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Asimov Press

@AsimovPress

2 months

We're excited about this one: We're openly sharing biology-focused story ideas that we’d like to publish. Check out the list and let us know if you’d like to write on any of these subjects! We’ll help you at every step along the way, and then pay you :)

Stories We'd Like to Publish

A list of essay ideas that we'd like to publish. Up for grabs!

press.asimov.com

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Asimov Press

@AsimovPress

3 months

Making the First Transgenic Ants 🐜 After seven years of work, ants were made to express a calcium sensor in their sensory neurons. When the ants detect pheromones, the sensor proteins fluoresce and can be used to directly record brain activity. Read:

Making the First Transgenic Ants

Engineered ants are helping to reveal the neuroscience of pheromone signaling.

www.asimov.press

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Asimov Press

@AsimovPress

30 days

Tinker is a short story about an AI that designs the chips needed to train its successors. Written by @RichardMCNgo , it weaves together themes in synthetic biology and chip fabrication to imagine a plausible future. Read & subscribe:

Tinker

A short work of speculative fiction.

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Asimov Press

@AsimovPress

9 days

Our first book about scientific progress, Origins, is now available. We learned a lot about printing—and starting a magazine—while creating this book. So we decided to write an essay about it! Buy the book, support our work, and learn more. 🔻

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Asimov Press

@AsimovPress

5 months

Welcome to Asimov Press, a new publishing venture that features writing about biology. Our magazine and books will cover a broad range of topics, including biosecurity, vaccine development, and the long arc of progress in genetic engineering. Learn more:

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Asimov Press

@AsimovPress

1 month

It was a joy to talk to @ElowitzLab about the dawn of synthetic biology. We asked: - Is the cell actually like a computer? - Is synthetic biology overhyped? - Why have physicists repeatedly made such great contributions to biology? Read & subscribe here:

Synthetic Origins

Michael Elowitz on the early years of synthetic biology and the programmability of living cells.

press.asimov.com

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Asimov Press

@AsimovPress

2 months

Our latest piece is about the “epigenetic-driven” theory of aging, and how we can reverse epigenetic damage at the cellular level. It was a pleasure to work with @ArtirKel on this one! Read it here:

Making Cells Young

In the laboratory, cellular reprogramming can reverse epigenetic damage and reset cells to a "young" state. Can we do the same for entire organisms?

press.asimov.com

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Asimov Press

@AsimovPress

16 days

7 billion male chicks are killed each year in the egg industry, simply because they can't lay eggs. New technologies can prevent this. In today's essay, @robert_yaman explores "pre-hatch" technologies that improve animal welfare. Read & subscribe:

Before They Hatch

New technologies, such as in-ovo sexing, on-farm hatching, and in-ovo vaccination can make the poultry supply chain both better for animal welfare and more efficient.

press.asimov.com

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Asimov Press

@AsimovPress

14 days

We visited @CultivariumFRO ! Cultivarium is a nonprofit building tools to help scientists work with 100+ non-model organisms -- not just E. coli and yeast. We'll publish an essay about their work for a forthcoming book. Thanks for the tour, @hhlee and Nili Ostrov!

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Asimov Press

@AsimovPress

5 months

The first Issue of our magazine will appear in March 2024. Its core theme will be Biosecurity, but we also have space for essays on other topics. Please pitch us at editors @asimov .com. A bit more on what we're looking for...

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Asimov Press

@AsimovPress

1 month

Today's essay tells the story of how artemisinin, a drug that has saved millions of lives, was found by Chinese scientists as part of a secret military project in 1971. @WendiYan5 went deep into the archives, drawing upon newly published Chinese texts.

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Asimov Press

@AsimovPress

23 days

Mars is the only serious candidate for terraforming. The moon has no atmosphere and Venus is too hot. But just how feasible is life on the Red Planet? In today's essay, @StorkDevon illuminates why nothing can grow on Mars* (*probably) Read it here:

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Asimov Press

@AsimovPress

3 months

Fast Biology 🚀 Cells are crowded and very fast places. Sugar molecules cruise at 250 mph, and ATP-making enzymes whip around 134 times per second. But these numbers seem made up. How do we know they're real? Our first editor's column, by @NikoMcCarty .

Fast Biology

Living cells are frenzied, crowded places. Numbers help us make sense of it.

www.asimov.press

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Asimov Press

@AsimovPress

3 months

We are seeking speculative fiction pieces, especially those that imagine positive and plausible biological futures. We pay $1,000 for short stories. Please send drafts to editors @asimov .com. Read on for more details...🧵

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Asimov Press

@AsimovPress

3 months

Scaling Phage Therapy 📈 Bacteriophages are viruses that kill bacteria. For 100+ years, many have hoped that they could save us from the growing threat of untreatable, drug-resistant infections. So why haven't they? 🧵

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Asimov Press

@AsimovPress

4 months

Announcing "Satellites." These are essays that briefly describe a biological idea. Our first: A beautiful piece by @trevor_klee , who explains how scientists can learn from Toyota's "Five Whys" approach to identify the root cause of molecular problems.

What Science Can Learn from Car Mechanics

Taiichi Ohno, a Japanese engineer who helped to create the Toyota Production System, once described a five-step system to identify the root cause of a problem. That same system should be applied to...

press.asimov.com

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Asimov Press

@AsimovPress

3 months

What synthetic biology topics would you like to see us cover in future articles? We'll add them to our list of ideas and commission writers to do it!

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Asimov Press

@AsimovPress

2 months

Our first piece of fiction is now live! THE VECTOR ZOO explores a future wherein a portion of humanity has given up on controlling vector-borne diseases, instead sheltering within sealed suits and sterile cities. Is there a better way forward?

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Asimov Press

@AsimovPress

4 months

Making the Micropipette A seminal tool for every wet-lab scientist, a micropipette is used to transfer small volumes of liquid. It laid the foundation for modern biology. Our first essay uncovers the inventors and lawsuits that made it all possible.🧵

Making the Micropipette

The innovation and litigation behind biology’s most ubiquitous tool.

www.asimov.press

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Asimov Press

@AsimovPress

2 months

Today’s essay examines potential scales for biomanufacturing, both below and above the level of the cell. Big thanks to @ElliotHershberg for working with us on this one. Read it here:

Beyond Steel Tanks

GLP-1 drugs could one day outsell iPhones, but there is not enough biomanufacturing capacity to make them. For solutions, we should look away from the factory.

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Asimov Press

@AsimovPress

4 months

All of our published essays now have registered DOIs. This will help us track how articles are cited over time, and (somewhat) quantify the impact that our published work makes on biotechnology research.

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Asimov Press

@AsimovPress

4 months

Researchers have been intentionally infecting people with pathogens for centuries. But the number of "challenge trials" almost doubled from the 2000s to the 2010s. What accounts for their newfound popularity? And how do we measure their value? 🧵 Read:

Deliberate Dysentery

The intentional infection of human beings with pathogens under study has been going on for centuries, but the number of challenge trials almost doubled from the 2000s to the 2010s. What accounts for...

press.asimov.com

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Asimov Press

@AsimovPress

3 months

In our latest piece, @Tom_J_Ireland , author of the book, "The Good Virus," explains why. Tom also highlights how synthetic biology and computational algorithms are resolving some of the long-standing challenges in using phage to treat patients. Read:

Scaling Phage Therapy

What it will take to transform bacteriophages into a 21st-century medicine.

www.asimov.press

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Asimov Press

@AsimovPress

16 days

Apply for this writing fellowship from our friends at Roots of Progress! We've greatly enjoyed working with @Atelfo , a fellow in the first cohort, on a piece that will be published in our second book.

Jason Crawford

@jasoncrawford

16 days

Announcing the 2024 @rootsofprogress Blog-Building Intensive, the second cohort of our 8-week program for aspiring progress writers to start or grow a blog. Learn about progress studies, get into a regular writing habit, improve your writing, and build your audience

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Asimov Press

@AsimovPress

5 months

Speculative Fiction We're after pieces that imagine positive, and plausible, biological futures. Science, rather than characters or plot, should be the focus. Explanations of technologies should be detailed and mechanistic. We really like "Lena" by qntm.

Lena

This was a very quick first draft, written in around two hours as part of my 30 More First Drafts project. You can now read the finished short story. This article is about the standard test brain...

qntm.org

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Asimov Press

@AsimovPress

5 months

Photo Essays Biotechnology is not only done in sterile, white-walled labs. There are entire gene-editing facilities devoted to algae and mosquitoes. But what do they look like? Photo essays demystify biotechnology by showcasing equipment, people, and places.

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Asimov Press

@AsimovPress

3 months

Fomites are inanimate objects that can spread pathogens. They were a secondary cause of a massive SARS outbreak in 2003 that infected 329 people in a Hong Kong apartment complex and killed 42. Engineered materials -- including cellulose sprays -- could help prevent a repeat. 🧵

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Asimov Press

@AsimovPress

3 months

Come join us!

Niko McCarty 🧫

@NikoMcCarty

3 months

On March 7th, @AsimovPress will host its first(!) event. It's a Sci-Fi Writing Night. Come start a short story, meet other writers, and hang out. The event is 5:30-7:30pm in downtown Boston. RSVP here! Or please share with others who might be interested.

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Asimov Press

@AsimovPress

4 months

This essay was written by @Meta_Celsus and will appear in Issue 01. It's fitting that our first essay for Asimov Press, a magazine about biotechnology, is about the underappreciated tool that made this field possible. Read it here:

Making the Micropipette

The innovation and litigation behind biology’s most ubiquitous tool.

press.asimov.com

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Asimov Press

@AsimovPress

3 months

In our latest piece, @tomough weighs the pros- and cons- of microbe-killing materials and sprays, including bleach, copper, and graphene. But a surprising winner emerged: cellulose, a sugar that plants use to build cell walls. Read:

Blocked Transmission

Fomites are inanimate objects that can transfer pathogens. What are the best materials and sprays to inhibit their spread?

www.asimov.press

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Asimov Press

@AsimovPress

5 months

Essays (1,200-2,000 words) An essay should explain a new way of thinking. We're after “timeless” articles that will inspire readers, and open up their eyes to a new facet of biotechnology. We love classics from Hamming, Feynman, etc. and hope to do the same for biology.

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Asimov Press

@AsimovPress

3 months

What might the world look like if a certain kind of biotechnology existed? What is the cost of not developing this technology? We’re excited by fiction that is evocative enough to encourage researchers to overcome a bottleneck or develop a new idea.

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Asimov Press

@AsimovPress

16 days

In-ovo sexing technologies allow farmers to identify which eggs will hatch into males and which will produce females. Male eggs can then be removed and destroyed before they feel pain.

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Asimov Press

@AsimovPress

16 days

To read more about how these pre-hatch technologies work, check out the full essay! Read:

Before They Hatch

New technologies, such as in-ovo sexing, on-farm hatching, and in-ovo vaccination can make the poultry supply chain both better for animal welfare and more efficient.

press.asimov.com

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Asimov Press

@AsimovPress

3 months

Predictive AI tools can also support the development of synthetic phages. These ‘ideal phages’ could be made with only the genes strictly necessary to infect and kill the bacteria at hand and be manufactured close to where they will be administered to treat a patient.

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Asimov Press

@AsimovPress

3 months

Cold-sprayed copper kills more than 99.9% of bacteria over two hours. A sprayable coating, derived from cellulose, also dries out materials about 50% faster than evaporation alone. It causes cells to dry out and die. Cellulose sprays are cheap and effective.

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Asimov Press

@AsimovPress

16 days

Two technologies for in-ovo sexing are already available at commercial scales. Last year, the in-ovo sexing capacity in Europe increased by 60 percent. And it was recently announced that in-ovo sexing is coming to the U.S. in 2025!

A Simple New Technique Could Make Your Eggs More Humane

A system that determines the sex of chicks before they hatch eliminates the need to destroy young males.

www.nytimes.com

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Asimov Press

@AsimovPress

23 days

If @StorkDevon and his research nonprofit manage to make a microbe capable of living on Mars, we may get closer to civilization in the stars. If they fail, they'll still discover useful things for life here on Earth. Read & subscribe here:

Why Nothing Can Grow on Mars*

Water is the most significant bottleneck in terraforming the Red Planet

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Asimov Press

@AsimovPress

3 months

Some examples of pieces we love: Lena Story of Your Life They May As Well Grow on Trees

They May as Well Grow on Trees—Asterisk

The Future of Genetically Engineered Livestock

asteriskmag.com

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Asimov Press

@AsimovPress

2 months

This piece was written by @AlexandraBalwit , a founding editor. You can read the article on our website here:

The Vector Zoo

Please note: The Arcade of Intentional Extinction will be closed for renovations between December 5th, 2126 and March 1st, 2127

press.asimov.com

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Asimov Press

@AsimovPress

3 months

The diversity of phages makes them a challenge to regulate. Regulators want to see a single, stable, well-characterized drug before giving the green light for it to be tested in a clinical trial, not dozens of different viruses; let alone ones that are often found in filth.

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Asimov Press

@AsimovPress

5 months

Deep Dives (2,500+ words) Data-driven explorations of a story, technology, place, or person. These pieces clearly describe key challenges, and articulate how biotechnology — or other means — are being used to solve them. These articles shed light on how hard-won progress can be.

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Asimov Press

@AsimovPress

3 months

Phages have been used to treat chronic infections, mostly in the former Soviet Union, since the 1920s—but were virtually forgotten in the Western world. But now, with at least 1 million people dying from drug-resistant bacterial infections every year, interest has resurged.

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Asimov Press

@AsimovPress

23 days

By combining extremophilic traits from organisms on Earth, a research nonprofit called Pioneer Labs hopes to demonstrate the "limits of life." They will combine genes and pathways found in microbes that have evolved high resistance to UV radiation, temperatures, and so on.

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Asimov Press

@AsimovPress

4 months

@weischoice It typically ranges from $500 for short ~1,000 word pieces to $2,000 for a 'Deep Dive'. More details on our article formats:

Pitch Guide

Asimov Press is commissioning essays, speculative fiction, books, and photo essays. Here's what we're looking for.

press.asimov.com

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Asimov Press

@AsimovPress

16 days

Poultry accounts for 96 percent of land animals eaten by Americans––far more in number than cows or pigs. Therefore, the poultry sector holds the clearest promise for technology to improve animal welfare.

Yearly number of animals slaughtered for meat

An interactive visualization from Our World in Data.

ourworldindata.org

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Asimov Press

@AsimovPress

16 days

Some poultry farms in the U.S. house more than 5 million chickens. The largest cow feedlots rarely break 100,000. With so many animals packed in one place, it's hard to guarantee their welfare. Fortunately, technology excels in areas where scalability is a key challenge.

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Asimov Press

@AsimovPress

16 days

20 million chickens die during transport each year in the U.S. On-farm hatching can reduce this. @VencomaticGroup offers one such technology; farmers place soon-to-hatch eggs in trays. When the chicks hatch, they fall a safe distance to the floor.

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Asimov Press

@AsimovPress

23 days

Any effort to terraform Mars is up against serious challenges––low pressures, biting temperatures, and toxic soil. More critically, Mars has very little available water; most of it is frozen in the poles (where temperatures plunge to -100°C) or else is extremely salty brines

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Asimov Press

@AsimovPress

3 months

Antibiotics cost as little as a few cents per dose while some of these bespoke phage products based on automated analysis of patients’ bacterial samples are likely to work out in the region of $20,000 per treatment. (In Georgia, phage therapies are sold over the counter.)

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Asimov Press

@AsimovPress

3 months

A few reasons: Phages are far more demanding to deploy than chemical antibiotics. For one, they are particular. There are estimated to be around 100 million different species of phage, and each one is incredibly choosy about which bacteria it will infect.

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Asimov Press

@AsimovPress

5 months

@merri_catherine No. We're always open for pitches. Issues will be published every 3 months, but we take pieces on a rolling basis.

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Asimov Press

@AsimovPress

16 days

Chicks that are not transported on trucks are possibly healthier. On-farm hatched chicks require 44 percent less antibiotic use than conventionally hatched chicks, according to one study.

Antimicrobial Use in On-Farm Hatching Systems vs. Traditional Hatching Systems: A Case Study

On-farm hatching is a relatively new method in the broiler industry, in which fertilized broiler eggs are transported to the farms at the stage of 17–19 days of incubation. Once hatched, the broiler...

www.mdpi.com

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Asimov Press

@AsimovPress

3 months

AI and synthetic biology may offer the best hope of engineering phages into products with the broad and versatile power of antibiotics. But for phage therapy to scale in low or middle-income countries, we will still need public-health-focused approaches.

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Asimov Press

@AsimovPress

3 months

Yet even after decades of research, media hype, and dozens of clinical trials and biotech start-ups that have come and gone, phage therapy has not scaled. Just a few of the 13 companies known to be working on phage therapy in 2004 are still active. Why?

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Asimov Press

@AsimovPress

3 months

All of this, and much more, is discussed in the piece. Subscribe to get future articles at !

Asimov Press

Asimov Press is a publishing venture that features writing about biology and explains how it is shaping our world through print and digital magazines, and books.

press.asimov.com

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Asimov Press

@AsimovPress

16 days

A trio of technologies—in-ovo sexing, on-farm hatching, and in-ovo vaccination—remove the need to handle and kill live chicks after they are born. They enable farmers, instead, to sex and vaccinate chicks before they hatch, thus reducing the number of baby chicks killed.

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Asimov Press

@AsimovPress

3 months

However, new technologies are making phage therapy more appealing to pharmaceutical companies. @felixbiotech @LocusBio The specificity problem can be combated with AI and machine learning: predicting phage-host relationships in silico rather than through exhaustive lab work.

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Asimov Press

@AsimovPress

4 months

Heinrich Schnitger was a 32-year-old German who viewed his work with "great contempt," because it forced him to use mouth pipettes. A 1915 survey found that 40 percent of workplace-related infections were directly linked to mouth pipetting.

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Asimov Press

@AsimovPress

23 days

While low water activity on Mars precludes existing life, maybe synthetic biology could create a microbe that could survive in these conditions. Engineering microbes to produce insulation using novel nanotechnologies or lichen to extract water from the air could work.

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Asimov Press

@AsimovPress

4 months

In 2004, Gilson sued Rainin, accusing them of “a campaign to disparage Gilson's Pipetman products and route customers to their own...product lines.” Gilson won $500,000 in damages, and Rainin lost their license to sell Gilson pipettes in the U.S.

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Asimov Press

@AsimovPress

16 days

It is easier to vaccinate an egg compared to a chicken. In-ovo vaccinated eggs also have a more consistent and uniform delivery across each embryo. Administering the vaccine pre-hatch also gives the chick’s immune system more time to fortify itself against pathogens.

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Asimov Press

@AsimovPress

4 months

The D’Autry-Gilson micropipettes were sold across Europe, but rights to the United States market were bought by Kenneth Rainin, a young California businessman. When Gilson's patent for the adjustable pipette expired in 1991, Rainin began to market a competing line of pipettes.

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Asimov Press

@AsimovPress

3 months

These high-tech approaches to streamlining and scaling phage therapy are beginning to attract attention from start-ups and investors. But phage therapy will also need to be affordable to combat the predicted millions of global cases of antibiotic resistance.

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@AsimovPress

16 days

In-ovo vaccination is another pre-hatch technology that will be good for welfare and the farmer's bottom line. Vaccination ensures that birds stay healthy and productive. An outbreak of a virus like Marek’s disease can cause tumors and paralysis across an entire flock.

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Asimov Press

@AsimovPress

4 months

Schnitger's first device had many issues. The device’s volume could not be adjusted, and it used polyethylene tips, which were too expensive to be disposable and thus made them prone to contamination. Scientists in Finland and the U.S. eventually solved both problems.

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Asimov Press

@AsimovPress

23 days

All life on Earth requires liquid water for survival. The lack of water on Mars would be the prevailing reason why nothing could grow there. The planet's soil is also a desiccant, meaning it quickly absorbs moisture.

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Asimov Press

@AsimovPress

3 months

Far-UVC light damages microbes without penetrating beyond the thin layer of dead skin cells that clings to the human epidermis. Though effective at deactivating viruses, lamps that emit far-UVC are expensive and have to be in “sight of” a surface in order to kill microbes on it.

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Asimov Press

@AsimovPress

4 months

Micropipettes haven't changed much since 1974, but innovations still spring up. In the last few years, scientists have open-sourced blueprints for a 3D-printed, adjustable micropipette and have made micropipettes that can pick up individual cells.

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Asimov Press

@AsimovPress

23 days

The thermodynamic availability of water is known as "water activity." The lower limit of water activity for existing lifeforms is 0.585, a record held by Aspergillus penicillioides, a fungus that can grow on dust. Liquid water on Mars has a water activity below 0.5.

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Asimov Press

@AsimovPress

8 days

@coffee_lipe @NikoMcCarty Yes! We see your order here and will ship a copy next week. Thanks for the support.

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Asimov Press

@AsimovPress

4 months

In Finland, a 26-year-old student made an early version of an adjustable micropipette after nearly swallowing "a piece of rat's brain" while mouth pipetting. In the U.S., Warren Gilson made an adjustable pipette with a gauge to more accurately assess the set volume.

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Asimov Press

@AsimovPress

3 months

A comprehensive disease-prevention strategy ought to address fomite transmission along with other modes. They can worsen outbreaks, including the one at Amoy Gardens. Diarrheal diseases—attributed to viruses that spread via fomite transmission—killed ~1.5 million people in 2019.

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Asimov Press

@AsimovPress

4 months

Fed up, Schnitger used a syringe and plastic tube to make a precursor to the modern micropipette. He did it in just 2 days. His device also had a spring-loaded piston and a second spring to shoot out residual liquid.

When a common problem meets an ingenious mind

The invention of the modern micropipette

www.ncbi.nlm.nih.gov

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Asimov Press

@AsimovPress

3 months

All this and more in our latest essay. Read it here: Follow us here, and subscribe at , to be notified of future essays. Asimov Press will always be free to read. Our mission is to make biotechnology make sense to more people.

Asimov Press

Asimov Press is a publishing venture that features writing about biology and explains how it is shaping our world through print and digital magazines, and books.

press.asimov.com

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Asimov Press

@AsimovPress

4 months

The micropipette’s history is a reminder that simple tools can have a large impact. Even a task as straightforward as transferring liquid from one tube to another can be accomplished by many different mechanisms, some of which are vastly superior to others.

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Asimov Press

@AsimovPress

4 months

Today, the popularity of human challenge trials is rising quickly. 284 human challenge trials have been conducted since 1980, and nearly doubled in number from the 2000s to the 2010s. Most trials have focused on malaria and influenza.

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Asimov Press

@AsimovPress

16 days

The hope is that the synergy between these pre-hatch technologies will cause the logistical challenges associated with handling live chicks to be automated away and replaced with humane, in-ovo solutions. Like most automating technologies, costs will lower and spur adoption.

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Asimov Press

@AsimovPress

3 months

Solutions such as handwashing are one way to prevent fomite transmission. But many people don't have access to clean water. We also need more surfaces that kill microbes, including viruses, on contact, or technology that directly kills pathogens lurking on surfaces.

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Asimov Press

@AsimovPress

5 months

@peterwildeford @AlexandraBalwit All of our articles will be sent out, for free, on Substack. Substack has an RSS feed, available here:

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