Jason Shepherd @JasonSynaptic Twitter profile | Pikagi

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Jason Shepherd

@JasonSynaptic

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🇿🇦🇳🇿🇺🇸Neuroscientist @UUtah . Molecular mechanisms of memory, repurposed transposons, and virus-like intercellular signaling.

Otago/Hopkins/MIT/Utah

https://t.co/jnZ2wjthKU

Joined July 2013

Don't wanna be here? Send us removal request.

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@JasonSynaptic

Jason Shepherd

3 months

New preprint 🚨 from the lab! Another paper years in the making from @AliciaRavens and Kaelan Sullivan (not on twitter). TDLR: we describe a new form of intercellular synaptic plasticity! It involves Arc and another cool protein IRSp53. 🧵/1

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Arc mediates intercellular synaptic plasticity via IRSp53-dependent extracellular vesicle biogenesis

Current models of learning and memory have focused on cell-autonomous regulation of synaptic strength; however, intercellular signaling between cells in the brain is critical for normal cognition....

www.biorxiv.org

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@JasonSynaptic

Jason Shepherd

1 year

Today I unexpectedly had to say goodbye to my best buddy. When I moved to SLC 10 years ago I was single and didn’t know a soul. Within a few months I had a new car, house, and a husky puppy. Never met a dog with more personality!

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Jason Shepherd

3 years

This one is for @DrNadiaChaudhri who continues to inspire and educate!

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Jason Shepherd

4 years

I had a magical night shooting #cometNEOWISE at the Great Salt Lake! You can just make out the forked tail here.

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@JasonSynaptic

Jason Shepherd

4 years

Pic of the day #16 - #COVID ー19 An incredible sunset at the @UUtah campus

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Jason Shepherd

3 years

I don't understand why there's even a "debate" over authorship (or why it is on a repeat cycle here). Not giving authorship credit for those who contributed ANY significant aspect to a paper, due to some arbitrary criteria such as "undergrad" or "lab tech" is just absurd.

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@JasonSynaptic

Jason Shepherd

4 years

🧵/ It's official, I am now a US citizen! One the eve of living in this country for 20 years, most of my adult life...I've been reflecting on what this means to me and other immigrants during this turbulent time in history.

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Jason Shepherd

3 years

On the anniversary of our paper coming out, I received the Feb issue of @NatGeo and my face is in it! Well, half my face. I don’t think the article is out online yet. So cool to have our work highlighted!

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Jason Shepherd

4 years

Well shit, my US naturalization ceremony is scheduled for NEXT Monday! I get to vote in this election after all.

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@JasonSynaptic

Jason Shepherd

4 years

Mt Olympus in Salt Lake City is one of my favorite views! Doesn’t hurt when the sky shows off too.

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@JasonSynaptic

Jason Shepherd

4 years

You get a lot of advice about how to run a lab as a PI. What you don't hear much about, is how invested you get in their wellbeing and how tough it can be to see them hurting. Crushed by some bad news today.

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Jason Shepherd

3 years

Have I mentioned that @UUtah is gorgeous?! Here's a pic I took of my lab's building, with some beautiful golden hour light.

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@JasonSynaptic

Jason Shepherd

8 months

Paper submitted vs Paper accepted…

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Jason Shepherd

2 years

Working from home has become such a chore!

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Jason Shepherd

5 years

It's finally official...promoted to Associate Professor WITH TENURE!! It's been a banner few weeks for me and the lab. Just want to thank my lab for their incredible hard work and to my mentors at @UUtah especially my chair Monica Vetter. It's been such a supportive place! /1

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Jason Shepherd

3 years

PIs...do you remember every convo you have with your lab members? Do they get annoyed when you can't remember what you told them last week? Because, I can barely remember what week it is or what I had for lunch...let alone what advice I gave for a specific experiment.

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Jason Shepherd

4 years

Early this morning (4:30am gah), I had the most peaceful few hours of 2020. I witnessed one of the few comets to be visible by the naked eye in my lifetime...just beautiful! (Took this literally near my house in the foothills above the Avenues of Salt Lake City).

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Jason Shepherd

1 year

“our study demonstrated that protein tissue-enrichment information can explain phenotypes of genetic diseases, which cannot be obtained by transcript information alone.” Large discordance between mRNA and protein enrichment! Now what RNA-seq folks?!

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A Quantitative Proteome Map of the Human Body

Proteomics analysis across human tissues from the GTeX resource reveals insight into tissue-specific pathways and phenotypes arising from genetic diseases.

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@JasonSynaptic

Jason Shepherd

3 years

Have I mentioned the @UUtah campus is gorgeous?! 😍

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@JasonSynaptic

Jason Shepherd

4 years

Arizona currently has more daily COVID cases than the entire European Union. Let this sink in. One US state has more cases than 26 countries that have 60x the population. Yet, I still see so much willful ignorance. Heartbreaking.

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@JasonSynaptic

Jason Shepherd

3 years

Maybe a controversial opinion: most new techniques in science just generate huge lists, which is easy. Much harder is to MAKE SENSE of those lists...but that work is not being rewarded or funded! Let's take gene ontology as an example, the lists are often organized this way...

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Jason Shepherd

3 years

After I totally bombed my first chalk talk. The head of the search committee, a very prominent neuroscientist, asked me if I was on drugs.

@StockMarketDrip

Stock Market Drip💧

@StockMarketDrip

3 years

What was your worst experience while on a job interview?

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Jason Shepherd

2 years

We are losing talented people in academia and it's hard to watch! The pandemic has and continues to highlight systemic stressors and while some face more hurdles than others, just about everyone I know has been hit in some way. Many are breaking. How do we right the ship?

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@JasonSynaptic

Jason Shepherd

1 year

How it started, how it’s going…

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@JasonSynaptic

Jason Shepherd

4 years

Should I wear this to my US citizenship ceremony on Monday?

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@JasonSynaptic

Jason Shepherd

4 years

Literally trillions of dollars will have to be injected into the economy to keep it afloat. The price tag of funding the science that could have helped prevent/mitigate/deal with this pandemic is a FRACTION of this! Imagine politicians actually listening to scientists.

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@JasonSynaptic

Jason Shepherd

4 years

Happy Thanksgiving from snowy Utah!

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@JasonSynaptic

Jason Shepherd

6 years

Super excited to share this science with the world, out in @CellCellPress ! Proud of my lab, this was a total team effort. Thanks to our collaborators @CedricFeschotte @BriggsGroup

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Jason Shepherd

5 years

Don’t go to the Dolomites, not very scenic...

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Jason Shepherd

2 years

Whhaatt?! "Patch clamp" meets scRNA-seq to live sample RNA from cells over time 🤯

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Live-seq enables temporal transcriptomic recording of single cells

Nature - Live-seq, a single-cell transcriptome profiling approach that preserves cell viability during RNA extraction using fluidic force microscopy, can address a range of biological questions by...

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@JasonSynaptic

Jason Shepherd

23 days

This is a reminder that international scientists face various hurdles and citizenship in some countries is worse than others. I had 2 students miss 4-6 weeks this year JUST to renew their visas (India and China). (have to admit that global south was confusing, coming from NZ)

@mayank_mchugh

Mayank Chugh

23 days

📢'The World Is Your Oyster' is for those who are born in global north countries--don't experience visa bureaucracy & emotional burden that non-white global south scholars do. Citizenship is a privilege that we need to recognize in the academe. 1/n

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Jason Shepherd

3 years

This is one of the things I love about live cell imaging, weird observations that you’ll never capture otherwise. Glia experts..what’s up with this?!

@BioKenLyon

Kenneth Lyon

3 years

#Neuronwatching Glia (orange) giving the business to a neuron (blue). Really strange, haha.

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@JasonSynaptic

Jason Shepherd

3 years

SLC putting on a show tonight! 😍

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Jason Shepherd

4 years

Pic(s) of the day #183 - #COVID ー19 When seasons collide! Guardsman pass, Utah.

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@JasonSynaptic

Jason Shepherd

2 years

A second year of $$ from a foundation grant was not renewed due to lack of progress over the last year. The lead PD had cancer, recovered, surprisingly became pregnant and then took extended maternity leave. I was transparent with these set backs and some technical hurdles, let

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@JasonSynaptic

Jason Shepherd

4 years

Fire and Ice. The Wasatch Mountains putting on a show above Salt Lake City!

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@JasonSynaptic

Jason Shepherd

1 month

NIH Fellowship reviews continue to be some of the worst I've seen in science. Prelim data is reviewed like it's a full paper or an R01 and reviewers forget that it's a single student doing all the work! Be critical, but put yourself in their shoes and then re-read your comments.

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@JasonSynaptic

Jason Shepherd

5 years

One of the things that kept me sane in academia is a creative outlet that also has the added bonus of Solitude and Nature. I haven't shared much of my photography on twitter, but this is prob my new favourite pic!

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@JasonSynaptic

Jason Shepherd

1 year

Exciting news...I can finally and officially announce Aera going live! Here's some history and origin story 🧵In 2018 we published our work showing that Arc can form virus-like capsids, as a hunch I submitted IP on the idea of using Arc capsids /1

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Aera Therapeutics | LinkedIn

Aera Therapeutics | 7,107 followers on LinkedIn. Enabling the next generation of transformative genetic medicines | Aera was founded with a vision to unlock the potential of genetic medicines across...

www.linkedin.com

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@JasonSynaptic

Jason Shepherd

4 years

My number one advice for new PIs is to recruit good people to your lab! I don’t just mean good at science, but genuinely good humans that take care of each other. @NewPI_Slack @FuturePI_Slack #AcademicChatter

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Jason Shepherd

3 years

Seeing red rock desert covered in snow is one of my favorite experiences! #utah

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Jason Shepherd

4 years

The world is a dumpster fire right now, so here's a pretty pic. This is a beautiful piece of art in the Great Salt Lake called Spiral Jetty. Even though close to SLC, you can still get dark skies for capturing the Milky Way.

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@JasonSynaptic

Jason Shepherd

3 years

The reality of COVID hit home today...my grandfather died in South Africa. While he had a good innings of 92, he died in the hospital suddenly and alone (no visitors). No funeral either. A reminder that the rest of the world is far from going back to normal.

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Jason Shepherd

3 years

Today...was a lot. Here's a moment of peace, from an alpine lake in Oregon.

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@JasonSynaptic

Jason Shepherd

8 months

Haven't seen a Nature paper on synaptic plasticity in a while! This paper from Ulli Bayer's group shows that CaMKII's role in LTP induction is not enzymatic/phosphorylation of substrates like the AMPARs but a "structural" interaction with the NMDARs.

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LTP induction by structural rather than enzymatic functions of CaMKII

Nature - Several independent lines of evidence demonstrated long-term potentiation induction by a structural function of calmodulin-dependent protein kinase II rather than by its enzymatic activity.

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@JasonSynaptic

Jason Shepherd

5 years

Today I was honored to receive the Jon Huntsman Presidential Endowed Chair from @RuthVWatkins and @MikeGoodMD . Thanks to the Huntsman family for their generous gift to @UUtah @UofUHealth . Amazing to see such an investment in people! (And yes, I get to keep the actual chair!).

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Jason Shepherd

3 years

Every place has hidden beauty, you just have to find it. Every couple of winters, conditions are just right for these beautiful ice sheets to form on #Utah Lake!

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@JasonSynaptic

Jason Shepherd

4 years

Pic(s) of the day #184 - #COVID ー19 The Great Salt Lake, Utah.

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@JasonSynaptic

Jason Shepherd

5 years

Since I've picked up photography, some of my most exciting moments have been when Nature puts on a show...and being one of the few to see it! (hmmm...maybe this is also why I'm a scientist 🤔)

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Jason Shepherd

1 year

New preprint 🎇! 🧵about @JunjieXu15 's exciting work on another retrotransposon derived Gag-like gene that has ALSO retained the ability to make beautiful virus-like capsids! 5 years ago we showed that Arc forms endogenous capsids and an obvious Q /1

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@JasonSynaptic

Jason Shepherd

4 years

What it takes to get an R01 these days! ( @OdedRechavi did I do it right?!)

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@JasonSynaptic

Jason Shepherd

5 years

I posted a pic of the lab looking out from inside. Here’s a phone pic of the lab (glass building bottom center) looking back, with the beautiful Wasatch mountains in the back. @UUtah

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@JasonSynaptic

Jason Shepherd

1 year

Perhaps one of my most epic pics of Ranger..caught in the desert during a rare blizzard.

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Jason Shepherd

9 months

I'm constantly reminded about this....

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Jason Shepherd

3 years

My PD got his NRSA SS today. Direct quote "No presentation or manuscript since starting his postdoc position since 2019. Based on the preliminary data the progress as a postdoc has been slow." AYFKM?! This PD started at the END of 2019 and I dunno...something happened in 2020.

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Jason Shepherd

4 years

Talking about work/life balance, getting out into Nature here in Utah has literally been as helpful as having therapy sessions! This magical view is deep in the San Rafael swell overlooking the Green river.

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Jason Shepherd

2 years

The world is a bloody mess! So here’s some peacefulness for your timeline.

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Jason Shepherd

4 years

Last night I slept in my car at one of the view points. This morning a lovely family got there super early and started cooking a feast. I stumbled out of my car and despite all that’s going on, they offered me a plate of Salvadoran food and damn...what a way to start the day.

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Jason Shepherd

4 years

2020 has been a string of bad news, so when something nice actually happens...you need to feel good about it! Just got asked by @NatGeo if they could highlight our work in an article!!

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@JasonSynaptic

Jason Shepherd

3 years

Winter in the #Wasatch can be magical! #SaltLakeCity

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Jason Shepherd

4 years

It’s not much but donating boxes of gloves and some safety glasses to our health workers at the hospital @UofUHealth

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Jason Shepherd

1 year

Honored to receive a Brain Research Foundation @TheBRF Innovations award! Stay tuned for a preprint that forms the basis of this project.

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Innovative Neuroscientist at U of U Health Recognized for “Risky” but Rewarding Brain Research

Jason Shepherd was just one of three neuroscientists nationwide selected to receive the award

uofuhealth.utah.edu

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@JasonSynaptic

Jason Shepherd

3 years

I had seen pics of the aurora, but what I wasn't sure of was how it looks by eye. What's missing from images is the dynamic nature of the shifting colors...beautiful sheets of ionized atoms chasing each other across the sky. This was a random "ghost-house" I found in Iceland!

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Jason Shepherd

3 years

Starry night dreamin' in the desert. (portrait orientation so click to view properly)

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Jason Shepherd

2 years

The weather finally cleared… the view from our Airbnb ❤️

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Jason Shepherd

5 months

Big few days! Submitted an R01 yesterday but more importantly.. @AliciaRavens brilliantly defended her PhD thesis today! PhD #4 from the lab.

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Jason Shepherd

6 years

Pet peeve: When I download a PDF of a paper, I want to see ALL the figures! Why do journals make it so hard to find the supplementary figures?Just append them at the end of the PDF.

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@JasonSynaptic

Jason Shepherd

3 years

8 years ago exactly I stepped into an empty lab. It’s been a wild ride, with many ups and downs! Thanks to all current and past lab members, mentors, and collaborators for making this ride happen!

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Jason Shepherd

3 years

I’m curious; there’s a ton of discussion about how NOT to evaluate the impact of someone’s science (IF, elite journals, H-index, citation numbers, prizes etc). So, what do people think are the best ways to evaluate science? Or shouldn’t we even bother?

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@JasonSynaptic

Jason Shepherd

4 years

I'm truly disgusted by what's happening in this country right now. From the COVID mess to xenophobia to systemic racism. It's one cruel blow after another. I've made this country my home for almost 20 years, but feeling pretty demoralized. We can only go up from here, right?

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Jason Shepherd

5 years

Unpopular opinion: A few academics traveling less is not going to solve climate change. What will? More scientists in positions to enact policy; more scientists speaking up about climate change to the public; better science education for society in general = systemic change.

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Jason Shepherd

3 years

There's often perceived issues in academia that are amplified by social media "echo chambers". A recurring theme is what it takes to obtain a faculty position in neuro. Nice to see a scientific approach that dispels some of those myths from @NINDSnews !

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Jason Shepherd

5 years

Took a much needed break from civilization and backpacked into the Sawtooth mountains in Idaho. Never seen the milky way so clear by eye...just sat here for hours marveling!

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Jason Shepherd

4 years

Pic of the day #119 - #COVID ー19 Milky Way reflections in the Great Salt Lake. The bright light in the background is Salt Lake City, with Saturn and Jupiter directly above.

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Jason Shepherd

3 years

Folks, this is my “backyard”! Gorgeous fall hike today in the Wasatch.

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Jason Shepherd

3 years

Paper accepted!! This one literally took a decade all up. Super proud of @madeleineqks for carrying it over the finish line and overcoming such a horrible 2020! Stay tuned for it in @SfNJournals but here's the preprint version.

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The immediate early gene Arc is not required for hippocampal long-term potentiation

The immediate early gene Arc is critical for maintenance of long-term memory. How Arc mediates this process remains unclear, but it has been proposed to sustain Hebbian synaptic potentiation, which...

www.biorxiv.org

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@JasonSynaptic

Jason Shepherd

3 years

It me.

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Jason Shepherd

2 years

Timeline cleanse: #MilkyWay in the Sawtooth mountains. A serene alpine lake with just the stars as company.

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Jason Shepherd

5 years

This is the best thing you want to hear from an NIH PO! "Hi Jason, this is pretty much assured of funding, so you can go ahead and start making plans."

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Jason Shepherd

4 years

Today I picked up my dream car ( @FordMustang GT350R!) and took her for a ride! I’m in love 😍...guess now I’m a legit American 😂

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Jason Shepherd

2 months

I’ve made a lot of decisions based on what’s best for my career..and thats meant being far away from family for most of my adult life. So being able to backpack with my dad was a real special experience..and for 70, he did amazing (we really pushed it on this second day)!

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Jason Shepherd

2 years

cool cool! We (scientists) can't even agree on how information is stored in the brain, let alone retrieved...but we can definitely download/upload it.

@PopCrave

Pop Crave

2 years

Elon Musk’s brain-machine interface company Neuralink is currently looking for their clinical trial director to start testing brain chip on humans. “You will be able to save and replay memories. You could potentially download them into a new body or into a robot body.”

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Jason Shepherd

3 years

Merry Christmas twitter fam! What a year....happy to see it out. Thanks for coming along my photo "journey" this year! Hope I was able to bring some "escapism" to your TL.

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Jason Shepherd

3 months

It's a lab "two-fer"! Super excited to have @JunjieXu15 's paper out in @CellCellPress today! Here's the "open access" link. This is the first major paper from the lab that is not Arc related 😆 🧵/1

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Jason Shepherd

2 years

Ahhhh…good morning! #mountainliving

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Jason Shepherd

3 years

The thing about landscapes that pictures cannot capture..is the scale of things. Take this massive redrock alcove in Escalante NM. If you squint real hard you’ll see a tiny human in the center hill in the sunlight...the ceiling is prob ~500 ft high.

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Jason Shepherd

3 years

BIG IF TRUE!

@neubadah

Ubadah Sabbagh

3 years

President Biden: "Back in the sixties we used to invest a little over 2% of our GDP in pure research and investment in science. Today it's 0.7%. I'm going to change that." If the Biden administration brings us back to 2%, that would mean $418.6 billion for research today.

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Jason Shepherd

4 years

Happy Memorial Day. This was my view this morning!

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Jason Shepherd

2 years

person to that extent…one must have a “Plan B.” This PD's expertise was unique in the lab. But, sure sure...how's hiring been for all of you during the pandemic? Easy? Hell...it's been hard enough to retain folks and keep everyone sane/healthy. Sigh.

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Jason Shepherd

5 years

It's been a hot minute, but you may remember that we discovered some crazy biology, showing that the neuronal protein Arc can form virus-like capsids (). I'm super excited about a collaboration with @BriggsGroup , see this preprint /1

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Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins

The neuronal protein Arc is a critical mediator of synaptic plasticity. Arc originated in tetrapods and flies through domestication of retrotransposon Gag genes. Recent studies have suggested that...

www.biorxiv.org

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Jason Shepherd

2 years

Utah…putting on a show! 😍

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Jason Shepherd

3 years

Can I just say, receiving unsolicited emails from students/PDs who read your papers and want to ask Qs/or even just say they like the work..is the best!

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Jason Shepherd

28 days

A PI retired and didn’t send in his annual reports to the NIH and now ALL UCSD PIs will have their NOAs delayed 🤦🏻🫠

@stephaniemlee

Stephanie M. Lee

28 days

a tragic but unfortunately hilarious story that boils down to: one man didn't do his homework and the whole school is being punished

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Jason Shepherd

4 years

Reflection can take many forms. For me, I need time away from it all. One of my fav hikes in Utah to date was to this aptly named Reflection Canyon on Lake Powell.

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Jason Shepherd

5 years

Um...guys, an impact score of 11 is good, right?! I'm in a bit of shock 😮 right now...

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Jason Shepherd

1 year

As I was flying home from Boston..it struck me that I started grad school in the US in 2003..I’ve lived here continuously for 20 years! Almost half my adult life. Also, a reminder, always get the window seat!

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Jason Shepherd

3 years

Throw back to a year ago, when I had this magical evening of comet viewing at the Great Salt Lake to break up the pandemic dreariness!

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Jason Shepherd

2 years

I got this message from an admin LOL:“The use of private aircraft for business travel will not be reimbursed by the University.” I would love to know who these academics are..that fly in private planes!

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Jason Shepherd

4 years

Narrator: he wasn’t ready

@JasonSynaptic

Jason Shepherd

4 years

I’m ready!

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Jason Shepherd

2 years

Sadly, starting the long journey home today. As is always the case, time in this remote part of the world was too short. Despite its geography, was astounded at some of the Norwegian infrastructure..like this bridge, which seems to belong in Narnia!

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@JasonSynaptic

Jason Shepherd

3 years

Post the quietest pic you have...(I like this game)

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@shannonmstirone

Shannon Stirone💀

@shannonmstirone

3 years

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