Ed Emmott @edemmott Twitter profile

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Ed Emmott

@edemmott

8 months

The lab has just been awarded an 8-year grant to study coronavirus replication! 🍾🎉 Job ads will appear around end October but we are particularly looking for PDRAs with coronavirus reverse genetics experience or CL3 coronavirus-host interactions. ~Mar 2024 start.

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Ed Emmott

@edemmott

2 years

Confirmed in appointment and a permanent contract (as close to tenured as we get in the uk)! 🍾🎉 Massive thanks to all the lab members, mentors, collaborators and colleagues over the years who made this this happen.

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Ed Emmott

@edemmott

6 years

Just finished the latest @cstross book! In fairness, leaving the EU so we can reinstate the death penalty as human sacrifice to placate the elder god secretly running the government is probably the most coherent and internally consistent argument for Brexit I have heard...

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Ed Emmott

@edemmott

3 years

And its out! My/ @Emmottlab first PI paper “Characterising proteolysis during SARS-CoV-2 identifies viral cleavage sites and cellular targets with therapeutic potential”. This was a huge collaborative effort with 19 authors spanning 4 continents!

Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular...

Nature Communications - During SARS-CoV-2 replication, viral and cellular proteases play crucial roles and have been shown to be promising anti-viral targets. Here, Meyer et al. apply mass...

www.nature.com

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Ed Emmott

@edemmott

3 years

Fellowship wasn’t funded, but will have the whisky anyway. Big thanks anyway to the peer reviewers who were all hugely supportive of the proposal. Hopefully next time!

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Ed Emmott

@edemmott

2 years

Well that’s a good start to the day! Grant awarded 🎉

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Ed Emmott

@edemmott

3 years

Got a good email this morning 🎉! Will be hiring in the near future!

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Ed Emmott

@edemmott

1 year

The new @c4pr_liv single-cell proteomics lab is installed and open for business thanks to recent investment from @acmedsci , @BBSRC , @The_MRC and @LivUni

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Ed Emmott

@edemmott

5 years

I am delighted to announce that the @emmottlab will be opening its doors @c4pr_liv / @livuniIIB on November 1st. The lab will be using #MassSpec approaches, including single-cell proteomics ( #SCoPE2 ) to study positive-sense RNA virus replication and ribosome specialisation.

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Ed Emmott

@edemmott

4 years

Still a trickle of PhD applications coming through - I've put together some tips on applying for science PhDs in the UK - this can differ a little between countries. Other (UK) PI's do you have your own?

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Ed Emmott

@edemmott

4 years

I’m delighted to share the first @emmottlab preprint! In this paper we study protease activity in #SARSCOV2 infected cells. We found multiple unknown cleavage sites in viral proteins, and novel cellular targets of the viral proteases essential for virus replication.

bioRxiv

@biorxivpreprint

4 years

Characterisation of protease activity during SARS-CoV-2 infection identifies novel viral cleavage sites and cellular targets for drug repurposing #bioRxiv

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Ed Emmott

@edemmott

4 years

Paper accepted (middle author) and my first preprint as PI submitted! Today is a good day!

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Ed Emmott

@edemmott

3 years

Date night and celebrating first lab paper acceptance!

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Ed Emmott

@edemmott

3 years

Paper accepted, that’s a good start to the day!

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Ed Emmott

@edemmott

2 years

Looking forward to speaking on proteolysis during SARS-CoV-2 infection and single cell proteomics @CVRinfo later today!

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Ed Emmott

@edemmott

3 years

Keys collected! We now own a house!

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Ed Emmott

@edemmott

3 years

Our final new toy of the year moves into place!!! Can't wait to be running #SCoPE2 single-cell proteomics on this in the new year! @c4pr_liv

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Ed Emmott

@edemmott

3 years

I promised a thread going through our new paper so here we go! We wanted to study protease activity during SARS-CoV-2 infection... why?🧵

Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular...

Nature Communications - During SARS-CoV-2 replication, viral and cellular proteases play crucial roles and have been shown to be promising anti-viral targets. Here, Meyer et al. apply mass...

www.nature.com

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Ed Emmott

@edemmott

2 years

🎉🍾🎉! The @emmottlab will be advertising for a 3-year PDRA position in +ssRNA virology and mass spec-based proteomics in the next few weeks!

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Ed Emmott

@edemmott

3 years

This morning: Eldest: ‘Ed, why did you write a book on the coronavirus?’ Me: ‘That’s my PhD thesis’. Eldest: ‘But it wasn’t around yet!’ Me: ‘It’s not the only coronavirus 😂’

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Ed Emmott

@edemmott

4 years

Talk written! Looking forward to discussing the labs new preprint tomorrow!

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Ed Emmott

@edemmott

2 years

Small grant award on hCoVs! Thats a good start to the day!

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Ed Emmott

@edemmott

2 years

Install complete! Excited to start using our new CellenONE instrument to support single-cell/single-cell proteomics work here in the @c4pr_liv . bioBUBBLE to support higher-containment work should arrive shortly! Huge thanks to @BBSRC for supporting this with 21ALERT funding.

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Ed Emmott

@edemmott

4 years

Its great to see lots of people working on COVID-19 from other disciplines, but perhaps get someone who has actually worked on these viruses before involved? Its fairly painful to keep seeing papers coming out which ignore past coronavirus literature.

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Ed Emmott

@edemmott

1 year

I’ve posted a thread before, but seeing as it’s #phd application time again, time for a recap on how to get your application looked at: Most applications are clearly not competitive from the initial email - you need to get this right.

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Ed Emmott

@edemmott

6 years

Ok, so I’ve identified my future island lair. Now I just need funding to buy it and set up my underground lab... Plymouth's historic Drake's Island fortress on sale for £6m

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Ed Emmott

@edemmott

3 years

Time to celebrate OH’s first day as a consultant medical virologist!

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Ed Emmott

@edemmott

1 year

CellenONE bioBubble for CL2/2+ work installed!

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Ed Emmott

@edemmott

3 years

Is our government actually being run by covid-19 in a Boris suit?

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Ed Emmott

@edemmott

1 year

Paper published and NL63 plaque assay cooperating! A good science day!

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Ed Emmott

@edemmott

3 years

Personal in vivo transfection complete. Fully jab’d!

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Ed Emmott

@edemmott

5 years

It’s how I’d want to go...

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Ed Emmott

@edemmott

4 years

Great to see places stepping up on COVID funding! It would be nice if it was accessible to those of us with prior coronavirus experience, rather than channeling it through silos we can’t access... As a new PI, funding is the biggest obstacle preventing me from contributing more.

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Ed Emmott

@edemmott

3 years

Got the standard toblerone in today’s advent calendar and referred to it as wild-type...

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Ed Emmott

@edemmott

2 years

There’s been a big cat-shaped hole in our family since losing Cinnamon to lymphoma earlier this year, but today things started to get better. Meet Charlie and Cyril :)

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Ed Emmott

@edemmott

5 years

paper accepted :)

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Ed Emmott

@edemmott

4 years

UKRI COVID grant app submitted!

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Ed Emmott

@edemmott

4 years

Great start to the day! Email: 'We read your #preprint and have some data that we think could work well if you want to include in a revision. Lets talk!'. Big plus for #preprints and cooperation in science against #COVID19 !

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Ed Emmott

@edemmott

3 years

Just got feedback on my first set of lectures! It was good 😅🎉. Whisky to celebrate!

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Ed Emmott

@edemmott

4 years

Trying something a bit different this morning. Do you want to support coronavirus research into COVID-19? At Liverpool? I’ve just started a GoFundMe to raise funds in support of @emmottlab ’s #COVID19 research! Please share!

Supporting COVID-19 research at Liverpool, organized by Edward Emmott

I’m raising funding to support my labs research into COVID-19. My name is Ed E… Edward Emmott needs your support for Supporting COVID-19 research at Liverpool

www.gofundme.com

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Ed Emmott

@edemmott

4 years

Today is a pretty good day.

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Ed Emmott

@edemmott

4 years

After a short hiatus - life begins to return to @c4pr_liv as the @emmottlab returns to its coronavirus roots for SARS-CoV-2 work!

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Ed Emmott

@edemmott

4 years

More avoidable stupidity and mixed messages from the government. Not allowed to meet in groups over 6, and advised to avoid socialising, but encouraged to sit in a cinema full of people. BBC News - Boris Johnson urges people to ‘go to the cinema’

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Ed Emmott

@edemmott

2 years

Grant submitted a whole six hours ahead of the deadline!

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Ed Emmott

@edemmott

6 months

4-year lab birthday today! That’s gone fast!

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Ed Emmott

@edemmott

2 years

A benefit of #scitwitter is all the lovely #sciart . Finally treated myself to one which just arrived safely! Thanks @artologica !

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Ed Emmott

@edemmott

3 years

When school tells you to make a cake reflecting something from the last year, and both adults are virologists.... cakeronavirus results.

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Ed Emmott

@edemmott

4 years

Latest essential office addition arrived.

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Ed Emmott

@edemmott

5 years

My first first-author manuscript with @slavovLab and Marko Jovanovic, ‘Ribosome stoichiometry: from form to function’ is now published in @TrendsBiochem . We discuss evidence for, and emerging approaches to study ribosome specialisation. Read it here:

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Ed Emmott

@edemmott

3 years

Sometimes academia is a pretty awful career path. Other days it can be great! Today was the latter! - Seeing lab members getting settled and going so quickly! - First in-person @emmottlab lab meeting! Including welcoming new MSc student Georgia. - First in-person tutee meeting!

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Ed Emmott

@edemmott

4 years

Ah, the joys of writing the personal statement bits in grants. Anyone else die a little inside every time they have to write about themselves for these?

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Ed Emmott

@edemmott

4 years

This mornings breakfast view

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Ed Emmott

@edemmott

4 years

Walked back through the city centre. Lots of crowds, no distancing, few masks. We all want a return to normal, but pretending that it’s all over is just going to result in more cases and another lockdown. If we keep distance and wear masks we can keep things ‘more’ normal.

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Ed Emmott

@edemmott

3 years

We’ve updated our SARS-CoV-2 preprint investigating proteolysis by viral and host enzymes during SARS-CoV-2 infection! Lots of new data, and an author list now covering 4 countries on 3 continents! Read it here:

Characterisation of protease activity during SARS-CoV-2 infection identifies novel viral cleavage...

SARS-CoV-2 is the causative agent behind the COVID-19 pandemic, and responsible for over 100 million infections, and over 2 million deaths worldwide. Efforts to test, treat and vaccinate against this...

www.biorxiv.org

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Ed Emmott

@edemmott

9 months

So, Anna and I just finished making these… #ringram

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Ed Emmott

@edemmott

4 years

Covid grant rejected :/ Time for wine!

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Ed Emmott

@edemmott

3 years

Belated lab birthday celebration after the Euston chaos last week! The @emmottlab is now 2 years old! Lots of excitement over the last 12 months with @StephenNTD , Sophie and Georgia joining the lab and the labs first paper being published!

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Ed Emmott

@edemmott

3 years

After a few years break, I get to return to avian coronavirus research! Thanks Houghton Trust!

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Ed Emmott

@edemmott

3 years

And it’s finally out! Our paper on performing and optimising SCoPE2-based analysis is now out in peer-reviewed form in @NatureProtocols ! You can read it’s preprinted version on @biorxivpreprint here:

Multiplexed single-cell proteomics using SCoPE2

Many biological systems are composed of diverse single cells. This diversity necessitates functional and molecular single-cell analysis. Single-cell protein analysis has long relied on affinity...

www.biorxiv.org

Prof. Nikolai Slavov

@slavov_n

3 years

1⃣Developing a method is just the first step. ✔️ 2⃣Helping others adopt it is the second step 👇 Thanks to @aleks_petelski , @edemmott and the entire @slavovLab team for this @NatureProtocols article!

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Ed Emmott

@edemmott

3 years

Celebrating OH nature paper with burgers. (We’re classy here)

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Ed Emmott

@edemmott

3 years

Email saying a grant outcome is delayed. So ordered ~a kg of nice cheese. That’s a normal, healthy response right?

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Ed Emmott

@edemmott

4 years

Thanks @SelectScience for interviewing on SARS-CoV-2. We covered the role of omics, especially mass-spec, and our latest preprint where we studied changes to the N-terminome following SARS-2 infection, as well as the COViD-19 MSC the lab is a part of!

Understanding SARS-CoV-2-host interactions

We speak with Dr. Ed Emmott, founder of The Emmott Lab & COVID-19 Mass Spec Coalition member, about his latest research

www.selectscience.net

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Ed Emmott

@edemmott

3 years

14yo back from school. All the kids talking about vaccine. Lots hesitant because ‘the healthcare body didn’t think it was safe to recommend to kids’. While this isn’t correct it’s an entirely predictable and avoidable reading of JCVI advice.

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Ed Emmott

@edemmott

5 years

If anyone wants to start playing with TMTpro/16plex in Maxquant (1.6.7.0), you can find my modifications.xml and a mqpar file to load these up for MS2 analysis with correction factors for lot UH290428 at my dropbox folder:

MQ_TMT16plex

Shared with Dropbox

www.dropbox.com

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Ed Emmott

@edemmott

4 years

Covid grant rejected for ‘not having impact within within the next 12 months’. Clinician partner (virologist): ‘are they cracked? I read your grant?!’ Possibly biased but definitely helped my mood :)

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Ed Emmott

@edemmott

4 years

This! There’s decades of work out there on avian coronavirus which has a lot in common with the new data coming out. Just because it’s a ᶜʰᶦᶜᵏᵉⁿ virus doesn’t mean the data should be ignored.

Kevin Maringer (he/they) 🏳️‍🌈🔬🦟🦠

@MaringerLab

4 years

@soragnilab Agreed. We saw the same with Zika. While people from other fields may have much to contribute it’s important to first do the research and read up on the extensive coronavirus literature (from related viruses) already out there.

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Ed Emmott

@edemmott

7 months

Not a bad evening.

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Ed Emmott

@edemmott

3 years

Journals, please don't ask for corresponding authors to input full addresses, emails and telephone numbers for every author on initial submission. Theres 17 on this paper and I'm losing my will to live. An email and institution is fine surely?

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Ed Emmott

@edemmott

4 years

Move-in day waiting for my stuff to arrive. I could get used to the view.

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Ed Emmott

@edemmott

3 years

The @c4pr_liv is getting into high-throughput proteomics with our new @opentrons liquid handler!

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Ed Emmott

@edemmott

3 years

Me attempting to fit my SGM talk to 12 minutes...

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Ed Emmott

@edemmott

5 years

:D

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Ed Emmott

@edemmott

6 months

Actually something positive in the news for once - - chickenpox vaccine finally being made standard for children.

Give toddlers chickenpox jab, advisers tell NHS

All UK children should be protected against the virus at 12 and 18 months of age, advisers tell NHS.

www.bbc.co.uk

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Ed Emmott

@edemmott

1 year

New instrument 2/2 incoming! Hello timsTOF HT!

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Ed Emmott

@edemmott

3 years

@SGriffin_Lab @TigressEllie @jneill @adamhamdy And the constant mention of ‘natural infection’ and ‘natural immunity’ in the press coverage 🤮. Just designed to try and convey that infection is fine and that the nasty vaccine is ‘unnatural’/bad. You wonder if these people actually want things to get better!

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Ed Emmott

@edemmott

3 years

Crosby beach time

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Ed Emmott

@edemmott

1 year

Excellent start to April - latest paper now out! Glad to have contributed - our lab is now using this workflow to study viral PTMs at single-cell level!

Slavov Laboratory

@slavovLab

1 year

Today @naturemethods published prioritized mass spectrometry proteomics. Applying it to single-cell proteomics (pSCoPE), we: ◼️Increased data completeness to 93% ◼️Doubled proteome coverage ◼️Increased the dynamic range

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Ed Emmott

@edemmott

5 years

One month today I start my new job in a different country. It’ll be a busy month 😅!

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Ed Emmott

@edemmott

3 years

Overhearing 7yo remote lesson and they are covering todays international day for women & girls in science 👏

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Ed Emmott

@edemmott

2 years

This weeks fun. Have I run my last manual western?

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Ed Emmott

@edemmott

3 years

Yep. ‘Shocking’ findings unless you’ve studied transmission of GI or respiratory viruses previously, or have children…

Stephanie N. Langel

@stephanielangel

3 years

This part. Not trying to brag but… raise your hand if you always thought kids played a large role in #SARSCoV2 #transmission

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Ed Emmott

@edemmott

7 months

The Recently-Independent Virologists Retreat (RIVR) 2024 will be on Jan 9-10th 2024 (date changed!) in Liverpool. Booking will open in the next week or two. If you are a new group leader in virology in the UK and not yet on the RIVR mailing list please get in touch to be added!

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Ed Emmott

@edemmott

5 years

Now I'm 'website-official' 😃:

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Ed Emmott

@edemmott

3 years

V3 of our preprint on SARS-CoV-2 proteolysis updated: As before, any comments/suggestions... typos... welcome!

Characterisation of protease activity during SARS-CoV-2 infection identifies novel viral cleavage...

SARS-CoV-2 is the causative agent behind the COVID-19 pandemic, and responsible for over 170 million infections, and over 3.7 million deaths worldwide. Efforts to test, treat and vaccinate against...

www.biorxiv.org

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Ed Emmott

@edemmott

1 year

Merry Christmas from the @c4pr_liv !

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Ed Emmott

@edemmott

4 years

I think rather than saying lab-based studies are lacking, or slow to pick up the pace maybe consider why? The near total absence of funding for lab-based studies compared to clinical or epidemiological studies is probably a good place to start.

Harvard Medical School

@harvardmed

4 years

An analysis of studies on SARS-CoV-2 reveals that basic lab-based studies on the microbiology of the virus, including research on its pathogenesis and mechanisms of viral transmission, are lacking (via @medical_xpress )

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Ed Emmott

@edemmott

4 years

First grant of the day submitted. Now coffee time!

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Ed Emmott

@edemmott

3 years

At least half this mornings carriage not wearing masks. Well done @BorisJohnson . You’ve successfully trashed Covid control measures.

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Ed Emmott

@edemmott

3 years

Today I made pie.

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Ed Emmott

@edemmott

1 year

Grant submitted!

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Ed Emmott

@edemmott

4 years

Weird to think it was only a year ago I was living in Boston and had just signed my contract to start my own lab!

Ed Emmott

@edemmott

5 years

I am delighted to announce that the @emmottlab will be opening its doors @c4pr_liv / @livuniIIB on November 1st. The lab will be using #MassSpec approaches, including single-cell proteomics ( #SCoPE2 ) to study positive-sense RNA virus replication and ribosome specialisation.

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Ed Emmott

@edemmott

1 year

After two months buried in grant apps/teaching/conferences, I got to put on my lab coat, pick up a pipette and do some cell culture again. It was great! 🤣

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Ed Emmott

@edemmott

1 year

Girls have been having fun getting me ready for #Eurovision

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Ed Emmott

@edemmott

4 years

Fellowship rejection :/ oh well. Time for some cake!

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Ed Emmott

@edemmott

2 years

Big collaborative grant gone in! Time to celebrate.

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Ed Emmott

@edemmott

3 years

On a brighter note - findaphd hasn't been updated yet, but there is now a fully-funded PhD studentship open for applications on the labs protease/single-cell work. Will repost when updated. Eligibility: UK, Deadline: end May. DM/email with any questions.

Mass-spectrometry-based proteomic analysis of protease activity during SARS-CoV-2 infection at...

PhD Project - Mass-spectrometry-based proteomic analysis of protease activity during SARS-CoV-2 infection at University of Liverpool, listed on FindAPhD.com

www.findaphd.com

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Ed Emmott

@edemmott

3 years

My first play with the @opentrons ot-2 and it’s working great!