📍 Vitamin B12 deficiency can occur with chronic metformin therapy
📍 Periodic measurement of Vitamin B12 levels should be considered in patients who are on chronic metformin therapy
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Ceftriaxone is assocaited with biliary pseudolithiaisis.
📍Biliary pseudolithiasis occurs due to significant excretion in bile combined with affinity to calcium for ceftriaxone.
📍The drug precipitates in the gall bladder forming pseudolithiasis.
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🎯Paracetamol (acetaminophen) is a nonselective COX inhibitor, which acts at the peroxide site of the enzyme
📍The presence of high concentrations of low peroxides at sites of inflammation, reduces its COX-inhibitory activity
🎯Indomethacin is about 20 times more potent than
🎯Amoxicillin is abosrbed much more rapidly and completely than ampicillin
🎯Ensuing lower concentration in gastrointestinal tract results in lesser incidence of diarrhea with amoxicillin
🎯Amoxicillin is preferred over ampicillin whenever oral administration is possible
📍Sotalol is classified under class III anti-arrhythmic.
📍Sotalol's anti-arrhythmic action is mainly attributed to potassium channel blockade.
📍Sotalol is a non selective beta blocker but lacks membrane stabilising action.