Dr. Ron DePinho @RonDePinho Twitter profile

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Dr. Ron DePinho

@RonDePinho

1 year

It’s 3 AM. A wife angrily awaits for her scientist husband to come home. He returns, she demands “where have you been!?” He says, “my colleagues went out for drinks, we met some flirty women and one thing led to another. Wife says, “LIAR! You were in the lab again weren’t you!”

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Dr. Ron DePinho

@RonDePinho

3 years

I’d certainly vote for him. 😉

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Dr. Ron DePinho

@RonDePinho

6 years

My friend Jim Allison just received a call from @JoeBiden on his #NobelPrize announcement.

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Dr. Ron DePinho

@RonDePinho

7 months

Ring of fire #eclipse in San Antonio. Magnificent.

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Dr. Ron DePinho

@RonDePinho

2 years

I completed my BDAY bike-my-age ride. 67 miles. Absolutely everything in my body hurts except perhaps my pride. 😊 I hope to stay healthy for my family, my lab, and the patients we serve. 💪🖖

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Dr. Ron DePinho

@RonDePinho

2 years

Happy birthday @JimAllisonPhD . Your discoveries has produced many more birthdays for others. @PamSharmaMDPhD

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Dr. Ron DePinho

@RonDePinho

6 months

Celebrating ⁦ @JimAllisonPhD ⁩ birthday. Not many bands have two Nobel laureates ⁦ @CarolynBertozzi ⁩

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Dr. Ron DePinho

@RonDePinho

3 years

U.S. physicians are reporting that virtually all hospitalized #COVID patients are unvaccinated. Don't be the last person to die from this virus or cause the death of another. Please #GetVaccinated

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Dr. Ron DePinho

@RonDePinho

2 years

Women are 2X more likely than men to die after receiving a combo of cancer immunotherapy drugs (checkpoint inhibitors). It’s not clear if the difference is due to side effects or because the treatment isn't working. We need more research on sex-specific differences in #cancer

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Dr. Ron DePinho

@RonDePinho

2 years

Hanging out with my 98 year old mommy. Happy Mother’s Day ❤️

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Dr. Ron DePinho

@RonDePinho

3 years

Any questions?

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Dr. Ron DePinho

@RonDePinho

3 years

For CAR-T to be successful in solid tumors, we need to solve key issues: increase trafficking of CAR-Ts to the tumor, maintain T cell viability, improve regimens for CAR-T expansion, and dampen immune suppressive mechanisms in the tumor microenvironment.

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Dr. Ron DePinho

@RonDePinho

3 years

Ninety seven years and going strong. My mom spends her day praying for all of her children, grandchildren and great grandchildren. Pure goodness ❤️

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Dr. Ron DePinho

@RonDePinho

4 years

My dad. My hero. Grew up poor. No education. WWII frontlines in Italy. Returned to live the American dream, own business and put all 5 kids thru college. #GreatestGeneration #GodBlessAmerica

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Dr. Ron DePinho

@RonDePinho

3 years

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Dr. Ron DePinho

@RonDePinho

1 year

The best Christmas gift. Spending time with blessed 98 year young mom. ❤️🎄

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Dr. Ron DePinho

@RonDePinho

2 years

So delighted that @mebottazzi & @PeterHotez have been nominated for the #NobelPeacePrize for their brilliant and compassionate work in developing #CovidVaccines for worldwide distribution. Bravo! 🙌🙏

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Dr. Ron DePinho

@RonDePinho

2 years

Masking up for the immunocompromised for whom the #covid #vaccine does not work. Be safe and #wearamask

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Dr. Ron DePinho

@RonDePinho

2 years

Happy birthday to the greatest mom! 98 years young and going strong. Proud to be your son. Love you mommy! ❤️❤️❤️

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Dr. Ron DePinho

@RonDePinho

1 year

Targeting alternative T cell checkpoints and myeloid suppressors reveals that #pancreascancer can be cured by #immunotherapy in faithful mouse models.

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Dr. Ron DePinho

@RonDePinho

7 months

My adorable 99 year old mommy. ❤️

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Dr. Ron DePinho

@RonDePinho

2 years

Move-in day for Joseph @BrownUniversity 🥲. Applied Math major. So proud of him and grateful for his gift of this totally ‘dad’ T shirt

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Dr. Ron DePinho

@RonDePinho

11 months

Remembering my beloved dad and hero today. Fought for freedom on the front lines in the fierce battle of Monte Cassino. Only one in his company to survive. God bless you dad ❤️🇺🇸

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Dr. Ron DePinho

@RonDePinho

1 year

Congratulations to Celeste Simon UPenn for receiving the ⁦ @AACR ⁩ Lily Clowes memorial award.

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Dr. Ron DePinho

@RonDePinho

4 years

Let’s not get caught flatfooted, again: long term effects from #COVID19

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Dr. Ron DePinho

@RonDePinho

2 years

Identification of tumor-reactive T cells using phenotypic markers is established in treatment-naive tumors. @NatureCancer paper shows CXCL13 is a robust marker that identifies tumor-reactive T cells before and after ICB, tracking with treatment response.

Single-cell meta-analyses reveal responses of tumor-reactive CXCL13+ T cells to immune-checkpoint...

Nature Cancer - Zhang and colleagues analyze single-cell data from patients treated with immunotherapy in five cancer types and find that CXCL13-expressing subsets are implicated in response to...

www.nature.com

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Dr. Ron DePinho

@RonDePinho

4 years

Why I exercise religiously

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Dr. Ron DePinho

@RonDePinho

2 years

Here for the exciting launch of the Allison Institute ⁦ @MDAndersonNews ⁩. Dawn of a new era in cancer cures for our patients.

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Dr. Ron DePinho

@RonDePinho

1 year

Twenty years ago, NCI program officer Suresh Mohla pushed for support of research focused on the TME. The prevailing view at the time was dominated by cancer genomics and cancer cell intrinsic hallmarks. He prevailed and here we are. Thank you for your vision Suresh! @theNCI

Anirban Maitra

@Aiims1742

1 year

The current issue of @Cancer_Cell on a holistic view of cancer - featuring a series of state of the art reviews on the entirety of the tumor ecosystem - is absolute dynamite 💥

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Dr. Ron DePinho

@RonDePinho

11 months

So grateful to be blessed with three amazing kids on this Father’s Day ❤️

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Dr. Ron DePinho

@RonDePinho

2 years

⁦ @POTUS ⁩ Biden remembered my daughter’s names. Class act.

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Dr. Ron DePinho

@RonDePinho

2 years

So pleased and proud to see @POTUS Biden relaunch the #cancermoonshot . A bit of history: I recall fondly our long talk about the idea a year before his rose garden announcement when he was Vice President. Lives will be saved by research and his vision 🙏

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Dr. Ron DePinho

@RonDePinho

3 years

Another year passes. Completed my birthday ritual of biking my age. And, yes, I’m feeling it! Got some drafting help from my awesome friends half way through to bring it home.

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Dr. Ron DePinho

@RonDePinho

3 years

I can attest that a truly decent person will be our next President.

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Dr. Ron DePinho

@RonDePinho

2 years

@POTUS Biden will deliver remarks about the "Cancer Moonshot" today on the 60th anniversary of JFK’s "We choose to go to the moon" speech. JFK’s vision was the inspiration for @MDAndersonNews Cancer #Moonshot , leading to major advances for #cancer patients. 👏💪🇺🇸

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Dr. Ron DePinho

@RonDePinho

3 years

Sad beyond words of the passing of my friend and cancer warrior, Jose Baselga. He was a major force that made precision cancer medicine a reality. His brilliance and courage saved many lives. Rest In Peace 🙏

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Dr. Ron DePinho

@RonDePinho

2 years

Hanging out with Captain Jim on a beautiful day on lake Conroe talking about T cells and life. @JimAllisonPhD @PamSharmaMDPhD

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Dr. Ron DePinho

@RonDePinho

7 months

Congratulations to ⁦ @DavidTuveson ⁩ ⁦ @CSHL ⁩ for his induction into ⁦ @theNAMedicine ⁩ for his critical contributions to pancreas cancer models. 👏👏

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Dr. Ron DePinho

@RonDePinho

3 years

Truly impressive results for Belzufifan (HIF inhibitor) prompts @US_FDA approval of the first drug for Von Hippel-Lindau-associated tumors. Great example of basic science illuminating lifesaving options for our patients. Bravo Bill Kaelin @DanaFarber

FDA Approves First Drug for Von Hippel-Lindau-Associated Tumors

Objective response or stable disease in 100% of renal cell carcinomas

www.medpagetoday.com

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Dr. Ron DePinho

@RonDePinho

1 year

Wishing my mom a very happy Mother’s Day. God willing we will soon celebrate her 99th birthday ❤️

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Dr. Ron DePinho

@RonDePinho

3 years

Although we've cut cancer deaths significantly over 30 years, too many people still suffer and die. Cancer remains the 2nd leading cause of U.S. deaths. This year, almost 2M new cases will be diagnosed and over 600,000 people will die. We can win this war!

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Dr. Ron DePinho

@RonDePinho

5 years

@BeschlossDC Gotta love this letter on Mother’s Day!❤️

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Dr. Ron DePinho

@RonDePinho

1 year

#Covid variants XBB and BQ.1 and BQ.1.1 are spreading around the world. @PeterHotez 's advice for parents: Make sure kids are up to date on their vaccines ... the new bivalent COVID boosters for kids as well as shots for flu and pneumococcus. #axiosvitals

Axios Vitals - Parents brace for the next virus

Flu appears to be peaking and RSV is on the decline. But instead of exhaling, parents are bracing for another wave of illness with an ominous rise in COVID cases.

www.axios.com

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Dr. Ron DePinho

@RonDePinho

3 years

My beloved 96 year old mom finally got her first #covidvaccine in NY. Relieved. We tried multiple times per day to make this happen. NY needs to do better for its citizens.

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Dr. Ron DePinho

@RonDePinho

3 years

Sad news. The passing of a friend and icon dr. Emil Freireich. He served @MDAndersonNews for 50 years and transformed the care of childhood leukemia. A life that saved many. 🙏

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Dr. Ron DePinho

@RonDePinho

2 years

The end of the beginning … off to @BrownUniversity

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Dr. Ron DePinho

@RonDePinho

9 months

Harald zur Hausen, virologist who linked viruses to cancer (1936–2023). A true gentelman whose genius saved millions of lives with his work on #HPV which ultimately led to the #Vaccine

Harald zur Hausen, virologist who linked viruses to cancer (1936–2023)

Nature - Nobel laureate who laid the foundations for vaccines to prevent cervical cancer.

www.nature.com

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Dr. Ron DePinho

@RonDePinho

1 year

Wonderful to hang out with an amazing person and scholar ⁦ @leonard_zon ⁩ ⁦ @harvardmed ⁩. Congratulations on election to the ⁦ @theNASciences ⁩ 👏👏

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Dr. Ron DePinho

@RonDePinho

2 years

Very proud of my former postdoc ⁦ @BoyiGan ⁩ ⁦ @MDAndersonNews ⁩ who is now a leader in ferroptosis and doing his part to train the next generation. His lab is a great one to join.

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Dr. Ron DePinho

@RonDePinho

3 months

ZERO! Cases of cervical cancer among nearly 30,000 Scottish women, ages 24 to 32, vaccinated as girls against #HPV , a virus which causes the cancer.

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Dr. Ron DePinho

@RonDePinho

1 year

Thank you to the entire team who collaborated on this important study. Targeting T cell checkpoints 41BB and LAG3 and myeloid cell CXCR1/CXCR2 results in antitumor immunity and durable response in pancreatic cancer.

Targeting T cell checkpoints 41BB and LAG3 and myeloid cell CXCR1/CXCR2 results in antitumor...

Nature Cancer - Gulhati et al. demonstrate therapeutic efficacy for combinatorial administration of 41BB agonist, LAG3 antagonist and a CXCR1/2 inhibitor in murine pancreatic cancer models,...

www.nature.com

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Dr. Ron DePinho

@RonDePinho

6 months

The one an only THE EDGE. A truly gifted artist and wonderful person. 🙏

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Dr. Ron DePinho

@RonDePinho

5 years

At the @EIHonors ceremony with my friend @drsanjaygupta . Congratulations for receiving the Ellis Island Medal of Honor.

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Dr. Ron DePinho

@RonDePinho

11 months

Very proud to share the amazing work of Jiexi Li, a rock star graduate student @MDAndersonNews , whose intelligence and determination answered a long standing mystery in cancer biology @Nature 👏

MD Anderson Cancer Center

@MDAndersonNews

11 months

A preclinical study revealed that KRAS regulates a Y chromosome gene driving metastasis and reducing anti-tumor immunity, offering novel insights into the sex-based disparities in #ColorectalCancer outcomes. @RonDePinho @JiexiLiPhD @Nature #KRAS #EndCancer

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Dr. Ron DePinho

@RonDePinho

1 year

Presence of alternative immune checkpoints 41BB and LAG3, combined with CXCR1/2 inhibitor, can reprogram the highly suppressive immune microenvironment of pancreas cancer. @NatureCancer #PancreaticCancer #immunotherapy

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Dr. Ron DePinho

@RonDePinho

1 year

My birthday ride (one day early). Beautiful sunny 70 degree day in #Houston . Slow but steady. Grateful to be healthy 🙏

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Dr. Ron DePinho

@RonDePinho

2 years

Symposium honoring Doug Hanahan who has all of the hallmarks of a great scientist, mentor and colleague. Thank you ⁦ @Johanna_A_Joyce ⁩ ⁦ @CoukosGeorge ⁩ 👏👏

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Dr. Ron DePinho

@RonDePinho

4 years

Annual birthday bike ride #65yearsyoung

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Dr. Ron DePinho

@RonDePinho

7 months

A must-read: Vaccine Research and Combating the Anti-Science Movement Go Hand in Hand @PeterHotez

Opinion | Vaccine Research and Combating the Anti-Science Movement Go Hand in Hand

An excerpt from Hotez's new book, The Deadly Rise of Anti-Science

www.medpagetoday.com

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Dr. Ron DePinho

@RonDePinho

3 years

One of his great qualities... he listens

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Dr. Ron DePinho

@RonDePinho

3 years

I took Alexis to Biden’s Xmas party in 2015, then 11 months later at MD Anderson’s 75th celebration, I brought alexis to our table and he said “alexis how have you been? I miss you”. He made a 15 year old girl feel respected and special. A truly good man.

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Dr. Ron DePinho

@RonDePinho

3 years

Nothing more beautiful than biology

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Dr. Ron DePinho

@RonDePinho

3 years

That’s earth from Mars. We are a spec of stardust riding thru the universe.

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Dr. Ron DePinho

@RonDePinho

1 year

Stunning beauty. Torres del Paine, Chile.

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Dr. Ron DePinho

@RonDePinho

1 year

Monica Bertagnolli will become head of NIH

Recently named cancer institute director may become head of NIH

Cancer researcher Monica Bertagnolli would take position vacated in 2021 by geneticist Francis Collins

www.science.org

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Dr. Ron DePinho

@RonDePinho

6 months

Grateful to ⁦ @katyperry ⁩ for supporting public health. 🙏

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Dr. Ron DePinho

@RonDePinho

6 months

Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. Accurate, fast and cheap ($3) assay detected this endogenous retroviral protein ORF1p in blood of patients with a variety of cancers: Ovarian, esophageal, CRC, etc.

Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Expression of the transposon protein LINE-1 ORF1p is pervasive in cancer, and the development of improved plasma ORF1p assays demonstrated highly specific pan-cancer utility with promise in early...

aacrjournals.org

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Dr. Ron DePinho

@RonDePinho

7 months

Here ⁦ @theNAMedicine ⁩ with one of its newest members and inspiration to many women scientists. #nobel

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Dr. Ron DePinho

@RonDePinho

4 years

The #1 cancer preventive is you. Practice a healthy lifestyle; avoid smoking, eat a good diet, get plenty of exercise and sleep, and practice stress management.

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Dr. Ron DePinho

@RonDePinho

6 years

Jim Allison has been a good friend and colleague for decades. I am so happy he won the #NobelPrize for his groundbreaking work in #Immune therapy. Honored to be with him in #NYC for the announcement. His science and passion has saved and will continue to save many lives.

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Dr. Ron DePinho

@RonDePinho

2 years

⁦ @ednacukierman ⁩ ⁦ @UNC_Lineberger ⁩ cancer center annual symposium. Rock star in defining the role of the stromal fibroblasts in the tumor microenvironment.

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Dr. Ron DePinho

@RonDePinho

1 year

Congratulations to ⁦ @kevansf ⁩ for the ⁦⁦ @theNASciences ⁩ award recognizing his breakthrough development of the KRAS inhibitor for #cancer . 👏

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Dr. Ron DePinho

@RonDePinho

4 years

Major breakthrough in our #COVID19 battle.

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Dr. Ron DePinho

@RonDePinho

9 months

A new class of molecules designed by Gerry Crabtree and Nat Gray which can tether cancer drivers to transcriptional activators to turn on pro-apoptotic gene expression. Very creative. @Nature

Rewiring cancer drivers to activate apoptosis

Nature - A new class of molecules can recruit downstream transcription factors or endogenous cancer drivers to cell death promoters and activate the expression of these genes.

www.nature.com

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Dr. Ron DePinho

@RonDePinho

2 years

Good memories with my friend ⁦ @katyperry ⁩

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Dr. Ron DePinho

@RonDePinho

5 years

Here in #Stockholm to see @MDAndersonNews Jim Allison receive the @NobelPrize tomorrow for his lifesaving work in #immunotherapy . Very exciting moment for all cancer researchers and patients. #endcancer #NobelPrize

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Dr. Ron DePinho

@RonDePinho

23 days

⁦ @MaraShermanLab ⁩ delivers a phenomenal talk on the role of pancreatic stellate cells in #pancreatic #cancer @aacr #aacr24 . Elegant, impactful work 👏👏👏

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Dr. Ron DePinho

@RonDePinho

3 years

Getting my shot at life. Wonderful to see the great team spirit of our ⁦ @MDAndersonNews ⁩ vaccinators who are saving lives #COVID19vaccine . Remember that vaccines don’t save lives, VACCINATIONS save lives. #VaccinesWork 😷

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Dr. Ron DePinho

@RonDePinho

3 months

I survived my bday ride of 69 miles 😰

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Dr. Ron DePinho

@RonDePinho

6 months

Doing SOUL MAN with the one and only - my bro man - ⁦ @JimAllisonPhD ⁩ and the amazingly talented ⁦ @CarolynBertozzi ⁩ on the keyboard 😎

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Dr. Ron DePinho

@RonDePinho

3 months

Deeply saddened to share that beloved colleague and respected scientist Judy Campisi has passed away. Groundbreaking discoveries in aging, devoted mentor, generous colleague, and incredible friend. She was the heart of the aging field. She will be missed 🙏❤️

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Dr. Ron DePinho

@RonDePinho

4 years

Anti-science condemns us to suffer tremendous losses from SARS-CoV2.

Prof Peter Hotez MD PhD

@PeterHotez

4 years

How does this even make any sense? It was a real honor for me to work with the White House Office of Science & Tech Policy when I served as US Science Envoy in the Obama Administration 2015-16. Hate to think that office became contaminated like the CoV Task Force?

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Dr. Ron DePinho

@RonDePinho

3 months

@WHO OKs low-cost #COVIDVACCINE developed @TexasChildrens @bcmhouston . Notably, its developers didn’t seek patent protection and freely licensed it to Biological E Limited, a global vaccine supplier based in India. $1.90 per dose. Bravo @PeterHotez & team to help the forgotten.

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Dr. Ron DePinho

@RonDePinho

1 year

Grateful to my biking brothers who inspired me to finish my 68 mile bday ride. 🙏🚴‍♂️

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Dr. Ron DePinho

@RonDePinho

2 years

⁦ @AACR ⁩ lifetime achievement award Tony Hunter ⁦ @salkinstitute ⁩ Many lives saved thanks to his his genius and discovery of tyrosine phosphorylation leading to TKIs. #endcancer 👏🙏

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Dr. Ron DePinho

@RonDePinho

11 months

Four generations from 9 months to 99 years. Love you mom ❤️

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Dr. Ron DePinho

@RonDePinho

10 months

Getting ready to celebrate mom’s 99th birthday! Pictured here with four generations.

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Dr. Ron DePinho

@RonDePinho

1 year

So excited to return to my #bronx roots to give a seminar at ⁦ @EinsteinMed ⁩. I owe much to the caring and gifted mentors of this special institution 🙏

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Dr. Ron DePinho

@RonDePinho

3 years

Something ain’t right when the #covid virus is afforded more reproductive rights than women in #texas .

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Dr. Ron DePinho

@RonDePinho

2 years

Hard to fathom that my boy is now all grown up and on his way to ⁦ @BrownUniversity ⁩. Missing him already 🥲

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Dr. Ron DePinho

@RonDePinho

5 years

Cervical cancer can be eliminated. We must do more to prevent this deadly disease

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Dr. Ron DePinho

@RonDePinho

5 years

Photos after the #NobelPrize with Jim Allison, Pam Sharma, Robert Allison, Fred Alt and @LyndaChin

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Dr. Ron DePinho

@RonDePinho

1 year

A new day. Beautiful sunrise over Brooklyn. I ❤️ NY.

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Dr. Ron DePinho

@RonDePinho

3 months

My visceral response to reviewer #3 has left me frozen.

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Dr. Ron DePinho

@RonDePinho

1 year

Having no friends is as deadly as smoking. Being with happy people makes you happier. And, finally, life is short, drink good wine. 🍷

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Dr. Ron DePinho

@RonDePinho

3 years

If clinically validated this RAS G12D inhibitor will be a game changer for many cancer patients. @MDAndersonNews @MiratiTx strategic research and development collaboration in solid tumors

MD Anderson and Mirati Therapeutics announce KRAS strategic research and development collaboration...

MD Anderson and Mirati Therapeutics today announced a strategic research and development collaboration to advance two new targeted therapies targeting two of the most frequent KRAS mutations in...

www.mdanderson.org

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Dr. Ron DePinho

@RonDePinho

2 years

My hero, my dad, our veteran (WWII). Miss him every day. 🇺🇸

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Dr. Ron DePinho

@RonDePinho

3 years

I'm pleased to share our review on "Metabolic Codependencies in the #Tumor Microenvironment" in @CD_AACR , together with exceptional #cancer scholars @prasenjitdey and @aleckimmelman .

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Dr. Ron DePinho

@RonDePinho

2 years

A beautiful mind who illuminated the path for women in science, unleashing the genius of half of humanity. Her greatest impact. 🙏👏

NRG Oncology

@NRGonc

2 years

Today is Marie Curie's birthday. She was the first woman to win a Nobel Prize, the only woman to win 2 Nobel Prizes & whose groundbreaking research led to the development of #radiotherapy . We celebrate Marie & all the amazing women working in radiation oncology. #WomenWhoCurie

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Dr. Ron DePinho

@RonDePinho

1 year

"Harnessing the Power of Discovery" @CD_AACR editors affirm commitment to publishing fundamental insights into cancer biology, recognizing the importance of basic science, which forms the foundation for translational and clinical studies. Bravo 👏

Harnessing the Power of Discovery

Summary:. Cancer Grand Challenges is an international funding initiative that aims to unite the world's best scientists to tackle some of cancer's toughest challenges by funding team science on a...

aacrjournals.org

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