Covalent BTK inhibition has provided a major advancement in treating B-cell malignancies, such as
#CLL
&
#MCL
.
But
#DYK
: CLL & MCL can evolve over time to evade covalent inhibition, presenting a growing unmet need for patients.
#LymSM
#LeuSM
Learn more:
Despite the clinical benefits of oral anticancer medications in B-cell malignancies, managing drug adherence remains a clinical challenge.
#leusm
#lymsm
Learn about factors that influence adherence & how you can help your patients overcome these barriers:
See results from a real-world database study assessing patient characteristics, treatment patterns, & clinical outcomes in patients w/ previously treated Mantle cell
#lymphoma
.
Published in Advances in Hematology:
#lymsm
#MCL
#RealWorldEvidence
New
#lungcancer
data from
@SWOG
published in
@JCO_ASCO
OS data from the phase II Lung-MAP sub-study S1800A, evaluating a
#VEGFR2
inhibitor + a
#PD1
inhibitor vs standard of care in advanced
#NSCLC
previously treated w/ IO and platinum chemotherapy:
#LCSM
The androgen signaling pathway is a key driver of
#prostatecancer
progression in
#mCRPC
.
The interaction between the androgen receptor (AR) & other molecular pathways leads to continued AR activation, resulting in disease progression.
#pcsm
Learn more:
#MantleCellLymphoma
(MCL) is a rare & aggressive B-cell
#lymphoma
. Presentation, characteristics, & course are heterogenous, making disease mgmt complex.
#lymsm
HCPs - Learn how biomarkers & other prognostic factors can help optimize therapy & outcomes:
In honor of
#ColorectalCancerAwarenessMonth
, we're highlighting the importance of:
1) Regular screening - the most effective way to detect
#CRC
in earlier stages.
2) Biomarker testing at diagnosis - to inform treatment decisions & improve outcomes.
#CRCsm
#GetScreened
Invasive disease-free survival (IDFS) & distant relapse-free survival (DRFS) are standardized, clinically meaningful endpoints in
#EarlyBreastCancer
#ClinicalTrials
.
Learn more about these endpoints & their significance in adjuvant
#breastcancer
trials:
Mantle cell lymphoma (
#MCL
) is a rare form of non-Hodgkin
#lymphoma
w/ significant unmet needs, particularly for patients who’ve relapsed/progressed after initial therapies.
#lymsm
HCPs: Learn more about the challenges & unmet needs for pts living w/ MCL:
At
#ASCO22
–
@SWOG
is presenting OS data from the Lung-MAP non-matched sub-study S1800A, evaluating a
#VEGFR2
inhibitor + a
#PD1
inhibitor vs standard of care in advanced
#NSCLC
previously treated w/ IO and platinum chemotherapy
View presentation details:
#Breastcancer
is a journey unique to each individual. Hear from Dr. Shaheenah Dawood about developing individualized therapy plans that account for patient specific factors, such as medication beliefs & family member involvement.
#BCSM
Learn more here:
For patients with HR+/HER2- early breast cancer, which feature(s) should be assessed to help determine the risk of disease recurrence?
Check your knowledge by clicking the images below & visit for more information.
#EarlyBreastCancer
#BreastCancer
#BCSM
#ASH23
- We’re excited to share new and updated data from our research in hematologic cancers, including three oral presentations, at the
@ASH_hematology
Annual Meeting in San Diego.
Check out our full lineup of presentations here:
#leusm
#lymsm
Thank you to all those who joined us for an excellent
#ESMO23
!
HCPs – You can visit the Loxo
@Lilly
congress hub to see the research we presented at this year's meeting, including new data in
#breastcancer
, as well as RET-driven cancers:
#CancerResearch
HR+ HER2-
#EarlyBreastCancer
generally has a positive prognosis, however ~20% of cancers will progress to incurable metastatic disease.
Click to learn more about the clinical & pathological factors associated with a higher risk of
#recurrence
:
#BCSM
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) have been recently updated for B-Cell Lymphomas, including mantle cell
#lymphoma
(MCL).
View the updated guidelines here:
#lymsm
#MCL
#MantleCellLymphoma
We are proud to be part of
@YaleCancer
's Consortium to Advance Equity in Early-Phase Clinical Trials
This program will increase access for underrepresented & minority patients to investigational new drug therapies & reduce barriers to trial participation:
Hypothetical case: 52 y/o perimenopausal woman presents w/ right breast mass & is diagnosed w/ HR+/HER2-
#EBC
. Clinical workup shows stage III disease, 6.5cm tumor, histologic grade 3, & 4+ ALNs.
#bcsm
Is there a high risk of recurrence?
Learn more here:
View the results from the largest cohort in monarchE, a phase 3 open label study of the addition of a CDK4 & 6 inhibitor to endocrine therapy in patients w/ HR+, HER2-, node-positive, high-risk
#earlybreastcancer
.
Published in
@OncJournal
:
#bcsm
We are excited to connect with the greatest minds in
#CancerResearch
from around the world at
#AACR23
!
To view the full lineup of Loxo
@Lilly
presentations showcasing new clinical data from our early phase
#oncology
pipeline, click here:
Managing patients w/
#breastcancer
requires multidisciplinary expertise from oncologists, nurses, pharmacists & others. As HCPs help patients navigate their
#patientjourney
, it is important to get the first treatment cycle right. Learn more here:
#bcsm
The risk of recurrence in HR+
#EarlyBreastCancer
shows a steep incline during the first 2 years after primary diagnosis.
Click here to learn more about this patient group and methods to guide them through their treatment journey:
#BCSM
#EBC
#BreastCancer
At
#AACR23
, see Dr.
@YoninaMG
present the first clinical data from our phase 1 study of a KRAS G12C inhibitor in patients with KRAS G12C-mutant advanced solid tumors.
#KRAS
#CancerResearch
View presentation details here:
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) have been recently updated for breast cancer, including updates in
#earlybreastcancer
.
Visit to see the latest version (Guidelines➡️Tx by Cancer Type➡️Breast Cancer)
#bcsm
#breastcancer
HCPs - It is important for patients with HR+/HER2- early
#breastcancer
to quantitatively understand their risk of recurrence.
#bcsm
#ebc
Learn more about methods to communicate those risks & how to help patients over the course of their treatment journey:
#ESMO23
Oral Presentation:
A preplanned overall survival interim analysis from the monarchE trial, including 5-yr efficacy outcomes in HR+, HER2-
#EarlyBreastCancer
patients at high risk of recurrence.
See the results here:
#bcsm
#breastcancer
Published in
@TheLancetOncol
:
Read the 4-year results from a preplanned analysis from monarchE, a phase 3 study of the addition of a CDK4 & 6 inhibitor to endocrine therapy in patients w/ HR+, HER2-, node-positive, high-risk
#earlybreastcancer
:
#bcsm
HCPs - For patients with HR+/HER2-
#EarlyBreastCancer
, clinical factors, such as ≥4 positive ALNs & stage III disease, are associated w/ a higher risk of recurrence.
Understanding these factors can help optimize adjuvant therapy.
#bcsm
Learn more here:
Results from a phase I/II clinical trial evaluating an investigational non-covalent (reversible) BTK inhibitor for the treatment of
#CLL
have been published in
@NEJM
.
Read the study results here:
#lymsm
#leusm
#BTKi
HCPs:
#DYK
~30% of patients with high-risk
#EarlyBreastCancer
will experience disease recurrence within 5 years?
As health care providers, it is important to recognize high-risk features to optimize adjuvant therapy.
#bcsm
#breastcancer
Learn more here:
Quiz: More than half of patients with HR+/HER2-
#MBC
have at least one disease-related factor that is more likely to confer a poor prognosis.
Check your knowledge by clicking the images below, then visit to learn more.
#bcsm
#breastcancer
#AACR23
attendees - Thank you to everyone who joined us in Orlando & online!
Visit the Loxo
@Lilly
congress hub to explore the research we presented at this year's meeting, including the first clinical data from our
#KRAS
G12C program:
#CancerResearch
With ~30% of patients with high-risk, HR+/HER2-
#EarlyBreastCancer
experiencing disease recurrence within 5 years, invasive disease-free survival (IDFS) is a meaningful endpoint in EBC clinical trials.
Want to learn more? Click here:
#BreastCancer
#BCSM
Hypothetical case: 50 y/o postmenopausal woman presents w/ right breast mass & is diagnosed w/ HR+/HER2-
#EBC
. Clinical workup shows stage II disease, 4 cm tumor, histologic grade 3, & 1+ ALN.
Is there a high risk of recurrence? Take the quiz & learn more
#ASCO23
attendees - Thank you to everyone who joined us in Chicago & online!
Visit the Loxo
@Lilly
congress hub to view the research we presented at this year's meeting, including updates in breast, hematologic, and pediatric cancers:
#CancerResearch
A real-world study of US oncology practices quantifies the characteristics and outcomes of a high-risk HR+, HER2-
#earlybreastcancer
population, defined by the clinicopathologic criteria used in the
#monarchE
trial.
#bcsm
Published in
@FutureOncol_FSG
:
NOW PUBLISHED in
@JCO_ASCO
: Updated results from the phase I/II BRUIN study, investigating a highly selective, non-covalent (reversible) BTKi in patients w/ covalent BTKi pre-treated
#MantleCellLymphoma
.
#lymsm
Read the results here:
Evaluating risk of recurrence can help HCPs appropriately identify & treat pts w/ HR+/HER2- EBC & avoid overtreatment of those at low-risk of recurrence. (6/6)
Want access to more EBC resources, including thought leader videos & infographics?
Click here:
In
@NEJM
, see the interim results from LIBRETTO-531, a phase III study of a highly selective RET-kinase inhibitor vs. cabozantinib or vandetanib in advanced, kinase inhibitor naïve, RET-mutant
#MedullaryThyroidCancer
.
See the results:
#PrecisionMedicine
Published in
@TheLancetOncol
, learn more about tumor-agnostic efficacy & safety of a selective RET inhibitor in pts w/ RET fusion-positive solid tumors other than lung or thyroid.
#CancerResearch
View the results:
We look forward to sharing new research from across our
#oncology
pipeline at
#AACR23
, including 2 oral presentations & 5 posters.
Visit us onsite at the Loxo
@Lilly
booth (1043) to learn more or explore our virtual congress page here:
#CancerResearch
Thank you to everyone who joined us in Chicago and online for the
#ASCO22
Annual Meeting!
Follow the link to visit the Loxo
@Lilly
virtual exhibit, where you can view our presentations and learn more about our latest research:
#CancerResearch
Published in
@JCO_ASCO
, an updated assessment of the safety & efficacy of a selective RET inhibitor in pts w/ RET fusion–positive
#NSCLC
treated in the phase I/II LIBRETTO-001 trial.
#lcsm
Learn more:
A key question for
#oncology
providers is how
#biomarkertesting
can be improved & streamlined for greater patient access.
To address this, we’ve partnered w/ organizations to find solutions to help overcome the barriers.
Learn more about these programs:
We’re excited to be at
#ESMO23
! We look forward to sharing our latest research in RET-driven
#NSCLC
&
#ThyroidCancer
, as well as new data in
#BreastCancer
.
Visit us onsite at the Loxo
@Lilly
medical booth (731) or click here to explore our congress hub:
At
#AACR23
, check out our poster presentation exploring the unique pharmacodynamic properties conferred by differential binding to BTK between covalent BTK inhibitors & a non-covalent BTK inhibitor.
#leusm
#lymsm
View the poster details here:
We're excited to be back in Chicago for
#ASCO23
and look forward to sharing updates from our research in breast, hematologic, and pediatric cancers.
Stop by the Loxo
@Lilly
booth (14007) or follow the link to explore our congress hub:
#bcsm
#leusm
#lymsm
See results from a U.S. real-world database study assessing clinical outcomes in patients with CLL/SLL who previously received treatment with a covalent BTK inhibitor and BCL2 inhibitor.
Published in Leukemia & Lymphoma:
#lymsm
#leusm
#RealWorldEvidence
Join Dr.
@ErikaHamilton9
as she presents efficacy & safety results by age from monarchE, a phase 3 study evaluating the addition of a CDK 4/6 inhibitor to ET in patients w/ HR+, HER2-, high-risk
#earlybreastcancer
.
#bcsm
#ASCO23
Oral Presentation:
#ESMO23
poster presentation – A preoperative window-of-opportunity study of an oral selective estrogen receptor degrader (SERD) in patients with ER+, HER2-
#EarlyBreastCancer
.
Read the study results from the EMBER-2 study here:
#bcsm
#BreastCancer
#SERD
Thank you to everyone who joined us in New Orleans for the
#AACR22
Annual Meeting!
As this year’s meeting comes to a close, please visit our virtual medical booth to view our presentations and learn about our latest oncology research:
#CancerResearch
NOW PUBLISHED in
@NEJM
:
Interim results from LIBRETTO-431, a phase 3 trial investigating front-line use of a selective RET inhibitor vs chemotherapy w/ or w/o pembrolizumab in RET fusion+ advanced
#NSCLC
.
Read the results here:
#PrecisionMedicine
#LCSM
At this year's St. Gallen Breast Cancer Conference, we're presenting results from the monarchE trial, a study of HR+, HER2-, node-positive,
#earlybreastcancer
patients at high risk of recurrence.
#SGBCC2023
#bcsm
Check out the poster here:
At
#ASCO22
we’re presenting the trial design of postMONARCH, an ongoing study in patients w/ metastatic HR+/HER2-
#breastcancer
that have progressed or recurred following the use of a CDK4 & 6i w/ endocrine therapy.
View presentation details here:
#bcsm
At the AACR-NCI-EORTC Conference, we’re sharing the first preclinical data from our orally available pan-KRAS inhibitors with selectivity over HRAS and NRAS.
See the presentation details here:
#Targets23
#KRAS
#CancerResearch
Now published in
@JAMAOnc
- Efficacy and safety from a pre-planned analysis of patients who received neoadjuvant chemotherapy in the
#monarchE
trial.
#earlybreastcancer
#bcsm
View publication here:
At
#ASCO23
, we're presenting a trial in progress for a phase 2 study evaluating the addition of a CDK 4/6 inhibitor to irinotecan + temozolomide in pediatric & adult patients w/ relapsed or refractory
#EwingSarcoma
.
#clinicaltrials
See the details here:
Attending
#ASCO22
? Join us for a presentation on the ongoing Phase I EMBER trial in patients with advanced breast cancer and endometrial endometrioid cancer who received our investigational SERD.
View presentation details here:
#breastcancer
#bcsm
#AACR23
attendees - See results from the phase 1/2 BRUIN study, investigating a highly selective, non-covalent (reversible) BTK inhibitor in Richter transformation.
#leusm
#lymsm
View the presentation details here:
Poster presentation at
#EHA2023
– A comparison of bleeding-related events in patients who received a highly selective, non-covalent (reversible) BTK inhibitor with and without antithrombotic agents.
#lymsm
#leusm
See the results here:
Thank you to everyone who joined us in Vienna and online for an exciting
#EHA2022
!
Follow the link below to visit the Loxo
@Lilly
virtual exhibit, where you can view our presentations and learn about our latest
#hematology
research:
#LeuSM
#LymSM
Check out our oral presentation at
#ESMO23
to learn about prognostic and predictive impact of estrogen/progesterone receptor and Ki-67 expression in pts w/ high-risk, HR+, HER2- early
#breastcancer
.
#BCSM
#EBC
Exploratory analysis from the monarchE trial:
Join us at
#ASCO22
, where we’ll be presenting on factors increasing the rate of treatment discontinuations in the monarchE trial.
View presentation details here:
#EarlyBreastCancer
#BCSM
Watch Dr. Shaheenah Dawood discuss the challenge of adherence & strategies to help patients overcome these barriers.
HCPs: Click here to access resources supporting adherence & persistence to oral medication in pts w/ breast cancer:
#bcsm
#breastcancer
At
#EHA2023
- Learn about the genomic evolution & resistance to a highly selective, non-covalent (reversible) BTK inhibitor in patients with CLL that were previously treated with a covalent BTK inhibitor (cBTKi).
#leusm
#lymsm
See the details here:
Aloha from
#PPLC22
! We are excited to join clinicians and researchers from around the globe to discuss the latest advances in patient care.
Stop by exhibit 202 to meet our medical team and learn about the research we will be presenting at this year’s meeting.
#LymSM
#CLL
#MCL
We're excited to join clinicians and researchers from around the globe at
#WCLC22
in Vienna!
Stop by exhibit booth 401 to meet our medical team and learn more about the work we are doing to improve the lives of people living w/
#LungCancer
#LCSM
At
#ASCO22
– New data from
@TheUSONetwork
’s MYLUNG Consortium:
Predictors of Biomarker Testing Among Patients with Metastatic Non–Small Cell Lung Cancer (mNSCLC).
View presentation details here:
#LCSM
#NSCLC
We're presenting the first preclinical data from our orally available
#KRASG12D
inhibitor that is selective against wild-type
#KRAS
.
Poster presentation at the AACR-NCI-EORTC Conference:
#Targets23
#CancerResearch
#EHA2022
kicks off this week! We look forward to joining the
#hematology
community to discuss the latest advances in patient care.
John Pagel, VP, & head of global hematology, served as a physician taking care of pts for 25 yrs. Hear what inspired him to join the Loxo
@Lilly
team
Lilly is committed to developing & delivering targeted treatments for people living with
#LungCancer
ICYMI: At
#ELCC22
, we shared updated data from the LIBRETTO-001 trial of a selective RET inhibitor in patients w/ RET fusion-positive
#NSCLC
Learn more:
NOW ENROLLING: A phase 1a/b study of our investigational FGFR3 inhibitor.
This is an open-label, multi-center, phase 1a/b study in patients w/ FGFR3-altered advanced
#urothelial
carcinoma & other solid tumors.
#clinicaltrials
Learn more here:
We’re excited to share new data for hematologic cancers, including three oral presentations, at this year’s
@ASH_hematology
Annual Meeting in New Orleans.
Learn more about our full lineup of presentations at
#ASH22
here:
#leusm
#lymsm
BRUIN CLL-322: A phase 3 open-label, randomized study of fixed duration non-covalent (reversible) BTKi + venetoclax & rituximab vs. venetoclax & rituximab in previously treated CLL/SLL.
#leusm
#lymsm
View the
#ASCO23
Trial in Progress poster:
Covalent BTK inhibition has transformed the mgmt of
#CLL
/
#SLL
, but many pts will require additional treatment.
While at
#PPLC22
, check out our poster presentation assessing a highly selective, reversible (non-covalent)
#BTKi
in previously treated CLL/SLL:
Interested in learning about our trial in progress examining a CDK 4/6 inhibitor combined w/ chemoimmunotherapy in pediatric & young adult patients w/ relapsed/refractory
#neuroblastoma
?
See the details here:
#ASCO23
#clinicaltrials
#PediatricTumors
"
Increased adherence to adjuvant therapy in HR+
#EarlyBreastCancer
has been associated w/ a decrease in all-cause mortality.
#bcsm
Strategies to improve adherence are centered around open & honest communication between the HCP & patient.
Learn more here:
At
#EHA2022
, we’re presenting results from the BRUIN phase 1b study of a highly selective, reversible (non-covalent)
#BTKi
in combination w/ a
#BCL2
inhibitor +/- immunotherapy for patients w/ relapsed/refractory
#CLL
.
View presentation details here:
#AACR22
attendees, we’re excited to share results from the BRUIN phase 1b study evaluating a reversible (non-covalent)
#BTKi
in patients with relapsed/refractory chronic lymphocytic
#leukemia
#CLL
. View the presentation details here:
#ESMOBreast23
– We are presenting results from a real-world UK study evaluating treatment patterns & clinical outcomes of a CDK 4 & 6 inhibitor in patients with HR+, HER2- metastatic breast cancer.
See the details here:
#bcsm
#MBC
#RealWorldEvidence
We’re excited to join the
#hematology
community in Houston for
@SocietyofHemOnc
’s 10th annual meeting!
#SOHO22
If attending, be sure to stop by booth 150 & meet our medical team.
To learn more about our latest
#bloodcancer
research & pipeline, visit:
Join our poster discussion at
#ASCO23
to learn about long-term safety with ≥ 12 months of a non-covalent (reversible) BTK inhibitor in patients with relapsed/refractory B-cell malignancies.
#lymsm
#leusm
View the presentation here:
#ESMOBreast23
attendees - Interested in learning about the preclinical characterization of an oral selective estrogen receptor degrader (SERD) with activity in a brain metastasis model?
See the details here:
#bcsm
#breastcancer
#SERD
Trial in Progress at
#ASCO23
:
BRUIN CLL-314: A phase 3, open-label, randomized study of a non-covalent (reversible) BTKi vs. ibrutinib in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL).
#leusm
#lymsm
Learn more here:
We are excited to be at
#ESMOBreast22
! Stop by exhibit booth 27 to meet our medical team. Or, if attending online, visit our virtual exhibit to connect & learn about the research we’ll be presenting at this year’s meeting.
Visit our virtual booth:
#bcsm
See our poster presentation at the St. Gallen Breast Cancer Conference, describing real-world patient characteristics, treatment & long-term outcomes in pts w/
#earlybreastcancer
at a high risk of recurrence in Scotland.
#SGBCC2023
#bcsm
View the poster:
We’re looking forward to presenting new data from across our
#oncology
portfolio at the
#ASCO22
Annual Meeting.
Developing innovative new medicines for people living with
#cancer
is at the center of what we do.
Learn more about our presentations here: