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Gaurab Chakrabarti Profile
Gaurab Chakrabarti

@GaurabC

3,341
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md/phd using biology to solve hard problems, co-founder & CEO of @Solugen . Thoughts on chemicals, climate, and cancer

United States
Joined December 2008
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@GaurabC
Gaurab Chakrabarti
2 years
'21 was a great year for biotech advances. Of course, mRNA was the year's star thanks to COVID. However, there were 5 other biotech advances that were ridiculously exciting, too. A thread:
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@GaurabC
Gaurab Chakrabarti
1 year
What does humanity look like in 1 million years?
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@GaurabC
Gaurab Chakrabarti
6 months
I asked chatGPT to create 8-bit/pixelated versions of climate tech startups in DALL·E 3. I'm digging this future. 1. @CFS_energy fusion reactor
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@GaurabC
Gaurab Chakrabarti
1 year
@sama That ideas and technologies take off based on how will they are distributed and communicated (60-70%) and not just on how good the idea or tech is (30-40%).
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@GaurabC
Gaurab Chakrabarti
2 years
2.) @DeepMind 's AI solving protein structure AlphaFold was able to help solve protein structures that have remain un-resolved for years. Many predicted structures were comparable in quality to experimental structures.
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@GaurabC
Gaurab Chakrabarti
2 years
1.) Ultrasound as an on/off switch for cell therapies Off-target toxicity of CAR T therapy is an issue due to premature activation. This @UCSanDiego team solved this by engineering a gene circuit in CAR T cells activated by ultrasound at the tumor site
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@GaurabC
Gaurab Chakrabarti
2 years
3.) Artificial nose Using the olfactory receptor from mosquitos, this group made a sensor to detect octanol to part per billion levels in human breath. This could be a cool breath-based diagnostic or a way to record and present scents in the metaverse.
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@GaurabC
Gaurab Chakrabarti
2 years
5.) Deeply implanted sensors that don't need battery power Using ultrasound, this group was able to create implantable sensors that could measure oxygen levels CENTIMETERS deep within a tissue.
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@GaurabC
Gaurab Chakrabarti
1 year
@BornAKang To demonstrate the level of their wealth
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@GaurabC
Gaurab Chakrabarti
2 years
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@GaurabC
Gaurab Chakrabarti
2 years
4.) Atomic resolution for electron microscopy imaging Solving two major issues in electron microscopy, this group relied on ptychography, a technique that uses coherent scattering and multiple overlapping illumination to increase EM resolution
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@GaurabC
Gaurab Chakrabarti
3 years
From our $7000 PVC reactor in 2017 to our pilot plant optimizations in 2018 and 2019, to introducing our 10,000 tpy Bioforge that sequesters and offsets over 30,000 tpy of CO2 equivalents...we are just getting started!
@sethbannon
Seth Bannon 🌻
3 years
This is what scaling up synthetic biology looks like. Let’s end the climate crisis. Let’s improve safety by ending plant explosions. Let’s make products that are carbon negative. Let's build our sustainable future with synthetic biology. @solugen 's Bioforge is this future.
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@GaurabC
Gaurab Chakrabarti
1 year
Wild to the think that the last ice age (20k yrs ago) was “only” an avg of ~4C colder than it is today. Makes you realize that an avg increase of 4C will be quite dramatic.
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@GaurabC
Gaurab Chakrabarti
2 years
What makes a geological formation ideal for CO2 storage? The 4 most important criteria: 1. Formation porosity and permeability 2. A depth >800 meters 3. An impermeable caprock 4. Thick and continuous over a large area Why?👇
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@GaurabC
Gaurab Chakrabarti
2 years
Of course, this list isn't exhaustive and there were many, many cool advances that I'm sure will shape much of the research landscape in 2022!
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@GaurabC
Gaurab Chakrabarti
6 months
This is a really big deal for @solugen . I suspect we’re now just starting our Golden years of productivity
@solugen
Solugen
6 months
🚨Expansion Alert! We're excited to announce our second Bioforge, part of a strategic partnership with ADM. This new facility will allow us to meet growing demand for our sustainable products & drive innovation in new markets. Full announcement here:
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@GaurabC
Gaurab Chakrabarti
6 months
Everyone wants to be in climate tech, but no one wants to calculate the mass balance.
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@GaurabC
Gaurab Chakrabarti
2 years
Loving the @lowercarbon holiday gift! mother-in-law: What does Unf Double Star K mean? me: It's a cult thing MIL: Oh that's sweet. love working with this team. thanks, @sacca & @claydumas !
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@GaurabC
Gaurab Chakrabarti
1 year
2023 prediction: distributed biomanufacturing will be the 'it' thing. (obviously a little biased, <3 @solugen
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@GaurabC
Gaurab Chakrabarti
3 years
expecto patronum, but for carbon dioxide instead of Dementors
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@GaurabC
Gaurab Chakrabarti
2 years
This piece on @solugen is doubly exciting for me because it was @ashleevance ’s biography on @elonmusk that gave me the courage to marry deep tech and business to start Solugen. Also, the intro is hilarious…but don’t huff gasoline kids
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@GaurabC
Gaurab Chakrabarti
2 years
Shout out to the best solo-capitalist I’ve ever worked with, @zalzally from @refactor ! Most humble vc with killer instincts. Has helped us logic through some hard decisions @solugen & knows exactly the right q’s to ask even when he’s not the expert in a topic
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@GaurabC
Gaurab Chakrabarti
6 months
@typesfast Yea but water doesn’t inhibit adenosine receptors, which leads to less water reabsorption () p.s. thank you for giving me an opportunity to use my medical degree. Now back to slinging chemicals
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@GaurabC
Gaurab Chakrabarti
6 months
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@GaurabC
Gaurab Chakrabarti
2 years
The fractal brilliance of cabbage
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@GaurabC
Gaurab Chakrabarti
6 months
An important update to the scientific method…
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@GaurabC
Gaurab Chakrabarti
3 years
Can we just stop investing in garbage and just focus all of our money and efforts on fixing this shit? We need a WWII like effort with the smartest people focused on global warming and nothing else #ClimateCrisis
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@GaurabC
Gaurab Chakrabarti
1 year
@proetrie Andrew Wakefield publishing vaccine link to autism.
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@GaurabC
Gaurab Chakrabarti
1 year
What’s not going to change in 10 years?
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@GaurabC
Gaurab Chakrabarti
1 year
Texas friends: don’t forget to disconnect and drain your hoses!
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@GaurabC
Gaurab Chakrabarti
3 years
@swetac That carbon sequestration isn’t going to get us out of this. We need to stop burning fossil fuels
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@GaurabC
Gaurab Chakrabarti
2 years
Thank you @sethbannon ! I’m quite convinced that financial success always follows impact
@sethbannon
Seth Bannon 🌻
2 years
🔥 Co-founder / CEO @GaurabC at the Solugen board meeting today: "It's important to remember why we're here. Our mission at Solugen is to reverse climate change. That's it."
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@GaurabC
Gaurab Chakrabarti
3 years
@sacca @solugen Thanks @sacca . We’re looking into Bay Area for next r&d facility
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@GaurabC
Gaurab Chakrabarti
1 year
The quality of my Twitter feed seems to be declining. Anyone else noticing this?
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@GaurabC
Gaurab Chakrabarti
6 months
@Rainmaker1973 Same chin energy
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@GaurabC
Gaurab Chakrabarti
5 months
Man, I wish people would get this riled up about climate tech leadership
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@GaurabC
Gaurab Chakrabarti
2 years
Calling this language is a stretch...but it is amusing to think that fungi are just chatting it up on the forest floor, telling eachother hilarious jokes. Such fun guys.
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@GaurabC
Gaurab Chakrabarti
2 years
Climate change is not the problem. It is a consequence of the problem.
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@GaurabC
Gaurab Chakrabarti
1 year
Industrial retrofits are just getting started! When we started @solugen , our first Bioforge facility was built on an old polyethylene wax distillery that exploded and blew out all of the windows in a 5-mile radius.
@environment
Bloomberg Law: Environment
1 year
New Jersey is shifting towards maximizing cheap, renewable energy. Watch the implosion of the Logan Generating Station.
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@GaurabC
Gaurab Chakrabarti
3 years
Would totally binge a @netflix series just on the stories of different Gringotts vaults. Probably the only show on a bank I’d watch tbh
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@GaurabC
Gaurab Chakrabarti
6 months
Happy Diwali! May the Light keep us all energized
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@GaurabC
Gaurab Chakrabarti
2 years
One of the best @solugen deep-dives I've seen
@Jeff_Burke14
Jeff Burke ⠕
2 years
1/ @solugen : The first carbon negative molecule factory Just two months ago, @solugen raised +$350M to scale their solution to building carbon negative chemicals Their breakthrough may be one of the most pivotal unlocks to fighting climate change Let me explain what they do:
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@GaurabC
Gaurab Chakrabarti
1 year
Ideas and technologies take off based on how will they are distributed and communicated (60-70%) and not just on how good the idea or tech is (30-40%).
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@GaurabC
Gaurab Chakrabarti
1 year
Hybrid biological and ai beings?
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@GaurabC
Gaurab Chakrabarti
1 year
Sometimes I worry deep tech companies over index on being a “platform tech” as an excuse to be unfocused. Difficult to build a predictable revenue business if nothing gets to the finish line.
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@GaurabC
Gaurab Chakrabarti
6 months
10. and of course, @solugen decarbonizing chemical manufacturing using the bioforge
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@GaurabC
Gaurab Chakrabarti
3 years
@sacca spot on as usual. So lucky to have him and @claydumas as investors in @solugen . Now, if you’ll excuse me, going back to work to unfuck our planet.
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@GaurabC
Gaurab Chakrabarti
3 years
@MaxCRoser @paulg While this is correct, if folks *think* they are doing something to be sustainable, they are more likely to conduct activities that might actually be far more sustainable
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@GaurabC
Gaurab Chakrabarti
1 year
The fact that world's adult diaper sales might soon outpace baby diaper sales should be a concern for population collapse.
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@GaurabC
Gaurab Chakrabarti
1 year
The single greatest biological waste product in the history of the earth? Oxygen. Re: photosynthesis
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@GaurabC
Gaurab Chakrabarti
1 year
👀
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@GaurabC
Gaurab Chakrabarti
6 months
2. @Climeworks direct air capture plant
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@GaurabC
Gaurab Chakrabarti
2 years
Taking a breather with our friend Herbert
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@GaurabC
Gaurab Chakrabarti
3 years
As usual, @sacca taking things to the next level! Thanks for all you do to unfuck the planet at @Lowercarbon and for the @solugen shoutout
@HarryStebbings
Harry Stebbings
3 years
This is one of the most proud I have ever been releasing an episode. This with @sacca covers everything from parenting to relationships with money to investing in Uber & Twitter and more. To Chris, for making this 7 year wait so fricking worth it. 🚀
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@GaurabC
Gaurab Chakrabarti
6 months
9. @living_carbon plants enhanced to store more co2
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@GaurabC
Gaurab Chakrabarti
12 years
Very cool: @CellCellPress : #ABCsHumanDisease : As a guide to our review issue, we're going from A-Z, highlighting Tx for common diseases
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@GaurabC
Gaurab Chakrabarti
2 years
This is the single greatest Chief Scientist in climate. @CarbonWrangler is a boss!!
@Carbon_Direct
Carbon Direct
2 years
It's official: Dr. Julio Friedmann (a.k.a. the @CarbonWrangler ) has joined Carbon Direct as full-time Chief Scientist to catalyze the #carboneconomy
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@GaurabC
Gaurab Chakrabarti
4 months
The harsh truth about the chemicals industry is that sustainability isn’t as critical to customers…yet. The hierarchy of what gets chemical customers over the finish line: 1. Price point 2. Product performance 3. Consistent delivery and availability 4. Sustainability
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@GaurabC
Gaurab Chakrabarti
2 years
The first lesson of understanding China is to ignore what they say to the West and pay attention to what they say to others.
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@GaurabC
Gaurab Chakrabarti
6 months
3. @fervoenergy geothermal energy
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@GaurabC
Gaurab Chakrabarti
1 year
Feels like all the crypto bois are now ChatGPT/AI experts ("How ChatGPT will change [X] forever"). I hope this doesn't ruin the value of a legit technology.
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@GaurabC
Gaurab Chakrabarti
1 year
I think this is why if you’re thinking big, you HAVE to think about infrastructure, real estate, and localized economies. It is the key to the problem.
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@GaurabC
Gaurab Chakrabarti
3 years
@HarryStebbings You should check out how @solugen does this with its BioForges in the chemicals industry --> Sell bioreactors and then sell our catalysts on a recurring basis:
@sethbannon
Seth Bannon 🌻
3 years
This is what scaling up synthetic biology looks like. Let’s end the climate crisis. Let’s improve safety by ending plant explosions. Let’s make products that are carbon negative. Let's build our sustainable future with synthetic biology. @solugen 's Bioforge is this future.
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@GaurabC
Gaurab Chakrabarti
1 year
@paulg Growing chemicals and materials @solugen
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@GaurabC
Gaurab Chakrabarti
2 years
@TrungTPhan You should checkout how @solugen used cancer cells as an insight to make the world's most efficient chemical plants!
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@GaurabC
Gaurab Chakrabarti
6 months
The finest deeptech founders and scientists discuss their failed experiments with as much enthusiasm as their breakthroughs. Mistakes will be made, but that's good because it means decisions are being made.
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@GaurabC
Gaurab Chakrabarti
2 years
But if it takes you 20+ years to turn off the tap bc of lobbying, you might need to soak up some of that overflowing water...
@CharlieJGardner
Dr Charlie Gardner
4 years
Carbon capture sounds nice and all, but if your bath is overflowing you don’t invest in magical technologies to soak up the water from your floor. You turn off the tap
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@GaurabC
Gaurab Chakrabarti
3 years
@paulg Just wait till you meet the company with Rick and Morty as co-founders
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@GaurabC
Gaurab Chakrabarti
2 years
Tardigrades can take a 30 year break from being alive and just get right back to it like nothing ever happened.
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@GaurabC
Gaurab Chakrabarti
2 years
Would make great value investors
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@GaurabC
Gaurab Chakrabarti
6 months
4. @BoweryFarming vertical farming
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@GaurabC
Gaurab Chakrabarti
1 year
@paulg High-integrity carbon offsets.
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@GaurabC
Gaurab Chakrabarti
1 year
Carbon sequestered
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@GaurabC
Gaurab Chakrabarti
4 years
@andrewchen While measles virus certainly has much higher R0, the symptoms are much more apparent and more quickly recognizable vs those with COVID. Thus, the ability to detect measles quickly helps contain its spread despite the virus having an R0>10. COVID spread is much more insidious
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@GaurabC
Gaurab Chakrabarti
7 months
@shaylekann @IanRountree sell stuff. make money. that's my deeptech playbook
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@GaurabC
Gaurab Chakrabarti
3 years
Today, we're so excited to announce that Dr. David Weiner has joined Solugen as our VP of Technology. His experience and accomplishments in biomanufacturing are unparalleled, having brought multiple products/companies to scale as well as IPO and acquisit…
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@GaurabC
Gaurab Chakrabarti
6 months
Fuel's dilemma: competing against fossil fuels demands colossal scale. Yet, many cleantech startups leap before they look, aiming to dethrone giants like Shell overnight. It's like trying to become Amazon without first mastering the art of selling books. Strategy isn't just…
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@GaurabC
Gaurab Chakrabarti
2 years
@elamadej probably a more efficient way to teach compassion to large groups of people
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@GaurabC
Gaurab Chakrabarti
1 year
Finish that book in your bag. A well read book is better than an unread, well-travelled one.
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@GaurabC
Gaurab Chakrabarti
1 year
People falling for scammers. The scams will likely change, but people won’t
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@GaurabC
Gaurab Chakrabarti
2 years
Learned that @DannyDeVito produced GATTACA…this man’s talent knows no bounds @alwayssunny
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@GaurabC
Gaurab Chakrabarti
6 months
This is why I’ve bet my career on building physical things.
@jburnmurdoch
John Burn-Murdoch
6 months
NEW: Generative AI is already taking white collar jobs An ingenious study by @xianghui90 @oren_reshef @Zhou_Yu_AI looked at what happened on a huge online freelancing platform after ChatGPT launched last year. The answer? Freelancers got fewer jobs, and earned much less
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@GaurabC
Gaurab Chakrabarti
1 year
How many induction stove companies about to get started?
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@GaurabC
Gaurab Chakrabarti
3 years
With longer term space travel becoming real, I wonder what drugs will become ‘hot’? Radioproctectants and “bone health” medicines come to mind
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@GaurabC
Gaurab Chakrabarti
1 year
SPACtacular Ventures: A PE fund that buys out SPAC'ed companies with terrible valuations, but real revenue.
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@GaurabC
Gaurab Chakrabarti
2 years
2021 was a great inflection point for climate, we can’t forget this positive momentum despite the scary data. I’m hoping 2022 will continue with this momentum!
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@GaurabC
Gaurab Chakrabarti
6 months
8. @FormEnergyInc grid scale energy storage using batteries
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@GaurabC
Gaurab Chakrabarti
3 years
@morganhousel , this one’s an instant classic tbh
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@GaurabC
Gaurab Chakrabarti
3 years
@paulg Started this practice while going through ycw17. Got the cheapest notebooks we could find, yet they contain the most important learnings for @solugen
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@GaurabC
Gaurab Chakrabarti
6 months
5. @H2GreenSteel Green steel manufacturing
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@GaurabC
Gaurab Chakrabarti
6 months
6. @PureCycleTech plastic recycling
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@GaurabC
Gaurab Chakrabarti
3 years
This is the flex we need
@demishassabis
Demis Hassabis
3 years
Last year we presented #AlphaFold v2 which predicts 3D structures of proteins down to atomic accuracy. Today we’re proud to share the methods in @Nature w/open source code. Excited to see the research this enables. More very soon!
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@GaurabC
Gaurab Chakrabarti
9 months
@wolfejosh Or chemicals
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@GaurabC
Gaurab Chakrabarti
2 years
OH folks using ammonia and pneumonia interchangeably. Both can kill you one from a chest infection the other from a tragic cleaning accident…
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@GaurabC
Gaurab Chakrabarti
1 year
I’ve made this mistake twice in hiring, thinking the second case was different bc of the person. False. It’s always the same
@gokulr
Gokul Rajaram
1 year
Founders: If a Title is the only reason someone won’t accept a role, it’s a huge red flag. With a Titleless company, you can weed out such candidates quickly.
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@GaurabC
Gaurab Chakrabarti
1 year
Perhaps another example of when one should not “move fast & break things”
@AkshatRathi
Akshat Rathi
1 year
I know this is not the main point, but this startup pumping sulfur into the atmosphere is selling carbon offsets tied to something they know they cannot measure or verify. AND THERE ARE PEOPLE BUYING IT.
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@GaurabC
Gaurab Chakrabarti
1 year
@ElliotHershberg You should take a look @solugen Bioforges!
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@GaurabC
Gaurab Chakrabarti
1 year
@KennethHayworth What is preventing individuals discussing this?
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