Paul Kiesow @KiesowPaul Twitter profile

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Paul Kiesow

@KiesowPaul

1 year

Baka Karasu 烏

@BakaKarasu

1 year

@KiesowPaul This has "summoning the Kali of Time to renegotiate the contract" vibes ;-) (You look great.)

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Paul Kiesow

@KiesowPaul

1 year

Seventy-first birthday greetings!

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Paul Kiesow

@KiesowPaul

3 months

Have done due diligence investigating rapamycin, listening, observing visible results. Rapamycin is a dead end with many unwanted effects—classic example of animal studies not transferring to humans. It affects differentiation & autophagy, which may account for animal successes.

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Paul Kiesow

@KiesowPaul

1 month

(1 of 2) I turn 72 in June. The really hard stuff comes now. Lots of bad things (aging-wise/disease conditions) are imminent or happen on the way to 80—many septuagenarians won't make it there alive, quite apart from the mundane task of maintaining a youthful appearance & affect.

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Paul Kiesow

@KiesowPaul

9 months

The thymus gland is programmed to go offline at about age 65 with ramifications for immunity. Losses in one's immune response make infectious disease and even cancer more likely: Intrathymic Somatotropic Circuitry—consequences upon thymus involution

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Paul Kiesow

@KiesowPaul

3 months

Septuagenarian to octogenarian, sans senescence: indeed an unforgiving gauntlet, yet eminently doable. One I'm running right now. 😉

Paul Kiesow

@KiesowPaul

5 months

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Paul Kiesow

@KiesowPaul

9 months

Metformin summarily reduced any fixation w/ eating and has brought about intermittent daily fasting without my even being aware of it. It resets one's metabolism in my opinion and can be implemented after age 40. A1c of 5.0, O2 98%, complete GI balance, no workout/dietary program

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Paul Kiesow

@KiesowPaul

9 months

July 2004 — 52 y.o. No disrespect to the many high-profile life extension players, but let's be honest: practically no such result even comes close. In this photo, I had been involved in my anti-aging protocols for more than 15 years—no exercise regimen, no special diet.

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Paul Kiesow

@KiesowPaul

11 months

Selegiline has been hiding in plain sight and may be principally responsible for my youthful preservation and vigor. Other important things, such as EPA fish oil, metformin & NAD, affect metabolic health. The brain and its structures direct traffic and must do so smart & strong.

Paul Kiesow

@KiesowPaul

11 months

@LivingForever8 Reposting this picture needs to happen as a specific head-to-head comparison with David Sinclair since he is 52 and I'm shown at that exact same age. As for attribution, I had been taking selegiline for seven years; brain preservation per se is not in his wheelhouse—nor in BJ's.

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Paul Kiesow

@KiesowPaul

1 month

• HMB (β-hydroxy-β-methylbutyrate) 3.5 grams • Leucine 4.5 g — • Arginine 4 g — hGH secretagogue, activates mTOR • Hyaluronic acid 2.2 g • Creatine monohydrate 5 g — converts adenosine diphosphate back to ATP • Taurine 4 g • Collagen peptides 9 g

Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein...

Maintenance of skeletal muscle mass is contingent upon the dynamic equilibrium (fasted losses–fed gains) in protein turnover. Of all nutrients, the single amino acid leucine (Leu) possesses the most...

www.ncbi.nlm.nih.gov

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Paul Kiesow

@KiesowPaul

1 year

Upped EPA/DHA to 8+ grams/day for one week now. Naturally, a bit early to tell, but I feel great! TY to Julia B. and Miss Mitochondria for investigations and thoughtful input.😁

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Paul Kiesow

@KiesowPaul

4 months

Retaining one's thymus deserves more attention. Its 'normal' involution (atrophy/disappearance) after about age 60 is like the loss of key chess pieces in the game of life, yet this need not be so. Preservation and rejuvenation have been demonstrated.

Paul Kiesow

@KiesowPaul

9 months

The thymus gland is programmed to go offline at about age 65 with ramifications for immunity. Losses in one's immune response make infectious disease and even cancer more likely: Intrathymic Somatotropic Circuitry—consequences upon thymus involution

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Paul Kiesow

@KiesowPaul

1 month

Selegiline 1.25 mg/day, six days per week. A quite low dosing schedule that protects nigrostriatal dopaminergic neurons, as well as against a range of α-synucleinopathies.

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Paul Kiesow

@KiesowPaul

5 months

1.) metformin 1g — 21 years 2.) selegiline 1.25mg — 19 years 3.) nicotinamide mononucleotide 1.3g 4.) dehydroepiandrosterone 75mg 5.) EPA/DHA 1.5g — 15 years

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Paul Kiesow

@KiesowPaul

7 months

Forty- and 50-somethings monetizing LE regimens—perhaps before being aged out by changes in appearance. Apart from hype, "gurus emeritus" or methylation test results, people deserve more: visibly compelling anti-aging results at 60 and beyond may be better arbiters of efficacy.

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Paul Kiesow

@KiesowPaul

9 months

Seventeen years selegiline—one of my four aces. Selegiline/deprenyl protects against 'normal' loss of nigrostriatal dopaminergic neurons after age 40, as well as against a range of α-synucleinopathies. Brain compromise = LE queen taken

Monoamine Oxidase-B Inhibition Facilitates α-Synuclein Secretion In Vitro and Delays Its Aggregat...

Cell-to-cell transmission of α-synuclein (α-syn) pathology is considered to underlie the spread of neurodegeneration in Parkinson's disease (PD). Previous studies have demonstrated that α-syn is...

www.ncbi.nlm.nih.gov

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Paul Kiesow

@KiesowPaul

10 months

Father & Son at post-reception get-together August 6, 2023 under the gazebo overlooking SF bay. Free-range egg, Will finishing his nectarine—from their mini-farm. Great times!

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Paul Kiesow

@KiesowPaul

3 months

I quit resveratrol six months ago. It passes muster as a sort of placebo, and in smaller doses it's likely *another decent/benign polyphenol. However, gram+ dosages carry potential unintended consequences/risks. Honestly, could sense no benefits.

Paul Kiesow

@KiesowPaul

5 months

@davidasinclair Recently eliminated resveratrol, which may possess 'sidelined' side effects. Fisetin is cozy, like a warm cup of chamomile tea. DHT, prominent cause of follicular atrophy/hair loss; 5-alpha-reductase inhibition counters it. Cheers

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Paul Kiesow

@KiesowPaul

5 months

Adding vitamin K2-MK7 plus vits K1 & 2 My sister-in-law, 83, shattered her arm two years ago. Doctors took a wait-and-see re surgeries. Went on vit K2-MK7. PTs and orthopedists were surprised, given age and severity. K, more than about bones.

You Complete Guide to Vitamin K2 MK7, Benefits, Sources, and More

Learn how vitamin K2 MK7 differs from vitamin K1 & discover its benefits, signs of deficiency, and how you can incorporate it into your diet.

well.org

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Paul Kiesow

@KiesowPaul

6 months

Question to all antiaging and LE folk: What are your top-three essential nutraceutical and nutritional supplements to support health, preserve youthful vitality and mental clarity?🙂 (I'll tell you mine if you tell me yours.)

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Paul Kiesow

@KiesowPaul

24 days

LE/anti-aging pursuits extend to my mid-30s. They have worked. With zero internal medicine issues (yes, zero), I'm uniquely positioned to preempt pending insults with a reservoir of defensive measures. The human body is actually frail and ephemeral. Constructing a stasis is huge.

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Paul Kiesow

@KiesowPaul

12 days

Bushy enough. Adding KGF (keratinocyte growth factor) hasn't hurt. Most of what you see here is either from finasterine, or good livin' and genes ~ although my bro is totally bald.

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Paul Kiesow

@KiesowPaul

3 months

People should pay more attention to cell loss—skeletal muscle, organ, lean body mass diminishment—an unequivocal trend in age progression. As for sarcopenia, strength training and even steroids merely increase muscle fibers/thickness; they don't replenish muscle cells. Yet . . .

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Paul Kiesow

@KiesowPaul

11 months

DAY 4 serialization The answer is that by 70 most people’s appearance has changed so markedly they’re no longer ‘players’ in the youth preservation game. So, how is age progression assessed: DNA methylation patterns, blood work, inflammation? The gold standard is physiognomy.

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Paul Kiesow

@KiesowPaul

1 year

The kicker: Triglycerides 115 last blood draw. After markedly upping fish oil intake—BOOM, half that at 60 mg/dL

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Paul Kiesow

@KiesowPaul

5 months

BTW,

Frontiers | Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimen...

Metformin has been proposed to operate as an agonist of SIRT1, a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase that mimics most of the metab...

www.frontiersin.org

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Paul Kiesow

@KiesowPaul

11 months

DAY 1 Tweet serialization I'm noticing that I have apparently stopped aging. Between age 70 and 80 much happens and it happens fast. Film stars, media personalities, influencers, notable and powerful people—even gerontologists—begin to “age out” as they approach 80. . . .

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Paul Kiesow

@KiesowPaul

2 months

@YasonWave @deantaplin @BakaKarasu @BeamsOfEnergy Metformin 1g — 21 years for AA only Selegiline 1.25mg — 19 years (few have even heard of it) Nicotinamide mononucleotide/NMN 2.8g (NAD+ slam dunk) Dehydroepiandrosterone/DHEA 75mg — 33 years

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Paul Kiesow

@KiesowPaul

11 months

DAY 3 serialization . . . young people wary of cosmetic issues, seeking preserved youth and aging indemnity; mid-lifers boasting age regression and workout muscles—some sporting shaved heads, cordial botox stares. How many 70+ folks does one encounter looking two decades younger?

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Paul Kiesow

@KiesowPaul

2 months

On the steepest ramp of aging acceleration: Decade Eight. The AA degree-of-difficulty is practically at its height RIGHT NOW. Do I have a general plan? No, I have a specific, targeted, proactive 'high-amplitude' plan—to the extent not every detail is suitable for general posting.

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Paul Kiesow

@KiesowPaul

25 days

L-leucine, isoleucine, taurine, creatine, hydroxymethylbutyrate (HMB), arginine and collagen peptides have been studied specifically for skeletal muscle maintenance. I take them all daily.

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Paul Kiesow

@KiesowPaul

5 months

Piece by Steve Hill for @LifespanIO . Addresses NMN's past, present, future. Mentions high cost; NMN is about as much as many items in people's stacks. Cardiologists are seeing 'deathbed' cardiomyopathy patients perk up, and Hill alludes to such efficacies.

Nicotinamide mononucleotide (NMN): Benefits and Side Effects

Nicotinamide mononucleotide (NMN) is a precursor of the coenzyme NAD+, which serves critical functions in our cells. The decline of NAD+ with age is associated with the development of some age-rela...

www.lifespan.io

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Paul Kiesow

@KiesowPaul

2 years

My son Will Kiesow just received his M.D. He turns 28 in July. Celebrating with Dad!

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Paul Kiesow

@KiesowPaul

2 months

Per the TRIIM study, the thymus need not 'involute'/fade away as it does for most.

Paul Kiesow

@KiesowPaul

5 months

@deantaplin @BakaKarasu @BeamsOfEnergy The TRIIM studIes highlight the importance of thymus health & preservation in maintaining the integrity of one's immune system. I will tell you with a straight face my immune system is at least as robust as it's ever been. No infections, no fear.

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Paul Kiesow

@KiesowPaul

2 months

Someone mentioned K: for four full decades, I've used Morton Lite Salt—an equal balance of potassium and sodium chloride—as my all-use salt. Its balance of potassium is key. This Morton product has been lurking under the radar since its introduction in 1973.

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Paul Kiesow

@KiesowPaul

1 year

Breaky, 4 p.m. Broccoli rabe, limas, garden peas, surti papdi lilva beans, country ham, EVOO. Serves one. 😉

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Paul Kiesow

@KiesowPaul

15 days

Metformin affects NF-kB transcription of genes. Underscored here are pleiotropic effects of metformin in eliminating the susceptibility to common aging-related diseases via its effects to the modulation of NF-kB signaling. Metformin, my #3 go-to 21 years

NF-κB as the mediator of metformin's effect on ageing and ageing-related diseases - PubMed

Ageing can be defined as the progressive failure of repair and maintenance systems with a consequent accumulation of cellular damage in nucleic acids, proteins, and lipids. These various types of...

pubmed.ncbi.nlm.nih.gov

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Paul Kiesow

@KiesowPaul

2 months

A typical octogenarian may have lost 24 percent of brain mass and be medically seen as normal—and will die at age 86 of natural causes. If that individual possessed a healthy, fully intact brain. . . . Perhaps this aging brain is aging itself.

Paul Kiesow

@KiesowPaul

11 months

@LivingForever8 Sounds like a sophism, but the brain likely controls nearly everything regarding mammalian aging.

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Paul Kiesow

@KiesowPaul

2 months

Thank you 1K followers for listening. 😃

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Paul Kiesow

@KiesowPaul

4 months

Liking my January 2024 panel — 53 parameters CBC, Chemistry, Coagulation, GI, Liver enzymes, Kidney function, Nutrition markers, Cardiac/lipi, Glucose/HbA1c, BP, Weight: ALL ideal values, including several immunity/'inflammaging' components (sorry, no CRP or others this round)🙂

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Paul Kiesow

@KiesowPaul

1 year

For those itchin' to see my face sans whiskers, one of the few times I did not have 'em. In the hot & humid tropics—shaved to stay cool and see what had been lurking underneath. My 54th birthday, June 2006

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Paul Kiesow

@KiesowPaul

7 months

Trees don't regress to saplings, yet extreme longevity can be seen in the otherwise unassuming form of a large thriving oak. If aging were to stop in a human, it might be revealed as nearly complete homeostasis housed in the adult human form—not as an adolescent or teenager.

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Paul Kiesow

@KiesowPaul

10 months

At Palo Alto Hills Golf & Country Club for my son and daughter-in-law’s wedding reception.

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Paul Kiesow

@KiesowPaul

5 months

HAPPY NEW YEAR, Y'all 😎

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Paul Kiesow

@KiesowPaul

6 months

NMN stands out in another way: to boost NAD+ it need not be taken sublingually, and the presence or not of food in the stomach has minimal effect on its efficacy/bioavailability. Since November 2021, 650 mg twice daily, no skipped days. Lunulae appear 3-22

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Paul Kiesow

@KiesowPaul

8 months

Dr. Joseph Knoll said that a minuscule/'subclinical' amount of selegiline is effective in maintaining acquired specialized goal-directed cognitive behaviors—rather than just a stimulant like many other drugs: maintenance of brain performance against aging.

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Paul Kiesow

@KiesowPaul

1 year

From my May visit Blood Pressure: 122 mmHg / 74 mmHg Weight: 168.65 lbs Total cholesterol/HDL: 3.1 HbA1c: 5.0 Triglycerides: 60 mg/dL eGFR CKD-EPI: > 90 mL/min/1.73 m2 Na: 138 mmol/L

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Paul Kiesow

@KiesowPaul

4 months

Key in this study is hGH, presumably behind tissue replacement. D₃ and zinc are known immune supporters. Metformin also addresses glycemic issues sometimes seen with hGH. As for DHEA, I have taken it 30+ years; ditto for L-arginine, which can release hGH to an extent.

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Paul Kiesow

@KiesowPaul

16 days

Nunzio brought forth an epiphany that's also eminent common sense: almost no aging exists unaccompanied by cell number losses—skin thinning, sarcopenia, a substantial reduction in brain neurons, and those of organ/lean body mass. It hugely guides my antiaging agenda/protocols.

Nunzio Cuzzucoli

@NunzioCuzzucoli

4 months

@IsmanAnar @DanilaImmortal this is nothing new! today we ignore the only true and common knowledge that causes aging of all tissues, (cellular subtraction) aging manifests itself with the lack of cells that make up the tissues and if this is not remedied it is impossible to repair.

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Paul Kiesow

@KiesowPaul

2 years

I don't always smile, but I'm still happy . . . VERY happy about my hold on aging. (So humble.)

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Paul Kiesow

@KiesowPaul

1 year

By the time Parkinson's is diagnosed via a shaking hand or a dragging foot, it may have been active under the radar for decades—and destroying roughly half of the dopamine-producing neurons in the substantia nigra. (No mention of preventive selegiline)

Twist of fate: What happens when a top Parkinson’s researcher gets the disease?

Though therapies may come too late for him, Tim Greenamyre sees hope on the horizon for patients

www.science.org

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Paul Kiesow

@KiesowPaul

3 months

I have gathered a good bit of knowledge from observations, studies and personal experience regarding a great many supplements and strategies employed by antiagers across the spectrum. I will take questions and happily pass judgment😃on efficacies.

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Paul Kiesow

@KiesowPaul

1 year

First meal today, 5:30 p.m. Broccoli rabe, asparagus, lima beans, surti papdi lilva. I don't eat it because it's healthful, but because it's insanely delicious 😋

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Paul Kiesow

@KiesowPaul

1 year

At 71, lunulae suddenly appearing on great toenails. Timeline: Started 1g/day NMN November 2021; nails start growing out whiter sans ridges March 2022; December 2022 smoother more translucent; April 2023 lunulae appear. Only ever recall seeing them on my fingernails.

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Paul Kiesow

@KiesowPaul

1 year

"Nigral dopamine neurons are progressively lost during normal aging." I circumvented this "normal aging" atrophy/death of substantia nigral neurons by using the MAO-B inhibitor deprenyl (selegiline) from 1996 - 2014. Just resumed it.

The Effects of Aging on Substantia Nigra Dopamine Neurons

www.ncbi.nlm.nih.gov

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Paul Kiesow

@KiesowPaul

1 month

Interesting that a half-dozen following accounts disappeared immediately after I came out as an advocate of activating mTOR ~ as opposed to inhibiting it. I respect others' takes. However, one won't find a rapamycin supporter here. I strive to openly share and discuss, always.

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Paul Kiesow

@KiesowPaul

1 year

Most think of glucosamine mainly as a joint and connective tissue component.

Glucosamine Activates Autophagy In Vitro and In Vivo

Aging-associated changes in articular cartilage represent a main Osteoarthritis (OA) risk factor. Autophagy is an essential cellular homeostasis mechanism. Aging-associated or experimental defects in...

www.ncbi.nlm.nih.gov

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Paul Kiesow

@KiesowPaul

1 year

Do you remember when you joined Twitter? I do! #MyTwitterAnniversary (Twitter kindly wrote me an anniversary Tweet!)

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Paul Kiesow

@KiesowPaul

12 days

Quite a bushy head of hair, especially after applying pure KGF to temples, vertex and hairline. Pure growth factors, I was able to find and obtain. It's always about ADDING, not subtracting.😉

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Paul Kiesow

@KiesowPaul

1 year

Haircut today. Still the '70s 'Shag' . . . just a bit shorter

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Paul Kiesow

@KiesowPaul

4 months

My favorite cut of beef overall: USDA Choice New York strip steak. Baked potato, daikon salad, glass of aronia berry juice

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Paul Kiesow

@KiesowPaul

1 year

Rap has a list of adverse effects as long as one's arm. 1 g/d metformin has NONE, prolongs health span, reduces cancer incidence, optimizes glucose utilization, attenuates Electron Tranport Chain. I don't do the gym, period.

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Paul Kiesow

@KiesowPaul

8 months

Pic du jour Heading to my wife's 42nd b'day dinner

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Paul Kiesow

@KiesowPaul

8 months

This correctly speaks to the etiologies of Parkinson's, critical to forestalling even its precursors. Studies showing preclinical PD indicators [perhaps by AI] are fine. By then, patients are well down that road. Noticing is good—prevention, priceless. 17 years selegiline. 😎

Alpha Synuclein Scientific Resource Guide

@alpha_synuclein

8 months

Learn more about alpha synuclein oligomers and clinical implications for Parkinson disease here! 👩‍🔬

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Paul Kiesow

@KiesowPaul

9 months

Two decades of metf♥rmin: one gram per day, every day. Underestimation of this remarkable drug could work to one's disadvantage.

Mo Elsayed, MD

@MElsayedMD

3 years

Metformin: A diabetes drug with FASCINATING anti-aging and anti-cancer properties. Data shows it can improve response to cancer treatments. Our new study suggests that it can enhance tumor response to Y-90 radiotherapy in HCC. Manuscript here:

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Paul Kiesow

@KiesowPaul

11 months

Omega-3 EPA fish oil — A beautiful, powerful 'no-brainer' part of one's stack. Consequential in an expanding number of known areas. Rhonda and Dr. McGlory elucidate one. (Also HALVED my triglycerides in three months: 115 to 62.)

Dr. Rhonda Patrick

@foundmyfitness

11 months

Devastating us in old age, a short stint in the hospital can cause just enough atrophy that we may not be able to perform the basic activities of daily living - progressing us catastrophically towards early mortality. In my recent interview with Dr. Chris McGlory, Chris

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Paul Kiesow

@KiesowPaul

1 month

Gut microbiota are often implicated in whole-system health. At no time in my life has my GI resiliency and balance exceeded what it is now. At times I wonder if it has positively affected everything else. What have you learned about the microbiome's potential pervasive influence?

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Paul Kiesow

@KiesowPaul

11 months

(2 of 2) Works against toxic oligomerization/aggregation of α-synuclein and a blockbuster range of synucleinopathies, such as [including broader etiologies of] PD, AD, Lewy body dementia, multiple system atrophy (MSA).

Neuroprotective Function of Rasagiline and Selegiline, Inhibitors of Type B Monoamine Oxidase, and...

Synucleinopathies are a group of neurodegenerative disorders caused by the accumulation of toxic species of α-synuclein. The common clinical features are chronic progressive decline of motor,...

www.ncbi.nlm.nih.gov

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Paul Kiesow

@KiesowPaul

4 months

'Hot Tub Time Machine' Holmes created a bullet list of my 1998 stack:

Holmes1618

@Holmes1618

11 months

@KiesowPaul any changes to this stack? what's the top 10 on the list and why?

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Paul Kiesow

@KiesowPaul

1 year

(4 of 4) For 17 years, from age 45 to 62, I took 1.25 mg deprenyl/selegiline daily and I resumed this recently. Since my SN remains healthy, my current affect and movements are, as well. I look forward to deprenyl’s continuing brain protection as I progress forward from 71 to 80.

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Paul Kiesow

@KiesowPaul

8 months

Mixing things up a bit. . . . Recognize the hand model? That's also my wedding band. Only my partner and I craft them from the most precious and rare metal on earth: 999 solid rhodium.

Rhodium: Earth's Rarest and Most Expensive Precious Metal

Discovered in the early 1800s from a chunk of smuggled platinum ore, rhodium is the most valuable precious metal on the planet today, used mainly for keeping car emissions in check.

science.howstuffworks.com

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Paul Kiesow

@KiesowPaul

1 month

The youthful affect (behavior/kinesthetics) part comes from a healthy, intact nigrostriatal/dopaminergic pathway. You will recall why I believe this is so. ;-)

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Paul Kiesow

@KiesowPaul

2 years

Finally, someone comes out to state the obvious. Thanks for noticing and saying so. Morale builder.

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Paul Kiesow

@KiesowPaul

1 year

"Aging beyond young adulthood is associated with accumulating deficits in cognition and motor control. Among the neuronal populations most affected by aging, dopaminergic neurons of the substantia nigra are essential for volitional motor control and several cognitive functions."

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Paul Kiesow

@KiesowPaul

2 months

Adult net cell numbers ALWAYS wane. The body has fewer, and metabolic processes compensate for accumulating losses. Often, compensatory mechanisms foment a negative cascade. An antiaging linchpin remains the issue of cell losses—we're not here to let that happen. 😉

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Paul Kiesow

@KiesowPaul

3 months

Twenty-five percent of my 1952 birth cohort deceased; regretfully, the majority remaining face age-related disease conditions/chronic health issues; few look/comport youthfully. Increasingly difficult to present findings/successes sans unfruitful debate, crude insults.

Darkstar 🌚

@qwikphix

3 months

@KiesowPaul The weakness of X is the same weakness as all social media sites, that great messages can be drowned out by excessive adversarial replies. Be they genuine, or trolls, the effect is the same.

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Paul Kiesow

@KiesowPaul

1 year

Dr. Steve Horvath, Rhonda Patrick, Andrew Huberman on anti-inflammatory effects of fish oil supplementation, and effects on life expectancy of populations consuming high-fish diet 0:43 — ‘Aging’ Horvath & Patrick 1:45 — ‘Healthspan’ Patrick 4:36 — ‘Limiting Inflammation’ Huberman

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Paul Kiesow

@KiesowPaul

1 year

@Holmes1618 Just started taurine today. Good safety profile, findings showing significant promise, largely missing in collagen peptides, not present in most plant foods. PureBulk 300ct 800mg caps, standard delivery two days.📦

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Paul Kiesow

@KiesowPaul

6 months

Began antiaging pursuits as a 35 year old—so far it has worked. This proclivity conspicuously belongs to the young/middle-aged. In those older, disease conditions and facial appearance can sap enthusiasm and sense of youthful invincibility. Depends of the person, the regimen.

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Paul Kiesow

@KiesowPaul

11 months

(1 of 2) More than substantia nigra domaminergic neuron protection: selegiline impedes mitochondrial apoptosis, induces anti-apoptotic Bcl-2 protein family, fosters pro-survival brain- and glial cell line-derived neurotrophic factors.

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Paul Kiesow

@KiesowPaul

8 months

@ScienceofPD

Paul Kiesow

@KiesowPaul

9 months

Had been taking selegiline to reduce/arrest [normal and generally considered acceptable] substantia nigra dopaminergic neuron loss (13% per decade after 40); selegiline is now shown also to intervene in the synucleinopathies of AD, Lewy body dementia, multiple system atrophy, PD

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Paul Kiesow

@KiesowPaul

2 months

Experienced 3:48 totality in often-cloudy Erie, Pennsylvania. My 3rd total solar eclipse, yet the first when clouds didn't 'eclipse' the eclipse! Well worth the wait: 99% is but a dim day, then unequivocal magic—suddenly dark as night with the black-hole sun floating in gossamer.

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Paul Kiesow

@KiesowPaul

10 months

MAO-B inhibitor selegiline reduces *18F-THK5351 uptake in the brain With age, MAO-B increases 9% per decade. MAO-B *imaging is a biomarker for astrocytosis in various neurodegenerative conditions associated with cell death or activation of immune responses

Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

[18] F-THK5351 is a quinoline-derived tau imaging agent with high affinity to paired helical filaments (PHF). However, high levels of [18] F-THK5351 retention in brain regions thought to contain...

www.ncbi.nlm.nih.gov

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Paul Kiesow

@KiesowPaul

1 year

Methylation & Metformin ~ this just in . . .

Study may elucidate metformin's potential role in longevity through DNA methylation

A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 15, Issue 3, entitled, "Metformin use history and genome-wide DNA...

www.news-medical.net

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Paul Kiesow

@KiesowPaul

5 months

The paradigm of human aging is profoundly unique—not a conceit, just a fact. Murine, worm, yeast studies while sometimes elucidative, can easily be superfluous or inapplicable to human lifespan.

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Paul Kiesow

@KiesowPaul

11 months

@LaraPo8 @LivingForever8 The app says I am 42 in this pic taken when I was 70. There ya go. 😄

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Paul Kiesow

@KiesowPaul

5 months

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Paul Kiesow

@KiesowPaul

1 year

@philosophising4 @DeusOgee @SteveMitoengram @noobestjohn @MedEckardt @EwingT_PhD Here's, IMHO, a hidden gem from the late '80s: deprenyl/selegiline. Took 1.25 mg/day for 17 years . . . may have kept intact my substantia nigra's dopamine producing neurons. Resumed it 12 days ago. LE not possible without preserved brain heath and function.

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Paul Kiesow

@KiesowPaul

1 month

(I will do both.)

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Paul Kiesow

@KiesowPaul

1 month

Many of its side effects and adverse reactions seem associated with mTOR disruption, such as thrombocytopenia, mouth ulcers, slowed nail growth and wound healing. Apart from that, a number of adherents appear wan/drawn.

Paul Kiesow

@KiesowPaul

1 month

@Kott_95 Rapamycin's tempting from animal studies. Slowing protein deposition, cell proliferation, differentiation ~ including resultant autophagy ~ may work in caged short-lived animals. Inhibiting mTOR's conserved protein lay-down in one's 70s . . . for me, not for any amount of money.

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Paul Kiesow

@KiesowPaul

1 year

This p53 study just in. . . . and SIRT6 won't stay below the radar much longer'

Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear...

In mammalian cells, tumor suppressor p53 plays critical roles in the regulation of glucose metabolism, including glycolysis and oxidative phosphory...

www.pnas.org

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Paul Kiesow

@KiesowPaul

2 months

Today's rhetorical question: What percentage have done this?😉

Paul Kiesow

@KiesowPaul

2 months

@YasonWave @deantaplin @BakaKarasu @BeamsOfEnergy Metformin 1g — 21 years for AA only Selegiline 1.25mg — 19 years (few have even heard of it) Nicotinamide mononucleotide/NMN 2.8g (NAD+ slam dunk) Dehydroepiandrosterone/DHEA 75mg — 33 years

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Paul Kiesow

@KiesowPaul

5 months

Said I'd tell ya mine!😉OK, so these four happen to be among my Top Ten: Metformin for AA before it was known; NMN literally regressed my nails in four months; from 1996, selegiline (arcane, powerful) blocked brain aging; DHEA (see TRIIM study) since 1989.

Greg Fahy, Intervene Immune | Thymus Rejuvenation Progress Update

Summary In this session, Greg Fahy, Co-Founder of Intervene Immune and Principal Investigator of the TRIIM and TRIIM-X clinical trials, offered a sneak

foresight.org

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Paul Kiesow

@KiesowPaul

11 months

(2 of 2) . . . facilitates activity of nigrostriatal dopaminergic neurons with utmost selectivity and protects them from their age-related decay.

The striatal dopamine dependency of life span in male rats. Longevity study with (-)deprenyl -...

Long-term experiments on male rats revealed that better performers in the mating test are better learners in the shuttle box and the more active animals live significantly longer than their less...

pubmed.ncbi.nlm.nih.gov

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Paul Kiesow

@KiesowPaul

2 months

You can also just protect/rejuvenate it.

‘We want to give everyone a new thymus to reboot their immune system’

Thymmune founder says ARPA-H funding will bring ‘off-the-shelf’ thymus rejuvenation technology to human clinical trials.

longevity.technology

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Paul Kiesow

@KiesowPaul

22 days

Here's a circulating petition. For me, I do agree that aging is a disease condition, certainly a prodrome to a multitude of diseases. When Nir Barzilal sought FDA go-ahead for his TAME trial, a hurdle was getting them to begrudgingly countenance this notion of aging.

Age Reversal Unity

@agereversaluni

23 days

@KiesowPaul Please RETWEET

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Paul Kiesow

@KiesowPaul

11 months

Synucleinopathies successfully obviated:

Neuroprotective Function of Rasagiline and Selegiline, Inhibitors of Type B Monoamine Oxidase, and...

Synucleinopathies are a group of neurodegenerative disorders caused by the accumulation of toxic species of α-synuclein. The common clinical features are chronic progressive decline of motor,...

www.ncbi.nlm.nih.gov

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Paul Kiesow

@KiesowPaul

3 months

Fisetin & quercetin, two more carrying unrealistic hopes for rejuvenation via senolysis. Some studies have shown zero clearance in vivo. Dasatinib & navitoclax may work, yet hold safety concerns. A bigger question is whether mass clearance of senescent cells is such a great idea.

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Paul Kiesow

@KiesowPaul

1 year

Oh yeah, I took Deprenyl/selegiline for 15+ years until it was harder to obtain. My motor and mental affect/comportment is definitely like a young person's. I had better re-up and not rest on my laurels! 😃

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Paul Kiesow

@KiesowPaul

1 year

Preempting disease conditions and metabolic/physical aging has been the consistent goal. Yet, in 2016 after 18 months sans metformin [and years sans selegiline] my health began slipping—until resuming my stack. This month, as last August, my doctor issued a clean bill of health.

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