Alessio Ciulli @alessiociulli Twitter profile

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@dhall1994

Alessio Ciulli

@alessiociulli

2 years

Excited to debut XL01126 – a first-in-class PROTAC degrader for the protein kinase LRRK2, a high-profile target in Parkinson’s disease. Great #CeTPD collaboration with Dario Alessi @mrcppu team and @RuiMoreira_UL Please share, thread below

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Alessio Ciulli

@alessiociulli

2 years

Excited to share our latest work describing MN714 – first-in-class covalent inhibitor of SOCS2, a substrate adaptor of Cul5 E3 ligase. A >5-years long journey in the making full of twists and surprises. Please Retweet! Thread below 1/13

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Alessio Ciulli

@alessiociulli

1 year

The signage is up! It’s for real now, and it’s beginning to feel more and more like our new home #CeTPD @UoDLifeSciences @dundeeuni

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Alessio Ciulli

@alessiociulli

2 years

Honoured and humbled to receiving the prestigious Prous award. It recognises our group’s work over >10years on VHL PROTACs. It could not have been possible without the dedication and contributions of so many students, coworkers and collaborators and funders support. Thank you all

EFMC

@EuroMedChem

2 years

And congratulations to @alessiociulli for winning the EFMC Prous Institute -Overton & Meyer award 2022 for new technologies in drug discovery #EFMCISMC22

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Alessio Ciulli

@alessiociulli

4 years

I have decided to shut down all our group’s Labs activities by the end of this week. I am no longer comfortable with an official line of "business as usual". The time has come to act responsibly and come together into this. #SocialDistancing #FlattenTheCurve #WorkFromHome

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Alessio Ciulli

@alessiociulli

10 months

Excited to share our new review on Proximity-Based Modalities for Biology and Medicine | Just out ASAP in ACS Central Science @ACSCentSci

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Alessio Ciulli

@alessiociulli

4 years

Introducing Trivalent PROTACs: where cooperativity and avidity of binding go hand-in-hand to boost targeted protein degradation outcomes. Great collaboration with Danette Daniels group @promega Pre-print just out now - Let us know what you think!

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Alessio Ciulli

@alessiociulli

3 years

21 years ago I came to study in the UK because of the #Erasmus programme. It changed my life and was instrumental in my decision to return to do a PhD. It is sad and disappointing to learn that future generations will miss out from an opportunity, because of this decision.

The Independent

@Independent

3 years

UK ‘decided not to stay in Erasmus exchange programme’, EU says

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Alessio Ciulli

@alessiociulli

4 years

It’s hard to keep track of the protein degradation literature as it grows stronger day-by-day. Our #TPD journal club aims to provide a platform to help you stay on top of it! Here’s the latest Issue (August), Eds: Angus and Sarath. Hope you like it!

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Alessio Ciulli

@alessiociulli

5 months

Excited to debut our latest work where Dynamic Combinatorial Chemistry (DCC) meets bifunctional molecules (PROTACs). We have just posted our pre-print in @ChemRxiv @chemRxivBiochem Feedback welcome, and here’s a thread 🧵 👇 1/9

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Alessio Ciulli

@alessiociulli

7 months

We've updated our DCAF16-BRD4 preprint with lot new data: structure-design picomolar degraders, glues to a distinct E3 ligase (DCAF11) and revised title: Targeted protein degradation via intramolecular bivalent glues @UoDCeTPD @ollie_lh @georg_e_winter

Targeted protein degradation via intramolecular bivalent glues

Targeted protein degradation is a pharmacological modality based on the induced proximity of an E3 ubiquitin ligase and a target protein to promote target ubiquitination and proteasomal degradation....

www.biorxiv.org

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Alessio Ciulli

@alessiociulli

2 years

Happy to contribute with a review covering von Hippel-Lindau (VHL) ligands and PROTACs in the themed collection on induced proximity modalities in @ChemSocRev Great work @CJ_Diehl #OpenAccess =>

Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as...

The von Hippel-Lindau (VHL) Cullin RING E3 ligase is an essential enzyme in the ubiquitin-proteasome system that recruits substrates such as the hypoxia inducible factor for ubiquitination and...

pubs.rsc.org

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Alessio Ciulli

@alessiociulli

1 month

Cheers 🍻 to exactly 11 years of the group in Dundee @UoDLifeSciences @dundeeuni A great evening out marking a big milestone, now within our exciting new @UoDCeTPD !

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Alessio Ciulli

@alessiociulli

2 years

Big announcements today for our @UoDLifeSciences #TPD spin-out @AmphistaThera , doubling down on big-pharma deals with @bmsnews and @merckgroup Kudos Nicki and team! BMS, Merck KGaA push protein degrader ambitions with $2.3B Amphista partnerships

BMS, Merck KGaA push protein degrader ambitions with $2.3B Amphista partnerships

Bristol Myers Squibb and Merck KGaA are diving deeper into the protein degradation pool, with both inking partnerships with Amphista Therapeutics that together could bring in $2.3 billion for |...

www.fiercebiotech.com

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Alessio Ciulli

@alessiociulli

3 years

Thrilled to watch our trivalent PROTAC work finally out. So incredible journey from concept to practice, and again awesome collaboration with the amazing Kristin and @danetteldaniels @promega There’s a curious backdrop story on how it all started, keep reading below 👇🏼

Nature Chemical Biology

@nchembio

3 years

New work from @alessiociulli @danetteldaniels and coworkers reports trivalent PROTACs targeting two domains in the same protein that enhance protein degradation via increased avidity and cooperativity. Free to read:

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Alessio Ciulli

@alessiociulli

4 years

Please RT: we're recruiting 2x postdoctoral scientists to join our PROTAC drug discovery team in collaboration with @Boehringer

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Alessio Ciulli

@alessiociulli

2 years

Huge congratulations to @AmphistaThera on the grand-opening of their new research site at GrantaPark in Cambridge. Delighted to be able to join Nicki and team and connect with new ppl and friends to celebrate 🎊 🎉 a very feel good day!

Amphista Therapeutics

@AmphistaThera

2 years

Here is our co-founder, @alessiociulli cutting the ribbon! Our @grantapark office is officially open for business! Now it’s time to celebrate! #AmphistaMovesIn

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Alessio Ciulli

@alessiociulli

4 months

Excited to introduce CRBN-Midi: a construct engineered to accelerate biophysics and high-resolution crystallography of CRBN ligands and degraders design. A tour-de-force work at @UoDCeTPD by a fantastic team led by Alena Kroupova and David Zollman. 1/11

Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders

The ubiquitin E3 ligase cereblon (CRBN) is the target of therapeutic drugs thalidomide and lenalidomide and is recruited by most targeted protein degraders (PROTACs and molecular glues) in clinical...

www.biorxiv.org

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Alessio Ciulli

@alessiociulli

1 year

PLease RT! We have 4x opening at postdoctoral level to join our new @CeTPD_Dundee . Covering all range of disciplines, both academic in @farnaby84 team and in our drug-discovery teams @Boehringer and @AlmirallUS . DM for informal enquiries

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Alessio Ciulli

@alessiociulli

4 years

Check out our news story piece in @NatureNV on LYTACs: protein degraders that go extracellular. Congratulations to @CarolynBertozzi @StevenMBanik and coworkers on this beautiful work!

Nature News & Views

@NatureNV

4 years

Transmembrane and extracellular proteins can be targeted for degradation by a new class of potential drug molecules - read all about it in this great N&V by Claire Whitworth and @alessiociulli

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Alessio Ciulli

@alessiociulli

8 months

Very happy our work on improving VHL ligands is now out @ACSBioMed #jmedchem great teamwork with Michael Gutschow and co. at Bonn. We design a new di-Methyl analogue of VH101 (cmpnd 30) and qualify it as the most potent VHL inhibitor in vitro and in cell

Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel–Lindau E3...

Hypoxia-inducible factor-1α (HIF-1α) constitutes the principal mediator of cellular adaptation to hypoxia in humans. The HIF-1α protein level and activity are tightly regulated by the ubiquitin E3...

pubs.acs.org

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Alessio Ciulli

@alessiociulli

3 years

Nicole Trainor and I have offered a beginner’s guide to PROTACs and targeted protein degradation, now out in @The_Biochemist . We hope this will prove useful to the community, from degradation newbies to practitioners!

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Alessio Ciulli

@alessiociulli

6 months

Humble and touched to receive the #KEAwards2023 on behalf of @dundeeuni @AmphistaThera . This awards belongs to everyone at @UoDRIS @UoDLifeSciences @UoDCeTPD @advent_ls and many others who have contributed to the successful journey so far and commercial achievements of this Year

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Alessio Ciulli

@alessiociulli

2 years

Super-excited to host @CrisMayorRuiz from @IRBBarcelona as our invited speaker for the #CeTPD @UoDLifeSciences seminar series. Visit organised by @CharlCrowe @val_spiteri and Tom. Fantastic talk Cris and so looking forward to two days of science and fun!

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Alessio Ciulli

@alessiociulli

4 years

Completion of our @dundeeuni spin-off new-co Amphista therapeutics’s Series A investment announced today! Great news and congratulations to the whole team for this achievement. Read more here and below /1

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Alessio Ciulli

@alessiociulli

2 years

Happy to see this out in press now @J_A_C_S

Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood–Brain...

Leucine-rich repeat kinase 2 (LRRK2) is one of the most promising targets for Parkinson’s disease. LRRK2-targeting strategies have primarily focused on type 1 kinase inhibitors, which, however, have...

pubs.acs.org

Alessio Ciulli

@alessiociulli

2 years

Excited to debut XL01126 – a first-in-class PROTAC degrader for the protein kinase LRRK2, a high-profile target in Parkinson’s disease. Great #CeTPD collaboration with Dario Alessi @mrcppu team and @RuiMoreira_UL Please share, thread below

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Alessio Ciulli

@alessiociulli

2 years

Outstanding talk by Brian Lanman @Amgen on the discovery of first-in-class KRAS G12C covalent inhibitor Sotorasib. A fantastic tour de force of structure-based drug design

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Alessio Ciulli

@alessiociulli

2 years

It has been a privilege to contribute to the prestigious @AnnualReviews of Biochemistry. It’s special times to work on E3 ligases, and this piece by Angus and I attempts to capture some of the emerging interactions and concepts. #TPD #PROTACs #glues

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Alessio Ciulli

@alessiociulli

2 months

Excited and humble to be part of team KOODAC to innovate degraders of undruggable tumour drivers as molecular therapeutics for pediatric cancers funded by @CancerGrand We’re assembling a strong team in our group at @UoDCeTPD Reach out if you’re interested in joining the effort

University of Dundee

@dundeeuni

2 months

We’re excited to reveal that team KOODAC, which includes @alessiociulli of @UoDCeTPD , has been selected by @CancerGrand to receive up to $25m to take on one of cancer’s toughest challenges. Learn more 👉

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Alessio Ciulli

@alessiociulli

3 years

Excited to share our new pre-print: Amide-to-ester substitution as a strategy for optimizing PROTAC permeability and cellular activity | ChemRxiv

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Alessio Ciulli

@alessiociulli

3 months

So thrilled to witness structural and mechanistic insights coming out from us at @UoDCeTPD @UoDLifeSciences and from Brenda Schulman @MPI_Biochem and Gary Kleiger @UNLV_CoS ! Prime time for seeing the entire Cullin RING Ligase machines in actions on targets glued by our degraders!

Charlotte Crowe

@CharlCrowe

3 months

Excited to share our structural snapshots of MZ1-targeted Brd4BD2 ubiquitination in @biorxivpreprint ! @alessiociulli @UoDCeTPD We use cryo-EM to capture states of the dynamic Brd4BD2-MZ1-(NEDD8)-CRL2VHL-UBE2R-Ub complex 🔗

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Alessio Ciulli

@alessiociulli

2 years

We are happy to host and support students/scientists at any level from @Ukraine 🇺🇦 for temporary placements in our #CeTPD Labs #PROTACs #chemicalbiology @UoDLifeSciences . Get in touch #science @Sci_for_Ukraine

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Alessio Ciulli

@alessiociulli

2 months

We keep sharing our best and most-validated reagents with the community to advance research! Happy to see our construct designed for E.coli expression of recombinant CRBN-Midi protein now available via @Addgene to advance CRBN TPD research. 1/3

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Alessio Ciulli

@alessiociulli

6 months

Thrilled to announce the lineup of speakers and open applications for our symposium to mark the opening of @UoDCeTPD ! It promises to be a wonderful occasion to celebrate our field. Having so much fun to work in this with @val_spiteri @CharlCrowe @CraigMCrews Brenda and team!

Centre for Targeted Protein Degradation

@UoDCeTPD

6 months

We're thrilled to announce our line up of confirmed speakers for our Symposium in May 2024! We invite you to apply via the link below. We hope you are as excited as we are for 3 days of science and Scottish fun! Apply->

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Alessio Ciulli

@alessiociulli

1 year

We all want to glue our targets, but how? Here, we describe a new strategy to achieve just that: bridging across to an adjacent site to anchor an intrinsic E3 ligase interaction. Fantastic work @ollie_lh Matthias Angus Ken @TasukuIshida1 @georg_e_winter and all involved

Georg Winter

@georg_e_winter

1 year

In our recent paper with @alessiociulli we unravel a novel modality of targeted protein degradation: Intramolecular gluing of protein domains to generate a target-E3 ligase interaction surface. Live now on Biorxiv:

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Alessio Ciulli

@alessiociulli

2 months

Humble and proud of receiving this @CR_Horizons award on behalf of everyone at @UoDCeTPD @UoDLifeSciences and @Boehringer who’s made this collaboration possible and contributed to the scientific innovation from the team! In London with Kirsten, Stephanie, Aileen, and @VesnaVetma

Cancer Research Horizons

@CR_Horizons

2 months

🥇 The winners of the Further, Faster Together Award are… @dundeeuni , @Boehringer_UKI @EdinburghUni and Nuvectis – for a promising new approach to #PROTACs technologies. #IEAwards24 #OnMyHorizon #ProteinDegradation #Nuvectis

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Alessio Ciulli

@alessiociulli

5 years

Structures of the Cul5 ligase SOCS2 bound to EpoR and GHR reveals the structural basis of E3-substrate recognition - and ushers development of new E3 ligands as handles for targeted protein degradation #PROTACs . Paper just out in @NatureComms

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Alessio Ciulli

@alessiociulli

3 years

Do you want to ride the wave of #PROTAC #degraders ? I am building a new drug discovery team within my group @UoDLifeSciences in collaboration with @AlmirallUS , recruiting 1x team leader + 4x scientists. Do get in touch for informal enquiries:

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Alessio Ciulli

@alessiociulli

4 years

Please RT: We are looking for postdoctoral scientists to join and boost our efforts in protein degradation #TPD #PROTACs . Feel free to get in touch for informal enquiries - position 1/2

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Alessio Ciulli

@alessiociulli

1 year

Fantastic to host @D_B_McConnell and many of our @Boehringer colleagues and collaborators in Dundee @UoDCeTPD to celebrate the success of our continued partnership. Together since 2016 to innovate PROTAC drug discovery.

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Alessio Ciulli

@alessiociulli

4 years

Heroes

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Alessio Ciulli

@alessiociulli

2 years

Many congratulations @CarolynBertozzi and the other awardees. A much deserved recognition to their important and impactful work developing and applying chemistry to probe biology. A feel-good day for chemical biology, for sure!

The Nobel Prize

@NobelPrize

2 years

BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”

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Alessio Ciulli

@alessiociulli

4 years

Amid current WFH we’ve launched a monthly Journal Club covering #PROTAC and #TPD literature amongst others! Spearheaded by Siying, we are pleased to share our first Issue, edited by Siying and @farnaby84 Please RT and let us know what you think:

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Alessio Ciulli

@alessiociulli

2 years

The Dundee-Vienna axis strengthens! Our first #CeMM - #CeTPD collaboration paper with @georg_e_winter Group illuminate on the emergence and mechanism of E3 Ligase missense mutations to protein degraders. Great 🧵on the main findings 👇🏼

Georg Winter

@georg_e_winter

2 years

Happy to introduce a fantastic collaboration with @alessiociulli & team. We integrated functional genomics & structural bio to identify functional hotspots in hijacked E3s and found them mutated in patients relapsing from degraders 🧵👇

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Alessio Ciulli

@alessiociulli

1 year

Having great time strolling in Barcelona getting ready for Monday’s #BarcelonaBiomed #TPD conference and looking forward to meeting many friends and colleagues soon! @val_spiteri @Mark_A_Nakasone @ollie_lh @farnaby84 @AlenaKro @UoDCeTPD

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Alessio Ciulli

@alessiociulli

4 years

Two institutions with a tradition for innovation and a common vision can create something special when they come together. Proud of our fantastic joint PROTAC drug discovery team who are making the dream come true! @dundeeuni @UoDLifeSciences @Boehringer @D_B_McConnell

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Alessio Ciulli

@alessiociulli

23 days

Interested in developing degrader drugs that could save lives of kids with cancer? Look no further. We are recruiting 4 scientists at @UoDCeTPD to do just that as part of our @CancerGrand #CancerGrandChallenges KOODAC team. Role 1/4: Senior Lead Scientist

KOODAC Team Senior Lead Scientist - Dundee City (GB)

Position 1 - Senior Lead Scientist: Chemical Structural Biology / Medicinal Chemistry (KOODAC team) Unit: Centre for Targeted Protein Degradation F...

www.nature.com

Alessio Ciulli

@alessiociulli

2 months

Excited and humble to be part of team KOODAC to innovate degraders of undruggable tumour drivers as molecular therapeutics for pediatric cancers funded by @CancerGrand We’re assembling a strong team in our group at @UoDCeTPD Reach out if you’re interested in joining the effort

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Alessio Ciulli

@alessiociulli

4 months

So excited to be with my graduate student Tom Webb at Keystone Colorado for this conference. We had a great day skiing yesterday- a perfect prelude to what promises a fantastic 3-days of science. Come chat (and ski ⛷️) with us! @KeystoneSymp #KSProteinDeg24 #KSProximityTx24

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Alessio Ciulli

@alessiociulli

5 years

Check our latest review on bispecific small molecules that bring proteins together, including #PROTACs - just out in Curr Opin Chem Biol with @chiaramaniaci

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Alessio Ciulli

@alessiociulli

3 years

Wanna join a dynamic group of dedicated creative #TPD researchers and be part of an exciting new venture? Dundee’s Centre for Targeted Protein Degradation (CeTPD) is opening new roles and it could be for you! Feel free to reach out for informal enquiries

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Alessio Ciulli

@alessiociulli

2 years

Do you need to increase the cell permeability of your PROTAC? Check our those amide bonds.. and we’ve got a simple solution for you! 👇🏼

Adam Bond

@AdamBond_

2 years

Our amide-to-ester subsitution paper is finally out now in J Med Chem! Big thank you to co-first author @ToriKleinPhD , to Conner Craigon and to @alessiociulli and Scott Lokey for helping to put together this cool story! #TPD #medchem #PROTACs

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@alessiociulli

1 year

So excited for our #CeTPDnewhome Four years in the making, and it is finally happening! Fantastic team-work planning and executing such a big move, even if just across the road! @UoDLifeSciences

Valentina Spiteri

@val_spiteri

1 year

Team CeTPD has officially moved into our new home. Here’s a video of us settling into our new offices and labs. Despite moving hundreds of boxes, it’s been such a good week of team bonding! Can’t wait to get sciencing!🎉🎉 @alessiociulli @farnaby84 @UoDLifeSciences

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Alessio Ciulli

@alessiociulli

1 year

Happy time at the first ever @EuroMedChem Course on Targeted Protein Degradation. Great teaching and shared learning on protein degrader design. Kudos to team: host @Heitman_lab , co-organizer @UoDCeTPD Suzanne, and instructors @danetteldaniels Chun-Wa Chung @EndriuT @HartungIngo

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Alessio Ciulli

@alessiociulli

1 year

I am very excited to announce that our new @UoDCeTPD is now on Twitter! Please RT / Follow us! We look forward to share the latest from our Centre and to engage with the wider community and outreach across the globe about our work on TPD, glues, induced proximity and beyond.

Centre for Targeted Protein Degradation

@UoDCeTPD

1 year

We are delighted to officially launch our Twitter channel. Follow us to keep up to date with the Centre - our research, activity, and opportunities to work with us. Follow us on @LinkedIn as well: #TargetedProteinDegradation #PROTACS

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Alessio Ciulli

@alessiociulli

7 months

International Potluck dinner at @UoDCeTPD starting now! Fast becoming a tradition! Kudos to @val_spiteri for organizing and everyone for cooking their favorite dishes! 😋.

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Alessio Ciulli

@alessiociulli

3 months

Thanks @nchembio and Oliver for your covering of our work - we’ve enjoyed reading the highlight! @UoDCeTPD @UoDLifeSciences

Nature Chemical Biology

@nchembio

3 months

SH2 domains thought of as "undruggable" - A News & Views by Oliver Hantschel highlights recent work from @alessiociulli lab @NatureComms on an inhibitor of the SH2 domain of E3 ligase SOCS2. Read it here and the original article

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Alessio Ciulli

@alessiociulli

3 years

Pleased to see this story now out @ASBMB @jbiolchem @srochaliv @juliantyfrost : Von Hippel-Lindau (VHL) small molecule inhibitor binding increases stability and intracellular levels of VHL protein

Von Hippel–Lindau (VHL) small-molecule inhibitor binding increases stability and intracellular...

Von Hippel–Lindau (VHL) disease is characterized by frequent mutation of VHL protein, a tumor suppressor that functions as the substrate recognition subunit of a Cullin2 RING E3 ligase complex...

www.jbc.org

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Alessio Ciulli

@alessiociulli

3 years

Excited to take part in this event and share some of our work on #PROTACs #TPD and discuss current and future directions in the field with colleagues and friends @georg_e_winter Danette Daniels @promega Klemens Hoegenauer @Novartis and many others

EFMC

@EuroMedChem

3 years

Do not forget our 6th EFMC-YSN MedChemBioOnline on PROTAC and Small Molecules Development 📆January 28 (17:00 to 19:15 CET) More information & registration: The event is free and open to all thanks to the generous support of Symeres cc @YoungSciNet

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Alessio Ciulli

@alessiociulli

5 years

Please RT: Postdoc position available immediately in my group to investigate the structure, mechanism and druggability of new E3 ubiquitin ligases using structural cell biology. @UoDLifeSciences @DundeeUniJobs @mrcppu

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Alessio Ciulli

@alessiociulli

3 years

Excited to share our latest @biorxivpreprint ! Key finding: VHL ligand binding induces increase of target protein levels inside cells. Great work by @juliantyfrost in collaboration with @srochaliv @UoDLifeSciences Let us know what you think! 1/

bioRxiv

@biorxivpreprint

3 years

VHL inhibitor binding increases intracellular level of VHL #bioRxiv

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Alessio Ciulli

@alessiociulli

1 year

Excited to share our latest review in @COSB_CRSB We take a snapshot on current solution-based structural biology methods and studies of ternary complexes formed by PROTACs and molecular glues, and offer a forward-looking perspective of where the field may go next

Valentina Spiteri

@val_spiteri

1 year

Our review on the scope of using in solution sturctural biology techniques to study ternary complexes is now live! We have a lot of fun preparing this piece, with plenty of debates at the pub! @KevinHaubrich1 @alessiociulli @farnaby84 @FrankSobott

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Alessio Ciulli

@alessiociulli

2 years

Love these concise and highly informative med chem posts on newly disclosed drug structures. Great community service @drughuntersite @HartungIngo et al.

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Alessio Ciulli

@alessiociulli

30 days

So looking forward to @xingui_liu presenting her work on Lrrk2 degraders here at the @UF Drug Discovery Symposium from @UFPharmacy and to learn more about her new Lab and group #newPI #proudofalumni

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Alessio Ciulli

@alessiociulli

4 years

Chemical Biologists: Interested in starting a group working on protein phosphorylation or ubiquitination? Here’s a great opportunity to join @dundeeuni @UoDLifeSciences @mrcppu 👇🏼

MRC PPU

@mrcppu

4 years

Interested in becoming a Principal Investigator at the MRC PPU? We have an open position, deadline 31/08/20 #ChemicalBiology #SignalTransduction #ubiquitin #kinase #phosphorylation #MassSpectrometry

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Alessio Ciulli

@alessiociulli

1 year

we are arranging a #CeTPD delegation for this. will be so much fun! @farnaby84 @val_spiteri @ollie_lh

Cris Mayor-Ruiz

@CrisMayorRuiz

1 year

🔥🔥🔥 Registrations open for the #BarcelonaBiomed Conference "Proximity-inducing Pharmacology: Targeted Protein Degradation & Beyond"! 22-24 May #TPD #chembio @IRBBarcelona NO registration fee: run!!!🏃‍♀️🏃‍♀️ Short talks & posters An amazing lineup of speakers & chairs😍 👇👇

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Alessio Ciulli

@alessiociulli

2 years

Congratulations to Conner for passing his Viva today with flying colours (and hat!). Thanks to thanks to the examiners @gpsapkota @sapkota_mrcppu and Becky Feltham @FelthamLab @WEHI_research for examining the thesis! #CeTPD @UoDLifeSciences

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Alessio Ciulli

@alessiociulli

6 years

Thought of PHD fingers as undruggable reader domains? Our fragment screening work, just out in ACS @ChemicalBiology , suggests otherwise: they are - at least - ligandable!

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Alessio Ciulli

@alessiociulli

2 years

Excited to see this finally out: SMARCA2 isoform-selective (90% identical bromodomain sequence) and orally bioavailable PROTAC degrader ACBI2 achieves efficacy in SMARCA4-deficient tumour models in vivo. Great teamwork @UoDLifeSciences #CeTPD @Boehringer @farnaby84 @ChemHaWei

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Alessio Ciulli

@alessiociulli

4 years

We continue to open our probes to the community! @Boehringer now provides free access to our dual Brd7/9 PROTAC degrader VZ185 (and the inactive negative control) on The compound was discovered by Vittoria Zoppi @sjz_hughes @chiaramaniaci @EndriuT

UoD Life Sciences

@UoDLifeSciences

4 years

We are delighted to to announce that the latest PROTAC compound, VZ185, developed by @alessiociulli 's is available for #OpenScience . Watch the story on @Boehringer portal #opnMe and order the #molecule for free.

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Alessio Ciulli

@alessiociulli

3 years

New PK data on OpnMe portal qualifies the Smarca2/4 (Brg1/Brm) degrader ACBI1 as appropriate for in vivo studies. Sharing this data enables the field to make best use of the compound #openaccess @Boehringer @UoDLifeSciences

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Alessio Ciulli

@alessiociulli

2 years

Nice to see this out and great work @CraigMCrews and Lab. Look forward to seeing it presented soon. So many untapped opportunities in this space

Craig Crews

@CraigMCrews

2 years

Ever wanted to dephosphorylate just a single phosphoprotein instead of blocking all downstream kinase substrates with a kinase inhibitor? Check our new PoC paper describing PhosTACs that recruit phosphatases to selected phosphoproteins. #PhosTACs

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Alessio Ciulli

@alessiociulli

2 years

Super-excited to work with @Tocris to make our #BromoTag technology more widely available and to develop next-generation #BromoTag systems #CeTPD @UoDLifeSciences

University of Dundee

@dundeeuni

2 years

Today we announce a new partnership with @biotechne to commercialise technology developed here at the University that enhances the understanding of undruggable diseases. Read more about this exciting project 👉

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Alessio Ciulli

@alessiociulli

2 years

Check out our Dundee-BI team work to develop ACBI-2, an orally bioavailable VHL-based PROTAC that selectively degrades SMARCA2 (Brm) over SMARCA4 (Brg1) and shows TGI in mouse xenographs models of lung cancer in vivo

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Alessio Ciulli

@alessiociulli

3 years

Join me in January at @KeystoneSymp Targeted Protein Degradation! Collaborate with #ProteinDegradation #Proteasome #Ubiquitin and #DrugDiscovery experts in Vancouver. #KSPDegradation22

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Alessio Ciulli

@alessiociulli

2 years

Very proud of this news @farnaby84 #CeTPD : Will Farnaby becomes Principal Investigator in CeTPD http:////www.lifesci.dundee.ac.uk/news/2022/mar/11/will-farnaby-becomes-principal-investigator-cetpd

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Alessio Ciulli

@alessiociulli

2 years

Over the moon as Amphista therapeutics snaps this Year’s Scrip Award! So proud of the A-team led by Nicki and Ian, what an amazing achievement! @EndriuT @sjz_hughes you rock!

Scrip, Citeline Commercial

@PharmaScrip

2 years

Well done to Amphista Therapeutics’ $53m series B for taking home the trophy for Financing Deal of the Year #ScripAwards

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Alessio Ciulli

@alessiociulli

4 years

Excited to launch the start of a new collaboration on #TPD #PROTACs between @UoDLifeSciences and the Barcelona-based pharmaceutical company Almirall. Check this space - more to follow soon as we build the team !

University of Dundee

@dundeeuni

4 years

The University is to partner with global biopharmaceutical company Almirall to develop new treatments for severe skin diseases with high level of unmet medical need @UoDLifeSciences @alessiociulli @UoDRIS

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Alessio Ciulli

@alessiociulli

3 years

A positive of the 2020 Lab shutdown is that we got to write more reviews than we would have done otherwise. Here are three so far: 1) Synthetic and medicinal chemistry of phosphotyrosine analogues, with @n_makukhin in @rsc_medchem /1

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Alessio Ciulli

@alessiociulli

1 year

Super-excited to announce this! The count-down begins -362 days to Cetpd’s opening scientific symposium @UoDCeTPD @UoDLifeSciences

Centre for Targeted Protein Degradation

@UoDCeTPD

1 year

We invite you to save the date! We will be hosting”Protein Degradation in Focus, a special symposium to celebrate the opening of CeTPD in Dundee” on 19-22 May 2024. Scientific co-organisers, @alessiociulli , Brenda Schulman, @CraigMCrews , @val_spiteri & @CharlCrowe !

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Alessio Ciulli

@alessiociulli

3 years

Good-news Friday! With our newly announced Dundee’s Centre for Targeted Protein Degradation and Dundee’s TPD spin-off Amphista therapeutics we feel happy to contribute to and proud to be a part of our thriving innovating community @dundeeuni @UoDLifeSciences

University of Dundee

@dundeeuni

3 years

The University of Dundee is one of the best universities in the UK for producing successful spinouts, according to a new report 💼 🔬 Read more 👉

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Alessio Ciulli

@alessiociulli

1 year

Proud to join our @CeTPD_Dundee outreach team for its first public event showcasing our degrader activities! Thanks @dundeewomenfest @engageUoD @UoDLifeSciences for hosting us

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Alessio Ciulli

@alessiociulli

4 years

I am in deep shock, still. Huib was a wonderful scientist and colleague and fun to talk science with at conferences. This is how I like to remember him.

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Alessio Ciulli

@alessiociulli

3 years

Recommended weekend read, from Brenda and Wade:

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Alessio Ciulli

@alessiociulli

1 year

Best TPD chair ever, feeling at home in Barcelona. Thanks @HartungIngo for the impeccable day at the helm!

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Alessio Ciulli

@alessiociulli

2 years

Excited to participate to my first #Faseb @FASEBorg conference, and the mother of all too! Great welcoming remarks by @paganolab

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Alessio Ciulli

@alessiociulli

4 years

The power of collaboration: Congrats to Scott Lokey @ucsc and Lokey Lab grad-student Tori Klein on their work on 'Understanding and Improving the Membrane Permeability of VH032-Based PROTACs' now published in @ACSMedChemLett

Understanding and Improving the Membrane Permeability of VH032-Based PROTACs

Proteolysis targeting chimeras (PROTACs) are catalytic heterobifunctional molecules that can selectively degrade a protein of interest by recruiting a ubiquitin E3 ligase to the target, leading to...

pubs.acs.org

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Alessio Ciulli

@alessiociulli

3 months

It was fun and a pleasure to do this little interview with @ThatsTVScotland on behalf of all our colleagues and collaborators @UoDCeTPD @CeMM_News briefly explaining our “protein sandwich” recently published at @Nature - thanks for the opportunity.

That's TV Scotland

@ThatsTVScotland

3 months

"We called it like a protein sandwich." @alessiociulli from @UoDCeTPD has led research into defining a new class of molecular glue which could significantly enhance cancer and neurodegenerative disease treatments.

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Alessio Ciulli

@alessiociulli

8 months

What an inspiring story. So wonderful to listen to such an honest, humble, authentic and so worthy recipient. Love how she highlights the power of perseverance in spite of adversities and offers wise advice of focusing on what you can do. Science celebration, at its best

The Nobel Prize

@NobelPrize

8 months

“Ten years ago I was kicked out and forced to retire.” Our new medicine laureate Katalin Karikó ( @kkariko ) told us how much it means to be awarded the Nobel Prize after a scientific career that has been full of challenges. Ten years ago, Karikó was still doing all her…

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Alessio Ciulli

@alessiociulli

3 years

Happy to see the “Next Generation Therapeutics” Section of Curr Opin Chem Biol finally out. It has been a pleasure to share and co-edit with Ingrid Wertz @bmsnews . Check our Editorial summary and all Section reviews at

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Alessio Ciulli

@alessiociulli

4 years

Pls Retweet! PhD position available in my lab to develop novel approaches to study #PROTAC mode of action. Funded as iCASE industrial collaboration with @Tocris - app deadline 31st March. Feel free to get in touch informally for more info

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Alessio Ciulli

@alessiociulli

2 years

Strolling Barcelona at night with our colleagues from Almirall. Getting ready for exciting #PROTAC science tomorrow @MarieLarraufie @AlenaKro and team. Great to meet in person, finally

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Alessio Ciulli

@alessiociulli

3 years

This made my day! So many of these resonate, especially #11 😂

A. Harper Tytla

@avtytla

3 years

I figured the chemical biologists were due for one of these

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Alessio Ciulli

@alessiociulli

1 year

So happy to finally host @danetteldaniels in Dundee, on behalf of all #CeTPD ’ers. A visit long overdue since being canceled in 2020 due to the pandemic. Great talk on the fantastic work she and team are doing @foghorntx bringing degraders to the clinic.

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Alessio Ciulli

@alessiociulli

2 months

I knew dinner with @ChemEpi would be open to surprises but never imagined inwould be treated to Espresso Tonic! Classy!

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Alessio Ciulli

@alessiociulli

4 years

Our new paper describing stereoselective syntheses of bumped-JQ1 allele-selective BET inhibitors, and ligand binding validation, is now out in @OrgBiomolChem Check out the new route developed by @AdamBond_ @EndriuT , and let us know what you think!

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Alessio Ciulli

@alessiociulli

2 years

Paper free to read in @nchembio : .

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Alessio Ciulli

@alessiociulli

4 years

Excited to share our work on #PROTACs at @NatureConf #TranslationalChemBio20 tomorrow: degrader session with Ingrid Wertz, @LabThoma and Gregory Michaud. Enjoying the cool virtual format of 15-mins talks per session followed by Q&A to all speakers

Translational Chemical Biology

I just registered for this event!

conferences.nature.com

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Alessio Ciulli

@alessiociulli

4 years

Check out this month's Issue of our JC. Covers a lot of cool recent #TPD #PROTAC efforts at degrading KRAS + the Landmark paper feature is back! Edited by @ZhongSiying Nicole and Ryan.

SiyingZhong

@ZhongSiying

4 years

The July issue of the Ciulli Group Journal Club covering #TPD #PROTAC (+ other interesting) papers is now online. It has been great working with Ryan and Nicole to produce the July issue.

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Alessio Ciulli

@alessiociulli

2 months

Happy to be contributing to this work qualifying a novel biosensor-based assay platform for #proximity pharmacology, with @CharlCrowe @UoDCeTPD and our collaborators @DBS_GmbH and @AstraZeneca

Charlotte Crowe

@CharlCrowe

2 months

Excited to share our latest preprint with @alessiociulli @UoDCeTPD @DBS_GmbH @AstraZeneca ! A new biosensor technology for measuring PROTAC binary and ternary complex formation (ka, kd and KDs) by FRET 🧬 Applied here to CRBN and VHL PROTACs 🔗

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