has blinders on for the most part. As do nutritionists. Myself, @exfatloss , @Outdoctrination , @anabology We will give you the science. We don’t care about your bias.

0.005 Seconds (102/300)

@seconds_0

6 months

@fire_bottle Ive been going down the BCAA / isolucine restriction rabbithole ever since I read you and exfatloss initial discussions and its crazy that there are dozens of papers citing this over the last few years with zero popularity?

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FireInABottle

@fire_bottle

2 years

A friend had a cow come up lame. She ask if I’d help. My kitchen at the moment. (The scaffolding is because I’m repainting.) This is normal, right?

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FireInABottle

@fire_bottle

4 years

Everyone who wants better meat. Lack of medium scale/competitively priced slaughter and meat processing capacity is an EXISTENTIAL problem. We need to talk about it. NOW.

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FireInABottle

@fire_bottle

4 years

"The mechanism we use to trick our cells into thinking that we are feasting is feasting." This is a weight loss approach that's probably different from others you've seen. The Feasting Mimicking Diet.

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FireInABottle

@fire_bottle

7 months

It has been known since 1969 that obese humans have high circulating Branched Chain Amino Acids (BCAAs - valine, leucine and isoleucine) and low circulating glycine. That is why when I go to the Asian store I always grab some pigs feet. Right now I have beef tendon!!

FireInABottle

@fire_bottle

7 months

100g of meat picked from cooked pigs feet has: 12g fat 0.36g Isoleucine 3.5g glycine 10:1 gly/iso ratio 100g of 80% lean ground beef has: 16g fat 1.2g isoleucine 1.2g glycine 1:1 gly/iso ratio Interesting because:

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FireInABottle

@fire_bottle

4 years

Have you ever wondered, what is PUFA and MUFA? Or why do plants even make so much PUFA if it’s so bad? Wonder no more.

The What's, Why's and Where's of Fat - Fire In A Bottle

There are three basic kinds of fat, Saturated Fat (SFA), Monounsaturated Fat (MUFA) and Polyunsaturated fat (PUFA). Fats are also called “fatty acids”, hence the term PUFA: PolyUnsaturated Fatty...

fireinabottle.net

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FireInABottle

@fire_bottle

3 years

OMG, I just got test results! It's working!! Five weeks on sterculia oil my desaturase index has dropped from 2.1 to 1.63. I'm going to really put this to the test as a weight loss concept in January. Details here:

The SCD1 Theory of Obesity Part 2 - The Post Obese Metabolism and What You Can Do About It - Fire...

Insulin and leptin are in a battle over SCD1 levels. Low SCD1 means saturated fat which leads to leanness. High SCD1 levels lead to unsaturation which leads to fatness.

fireinabottle.net

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FireInABottle

@fire_bottle

6 months

Many are concerned about the recent trend of protein restriction. The evidence suggests that a reasonable daily minimum is: 44g total protein Half from a high quality source like eggs, dairy or meat Half from collagen/gelatin/broth

From the SaturatedFat community on Reddit: How Much Protein Do You Need? - Fire In A Bottle

Explore this post and more from the SaturatedFat community

www.reddit.com

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FireInABottle

@fire_bottle

5 months

Obese humans have more muscle than lean humans and we are better at defending that muscle. We are in protein-sparing mode. This is important if you are considering restricting protein.

Obese Humans Are in Protein-Sparing Mode

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FireInABottle

@fire_bottle

8 months

Metabolic rate is king. Calories are pawns.

FireInABottle

@fire_bottle

8 months

@JTayScience @SamuelWelsh10 @exfatloss If it is about excess energy intake, why did the humans on protein restriction lose weight and fat while the humans on normal protein and the same (or less) calories did not?

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FireInABottle

@fire_bottle

6 months

Does this sound like you in the winter?

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FireInABottle

@fire_bottle

7 months

This is what restoring insulin sensitivity on the Emergence Diet can look like. Caputo Fioreglut flour roll, Manda Headcheese, pickled onions and my neighbors greens. Very low BCAA/high glycine - Headcheese is mostly pork skin and snouts. The food is good here.

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FireInABottle

@fire_bottle

6 months

💥💥💥 I couldn’t be prouder. I’ve been posting that German sausage has pork skin in it (collagen) but that this is illegal here. Loophole: this is only true under USDA inspection, local butcher shops are exempt and can put pork skin in the sausage and these guys DID IT!!!!

Max Gulhane MD

@MaxGulhaneMD

6 months

Pig skin, high collagen Pregnancy Sausage?! Arthritis Sausage Gut healing sausage h/t @fire_bottle for the initial idea

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FireInABottle

@fire_bottle

7 months

Torpid animals go into “muscle sparing” mode. They lose the ability to break down BCAAs. This is what human obesity is. Instead of being metabolized, BCAAs are redirected towards causing insulin resistance (winter mode). If you get out of torpor, you can eat BCAAs again.

Shameer Mulji

@shameermulji

7 months

@fire_bottle If Very low BCAA/high glycine is a requirement for insulin sensitivity then how do bodybuilders and physique competitors maintain high insulin sensitivity on high protein diets?

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FireInABottle

@fire_bottle

1 year

Truth in marketing. Should you be able to call something “Buttercream” if it does not contain butter?

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FireInABottle

@fire_bottle

7 months

I’m really struggling to understand the rationale behind a “plant-based” or “animal-based” diet. My current diet combines the best plant and animal based foods: starch and gelatin. It’s going quite well, thanks. Why take either one off of the table?

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FireInABottle

@fire_bottle

7 months

Even if you’re restricting fat AND branched chain amino acids, you can still have collagen foods: Bone broth Gelatin Baked pork rinds Pigs feet Beef tripe Headcheese Aspic

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FireInABottle

@fire_bottle

4 years

It was a pleasure to introduce @KetoCarnivore to one of my favorite cuts of beef - the culotte. She introduced me to lamb brains. She didn’t want any croissants, though.

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FireInABottle

@fire_bottle

3 years

David went from a beer belly to almost a six pack in five months on a high-calorie version of The Croissant Diet (TCD). He tracked his food consumption closely! Cheeseburgers (with buns), croissants and Haagen Das!

David's Story - Fire In A Bottle

David is wroking his way to a six pack on The Croissant Diet while eating up to 5000 calories per day!

fireinabottle.net

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FireInABottle

@fire_bottle

4 years

BG and alcohol: I made a largish batch of Mac-n-cheese as a test meal. I ate it yesterday sober at 1:30pm. 1HR post-prandial BG was 189, 2HR was 128. Tonight. Ate the SAME quantity of the SAME BATCH of mac-n-cheese. Wine before and after, 1HR PP BG was 112. 2HR PP was 102.

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FireInABottle

@fire_bottle

6 months

My most common thought while listening to myself talk while editing video: “Shut up, nerd.”

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FireInABottle

@fire_bottle

10 months

Obese humans struggle to burn glucose. Glucose is highly thermogenic. Why can't obese humans burn glucose and how can we burn it again? New video from Fire In A Bottle.

Cornflakes for weight loss?! You betcha. (With SEA)

Carbohydrates can be highly thermogenic IFF you have the ability to burn them efficiently. Most obese humans do not. This video looks at the reasons why ob...

www.youtube.com

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FireInABottle

@fire_bottle

3 months

I am restricting BCAAs but I’m not restricting protein! Collagen is my go to. It is the best source of glycine and arginine. And that means oxygen. I’ve got some pork trotters on the stove ATM.

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FireInABottle

@fire_bottle

7 months

I wish it weren’t going this way. An honest review of the literature makes the dangers of unbalanced MUFA very clear. MUFA is the middle ground that all sides can agree to on a political level. The science tells a different story. A starting place :

How Olive Oil Makes You Fat

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anabology

@anabology

7 months

I predict that the normie anti-seed oil crowd are going to “win” in the US, with restaurants all changing to bug oil™ or olive oil. Then, we get the MUFAnation of America. Everyone will be fatter/more diabetic and the pro-seed oil folk will look like geniuses. It’s a trap.

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FireInABottle

@fire_bottle

2 years

Oxidized Seed Oils Cause Diabetes. This is the science behind it and it's pretty easy science. New post at Fire In A Bottle. If you'd prefer to watch the video, check my response to this Tweet.

Oxidized Seed Oils Cause Diabetes - Fire In A Bottle

The activity of the enzyme D6D, which converts linoleic acid to oxylipins - plays a causal role in diabetes.

fireinabottle.net

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FireInABottle

@fire_bottle

7 months

Todays Emergence Diet dinner. Cassava Gnocchi with slow simmered beef tendon. A sprinkle of Parmesan.

FireInABottle

@fire_bottle

7 months

Emergence Diet recipe idea. Cassava Gnocchi with Fioreglut flour. All the starch, none of the BCAA. They take about 10 minutes once you’ve done it before. I use this recipe but add baking powder. I don’t bother putting grooves in them.

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FireInABottle

@fire_bottle

2 years

Ready to serve.

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FireInABottle

@fire_bottle

6 months

Chicken and egg question. Does weight loss lead to insulin sensitivity (IS) or the other way? I restricted BCAAs and my fasting BG dropped 25 points. Then I lost almost 15 pounds in 28 days. This morning BG was 84. Still plenty of weight to lose. IS can proceed weight loss.

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FireInABottle

@fire_bottle

2 years

Low-PUFA Lard is available! Firebrand Meats is now offering 4 lb buckets of rendered lard. Our last test showed FBM lard had only 6% linoleic acid compared to 15.6% for Smithfield bacon!

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FireInABottle

@fire_bottle

3 years

So I invented a new ingredient: “Beef Flour”. If suet is hard enough you can chop it in a food processor until it’s nearly as fine as flour and mix it in with the dry ingredients. I made beef flour croissants (with bread flour).

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FireInABottle

@fire_bottle

4 years

Beautiful scene tonight courtesy of the Hector Grazing Assiciation in the Finger Lakes National Forest. And carnivores everywhere rejoiced.

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FireInABottle

@fire_bottle

4 years

Another favorite Julia Child quote - and I’m paraphrasing - “if you’re afraid of butter, use cream.”

Shaza

@OZmandia

4 years

Julia Child was way ahead of her time! “The only time to eat diet food is while you're waiting for the steak to cook.” ― Julia Child @KemMinnick @SteakAndIron @LIHF_Living @KetoCarnivore @LowOxCoach1 @fire_bottle @DrPaulMason #BBLVD

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FireInABottle

@fire_bottle

3 years

Back when I ran the butcher shop I’d always say “Merry Cheeseburger Christmas” to try to get people to buy more ground beef at a Christmas because everyone would buy the fancy beef roasts and we’d be left with a mountain of ground beef.

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FireInABottle

@fire_bottle

7 months

My broader thesis is that obese humans have unintentionally kicked on the program of mammalian torpor. Torpid animals are in a muscle-sparing state. The enzyme BCKDH is inhibited. (Breaks down BCAAs) If you get out of torpor eat all the BCAAs you want!

Ben Nichols

@ben63147361

7 months

@fire_bottle Serious question not trolling – what if the non-obese people are just using up branched-chain amino acids better and therefore they’re lowering plasma? In other words, they have more active muscles, and muscles use branched-chain amino acids

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FireInABottle

@fire_bottle

8 months

@hubermanlab @BioLayne Intervention trial showing inflammatory response to dietary linoleic acid depends on your fads1 (D6D) genotype. D6D limits conversion of LA to oxylipins. Supplemental has detailed listing of oxylipins. Supplemental: Paper:

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FireInABottle

@fire_bottle

2 years

Making bread. This bread is made with butter…. No veg oil! ⁦ @SeedOilDsrspctr ⁩ ⁦ @elizmegs ⁩

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FireInABottle

@fire_bottle

4 years

My podcast with @CarnivoreMD is out!

How Linoleic Acid is making you fat and Stearic Acid might just be the remedy with Brad Marshall,...

www.paulsaladinomd.co

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FireInABottle

@fire_bottle

2 years

How Seed Oils Cause Obesity! The panel discussion is live with David Gornoski, featuring @TuckerGoodrich , @drcateshanahan , @Peter_InNorfolk and Dr. Ray Peat, the legend himself!

My Big Fat Panel: How Seed Oils Cause Obesity - A Neighbor's Choice by David Gornoski

David Gornoski sits down with Dr. Cate Shanahan, Dr. Ray Peat, Tucker Goodrich, Brad Marshall, and Dr. Petro Dobromylskyj. The conversation revolves around the question of what causes obesity. What...

aneighborschoice.com

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FireInABottle

@fire_bottle

2 years

Happy New Year! I’m helping a friend cut up her on-farm slaughtered grassfed Brown Swiss-Jersey cross cow. Will update.

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FireInABottle

@fire_bottle

6 months

A clinical trial of canola oil and safflower oil in humans showed a dramatic increase in DNL (making fat) and oxylipin production compared to butter. Canola oil (oleic acid, linoleic acid & a-linolenic acid) was worse than safflower (mostly linoleic)

Throw Out Your Canola Oil!

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