bryan dickinson @chembioBryan Twitter profile

Pinned Tweet

bryan dickinson

1 month

Also here is a Research Briefing for some behind the scenes and more context

Masked acid chlorides for proximity labelling of RNA

Nature Chemistry - A non-radical proximity labelling platform — BAP-seq — is presented that uses subcellular-localized BS2 esterase to convert unreactive enol-based probes into highly...

www.nature.com

bryan dickinson

@chembioBryan

1 month

Our new proximity labeling technology is now published!! This new subgroup is doing some amazing work - more to come!

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Last Seen Profiles

@KailynWiseman

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@_skywoozi

@Josh4Miller

bryan dickinson

@chembioBryan

4 years

We just received an emergency overnight package of #COVID testing supplies from China. Every bit of empty space in the package was stuffed with PPE for us This is a global problem and working together is the only way we are going make it. Thank you to my Chinese counterparts

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bryan dickinson

@chembioBryan

4 years

Message from @UChicago to recently tenured faculty: Now that you are tenured you might feel the urge to keep doing what made you successful. Fight it. We want you to feel safe to fail. Fail often. Use your tenure to make a difference. Inspiring & beautiful. A true university.

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bryan dickinson

@chembioBryan

4 years

Our lab tradition is that when someone leaves the group, an instrument is named in their honor. Today we had a special ceremony for Dr. Julia Zinkus-Boltz, our first graduate student. It is a somber and serious occasion.

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bryan dickinson

@chembioBryan

3 years

My incredible @UChiChemistry colleague Chuan He (not on twitter) found a way to perturb RNA regulatory pathways to make essentially ANY plant gigantic! Giant potatoes! More rice! This is a huge deal for world hunger

RNA demethylation increases the yield and biomass of rice and potato plants in field trials

Nature Biotechnology - Rice and potato plants are more productive after epitranscriptome engineering.

www.nature.com

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bryan dickinson

@chembioBryan

4 years

Just lost a postdoc applicant due to the simultaneous issues of COVID-19 and visa stress...decided not to stay in the US for postdoc. Totally understandable - and a clear demonstration of how f***ed 2020 is.

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bryan dickinson

@chembioBryan

2 years

@grassisgreenre Also “weigh paper” is just hamburger patty paper. It’s all a sham

UltraPaper Hamburger Patty Paper, 5.5" x 5.5" Squares (Pack of 1000)

Waxed burger patty paper is an affordable option for storing and maintaining the moisture, flavor, and consistency of your favorite foods. Found the perfect recipe for home cooked hamburgers? Place a...

www.amazon.com

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bryan dickinson

@chembioBryan

6 years

To those that did not get @NSFGRFP - I remember when I found out I did not get it. It felt like doors were closed. Well 12 years later I'm a professor at @UChicago w/ a group of 13 amazing grad students and postdocs. Every future is still available to you inspiredby @Gassensmith

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bryan dickinson

@chembioBryan

3 years

In non-science news I’m proud of - I finally finished my new desk. Ive been working on a pile of boxes for 9 months. That motivated me to step up my woodworking hobby - which has also been helpful for coping with 2020! Its all cherry with a design inspired by pergolas.

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bryan dickinson

@chembioBryan

5 years

View from my office ⁦ @UChiChemistry ⁩ ⁦ @UChicago ⁩ - it’s like living in a Fall snow globe here right now

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bryan dickinson

@chembioBryan

5 years

Excited to share our recent work on CIRTS: “humanized” #RNA -targeting CRISPR/Cas systems. This technology allows us to control gene expression at the RNA level by exploiting RNA regulatory mechanisms (degradation, translation, editing, etc.) 1/n

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bryan dickinson

@chembioBryan

3 years

Absolutely amazing. So incredibly proud to be a scientist right now. I hope people get what a big deal this is. Here is my wife - getting a tiny bit of relief - after spending months on the frontline dealing with misery. Proud of her, @pfizer , the whole system. There is hope....

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bryan dickinson

@chembioBryan

4 years

Indeed. If you are applying to grad school in chemistry and want to apply to UChicago (or are mentoring someone in that position) email me just to say "hi" and I'll get them an application fee waiver. No justification needed and no nationality requirement. Also no GRE this year

Mark Levin

@LevinChem

4 years

Fun fact - faculty are allowed to give out an unlimited number of these fee waivers at @UChiChemistry . Send me a DM or email and I'll gladly share!

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bryan dickinson

@chembioBryan

5 months

Would you be surprised to learn that acid chlorides are not only compatible with biological research, in water mind you, but are in fact, AMAZING? Read on to see the answer… 1/n

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bryan dickinson

@chembioBryan

5 years

What a nice surprise from the group this morning! I learned a lot from going through tenure - but one key lesson is to build a group culture that is both fun and legitimately passionate about their science. This group of mine just blows me away!

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bryan dickinson

@chembioBryan

1 year

Apparently this is someone’s dorm room door to prep for my final tonight! Good luck to the amazing @UChicago undergrads I had the privilege of meeting this quarter. You are all awesome.

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bryan dickinson

@chembioBryan

4 years

Our most recent work is now online at @ACSCentSci . Small molecule control of programmable epitranscriptomic systems and first early stage in vivo applications of #CIRTS . Very excited about the future of this project area!!

Small Molecule-Inducible RNA-Targeting Systems for Temporal Control of RNA Regulation

All aspects of mRNA lifetime and function, including its stability, translation into protein, and trafficking through the cell, are tightly regulated through coordinated post-transcriptional modifi...

pubs.acs.org

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bryan dickinson

@chembioBryan

7 months

Our newest work from grad student @YangCao_awesome is out! Check out "Translational activating RNAs" ("taRNAs"), an RNA-based platform technology to up-regulate target gene expression at the mRNA level: 1/n

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bryan dickinson

@chembioBryan

4 years

I updated my twitter profile to better reflect my identity and reality....

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bryan dickinson

@chembioBryan

5 years

PSA to prospective grad students: Spend more time looking internally (what do YOU need for success). What science TRULY excites you? What mentorship and support structures do you need? What outside-of-lab lifestyle will keep you happy and motivated during grad school? (1/3)

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bryan dickinson

@chembioBryan

4 years

My group has an immediate postdoc position open for a candidate with a strong background in synthesis. Well-funded project and an opportunity to learn chembio while leveraging synthetic skills in a collaborative environment. DM or email me with questions

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bryan dickinson

@chembioBryan

5 years

Medium-throughput screening using a system to run gels with 200 protein samples at a time. This monster makes me want to get back into lab and do some science....

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bryan dickinson

@chembioBryan

1 year

Such an honor for the team! Thanks for all the support for our work from the community.

ACS Publications Bio & Med Chem Content

@ACSBioMed

1 year

🏅 Congrats to Bryan Dickinson ( @chembioBryan ), winner of the first annual #ACSChemBiol Young Investigator Award! Read all about Bryan's work and contributions to the field of chemical biology here ➡ @ACS_DivBioChem

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bryan dickinson

@chembioBryan

4 years

Checkout our new paper We develop a new #directedevolution system to rapidly evolve selective binding between proteins, which we combine with ancestral reconstruction to probe how historical contingency effects molecular #evolution outcomes. More later

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bryan dickinson

@chembioBryan

2 years

Check out our recent paper on a chemical method to catalyze the rearrangement of m1A to m6A on RNA! Tweetorial thread below! 1/n

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bryan dickinson

@chembioBryan

3 years

a really happy day for us. ⁦ @pfizer ⁩

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bryan dickinson

@chembioBryan

5 years

5 years ago on this day building my lab was informally started when my wife helped my load up a pickup truck with used lab equipment to ship to Chicago. That incubator (tan) was $9 - and every paper we've published has relied on it. Hope it lasts the next 50 years!

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bryan dickinson

@chembioBryan

11 months

Check out our most recent paper out in @cell_res ! In this work, we evolved a new custom reverse transcriptase that is sensitive to RNA Nm modifications (alcohol methylation), and installs mutations at each modification site, as a new mapping method 1/n

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bryan dickinson

@chembioBryan

5 years

Glad our paper is out! We spent several years now working on proximity-dependent split T7 RNAP biosensors. Now, we’ve split an esterase as a biosensor. Why? Because it can generate small molecules, and small molecules are super powerful! 1/n

ACS Central Science

@ACSCentSci

5 years

Read our latest #ASAP ! A new split esterase biosensor system allows for inducible activation of small molecule imaging agents & bioactive molecules, with applications in bioanalysis & synthetic biology. @chembioBryan @JCLewisLab @lippertlab #ChemTwitter

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bryan dickinson

@chembioBryan

2 years

What a lovely, lovely day. I gave my next promotion talk to my amazing colleagues and friends @UChiChemistry @UChicagoPSD @UChicago . My day started with surprise balloons at my office...here is @YangCao_awesome and Victoria setting up. Definitely got the feels... 1/n

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bryan dickinson

@chembioBryan

3 years

Our most recent paper on @ChemRxiv - an evolutionary system for optimizing PPI inducers #PACE #continuous #evolution #synbio

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bryan dickinson

@chembioBryan

3 years

Happy to present our newest work! Grown out of frustration with current chemical tools, we developed a new pan-active DHHC inhibitor for the study of protein S-acylation (palmitoylation)

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bryan dickinson

@chembioBryan

2 years

Are you a chemical biologist looking for a faculty position? Do you want to use your skills to address questions and problems in cancer? Do you enjoy collaboration? Will you be my friend? If you answered all of these questions 'yes', then apply to:

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bryan dickinson

@chembioBryan

2 years

So excited for my colleague Chuan to take the helm for the chembio community! @ChemicalBiology is and always has been one of my favorite chembio journals to pick up and just read random papers from. The future is bright

UChicago Chemistry

@UChiChemistry

2 years

Congratulations to Chuan He for his appointment as editor-in-chief for ACS Chemical Biology of @ACSPublications

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bryan dickinson

@chembioBryan

4 years

You know, I made it this far without ever publishing a paper in @angew_chem ... I think I’ll be fine continuing that

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bryan dickinson

@chembioBryan

1 month

Our new proximity labeling technology is now published!! This new subgroup is doing some amazing work - more to come!

Bioorthogonal masked acylating agents for proximity-dependent RNA labelling

Nature Chemistry - RNA localization is key to regulating cellular function but is challenging to measure in an unbiased manner. Now a combination of enol-masked acylating probes with a...

www.nature.com

bryan dickinson

@chembioBryan

5 months

Would you be surprised to learn that acid chlorides are not only compatible with biological research, in water mind you, but are in fact, AMAZING? Read on to see the answer… 1/n

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bryan dickinson

@chembioBryan

5 years

Early birthday present. Wife commissioned a family portrait. It’s me (scientist), her (doctor), our two kids (ninjas with lightsabers, 2 and 5) fighting off zombies and zombie penguins. This is literally the perfect representation of my life. Just perfect

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bryan dickinson

@chembioBryan

4 years

Glad this work is finally out! Lots to say about this: First a summary. We discovered a new enzyme with S-deacylation activity (it removes lipid modifications from proteins) called "ABHD10" - which previously did not have a known role 1/n

Nature Chemical Biology

@nchembio

4 years

Work from @chembioBryan @YangCao_awesome @CBwolfTQ @RahulSKathayat identifies ABHD10 as an S-depalmitoylase that modulates the activity of PRDX5. Readable link at .

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bryan dickinson

@chembioBryan

4 years

6 years ago on this day my wife and I loaded up a pickup with used explosion-proof freezers and a 60 year old incubator in Boston, and then moved to @UChicago to start our next adventure together. Time flies! But that incubator still chugs away in my lab

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bryan dickinson

@chembioBryan

8 months

Excited to share our group's most recent work out today in @CellReports : In this paper, we discover ERK1/2 are regulated by dynamic lipidation - illuminating a new layer of control for these critical cellular kinases 1/n

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bryan dickinson

@chembioBryan

1 year

If you try to force academic labs to go through a laborious MTA process to share your published DNA vector you should lose your NIH funding. Its not 1995. Your DNA has no value, I promise. We'll just synthesize it. Use @Addgene you jabronis.

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bryan dickinson

@chembioBryan

4 years

PSA to chemistry & chemical biology postdocs - you should apply for the K99 through GM. I would be happy to give insights (4x study section for these) of what makes a successful app if there was community interest. One thing is clear - if you don’t apply you won’t get it

Jason Sheltzer

@JSheltzer

4 years

Here are the award rates for 11 different postdoc fellowships in 2019. There’s a huge variation in success rates: four different organizations fund fewer than 6% of applications that they receive, while the success rates for the K99 and F32 are >24%.

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bryan dickinson

@chembioBryan

3 years

Chembio at @UChiChemistry is pretty epic…

The University of Chicago

@UChicago

3 years

Nobel Prize-winning biochemist Jack Szostak will join the #UChicago faculty as a University Professor in the Department of Chemistry and the College.

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bryan dickinson

@chembioBryan

5 years

I'm thinking that I might be one of the only people who agreed to review papers and grants right now....quite a backlog. THANK YOU to whoever is reviewing our papers right now =)

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bryan dickinson

@chembioBryan

4 years

Check out our most recent work in @ChemicalBiology - we use Darwinian evolutionary principles to essentially perform thousands of protein-protein interaction biochemical assays in ~2 days

A Phage-Assisted Continuous Selection Approach for Deep Mutational Scanning of Protein–Protein...

Protein–protein interactions (PPIs) are critical for organizing molecules in a cell and mediating signaling pathways. Dysregulation of PPIs is often a key driver of disease. To better understand the...

pubs.acs.org

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bryan dickinson

@chembioBryan

5 years

PSA to young scientists: if you have not converted your talk from 4:3 to 16:9 do it now! So much better and all seminar rooms I have been in since I switched (~9 months now) are optimized for this modern ratio. Don’t fear the change - its great! Your advisor will follow suit 😉

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bryan dickinson

@chembioBryan

5 years

On the plus side, -20 degree weather is perfect for making ice cream. Plop the kitchen aid outside and 20 min later out comes salted caramel ice cream. The many benefits of Chicago winters people don’t know about 😉

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bryan dickinson

@chembioBryan

3 months

Check out our recent review on the synthetic biology of RNA-targeting for therapeutics, in honor of my incredible @UChicago @UChiChemistry colleague, Chuan He’s 2023 @WolfPrize_

Engineered RNA‐Binding Proteins: Studying and Controlling RNA Regulation

The complexity of eukaryotic organisms is intricately tied to transcriptome-level processes, notably alternative splicing and the precise modulation of gene expression through a sophisticated...

onlinelibrary.wiley.com

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bryan dickinson

@chembioBryan

1 year

That feeling when… your grad student explains her secret Santa present is for her amazing mentor who is so supportive and helpful…you stand up to get your present…only to awkwardly realize she is referring to your postdoc. You sit down. Or maybe throw a fit? 😂😂😂

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bryan dickinson

@chembioBryan

2 years

To all the peptide haters....this could be a game changer. Its a "boring", almost entirely natural, linear peptide...

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bryan dickinson

@chembioBryan

4 years

Big congrats to a team effort between @UChicago @UChiChemistry and @argonne interrogating PLpro from SARS-CoV-2, the virus that causes COVID-19. This protein is a viable drug target for antiviral development, which could be accelerated by this work. 1/n

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bryan dickinson

@chembioBryan

6 months

Another very cool application of our split RNAP biosensor technology from the Saito lab in Kyoto. Split RNAPs + split antibodies = intracellular detectors for everything! Bonus fact - the first author (Shodai) will be doing the team soon!

Target-dependent RNA polymerase as universal platform for gene expression control in response to...

Nature Communications - Controlling gene expression in response to the intracellular molecule of interest is challenging. Here, the authors repurposed antibody variable regions to control gene...

www.nature.com

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bryan dickinson

@chembioBryan

2 years

Congrats to my colleague Chuan for being awarded the @UChicago graduate mentorship award. A world-class mentor.

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bryan dickinson

@chembioBryan

5 years

Excited to share our most recent work: Here we developed a versatile selection platform to create reverse transcriptases that "encode" RNA chemical modification in mutations for quantitative, high-throughput analysis by sequencing 1/n @naturemethods

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bryan dickinson

@chembioBryan

3 years

I just, I gotta say. I'm proud of you all. This revolution has been a huge success. Yay us! Pat, pat on the back. Pat on the back. Happy Halloween!

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bryan dickinson

@chembioBryan

5 years

“Dad, I know what Avenger you should be. He’s a scientist like you, but he’s also a superhero!” Me: “Actually, all scientists are secretly superheroes. But don’t tell anyone” Happy Halloween!!!

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bryan dickinson

@chembioBryan

3 years

What a great night of celebration of chemistry @UChiChemistry @KrishnanYamuna @rmoellering14

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bryan dickinson

@chembioBryan

1 year

I'm not gonna lie... @OpenAI wrote a basically perfect answer to the perennial question "what is chemical biology?"

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bryan dickinson

@chembioBryan

2 years

Thanks to @christhechang @DanNomura and everyone else @UCB_Chemistry for hosting me as Melvin Calvin Lecturer. Such a privilege to visit this very special department that was so influential to me. Going home energized from all of the exciting science and people at Berkeley!

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bryan dickinson

@chembioBryan

4 years

Feeling oddly professorial today - Rushing to the first day of winter class in the crisp cold, with a stack of problem sets, excited and nervous about the new @UChicago quarter. I feel incredibly fortunate to get to do what I do for a living.

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bryan dickinson

@chembioBryan

3 years

Out today: collaborative project with @JCLewisLab on evolution technology development for biocatalyst engineering #pace #pacs #synbio Also our lab's third paper in @ACSCentSci ! Its an honor to have this work out in such an awesome journal.

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bryan dickinson

@chembioBryan

4 years

I support the current bailout - its needed For reference though, here is how the annual NIH budget (in red), meant to fund ALL of biomedical research, compares to the current $1T bailout proposal (in blue) Not only can we afford to invest more in science, we can't afford not to

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bryan dickinson

@chembioBryan

5 years

Setting a new standard in committing to conference attendance, Prof Pohl from @IUBChemistry had her car burst into flames on the way to @SIUC - saved her suit and laptop before the whole thing burned to the ground. And made it for her talk...

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bryan dickinson

@chembioBryan

11 months

Calling all chemical biologists: Mark your calendars Sept 7-12, 2024 for the @EMBO Chemical biology conference at @embl in Heidelberg. Should be the must-attend chembio conference of the year!

Chemical biology 2024

www.embl.org

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bryan dickinson

@chembioBryan

5 years

Celebrating tenure with my awesome group. They humored me and joined in for @marzbrewing south side beer and arcade games. If you told Mortal Kombat-playing 12 yo Bryan he’d be playing Mortal Kombat with his lab as a tenured professor one day, he would not have believed you. Wild

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bryan dickinson

@chembioBryan

3 years

Check out our recent review on RNA-targeting technologies, framed around bifunctional recruitment approaches (small molecule-, oligo-, or protein-based). Exciting times in the field!

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bryan dickinson

@chembioBryan

3 years

Our new DHHC inhibitor story is out now in @ChemicalBiology . This was a huge amount of work over years and required an incredible team effort. Let us know if you want some CMA - and look out for more molecules and screening approaches coming next!

Development of an Acrylamide-Based Inhibitor of Protein S-Acylation

Protein S-acylation is a dynamic lipid post-translational modification that can modulate the localization and activity of target proteins. In humans, the installation of the lipid onto target...

pubs.acs.org

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bryan dickinson

@chembioBryan

1 year

Check out our most recent collaborative work - using our split T7 biosensor system to control oncolytic viruses with clinically-approved small molecules 1/2

Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies

Nature Communications - The large coding potential of vaccinia virus (VV) vectors is a defining feature. Here the authors present vaccinia virus vector-adapted chemogenetic switches enabling...

www.nature.com

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bryan dickinson

@chembioBryan

4 years

@emmersbrown @brianvastag @microbeminded2 If you want more info for the story my wife is an ER physician in Indiana who is seeing the chaos first-hand. DM me for contact

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bryan dickinson

@chembioBryan

5 years

Congrats to my postdoc @beckchemistry for accepting a tenure-track faculty position in Chemistry at Eastern Illinois University @eiu . I still can't believe someone let ME be a professor 🧐. Now their making my peeps profs too? Heady man.... 😏

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bryan dickinson

@chembioBryan

5 years

Monday night cocktail to discuss science and strategy with @KrishnanYamuna . You don’t have to be friends with your colleagues, but life is SO much better when you are!

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bryan dickinson

@chembioBryan

4 years

Check out our most recent work on @ChemRxiv ! CIRTS biosensors for small molecule control of RNA regulation - even in vivo!

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bryan dickinson

@chembioBryan

3 years

Wow. Description of Growth Mindset vs Fixed Mindset from my second grader's class. This is applicable to everyone at every stage of their career in science. So much knowledge here that we should all be reminded of.

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bryan dickinson

@chembioBryan

5 years

Most awardees had quotes from people discussing their science or “tenacity”. Me? I’m apparently an “intellectual tequila shot”. Thanks for the surprise kind words @KrishnanYamuna . Also? Yes - I still dress up for Halloween every year 😉 @halocures

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bryan dickinson

@chembioBryan

5 years

Chuan receiving the ACS ChemBio Lectureship award from @ChemicalBiology at @AmerChemSociety - so deserving for my @UChiChemistry colleague who is an incredible scientist and mentor. Way to go Chuan!

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bryan dickinson

@chembioBryan

1 year

Humbled

GlazerLab

@GlazerChemLab

1 year

Celebrating the ACS Chem Bio Award to ⁦ @chembioBryan ⁩, with ⁦ @AlisonNarayanUM ⁩, Wilfred van der Donk, ⁦ @christhechang ⁩, Yimon Aye, Hosted by Chuan He & ⁦ @ACS_DivBioChem ⁩ ⁦ @GiedrocLab ⁩. What a way to kick off #ACSSpring2023 !

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bryan dickinson

@chembioBryan

4 years

One of today’s homeschool projects

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bryan dickinson

@chembioBryan

6 years

We have several post-doc openings in our group in multiple areas funded by NIH and NSF - including protein engineering, synthetic biology, and directed evolution. Exciting science on horizon. Apply and please retweet! Working in a young lab is a springboard to a great career!

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bryan dickinson

@chembioBryan

2 years

A personal, funny, and deep talk from @lingyinli1 @Stanford_ChEMH at @OHSUSOM . Feels like yesterday we were postdocs…now she is dominating the world!

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bryan dickinson

@chembioBryan

3 years

Yearly reminder. Congrats to all who got the GRFP - its a nice thing to have. To everyone who did not get one - it does not matter in the slightest. Go work hard in the pursuit of science YOU are passionate about in grad school and things will be just fine.

bryan dickinson

@chembioBryan

6 years

To those that did not get @NSFGRFP - I remember when I found out I did not get it. It felt like doors were closed. Well 12 years later I'm a professor at @UChicago w/ a group of 13 amazing grad students and postdocs. Every future is still available to you inspiredby @Gassensmith

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bryan dickinson

@chembioBryan

3 years

@ChemicalBiology Our most recent work in ACS Chem Bio disclosed "PACS-DMS", a phage selection-based approach for performing deep mutational scans of protein-protein interaction interfaces. This is a method we are using more and more in the lab....

A Phage-Assisted Continuous Selection Approach for Deep Mutational Scanning of Protein–Protein...

Protein–protein interactions (PPIs) are critical for organizing molecules in a cell and mediating signaling pathways. Dysregulation of PPIs is often a key driver of disease. To better understand the...

pubs.acs.org

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bryan dickinson

@chembioBryan

1 year

The NIH having to state that study section members cannot use ChatGPT to write their reviews is a sign that are all woefully unprepared for the world we about to enter...

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bryan dickinson

@chembioBryan

5 years

Just had a nice dinner with my organic and chembio colleagues @UChiChemistry ( @rmoellering14 @KrishnanYamuna ). Quite an impressive group to be around - and @LevinChem and @WeixinT aren't even here yet! This is definitely a great time to be @UChicago

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bryan dickinson

@chembioBryan

2 years

Chicago has such a wonderful Ukrainian population. So many of our friends, businesses we go to, and people we interact with are Ukrainian. Seeing hundreds of them pour into the stress, holding flags silently, breaks my heart

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bryan dickinson

@chembioBryan

3 years

Me: Do you know why scientists wear lab coats? Kiddo: To look cool, right? Me: exactly 😂

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bryan dickinson

@chembioBryan

5 years

Are you sure your western didn't work? Let's take a look. Hold on, I think you accidentally opened a dental x-ray. It's what??? 🤪

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bryan dickinson

@chembioBryan

3 years

Read our work out now in @ACSSynBio . An evolution system and protocols for creating molecular glues. This is a new area we are diving head-on into. If you have proteins of interest you would interested in genetically encodable glues for, let us know!

A System for the Evolution of Protein–Protein Interaction Inducers

Molecules that induce interactions between proteins, often referred to as “molecular glues”, are increasingly recognized as important therapeutic modalities and as entry points for rewiring cellular...

pubs.acs.org

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bryan dickinson

@chembioBryan

4 years

Video of the ceremony

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bryan dickinson

@chembioBryan

5 years

Our group tried to have a chill cookout but it turned into a DDR party. Scientists who dance together science together. Or maybe we’re just big nerds. Either way - special group 😉

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bryan dickinson

@chembioBryan

2 years

Check out our most recent work. We designed fluorescent probes for DHHC proteins (lipid transferases) based on cofactor recognition (CoA) rather than substrate recognition. Led by Saara-Anne and @CBwolfTQ in our group!

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bryan dickinson

@chembioBryan

2 years

Very exciting paper out on discovery that Cln5 is a protein S-Deacylase! This is the second protein annotated using our probes (in addition to Abhd10) and we are thrilled to have been able to contribute to this work.

Cln5 represents a new type of cysteine-based S-depalmitoylase linked to neurodegeneration

Cln5 structure reveals thioesterase activity among N1pC/P60 proteins, stressing the role of S-depalmitoylation in neurodegeneration.

www.science.org

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bryan dickinson

@chembioBryan

6 years

Me to 1st year student: "I'd love to see a structure of this protein, I know you have classes and stuff, and we've never done structural biology, but see what you can do, maybe just express it" 8 weeks later, strolls into my office with 1.6A data... Days like this keep you going!

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bryan dickinson

@chembioBryan

5 years

Re this week’s university scandals: @uchicago disbanded sports in 1939 (we were actually really good at football back then - we won the first heissman!) because such competitive college sports were deemed inconsistent with our academic mission. Prescient view 80 years ago.

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bryan dickinson

@chembioBryan

1 year

Celebrating one another, with the team. Truly - that this is my “job” is surreal. Amazing people, amazing scientists.

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bryan dickinson

@chembioBryan

1 year

Lovely night with my inspiring @UChiChemistry Chembio colleagues @WeixinT @rmoellering14 @KrishnanYamuna Jack and Chuan. Too many things to celebrate together.

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bryan dickinson

@chembioBryan

2 years

Celebrating our most recent NIH grant submission with one of our subgroups! Gotta celebrate the submission, not the the outcome. The parts we have control over are done. Now the universe is in the drivers seat…

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bryan dickinson

@chembioBryan

5 years

My advice (in order) is: 1) Find a PI that excites you and will mentor you in the ways you need, 2) who has a set of projects of which the science REALLY (legitimately) motivates you, and 3) that is in an environment that will allow you to have a simple happy personal life. (3/3)

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bryan dickinson

@chembioBryan

5 years

Key to happy assistant prof life? Find a place with good colleagues. Especially junior colleagues.

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bryan dickinson

@chembioBryan

5 years

Wow - reviews back for two papers today. All the reviewers were thorough, fair, reasonable - and critical in helpful ways. What the heck is going on 2019? I am worried an asteroid is going to crash into Earth or something terrible tomorrow - this simply can't last =)

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bryan dickinson

@chembioBryan

2 years

Flattering, but also a little concerning to get such an award from the group today. Hopefully its just a very touching going away gift from my postdoc, Hua, who sadly is leaving for better things. But receiving praise on April 1 always makes you wonder....

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bryan dickinson

@chembioBryan

5 years

Pro-tip: don’t write NIH grants that look like randsome letters. Bold, underlined, bold and underlined, italics, and italics and bold, used at various times on the same page does not increase clarity for the reader 😉

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