The world celebrated the World DNA day last month. And here are stories of DNA of many kinds - how Lewy bodies might be impacting the DNA containing nuclei of cells, how gene expression is controlled by RNAi pathway & using DNA to understand ourselves:
#COVID19India
#COVID19
#coronavirus
In light of the many reports on coronavirus variant N440K lately, we would like to bring to your attention a few things:
1. The mutant is not new. We have been seeing it in South India since last year.
@CSIR_IND
@AndhraPradeshCM
(1/3)
More๐๐พ
From testing of DRDO and Dr Reddy Lab's 2-DG (2-deoxy-D-glucose) on coronavirus in cell culture at CCMB to successfully clearing the phase 3 trials, it will now be used on moderate to severe COVID-19 patients. DCGI approval has come.
Training on for doctors and academics from microbiology depts of hospitals of Warangal and
#Hyderabad
. They will be trained on RNA isolation and one-step RT PCR to test for
#COVID19
with reagents suggested by
@ICMRDELHI
. More trainings with more folks to happen the next few days.
Many congratulations to Avni Blotra for securing the Royal Society for Tropical Medicine and Hygiene Early Career Grants Award 2022. She will look into toxicity of venom components that stay after partial neutralisation by the Indian polyvalent antivenom against snakebites.
Here is a fresh preprint on genome analysis of SARS-CoV2 spread in India. The results show that a distinct cluster of virus population, uncharacterized thus far, which is prevalent in India - called the Clade A3i. (1/2)
3. Our main focus as a community should be on reducing the spread of coronavirus. The more it spreads, the more variants come up, the more mess we create by increasing uncertainties and fear.
So, see ๐๐พ
2. Though in controlled cell culture this variant makes more copies, it does not necessarily mean that it can compete with other variants just the same way in a real life pandemic where new variants keep coming up. Our genome studies say that N440K is now diminishing
(2/3)
More๐๐พ
Here is our next story in
#IAmAScientist
series. This time, we hear it from Manjula Reddy on how her career grew from loving chemistry to now mapping bacterial cell wall growth, and opening up new avenues in fighting
#AntibioticResistance
.
#WomenInSTEM
We license the dry swab direct RT-PCR COVID19 testing method to Capital Health Services India Pvt Ltd for commercialization. Way to go for ramping up COVID19 testing across the country.
@AIC_CCMB
@CSIR_IND
Mask up, avoid crowds by all means, maintain hygiene and good ventilation, and take your vaccine shots. They all help in preventing the spread of the virus in one way or the other.
Fin
Our brand new cryo-electron microscopy facility is up and running now. Inaugurated by
@shekhar_mande
, DG,
@CSIR_IND
, the facility will be open to scientists across research institutes, univs and industries to look at structures at atomic details.
#cryoEM
#structuralbiology
We understand you might be stressed and confused of what to do and avoid during these unprecedented times. Here is a list from us (thanks to
@WHO
guidelines) to chart out a roadmap for safer & healthier work spaces. Share these posters among others, and help them plan better too!
We r offering a new genetic testing method-Optical Genome Mapping, imaging tech to detect genomic abnormalities. Dubbed โNext gen cytogeneticsโ, clinical labs r adopting it globally coz it offers btr res vs current mol tech+detects a wide range of large genomic abnormalities. 1/3
A physicist came to understand biology and asked questions that were thought non-existent. Here's a story that shows why diverse thoughts and views make for better science research. This is Sankaranarayanan's journey by
@Visualscitories
&
@SomdattaKarak
.
Faster testing is the need of the hour in COVID19 surge. We are positive dry swab based direct RT-PCR testing will be a game-changer. With existing infrastructure it will ramp up testing 2-3 fold. We are training ICMR-approved labs. Book your slot now.
Time for the next
#CCMBBiologue
- this time with
@OdedRechavi
from
@TelAvivUni
on transgenerational memory. He will talk of RNA inheritance in nematodes that help in transmitting parental experiences into their progeny, and impacting their behavior.
We have started training volunteers for
#COVID19
#diagnostic
testing using RT-PCR. We start with students from
@HydUniv
and
@csiriict
. Video call for the theoretical discussions and in lab for the nitty gritty of doing the actual tests. ๐ช to more testing in Telangana!
Many congratulations to Sankaranarayanan for his election as EMBO Associate Member this year. 67 new members from 22 countries join the
@EMBO
community of 1900 plus members, shaping the roadmap of life science research.
Read more here:
CCMB's PhD applications for the Jan 2024 program is now open:
Ours is a place for life scientists to explore biology across scales, from molecules to cells to populations. If this interests you, apply soon!
The 10,000 Genome Project led by CCMB,
@IGIBSocial
,
@FollowDbtNibmg
and
@CBR_IISc
with 16 other institutes is now completed! This is a key milestone towards finding Indian population specific genetic variants & working towards more effective healthcare.
Here is a new series - I'm a Scientist. Through this, we want to show you the spirit of scientists at CCMB, the questions that drive them and challenges they want to resolve. We start with
@Mihir_Tri
's story who is navigating his path as a young researcher
CCMB is looking for scientists with expertise in computational biology, infectious disease biology, plant biology, ecology & evolution, and structural biology. Check out the details here:
@CSIR_IND
@IndiaBioscience
Have you been inside a BSL-3 lab that grows virus? If not, take a sneak peek into how ours looks like, which is busy growing
#coronavirus
for vaccine development to testing drugs and disinfectants. Article by
@SomdattaKarak
@CSIR_IND
#CSIRfightsCOVID19
#longthread
With
@csiriict
we did a study from 10 Sewage Treatment Plants (STP) and a gated community in Hyderabad to look for SARS-CoV-2 RNA. These STPs get 40% of sewage in the city. We estimated viral load in those samples using RT-PCR.
@CSIR_IND
1/n
Many congratulations to GR Chandak for the JC Bose fellowship.
He focuses on understanding the genetics and epigenetics of complex diseases such as diabetes and pancreatitis.
Read more on his work here:
@CSIR_IND
Many congratulations to Radhika Khandelwal, PhD student with Yogendra Sharma, at CCMB for her selection in the upcoming
@lindaunobel
Laureate meeting. It's truly a privilege and pleasure to be represented by our students on such a forum.
@CSIR_IND
Study from
@Jahnavijoshi2
's lab highlights the ecological richness of Western Ghats of India. It hosts plant species evolved across mns of years incl the more recently evolved. It's a living museum of plant species, supporting birth of new species too.
1/2
This Technology Day, CCMB celebrates the achievements of our scientists in fighting COVID-19 pandemic. We have newer testing methods, grown coronavirus and used it for developing vaccines, sequenced the virus and looked at its air-borne transmission - to name only a few.
Join us on Apr 24, 11am onward to understand the coronavirus. With experts from CCMB, we will talk of how the virus spreads, how it changes with time, how we avoid its spread and changing, how to manage the disease it causes.
Join here for the discussion:
Did you think biology and maths are apart from each other? Let's look into the beauty of shapes in life forms in the next
@CBiologue
on 17 Aug. Manu Prakash
@PrakashLab
from
@Stanford
will make us think of geometry of cellular forms.
@CSIR_IND
CCMB Open Day happens today on the campus PHYSICALLY after a gap of 2 years. We couldn't be more thrilled about inviting all the excited people, especially the children to show our work. If you are in Hyderabad today, CCMB is where you want to be!
@CSIR_IND
Many congratulations to Parijat Sarkar for the NASI-Young Scientist Platinum Jubilee Award 2021 in the field of Bio-medical, Molecular Biology and Bio-technology.
@CSIR_IND
Running a science lab requires many skills that lab heads are often not trained in. And this is why
@EMBO
,
@IndiaBioscience
and we are conducting courses on lab leadership. Apply by 1 Apr.
Many congratulations to Thangaraj for his JC Bose Fellowship. This is a recognition to active scientists for their outstanding achievements. Check more on Thangaraj's work here:
@IndiaDST
@serbonline
@CSIR_IND
Many congratulations to Amit Chattopadhyay for the GN Ramachandran Gold Medal by CSIR, India. It is an award to celebrate scientists with outstanding contribution in progressing human knowledge in their field of specialization in India in the last 10 yrs.
Many congratulations to
@meiosiva
for the third prize in the INYAS-SARANSH Three Minute Thesis Competition.
This was a national competitions for PhD students to present their thesis work in a 3 min non-technical ppt accessible to non-experts.
History, politics and molecular biology - all come together here. This is one story of how DNA fingerprinting technology was used at CCMB to find remains of a popular icon. These remains that aim to protect people's history.
1/2
@ccmb_csir
The Inter Ministerial Central Teams members visit us today to understand how we conduct the
#Covid19
tests. This is key for policymakers to check preparedness of testing centres across the country.
@CSIR_IND
Many congratulations to
@BhartiDpuram
on winning the third place in poster presentation at Early Career Biogeography Conference, Amsterdam by the International Biogeography Society. She presented her work on the drivers of genetic diversity in soil predatory arthropods.
#LaCONES
Many congratulations, Sankar to be a Board of Reviewing Editor at
@eLife
! Sankar's lovely work in understanding structure and function of proteins makes this possible. Check more on his work here:
Presenting the latest story from Sankaranarayanan lab - one that started ~900 million years back in choanoflagellates, the unicellular ancestors of multicellular animals, on how policing in protein production machinery got more sophisticated in animals.
CCMB now has a working platform to develop mRNA vaccines. In principle, one can insert an mRNA to make a protein of a pathogen of concern in our cells. This can train the recipient's immune system to evade the real pathogen, if it infects.
@CSIR_IND
Our dry swab-based direct RT-PCR testing is a simple, inexpensive and safe method for
#coronavirus
#diagnostics
, approved by
@ICMRDELHI
. In this method, sample collection centres can send the dry swab samples directly to testing centres, w/o the liquid Viral Transport Medium.
1/n
Many congratulations to Sharada for the second prize in poster presentation at the Indian Zebrafish Investigators Meeting (IZIM), 2022 held at IISER Pune.
@CSIR_IND
Many congratulations to GR Chandak for being elected as the Fellow of The World Academy of Sciences (TWAS) in recognition of his contribution to science and its promotion in the developing world.
@CSIR_IND
Time for us to start growing the
#coronavirus
in human lung epithelial cells - a system closer to reality. So far we had been growing them in cells from monkeys. This will be done in a public-private collaboration with
@EyestemResearch
#CSIRfightsCOVID19
If you have some experience with RNA handling and want to work in
#COVID19
testing, we are now training interested volunteers. Fill the form, and join the drive.
Finally, here it is... After lots of discussion... We
@ccmb_csir
have planned to train the interested volunteers for
#COVID19
testing ... Let's unite to fight against covid19
Please fill your details here
Finally we are gearing for an Indian genome database. It is important for us, as a country to have our own genome database because our population genome is unique, and different from the western population's database that is used today as a standard.
Being there for the tigers even as we go through one of the biggest crises of the century. A white tiger with neoplastic growth is being treated at
#LaCONES
with
#COVID19
precautions. This takes well-trained vets invested in the purpose. A happy
#InternationalTigersDay2020
!
Puran's group figures out a novel technique for gene delivery in malarial parasite, Plasmodium falciparum. Their technique brings in a cheaper possibility that can work in low-resource setting - a usual scenario in malaria endemic regions.
@CSIR_IND
Many congratulations to Priyadarshini Sanyal, PhD student from Vinay Nandicoori's lab for her best poster award at the Biological Transactions - From Molecules to Organisms (BTMO 2023) conference, held at IISc from 18-21 Jan.
@CSIR_IND
Our PhD applications are now open. From what makes living populations to the atomic details of biomolecules, CCMB offers lab working in biology across scales.
Check details here:
Apply by Mar 31!
@CSIR_IND
@AcSIR_India
Science communicators, take note of this
#CCMBBiologue
! This time we bring you
@samillingworth
. He will talk on poetry and games can start a dialogue between scientists and non-scientists.
Join us on Feb 12, 6pm IST (12.30pm GMT):
#scicomm
@CSIR_IND
Here are our freshly minted resources on keeping workplaces clean and healthy during
#COVID19
in Hindi. Thanks
@Mihir_Tri
for the translations.
@CSIR_IND
What a moment of pride and happiness it is for all of us! Many congratulations, Sankar! It is his fundamental work on understanding fidelity in protein synthesis machinery in our cells. Check more of his work here:
Ramesh Sonti's long & rigorous works to understand interactions between rice plants and disease causing bacteria led to development of the blight resistant Samba Mahsuri rice. A story of work to advance science, which then found its way to people's lives.
#science
#technology
Time for academia and industry to come together to fight the
#COVID19
. Together with VINS BioProducts Ltd we aim to develop vaccines against
#SARS_CoV_2
. We'll provide the viral culture and testing platform, they bring their expertise with antisera development.
#CSIRfightsCOVID19
Come, join us on Fb live tomorrow 10.30am on to discuss how
@CSIR_IND
labs have come together to face and fight COVID-19 in multiple ways. From PPE development to diagnostics to surveillance and drug development - we bring you all of this together in coherence.
#CSIRFightsCovid19
Join us tomorrow with
@joshiamitabhevo
at
@CBiologue
at 4pm. If you are a biologist, you will know the interest in looking for molecular mechanisms of traits in organisms. In this session, he will challenge this quest as an illusion.
We eagerly await
@ICMRDELHI
's approval for our dry swab testing method for
#COVID19
.
#NeedoftheHour
is faster testing methods without compromising on sensitivity. And this method is expected to save both time & money at current sensitivity.
We show an alternate technique using RT-nested PCR, equally sensitive as RT-qPCR. This method needs a simple PCR machine. This increases the possibility of many more labs doing COVID-19 tests thereby expanding testing capacity. (1/2)
@SivakumarPraka2
An Inexpensive RT-PCR Endpoint Diagnostic Assay for SARS-CoV-2 Using Nested PCR: Direct Assessment of Detection Efficiency of RT-qPCR Tests and Suitability for Surveillance
#bioRxiv
Dr
@drharshvardhan
unveils the Foundation stone of the Skilling, Training and Lecture Hall complex at CCMB. Our training programs, number of public events and our academic activities will get an extra boost with the complex up in the next one year.
Check out
@epis_tama
's story in our latest I am a Scientist series. Inspired by Sherlock Holmes and Feluda, she has become a detective too. She unravels the mysteries of cell membrane and its functioning.
Art by
@Visualscitories
, words by
@SomdattaKarak
Our Faculty Training Program for Genetics and Molecular Biology seeks applications from college teachers. Scan the QR code in the poster to find more details.
Apply here by 31 Dec:
CCMB is organizing OMICS-2021, the 13th Annual meeting of Proteomics Society of India. Join us and discuss the most cutting-edge developments using tools of genomics, proteomics, lipidomics and metalobomics.
Early registration ends Sept 30, 2021
@CSIR_IND
Conjunctivitis cases are on a rise in Hyderabad. Our clinician scientist, Karthik Bharadwaj advises on how to go about caring for yourself and your loved ones.
@CSIR_IND
Journalists, please take note. There is no data for us to yet say that the new virus population (Clade A3i) among Indians is any more or less dangerous than the other virus population (Clade A2) present here.
Here is a fresh preprint on genome analysis of SARS-CoV2 spread in India. The results show that a distinct cluster of virus population, uncharacterized thus far, which is prevalent in India - called the Clade A3i. (1/2)
Pluripotent stem cells can divide in 2 ways. They either give rise to more stem cells or specialized cell types & tissues of the body. The decision between the two is regulated by a protein named Nanog. A new paper by Chandra Shekar's lab
@emboreports
shows how this happens. 1/n
#ClimateChangeChallenge
2020 is here with a series of online interactive sessions for class 8-12 students and teachers (not just the science teachers). We will build
#changemakers
in
#schools
who will be empowered to understand & fight
#climatechange
in their local context (1/n)
It's time we pay attention to hygiene in shared toilets. They are notorious for spreading many microbial infections. And fluid dynamic studies now warn against the dangers of formation of aerosols containing the coronavirus, after an infected person flushes the toilet.
Many congratulations to GR Chandak for the Sun Pharma Science Foundation Research Awardees-2021 under Medical Sciences - Clinical Research.
Find more about his work here:
@CSIR_IND
@SunPharma_Live
Different cells have different antigens on their surfaces. There are antibodies which can specifically bind to these antigens. Many point of care
#diagnostic
devices immobilize antibodies on surfaces, and are used to find their partner antigens. Also used in blood typing (1/2)
Many congratulations to Dr Sonti. His work on understanding plant immunity has been phenomenal. Our Improved Samba Mahsuri rice has been a product of long work on plant physiology that his group has focused on.
Dr. Ramesh V. Sonti (Director, NIPGR) has been awarded "Prof. K. K. Nanda Memorial Lecture award 2019" of the society for his outstanding contributions in the field of Plant Physiology & Cognate Sciences, on Dec19, 2019, during Nat. Conf. of Plant Physiology at Kerala Agr. Univ.
Both D and L amino acids are present in our cells. Though D aa have important physiological roles, they are not used in building proteins. How does the protein building machinery know to choose one over the other?
@kuncha_santosh
et al review the current understanding, here.
Kuncha, Kruparani and Sankaranarayanan comprehensively review D-amino acids with respect to their occurrence and physiological roles, implications for chiral checkpoints required for translation fidelity, and potential use in synthetic biology
Congrats to Dr Manjula Reddy of โฆ
@CCMB_csir
โฉ for the โฆ
@InfosysPrize
โฉ in Lifesciences - her research brings hope for new classes of antibiotics
Congratulations to Sravanti Vaidya from the CCMB Research Grants team for bagging the Indian Research Management Initiative award from
@India_Alliance
.
@CSIR_IND
Saying yes to the new normal with
#CCMBBiolgue
. The good part - it is easier for us all to connect with stalwarts across the world. We start the series with Prof Grant Jensen. He'll talk on 'Potentials of electron cryotomography in unraveling the fundamentals of a cell' (1/2)
We are a country of more than a billion who look, speak and live differently. But when we looked into our DNA, it tells the story of our common ancestry from Africa, who started inhabiting India 65,000 years ago. Watch this video for more on this
#MiloCCMB
It is September. And that means it is time for CCMB's Open Day. We will be online and open for all from 23-26 Sept. There will be experimental demonstrations, discussions with scientists and competitions.
Please RT for better visibility.
1/2