Stunningly well done study. Direct neuronal activity imaging with MRI. They nailed it. Practical limits but all manageable. Added feature of visualizing depolarization AND hyperpolarization too.
With profound sadness I report that Leslie Ungerleider, an immensely influential neuroscientist, my colleague and mentor, and 2020 OHBM Glass Brain Awardee has passed away today.
@vdcalhoun
and I wrote a rebuttal to a surprising editorial in Brain (Brain, Volume 143, Issue 4, April 2020, Page 1045). I post in my blog what we submitted.
Last weekend, the NIH functional MRI facility received a second 7T. Excited to see what it will produce! Special thanks to
@neurocuriousity
and our core team for seeing this through!
30 years ago today, Eric Wong and I performed our first successful fMRI experiment. I wrote a paper some time ago describing that exciting time. Feeling grateful for all my colleagues and the serendipitous circumstances.
Developing two podcasts on "what has fMRI taught us about the brain" and "what are the current and future clinical applications of fMRI." Interested in any thoughts, insights, references, links, or people to include in the interviews!
In a few months, my MIT Essential Knowledge book, "FMRI" will be coming out. I wrote a bit about the process and the book itself in my latest blog post.
A strong argument against group mean comparisons for brain structure studies yet a strong motivator to dig into relevant networks and individual variations further.
Last week, NeuroImage invited me to (re)-join their team as Associate Editor, which precipitated the opportunity to write my perspectives as I declined and clarified why. Here is the exchange as I wanted to share more broadly.
One of the more beautiful and insightful papers I've read in quite some time: It addresses what it means to understand the brain mechanistically and across scales - with a compelling argument for network science.
Just in time for
#ohbm2023
we’re happy to announce the relaunch of the Aperture Neuro
@OHBM
’s low-cost open access journal.
Now on a new platform to facilitate quick turn around times for review and publication
If you see any talk at all at
#OHBM
, see Mark Woolrich's Keynote: Mapping Fast Transient Brain Network Dynamics . Such insightful use of fMRI, MEG, and EEG. With this talk, it feels as if the entire field has ratcheted decisively forward.
The legendary Bob Cox
@AFNIman
is retiring. His impact on fMRI has been immeasurable. In his honor, we are putting on a packed Festschrift open to all on Dec 14 from 9 AM to 4:15 PM EST. To register and get the zoom link, go here:
Our NIH summer course has finally started. The first lecture (mine) is available for viewing/download. It's a manic ramble through past present and future of fMRI. There's 35 lectures (3 per week) until the end of August.
I'm working with the NIH to produce podcasts where brain experts at the NIH and worldwide address how neuroimaging can lead to: understanding the brain and/or clinical applications. Here's my interview with Danny Pine - hopefully more to follow!
One of the coolest papers I've seen in quite some time. - coming out of Seong-Gi Kim's lab. "Contribution of Excitatory and Inhibitory Neuronal Activity to BOLD fMRI"
This past summer, Leslie Ungerleider won the Organization for Human Brain Mapping Glass Brain Award - its highest honor. Following the award, she was interviewed by Aina Puce
@aina_puce
. It's both captivating and deeply inspiring.
@OHBM
Since the great
@AFNIman
has retired, we are looking for someone to take over the keys to the NIH fMRI analysis kingdom. The group is extremely well supported - huge opportunity to make an impact on the future of fMRI/multimodal analysis. Apply here:
Devastatingly sad news. My good friend, colleague, and a treasured scientist at the NIH for over 20 years, Dr. Sean Marrett, has passed away today. I wrote a short obituary for him.
The NIH symposium for Leslie Ungerleider just ended. Deeply moving portrayal of her legacy, influence and beautiful qualities. She cared - about the science, the quality of communication, and about all the people she knew. The humanity that permeates the science came through!
Powerful demonstration of the superiority of multi-echo EPI for fMRI "...10 min of multi-echo data yielded better test-retest reliability than 30 min of single-echo data in independent datasets."
Look who's back at the NIH! Renzo Huber
@layerfMRI
has started work our fMRI Core Facility today! We are all so excited to be working with him again! So much fun and fruitful work to be done!
The Functional MRI Facility at the NIH, having two 7T scanners, three 3T scanners, supporting research of 30+ labs across institutes, is starting a search for a staff scientist who will join us to help keep it thriving and cutting edge.
Our paper just out in NeuroImage "Task-based dynamic functional connectivity: Recent findings and open question. Javier Gonzalez-Castillo was first author. Task-based DFC has much unique information to offer!
My section on Functional Imaging Methods at the NIH is looking for a post doc to do research advancing fMRI - anything including acquisition, processing, physiology, and applications! Please contact me if you are interested! Start date is very flexible.
Just back from
#OHBM2022
. The science was outstanding. Underneath - as seen by the shared joy of just being there together - we are all deeply social humans who cherish quasi-random REAL interactions! Now looking forward to two weeks of weeding my yard as it all settles in!
Bharat Biswal
@restingstate
is an old friend and colleague with an unassuming demeanor and a great sense of humor. Here we talk about the serendipity of his discovery of resting state as he was trying to understand the "noise." A few fun anecdotes and some wonderful insights.
The discovery of resting state fMRI changed neuroimaging as we know it. This week on
#Neurosalience
,
@fmri_today
chats with Prof. Bharat Biswal (
@restingstate
), the man credited with its discovery.
Listen on Anchor
Watch on YouTube
We are entering a new age of virtual conferences. Here's a new blog post of few of my thoughts on something we're all going to start to experience more.
An outstanding piece on the past, present, and future of fMRI: covering reliability, ME-fMRI, individual differences, and clinical translation by M.L. Elliot, A. R. Knodt, and A. R. Hariri. Worth a read for everyone who uses fMRI!
And two more from the archives...Bob and Karl, a classic moment. A giant in Neuroscience and brain imaging and a giant in fMRI processing bringing down the house.
Nice study out: on need for 1000's of individuals. A challenge is finding more specific/robust fMRI/structural signatures and using more homogenous populations for comparison. Multi-echo fMRI would help too. I'm hopeful.
I just gave a fun virtual talk today at the Brain Space Initiative - mostly on the last four years of our ventures, innovations, and experiments in layer fMRI
@layerfMRI
...found here:
The Journal Aperture
@ApertureOHBM
has been launched and is open for receiving papers - with over 30 editors ready: Receiving brain imaging methods and applications, papers, data, code, notebooks, tutorials, opinions...
Next week, Feb 18-19, a virtual BRAIN initiative workshop on Dissemination of Non-invasive imaging technologies will be held. No registration required. Agenda is packed with leaders in the field.
Recently I've been thinking more about the unique relationship between the field of fMRI and scanner vendors. I decided to jot them down a bit and welcome any insights, feedback, and comments.
Just finished reading this paradigm shifting and masterfully written book linking inflammation to depression. Best, most satisfying and compelling book I’ve read in a long time! Ed is a great scientist and an absolutely gifted writer.
My fMRI methods development lab at the NIH is still looking for a post doc. This is an opportunity to work with experts in acquisition, analyses, and applications of all things fMRI. High res, dynamic functional connectivity, and more...contact me if you are interested!
As the podcast,
@OHBM
Neurosalience starts its 4th year, I figured I would share with you the link to access all 62 episodes so far. I've had so many great discussions on modeling, structure, function, fMRI, clinical applications, history, and more!
I just published (with
@layerfMRI
and
@esfinn
) a short paper outlining tradeoffs, pulse sequences, processing, and general perspectives on "Challenges and Opportunities of Mesoscopic Brain Mapping with fMRI"
Sad news..Dr. James Hyde, my Ph.D. advisor and pioneer in Electron Spin Resonance and Magnetic Resonance, passed away at 90. Jim was a singular personality and a genius. Deeply insightful, creative, and driven. He will be missed but not forgotten.
The NIH NMR Center has just received delivery of a new 7T Siemens Terra! Congratulations to Alan Koretsky, Lalith Talagala and those here who decided that a broad range of cutting edge applications and questions needed cutting edge technology.
Tip for all scientific speakers: NEVER read your talk. Its immediately apparent and most of the audience’s brains just turn off. Speak naturally and the communication will be much more effective.
Spontaneous thought decoding during resting state: Requires connectivity based identification, deconvolution, then comparison with Neurosynth topics. Great work led by Javier Gonzalez-Castillo!
Something to listen to while self-confining: My latest "Brain Experts" podcast with Laura Lewis on her work pushing the temporal limits of fMRI as well as uncovering the human glymphatic system dynamics during sleep.
When considering impact on all of fMRI,
@AFNIman
and his work ranks very close to the top. AFNI has helped the field to efficiently EXPLORE the data, catalyzing new tools, applications, and insights. We are still trying to understand what the fMRI signal might reveal.
Our lab is starting our search to fill an open post-doc position. We are looking for someone who is passionate about pushing fMRI to its limits. If you are interested, let me know or, better yet, talk with me at OHBM in Singapore.
It was a deep honor and truly a delight to talk with Marsel about his history and the current state of brain imaging. We also discuss his classic 1998 paper "From Sensation to Cognition" which, in my opinion, is among the best ever written.
Dr. Marsel Mesulam, a neurology pioneer and OHBM co-founder, shares insights into his influential career and current research in an engaging conversation with
@fmri_today
in this week's
#Neurosalience
episode.
SP:
YT:
Nice paper by Gore et al, pushing idea that WM contains activity-relevant BOLD signal. Several papers showed this but hasn't caught on. Too subtle or just too difficult to cleanly differentiate from GM partial volume effects? mat
https://pubmed.ncbi.nlm.nih.gov/34999161/
A novel, non-smoothing approach to effectively suppressing thermal noise in fMRI. Potentially transformative for high-resolution studies. I'm interested what you think of this approach.
The tedana (TE dependent analysis) hackathon, organized by
@DanHandwerker
is going strong at the NIH. Working out how to best process multi-echo fmri data.
A key aspect to fMRI and brain imaging in general is to have best practices and standards in sharing and analysis. Here I talk with some leaders in the field working towards this goal and all that it involves. Enjoy!
Our new episode of Neurosalience is now live!
@fMRI__today
speaks to Jack van Horn,
@ten_photos
and
@RemiGau
about the OHBM Committee on Best Practice in Data Analysis and Sharing (COBIDAS). Read how it's tackling the reproducibility crisis in fMRI
READ:
Nice article. The key question is, after 7 months now, are there any successful replications of this study? Please let the twitter-spehere know of your successes and failures.
Over the past year, I have started a podcast: Brain Experts. Here is a brief summary as well as some nuts and bolts of how it got off the ground and a list of podcasts so far.
If you need to learn something related to human brain imaging methods, chances are Andy has made a tutorial about it. He's doing an amazing service to the field! Fun conversation!
New
#Neurosalience
episode is out! Featuring the maestro behind . Andrew Jahn &
@fMRI_today
explore the evolution of learning resources for fMRI analysis, leading up to 'Andy's Brain Book'.
YouTube
Spotify
@saraannhart
Make figures first and keep text super simple. Minimize jargon and clearly define and explain all terms and concepts. Make the point of the paper clear in the abstract, intro, and conclusion. Figure legends stand alone as many just look at the figures. Always try to add insight.
I'm really excited for the opportunity to host this and for wonderful work of the production team! We look to highlight topics, issues, findings, and people. If you have an idea for an episode, please let me know! I'm having a blast discussing all that OHBM is about!
The OHBM Neurosalience podcast is now live! Listen to the 10 min intro episode to find out what’s in store: a discussion between the host, Dr. Peter Bandettini
@fMRI_today
, and one of the podcast production team
@DrStick_Ray
.
Seong-Gi's group is perhaps the best in the world to the replicate DIANA experiment, but unfortunately, the results were negative even at higher field and a more continuous anesthesia protocol. Lots of great discussion ensued between us, and we helped write a paper.
99 years of fMRI experience. A fun trans-Pacific collaboration with late night zooms. But we couldn’t reproduce DIANA fMRI. Read about our attempt here. Comments welcome!
Just back from the High Field workshop at the University of Minnesota CMRR. View talks here... layer fMRI, novel sequences, hardware, new models for neurovascular coupling, DIANA (The author of DIANA, followed by mine on negative results), and much more!
Having fun today testing out our new local head gradient coil from Brian Rutt. 3-axis, torque balanced, insertable in 20 minutes, max gradient 120 mT/m, max slew 1200 T/m/s. Now it's on one of our GE 750's but this could be really useful at 7T and upwards.
Important paper and definitely appreciate how clearly written it is. Throw that task data in with the resting state scans...intrinsic connectivity measures are improved.
Latest preprint from
@NeurogenDuke
We investigate the relationship between scan time and reliability of intrinsic connectivity in 3 samples and demonstrate that adding task fMRI data to short resting-state scans boosts reliability and predictive utility.
Check out this brilliant and engaging
#ISMRM2020
talk by the radiant Renzo Huber showing his latest stunning whole brain VASO layer-resolved fMRI work. He makes a tour de force look easy!
It was an honor to be interviewed! As I have a hard time watching myself, I can say that I think it went well and that I said a few useful and interesting things! Having taken place in Singapore, I'll blame jet lag for anything too nonsensical or controversial.
Our next Oral History interview is with Peter Bandettini.
@fMRI_today
tells us about the start of OHBM and the unique challenges of working in the NIH and gives advice for early career researchers.
Super interesting paper. Brings to light the past controversy of BOLD contrast without clear neuronal activity. Is this additional activation attention, arousal. Is it related to the "global signal?" what are the mechanisms?
fMRI study by
@zviroth
@elimerriam
characterizes hemodynamic response in early visual cortex that is unrelated to visual input but instead reflects engagement in a task, is modulated by expected monetary reward, & may reflect neural quenching
#PLOSBiology