Yulab @YulabJin Twitter profile

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Yulab

@YulabJin

3 days

Since Enantioselective beta C-H activation in 2016, we have chased gamma and delta relentlessly, finally:

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Yulab

@YulabJin

2 years

A magic ligand and catalyst towards industrial scale C-H hydroxylation at room temperature with aqueous H2O2: . JACS Video:

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Yulab

@YulabJin

8 months

Presenting my 20 year progress on enantio CH activation in front of my mentor Professor Corey, and teacher Eric Jacobsen who taught me organometallic class then. Photo 1 siting next to my mentor getting ready; photo 2 feeling spoiled when Eric presented the Tishler Prize medal.

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Yulab

@YulabJin

2 years

Finally, a man-made catalyst for gamma methylene CH! Double bond and carbonyl alpha chemistry build 1,2-relationship well, now via beta and gamma CH , we provide new disconnections for 1,3 and 1,4. Many new reactions are coming soon.

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Yulab

@YulabJin

9 months

Developed H-donor catalyst for recruiting COOH, now H-acceptor catalyst for binding OH, Nature: 10.1038/s41586-023-06485-8. Enzymes can use multiple contact points to direct, we only have one, thus needs precise distance and geometry. @JacobsenLab @HoveydaLab @MillerGroupYale

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Yulab

@YulabJin

3 years

Meta-cyclophane transition state strike another gold in CHfunctionalization:Remote directing like enzymes, nature Chem ASAP

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Yulab

@YulabJin

2 years

Bond by bond Molecular editing of C3-C7 was daunting, to reverse the order looked impossible as we call this Apollo 17 moonshot. In addition to distance and geometry, we used chiral recognition to realize this feat for the first time, @nature

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Yulab

@YulabJin

1 year

Distance & geometry is emerging as key principle for ligand design to lower prohibitive TS. Molecular editing of saturated rings is made possible. Nature asap: . Licensed to the newly founded ArCHitect Therapeutics.

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Yulab

@YulabJin

1 year

Alternative [2+2] for BCB scaffold via two sp3 CH and two ArX bonds, not starting from pi orbitals. Ligand innovation is the key:

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Yulab

@YulabJin

4 years

The views expressed in the Hudlicky ACIE paper are unacceptable. As an immigrant to America I know the damaging effects of discrimination. I value diversity in the sciences, and want my students and colleagues to succeed regardless of gender, race, or sexual orientation.

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Yulab

@YulabJin

4 years

Our 100th JACS on C-H is the 100th small step towards protecting group free Enantio-CH activation:

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Yulab

@YulabJin

2 years

As promised, we are coming to hug gamma CH, methyl this time, soon will be methylene. Once again, all controlled by Distance and Geometry, not by stereo/electronic effects @J_A_C_S

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Yulab

@YulabJin

3 years

Receiving Somorjai award(so surprised and grateful) prompted me to revisit my PhD thesis intro on the breathtaking study from the giant in catalysis…

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Yulab

@YulabJin

3 years

Molecular editing of pharmacophores via multiple C-H activation is a powerful tool for exploring molecular diversity. Just submitted.

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Yulab

@YulabJin

6 months

Choosing TBHP for our first sp3 CH oxidation in 2003 was crazy enough @Giri_Research , but never thought sustainable aq H2O2 is possible. Once again, Ligand is the magic:

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Yulab

@YulabJin

3 years

From Soapsuds to drug molecules, science fiction or reality? Enzyme does this for metabolic energy routinely, why not us synthetic chemist! see

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Yulab

@YulabJin

2 years

Explore the universe of Lactone scaffold as potential pioneers for drug molecules: accessing various ring size, topology by different C-H activation reactions. Our seventh reaction for lactones just appeared in JACS ASAP. The next one is even more surprising...

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Yulab

@YulabJin

2 years

Connecting alkyl with olefin is not easy by Heck. C-H tandem reactions offers a alternative for building complexity in one-pot.

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Yulab

@YulabJin

2 years

The magic effect of Table Salts for CH activation discovered in 2007 fueled our journey for weak coordination promoted CH activation. Finally tasted the physical power of table salts in Dead Sea. Photo from a strong bond activation symposium. Curtesy from collaborator Doron.

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Yulab

@YulabJin

2 years

A wonderful experience of Zoom visit to Nebraska chem for Hamilton award lecture on CH activation. The list of past awardees included my mentor and all my heroes I learn orgchem from!

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Yulab

@YulabJin

2 months

Simple amide CONHOMe initially discovered for CH activation with Pd in 2008, turns out be a perfect single electron oxidant for Cu(I) to close a redox neutral CH reaction: without photo activation:

Copper-catalysed dehydrogenation or lactonization of C(sp3)–H bonds

Nature - Use of N-methoxyamides as oxidants enables controllable, redox-neutral, green catalysis of bimodal dehydrogenation/lactonization reactions with methanol as the only by-product.

www.nature.com

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Yulab

@YulabJin

4 years

"Hi-5": Odd numbers don't do well in cycloaddition, Hojoon invites isopropyl to join the 3+2 party! The beginning is always very hard, but equally exciting!

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Yulab

@YulabJin

10 months

Scaffold-oriented CH reaction. 3 CH activation build two scaffolds: cyclopentane & lactone for short total synthesis. @MartinTomanik beautifully done👍

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Yulab

@YulabJin

2 years

Learning fishing from ocean is not easy. Another whole morning with nothing and teammate had to go. I begged for the last cast, and within 30 second, a 35 cm long corbina is on! How many times we missed the last cast in experimental science, I think many!

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Yulab

@YulabJin

3 years

A wonderful colleague and Tabletenis playmate Ardem just won the prize for his study on how we feel mechanic touch. For sure his backhand touch for Tabletenis is pretty impressive.

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Yulab

@YulabJin

10 months

THE biggest challenge in CH activation: down or up-regulate the metal/substrate affinity. Enzymes use directing effect so effectively and elegantly that we do not even call them out. Can we mimic: ; @JacobsenLab @HoveydaLab @MillerGroupYale

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Yulab

@YulabJin

3 years

The ability to use native functional group to direct CH activation opens floodgate for magic transformations, many more to come this year...Grateful to Angew reviewers for letting this reaction see the light.

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Yulab

@YulabJin

1 month

Different from nitrene insertion, Sp3CH amination with simple NH donor has been one of the toughest tasks in our lab over the years.

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Yulab

@YulabJin

3 years

So grateful to BMS for their support to chemistry. Working with them on CH activation and drug discovery in the past 8 years is an amazing experience for my group. Looking forward to more collaborations!

Scripps Research

@scrippsresearch

3 years

With pioneering #chemistry that has transformed fields ranging from drug discovery to materials science, Prof. Jin-Quan Yu will be the inaugural holder of the Bristol Myers Squibb Endowed Chair in Chemistry @bmsnews @YulabJin

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Yulab

@YulabJin

2 years

we have done C-H lactonization including beta, gamma, delta and even 8-membered ones, beginning to develop lactamization the same way. See Angew Chem ASAP.

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Yulab

@YulabJin

8 months

Our late stage CH editing LSE mostly hit head & tail since our first publication with Pfizer (JACS 2011). Now we can access the juicy ribeye portion without touching the CH3, creating novel scaffolds and sp3 chemical space for drug discovery: JACS ASAP: Ligand, Ligand, Ligand!

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Yulab

@YulabJin

5 years

sorry, this photo is better taken

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Yulab

@YulabJin

1 year

Molecular editing of sp3 rings must overcome transannular strain to cross the river. Ligand does it by stabilizing multi-cyclic TS (fused, spiro, bridged). works for 4 to 8 membered rings! cant wait to use these tools to escape flatland in our drug discovery adventures! (Nature)

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Yulab

@YulabJin

2 years

Another clinic success molecule from very small library made by our CH reactions. Quality can outperform quantity. To all postdoctors, students dedicated to developing CH reactions, my hat off to you!

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Yulab

@YulabJin

2 years

10 years accumulation of 119 different templates for effective remote directing establishes Rule of Thump for how to design macrocyclophane TS as the sweet spot.

Empirical Guidelines for the Development of Remote Directing Templates through Quantitative and...

The ability to differentiate and selectively activate remote C–H bonds represents a perennial challenge in the field of C–H activation. Since its first report in 2012, a now-established “directing...

pubs.acs.org

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Yulab

@YulabJin

1 year

We have used bifunctional chiral MPAA ligands to control point and axial chirality in CH activation, now planar chirality via remote meta-CH activation, soon in Nature Chem. A great collaboration with Professor QiangHui Zhou, an outstanding alumnus from @BaranLabReads

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Yulab

@YulabJin

2 months

The most updated scheme in this Angew review is the new discovery on how ring strain of TS is engineered to design site-enantio selective catalysts, new chiral catalyst coming soon…

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Yulab

@YulabJin

2 years

Strong bond symposium at Dead Sea. So Nice to see David Milstein again. The rare inspiring metal ligand cooperation in pincer, is also relevant to our bifunctional ligands for CH activation.

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Yulab

@YulabJin

4 years

H index 100 only means we have broken 100 good CH bonds, Nothing more... still, salute to my co-workers for their hard work in the past 17 years.

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Yulab

@YulabJin

2 years

A great day for Scripps! The man on the right of this slide just won his second Nobel, congratulations!

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Yulab

@YulabJin

6 years

Cool! We forgot about this it was submitted so long ago :)

Nature Chemistry

@NatureChemistry

6 years

Palladium-catalyzed enantioselective C(sp3)–H fluorination using a chiral transient directing group strategy ($)

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Yulab

@YulabJin

2 years

Brief story on from covalent auxiliary to potassium salt via weak coordination and ligand discovery:. Still a lot to wrap up, but, hey, Dear Gamma and Delta CH bonds, we are coming to hug you too…

Palladium-Catalyzed Enantioselective β-C(sp3)–H Activation Reactions of Aliphatic Acids: A Retros...

ConspectusEnolate alkylation and conjugate addition into an α,β-unsaturated system have served as long-standing strategic disconnections for the installation of α- or β-substituents on carbonyl-con...

pubs.acs.org

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Yulab

@YulabJin

2 years

sp3CH Lactamization of amides derived from amino acids for rapid synthesis of drugs lenalidomide, brivaracetam and binders for E3 cereblon. Advance in CH activation depends on Ligand, Ligand and Ligand!

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Yulab

@YulabJin

3 years

Reply to Questions: Molecular editing, in our mind, is to modify molecules at any sites in any order with any transformations. It is just beginning, and our next challenge is to reverse the order and achieve higher turnovers, see the revised figure

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Yulab

@YulabJin

2 years

"Plenty of room at the bottom!" @ProfFeynman Pivalic acid, the simplest quaternary starting point: First mono-CH activation controlled by beta-lactonization; second and third by table salt and ligand effect. Numerous quaternary drug candidates can be made via 3 steps. In Angew.

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Yulab

@YulabJin

4 years

Despite the inconvenience, 5 great students defended thesis in 2020. Excited about the diverse chemistry they will do: Phosphorus, Machine learning, Polymer, catalysis, Silicon

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Yulab

@YulabJin

6 years

Reacting at one carbon but creating chiral centers at another carbon far away is an intriguing challenge in chiral recognition.

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Yulab

@YulabJin

2 years

Speaking my mind on many questions about CH activation, from 4 challenges to 1 solution; from misconceptions to new concepts; from why choose Pd to hair-index:

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Yulab

@YulabJin

1 year

Graduate students interview weekend again, many questions and lot of explanations to do about what are the important challenges in CH activation for synthesis and drug discovery. This interview deliberates the big 4 in our lab:

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Yulab

@YulabJin

1 year

Group meeting on Oxo-Wall, a must learn concept for designing metal catalysts, again, on giant’s shoulder.

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Yulab

@YulabJin

2 years

Again and again, new ligand is the rescue to move CH activation technology forward step by step, many more useful reactions are on the way…

J. Am. Chem. Soc.

@J_A_C_S

2 years

Ligand-Enabled Pd(II)-Catalyzed β-Methylene C(sp3)–H Arylation of Free Aliphatic Acids @YulabJin @scrippsresearch @TotalSyntheses #Palladium #Methylene #Csp3 #CHFunctionalization #CarboxylicAcids

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Yulab

@YulabJin

3 years

For prospective students and postdoctors, we are not redesigning website, but providing an fresh update on our progress in the past decade, our current perspective of C-H activation field and what we are up to for the next decade:

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Yulab

@YulabJin

3 years

C-H Reactions designed for core motifs; H2O2 as the oxidant; 3 C-H in 4-step TS: ideality50, @baranlabreads ; complexity74, @SchreiberStuart

ChemRxiv

@ChemRxiv

4 years

Rapid Construction of Tetralin, Chromane, and Indane Motifs via Cyclative C−H/C−H Coupling: Four-Step Total Synthesis of (±)-Russujaponol F by jin-quan yu & co-workers

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Yulab

@YulabJin

2 years

Just beginning, we can see the moon now, still have to land, come on !

Yukun Lin

@YukunLin6

2 years

Reactivity and selectivity, we're still on the way!

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Yulab

@YulabJin

1 year

Depressed by the loss of such an energetic England team, but must applaud the best. 4 Elegant touches achieve beautiful molecular U turn twice. Score or not less important. He IS a player of genius.

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Yulab

@YulabJin

1 month

Finally, a very convenient CH activation method for precious sp3 heterocycles from common acyclic amino substrates, a real treat for drug hunters. Again, ligand design is the magic.

Nature Synthesis

@NatureSynthesis

1 month

Now online: Article by Hau Sun Sam Chan, Yilin Lu & Jin-Quan Yu @YulabJin Palladium-catalysed methylene C(sp3)–H lactamization and cycloamination enabled by chlorinated pyridine–pyridone ligands ($)

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Yulab

@YulabJin

1 year

First encounter with Peroxide oxidant as postdoctor with Prof Corey, then first independent publication on asymmetric CH oxidation with Pd in 2004. We also discovered a Cu catalyzed CH activation in 2006, but never dreamt about giving a lecture named after the hero Kharasch.

UChicago Chemistry

@UChiChemistry

1 year

Prof. Jin-Quan Yu from @scrippsresearch gave three exciting talks on his groundbreaking work on transition metal-catalyzed C–H functionalization chemistry. Prof. Jin-Quan Yu (left) receives the 2023 Morris S. Kharasch Lectureship plaque @UChicago from Prof. Guangbin Dong (right)

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Yulab

@YulabJin

5 years

Grateful forever for rescuing our first two papers on CH activation in 2004!

Angewandte Chemie

@angew_chem

5 years

40 since 2000! Jin-Quan Yu @YulabJin @scrippsresearch recently published his 40th contribution to @angew_chem since 2000. Latest Communication: Latest Review: Top Review on CH activation & CC Coupling:

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Yulab

@YulabJin

1 year

Would feel so bad for Messi and Dimaria if they lose, but this is a final both teams won the cup. It is the outstanding performance both delivered that will stay in everyone’s memory.

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Yulab

@YulabJin

2 years

Just saw this video on latest CH activation for drug discovery: . Correction: the CH hydroxylation paper was accepted within 15 days, not 5. A few slips of tongue from Covid 😂

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Yulab

@YulabJin

10 months

Breath taking efforts from Pharma to find selective inhibitor for Sodium channels. Our CH editing of THF and THP scaffold in 2015 finds the the THF lead (vertex collaboration with Dean Stamos)optimized to give 30k fold selectivity. Medicine for acute pain, very much needed.

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Yulab

@YulabJin

5 years

ChemRxiv allows many potential users to access chemistry that may not be appreciated by just one or two reviewers.

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Yulab

@YulabJin

3 years

C&EN starts to choose from ChemRxiv, getting ahead of review process which can potentially take forever. Good for readers.

C&EN (Chemical & Engineering News)

@cenmag

3 years

With a #palladium catalyst and sodium percarbonate, @YulabJin and coworkers brought together aryl and aliphatic carboxylic acids to make a variety of compounds commonly used in pharmaceuticals:

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Yulab

@YulabJin

2 months

From Asking a curious question in 2001 to now numerous applications in drug discovery and total synthesis, the key is the bifunctional ligand !

Angewandte Chemie

@angew_chem

2 months

Palladium (II)-Catalyzed C-H Activation with Bifunctional Ligands: From Curiosity to Industrialization (Jin-Quan Yu and co-workers) @yulabjin @scrippsresearch #AngewandteReview

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Yulab

@YulabJin

1 year

One of the most accomplished immigrant chemists Kharasch: Cu, peroxide; also served the country during war via rubber and vaccine tech. his bothers grandchildren flew in to the lecture, what a memorable event.

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Yulab

@YulabJin

3 years

Transformer-like ligands with two faces for dual functions: activate CH and O2. This concept is Certainly transforming CH activation chemistry in our laboratory.

Jake Yeston

@JakeYeston

3 years

In @ScienceMagazine this week, @YulabJin reports an optimal ligand for palladium-catalyzed heteroarene hydroxylation straight from oxygen

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Yulab

@YulabJin

1 year

Ligand innovation is the key for inventing new reactions.

Angewandte Chemie

@angew_chem

1 year

Formal gamma-C-H Functionalization of Cyclobutyl Ketones: Synthesis of cis-1,3-Difunctionalized Cyclobutanes (Jin-Quan Yu and co-workers) @scrippsresearch @YulabJin

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Yulab

@YulabJin

3 years

C–H bond breakers seek smarter tools by Dr Boerner. Broad range of perspectives on CH activation.

C–H bond breakers seek smarter tools

Chemists want to selectively take apart any C–H bond in an organic molecule and install something new. How can they expand their C–H activation toolboxes?

cen.acs.org

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Yulab

@YulabJin

2 years

L,X-type transient directing group is emerging as a powerful tool for CH functionalization of native substrates, somewhat like how organocata explore reversible imine linkage

Total Synthesis

@TotalSynthesis

2 years

Pd(II)-Catalyzed Synthesis of Benzocyclobutenes by β-Methylene-Selective C(sp3)–H Arylation with a Transient Directing Group by P. Provencher, J. Hoskin, J. Wong, X. Chen, @YulabJin @scrippsresearch , @houk100 @uclachem , E. Sorensen @PrincetonChem in @J_A_C_S

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Yulab

@YulabJin

5 years

Another step towards the first example of comprehensive molecular editing..

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Yulab

@YulabJin

2 years

What a treat to see in close distance how Scripps chemistry help our BMS colleagues in drug discovery!

Martin Eastgate

@EastgateMartin

2 years

Amazing day at #BMSChemistry celebrating the 10th anniv. of our collab w/h @scrippsresearch ! Great to see my friends @YulabJin @BaranLabReads @DonnaBlackmond @EngleLab @_chrisgparker_ @Dawson_Group and Ben Cravatt in person, celebrating our science as a team! What a decade!!!

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Yulab

@YulabJin

5 years

Pd refuses to give Hi-5 after doing that for 50 years!

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Yulab

@YulabJin

2 years

When electronic and steric effects are absent, distance and geometry is a powerful sixth player who can score 3 points from remote. Enzyme uses this trick routinely without naming it

J. Am. Chem. Soc.

@J_A_C_S

2 years

Achieving Site-Selectivity for C–H Activation Processes Based on Distance and Geometry: A Carpenter’s Approach @YulabJin @scrippsresearch #CHActivation #Catalysis

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Yulab

@YulabJin

6 years

Chiral cyclobutane is a gold ring; Chiral cyclopropane is a diamond ring; for drug discovery; Again, from One to Many...

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Yulab

@YulabJin

7 years

Beta CH bonds can now be viewed as reactive and versatile functional groups, need to work on gamma and delta, long way to go

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Yulab

@YulabJin

5 years

A late 50th birthday present from students. Not me,the students are kicking the CH...

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Yulab

@YulabJin

6 years

Our perspective on asymmetric metallation of symmetric C-H bonds: Enantioselective C(sp3)‒H bond activation by chiral transition metal catalysts

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Yulab

@YulabJin

3 years

We develop CH reactions to: mimic widely used disconnection; rapid construction of common structural motifs.

Angewandte Chemie

@angew_chem

3 years

Advancing the Logic of Chemical Synthesis: C-H Activation as Strategic and Tactical Disconnections for C-C Bond Construction (Yu) @nelsonyslam @yulabjin @scrippsresearch

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Yulab

@YulabJin

5 years

Versatile with multiple transformations; practical with inexpensive oxidant and without column

ChemRxiv

@ChemRxiv

5 years

Ligand-Enabled β-C(sp3)–H Lactonization: A Stepping Stone for General and Practical β-C–H Functionalizations by Zhe Zhuang & Jin-Quan Yu ( @YulabJin )

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Yulab

@YulabJin

6 years

Editing 2 carbon centers of 4 in a small ring with stereocontrol

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Yulab

@YulabJin

1 year

When referee is looking to improve rather than shooting down the innovation, this is what happens: "Its noteworthy how well the team has responded to the criticism and suggestions provided by the referees" (On molecular editing of sp3 CH, with Nature, 2023).

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Yulab

@YulabJin

7 years

Yes the solution is supramolecular or bimetallic catalysis !

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Yulab

@YulabJin

10 months

Still remember the details of our first meeting at Scripps in 2008. He elegantly explained to me what qualify as a new reaction. Logic, insightful and inspirational. Will be immensely missed.

D-CHAB

@ETH_DCHAB

10 months

His knowledge and interests extended outward from chemistry and the natural sciences to literature, music, and the arts. He was a towering figure in the global success story of @ETH_en and its Department of Chemistry & Applied Biosciences @ETH_DCHAB . He will be sorely missed. 3/3

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Yulab

@YulabJin

4 years

Finally, practical and scalable through the long elusive Beta CH lactonization

Scripps Research

@scrippsresearch

4 years

An unprecedented technique, developed by chemists in Jin-Quan Yu’s lab at Scripps Research, simplifies the modification of compounds that are invaluable for applications ranging from #DrugDiscovery to ton-scale #manufacturing @YulabJin @nature

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Yulab

@YulabJin

2 years

What a great recognition of chemistry. Especially proud of my colleague and collaborator Ben 👏

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Yulab

@YulabJin

7 years

Our 200th publication happens to be on meta-C-H activation of a pharmacophore!

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Yulab

@YulabJin

11 months

To help pharma colleagues with our CH editing, even in a small way sometimes, has been the most rewarding in my career. Many exciting collaborations with @pfizer in the past decade, of course, with @bmsnews and @VertexScience , we had great success stories too, from LD to LO.

Scott Bagley

@BagPhos

11 months

For #SynthesisSaturday here's a new #ChemCollabs from @YulabJin and #PfizerChemistry out in @JOC_OL OL asap outlining a double directed C-H functionalization to 3-amino THPs

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Yulab

@YulabJin

4 years

One of My personal favorite CH reactions

Organic Process Research & Development

@OPRD_ACS

4 years

From @J_A_C_S & @YulabJin : A monoselective β-C(sp³)–H acyloxylation of carboxylic acids with TBHP. Rxns run in HFIP at 60 ⁰C/12 h with 10% Pd + a novel Cp-based mono-N-protected β-amino acid ligand; 28 examples, yields to 72%.

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Yulab

@YulabJin

1 year

Congratulations! I am as excited as when I launched my group website in Cambridge University in 2002! Go for it fearlessly and have fun !

Martin Tomanik

@MartinTomanik

1 year

I am thrilled to share that I'll be joining the Department of Chemistry at NYU @nyuchemistry as an Assistant Professor this summer. I’m extremely thankful for the support of my incredible mentors Jin @YulabJin , Seth @HerzonLab , Scott @MillerGroupYale and Jimmy @jimmywuchemist .

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Yulab

@YulabJin

4 years

A recent review: Challenging CH reactions from our lab are mostly driven by this MPAA “monster”, either enantioselective or remote...

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Yulab

@YulabJin

3 years

While several major challenges remain to be addressed, real breakthroughs can be anticipated via catalyst design in next 5 years.

Steve Ritter

@sritterz

3 years

You’ve come a long way baby: C–H activation started from an interesting idea and just kept getting more interesting. A new @cenmag article provides details

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Yulab

@YulabJin

4 years

We did gamma last year, so beta this year. The key is to have the option at will...

Angewandte Chemie

@angew_chem

4 years

Palladium-catalyzed beta-methylene C--H arylations of aliphatic alcohols now possible thanks to combination of L,X-type bidentate directing group and 2-pyridone ligand. @GuoqinXia @SchreiberStuart @brumelillo @YulabJin

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Yulab

@YulabJin

2 years

Directing CH activation from distal by native functional groups has transformative power in synthesis.

J Org Chem/Org Lett

@JOC_OL

2 years

Now showing in #OL in a colossal collaboration, Sorensen, Davies, Yu, and coworkers report an enantioselective formal synthesis of (–)-aflatoxin B2 enabled by multiple C–H functionalizations. Please have a look: @sorensen_group @Huw78347000 @YulabJin

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Yulab

@YulabJin

6 years

Get back to my early perfume chemistry adventure: this time, better muscone?

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Yulab

@YulabJin

7 years

When my Hair index was low...

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Yulab

@YulabJin

4 years

MetaMacrocyclophane is a sweet geometry for remote directing, proven again and again.

ChemRxiv

@ChemRxiv

4 years

A Directive Ni Catalyst Overrides Conventional Site-Selectivity in Pyridine C–H Alkenylation by jin-quan yu & co-workers

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Yulab

@YulabJin

4 years

Encouraging mentor, down to earth scientist, warm hearted friend, will be forever missed. Pioneering contributions to fragment based drug discovery. What a sad day 🙏

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Yulab

@YulabJin

7 years

HandinHand:Linking ligand for prostate cancer cell receptors to pharmacophores via CH activation without losing bioactive functional groups

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Yulab

@YulabJin

10 months

Congratulations, Masa! Keep up the amazing work!

Wertheim UF Scripps

@UFScripps

10 months

Meet new @UFScripps scientist Masayuki Wasa, Ph.D., a synthetic chemist who devises ways to build complex molecules from smaller parts, and then invents methods to study how they work. What's a synthetic chemist? Read on. #chemistry #biochemistry 🧪🧵1/2

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Yulab

@YulabJin

7 years

One On One : we needed 20 equivalent e-deficient Arene in 2009. Now finally down to 1 with a new catalyst! Coming soon...

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Yulab

@YulabJin

10 months

Nice progress in developing hybrid of carbohydrates and hydrocarbon fragments for drug discovery, but CH activation in carbohydrate still need much more powerful catalyst than Pd/MPAA, so we can run at room temperature in aqueous solution.

ACS Central Science

@ACSCentSci

10 months

C–H Glycosylation of Native Carboxylic Acids: Discovery of Antidiabetic SGLT-2 Inhibitors NEW #ASAP by Xiaoguang Lei, @YulabJin & co-workers #PekingUniversity @scrippsresearch Read it here:

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