Jesse G. Meyer, PhD @J_my_sci Twitter profile

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Jesse G. Meyer, PhD

@J_my_sci

3 months

Updating the to the current link for open postdoc roles in my group

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Jesse G. Meyer, PhD

@J_my_sci

3 years

I called the Google scholar and asked them to find 11,780 citations to my work

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Jesse G. Meyer, PhD

@J_my_sci

2 years

When you submit to Nature and they offer a transfer to Scientific Reports

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Jesse G. Meyer, PhD

@J_my_sci

3 years

Reading a new paper that's very similar to your project #AcademicChatter @OpenAcademics

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Jesse G. Meyer, PhD

@J_my_sci

4 years

11 years ago I finished undergrad with a 2.95 GPA Today I received an official offer for tenure track professor at a R1 university. You can do anything if you focus and work hard #AcademicTwitter #AcademicChatter #phdchatter #phdchat #progress

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Jesse G. Meyer, PhD

@J_my_sci

1 year

Our baby is almost 4 months old which is when babies start "sleep regression", meaning the baby starts fitting models at night

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Jesse G. Meyer, PhD

@J_my_sci

4 years

Want a faculty job? You better get your PhD from MIT, Harvard, Stanford, etc @AcademicChatter

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Jesse G. Meyer, PhD

@J_my_sci

2 months

The perfect genomics method name doesn't exi...

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Jesse G. Meyer, PhD

@J_my_sci

1 year

Good advice we got as new parents: Sleep when the baby sleeps Also: write grants when the baby writes grants

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Jesse G. Meyer, PhD

@J_my_sci

3 months

how some people think bioinformatics works

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Jesse G. Meyer, PhD

@J_my_sci

3 years

NEW RULE: If you submit a paper, you get the rest of the day off

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Jesse G. Meyer, PhD

@J_my_sci

1 year

when they call it "mass spectroscopy"

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Jesse G. Meyer, PhD

@J_my_sci

2 years

Trying out the new protocol @AcademicChatter @PhDVoice @OpenAcademics

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Jesse G. Meyer, PhD

@J_my_sci

1 year

Recent events around trainee salary and NIH budgets remind me of when I was applying for a K99 and UW Madison administrators would not let me request the full 75k/yr salary allowed by the NIH

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Jesse G. Meyer, PhD

@J_my_sci

2 years

Top 25 cities for life science research in the United States Los Angeles at number 7 Source:

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Jesse G. Meyer, PhD

@J_my_sci

3 years

BREAKING: the FDA just approved not validating proteomic results by western blot

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Jesse G. Meyer, PhD

@J_my_sci

2 years

A concerning trend is whoever makes the biggest omics dataset gets into Cell/Nature/Science, even if the quality of the underlying data is poor

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Jesse G. Meyer, PhD

@J_my_sci

6 months

🚨 It's here 🚨 The most comprehensive overview of modern proteomics ever written. ▶️ 19 figures ▶️ 17 chapters ▶️ 111 pages ▶️ 859 references Contributions from: ▶️ 19 authors ▶️ 13 institutions ▶️ 6 countries ▶️ 4 continents

Comprehensive Overview of Bottom-up Proteomics using Mass Spectrometry

Proteomics is the large scale study of protein structure and function from biological systems through protein identification and quantification. "Shotgun proteomics" or "bottom-up proteomics" is...

arxiv.org

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Jesse G. Meyer, PhD

@J_my_sci

2 years

Recently learned about 2 trainees who got scooped. Not because a group did the work faster- because the paper sat on their PIs desk for over 2 years. PI didn't understand it despite countless hours of discussion. PI would make nebulous objections and ask for irrelevant additions

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Jesse G. Meyer, PhD

@J_my_sci

2 years

Some personal news: we had a baby girl last Monday

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Jesse G. Meyer, PhD

@J_my_sci

2 years

Excited to announce that my group has moved to @CedarsSinai in Los Angeles to join the new Department of Computational Biomedicine led by @moorejh . My first day is today!

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Jesse G. Meyer, PhD

@J_my_sci

3 years

🚨BREAKING: Biden signs executive order banning validation of proteomic results by western blot #TeamMassSpec #proteomics #academicTwitter #phdchat @PhDVoice

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Jesse G. Meyer, PhD

@J_my_sci

2 months

🚨🚨🚨 BREAKING NEWS 🚨🚨🚨 Final six funding bills include a $300 million increase in the NIH budget! 🎉🎉🎉 Not huge but was expecting a cut 100 million more for Alzheimer’s 120 million more for cancer 75 million more for mental health 5 million more for opioid Source below

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Jesse G. Meyer, PhD

@J_my_sci

3 years

Interdisciplinary Project #AcademicChatter @OpenAcademics @PhDVoice

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Jesse G. Meyer, PhD

@J_my_sci

3 years

WATCH LIVE: footage of a manuscript submitted to Nature

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Jesse G. Meyer, PhD

@J_my_sci

2 years

The shortest paper ever published contains zero words

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Jesse G. Meyer, PhD

@J_my_sci

11 months

Here is a rough breakdown how I spend my time each day: 10% exercise 10% eating 20% emails 20% taking care of baby 30% writing proposals and papers 30% sleep 10% reviewing papers 40% research 10% service 20% administrative stuff

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Jesse G. Meyer, PhD

@J_my_sci

4 years

Are you graduating with your PhD soon? Do you have interest or expertise in any of the following: drug discovery mass spectrometry proteomics lipidomics metabolomics AND/OR: machine learning R python bioinformatics Please consider applying to my lab!

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Jesse G. Meyer, PhD

@J_my_sci

10 months

Do some people believe that transcriptomics is better than proteomics for generally getting an idea about new biology? (interpret 'better' however you want) Or do most people want to do proteomics instead but its too expensive and inaccessible so they do transcriptomics?

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Jesse G. Meyer, PhD

@J_my_sci

3 years

troubleshooting the mass spec

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Jesse G. Meyer, PhD

@J_my_sci

3 years

Extremely excited to share our work published in Nature Methods! The first example of shotgun proteomics without liquid chromatography, enabled by ion mobility. Wonderful collaboration with @nieminm @Pagliarini_Lab @Coon_Labs @naturemethods

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Jesse G. Meyer, PhD

@J_my_sci

3 years

Excited to officially announce that we received a Notice of Award for my group's NIGMS R35 MIRA. Huge thanks to everyone who helped with this, especially colleagues who read drafts, my group members, and the Biochem dept chair at MCW John Corbett

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Jesse G. Meyer, PhD

@J_my_sci

4 years

When you find out >200 people applied to the one job you wanted @AcademicChatter #phdlife #phdchat #jobhunting

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Jesse G. Meyer, PhD

@J_my_sci

2 months

We are launching a new PhD program in Health AI! Applications accepted this fall

PhD Program in Health Artificial Intelligence

The PhD program in Health Artificial Intelligence at Cedars-Sinai prepares students with rigorous training in AI algorithms and methods to improve patient care.

www.cedars-sinai.edu

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Jesse G. Meyer, PhD

@J_my_sci

6 months

How do you deal with the R01 review comment "investigators are excellent but have no record working together" when it would take years to do the proposed work together. Not rhetorical, what has worked for you in the past? Publish a tiny paper together? Never work with new people?

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Jesse G. Meyer, PhD

@J_my_sci

2 years

Have you ever collected to omics datasets and struggled to combine the results in a meaningful way? How can we automate multi-omic data integration? In our recent paper @OUPBioinfo we automate multi-omic data integration with machine learning!

Multi-omic integration by machine learning (MIMaL)

AbstractMotivation. Cells respond to environments by regulating gene expression to exploit resources optimally. Recent advances in technologies allow for m

academic.oup.com

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Jesse G. Meyer, PhD

@J_my_sci

1 year

New badge buddy. Thanks to those who wrote letters

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Jesse G. Meyer, PhD

@J_my_sci

3 years

Our new MS was installed last week!

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Jesse G. Meyer, PhD

@J_my_sci

6 months

This is so cool. A postdoc in my lab Sahar Javadi has made neurons all the way from iPSCs. These seem to from little bundles together

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Jesse G. Meyer, PhD

@J_my_sci

8 months

Its done! A complete draft of "A Comprehensive Overview of Modern Proteomics" along with the actual author order based on lines and figures added. Huge thanks to everyone who helped. Authors: expect an email with the whole draft for final comments soon.

Comprehensive Overview of Bottom-Up Proteomics using Mass Spectrometry

jessegmeyerlab.github.io

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Jesse G. Meyer, PhD

@J_my_sci

1 year

I am surprised and extremely grateful to be selected for the @asmsnews Research Award. It is an honor to be mentioned in the same sentence as @KM_Hines and @StacyMalaker . Huge thanks to @thermofisher for sponsoring this award.

Am Soc for Mass Spec

@asmsnews

1 year

Drum roll, please... Congrats to the @asmsnews 2023 Awards recipients! Join us in sending up a big virtual round of applause! We look forward to honoring them all in-person at #ASMS2023 . Full 2023 ASMS Awards announcement:

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Jesse G. Meyer, PhD

@J_my_sci

11 months

🚨Do you want to collect: Proteomics + Polar metabolomics + Lipidomics but worry about cost and throughput? In our new preprint, we describe a 5 minute/sample method to collect them all SIMULTANEOUSLY: @yumingjiang94 @IvanS_48 @ACovarrubiasPhD

Simultaneous Multi-Omics Analysis by Direct Infusion Mass Spectrometry (SMAD-MS)

Combined multi-omics analysis of proteomics, polar metabolomics, and lipidomics requires separate liquid chromatography–mass spectrometry (LC–MS) platforms for each omics layer. This requirement for...

www.biorxiv.org

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Jesse G. Meyer, PhD

@J_my_sci

3 years

Hard to believe it has been 1 year already Huge thank you to lab members and everyone who has helped me get started

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Jesse G. Meyer, PhD

@J_my_sci

3 years

Unofficial notice that my R21 is funded starting late summer! Incredibly grateful for this support from the NIA!

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Jesse G. Meyer, PhD

@J_my_sci

3 months

HHMI lab assembling a manuscript

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Jesse G. Meyer, PhD

@J_my_sci

3 years

We're hiring postdocs! Please RT @Chemjobber #chempostdoc #postdoc #hiring

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Jesse G. Meyer, PhD

@J_my_sci

3 months

I have interviewed a lot of people by now and surprised how many PhDs getting ready to graduate aren't allowed to preprint their work. It makes it harder for everyone. Why not preprint?

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Jesse G. Meyer, PhD

@J_my_sci

3 years

paper's title vs results section

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Jesse G. Meyer, PhD

@J_my_sci

4 years

Are you finishing your PhD soon? I'm #hiring a postdoc w/ experience or interest at least one of: #toxicology #neuroscience #MachineLearning #proteomics #metabolomics #lipidomics #systemsbiology #massSpectrometry Please retweet #AcademicChatter DM your CV and interests

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Jesse G. Meyer, PhD

@J_my_sci

3 months

Live footage of a postdoc assembling a paper for Cell

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Jesse G. Meyer, PhD

@J_my_sci

4 years

Applied for: NIH new innovator award Received: new total landscaping innovator award #AcademicChatter

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Jesse G. Meyer, PhD

@J_my_sci

2 years

Please check out the latest preprint from my group: Multi-Omic Integration by Machine Learning (MIMaL) Reveals Protein-Metabolite Connections and New Gene Functions 🧵1/

Multi-Omic Integration by Machine Learning (MIMaL) Reveals Protein-Metabolite Connections and New...

Cells respond to environments by regulating gene expression to exploit resources optimally. Recent advances in technologies allow the ability to gather information of cellular states of its compone...

www.biorxiv.org

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Jesse G. Meyer, PhD

@J_my_sci

4 years

What is the best "Omics" and why is it proteomics?

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Jesse G. Meyer, PhD

@J_my_sci

3 years

Words cannot describe how grateful I am to be included alongside so many scientists I look up to in this virtual issue "Rising Stars in Proteomics and Metabolomics" My sincerest thanks to @JohnRYatesIII and @JProteomeRes

Rising Stars in Proteomics and Metabolomics

pubs.acs.org

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Jesse G. Meyer, PhD

@J_my_sci

3 years

If you collect data that appears in a publication, you should at least be given the option to contribute as author

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Jesse G. Meyer, PhD

@J_my_sci

13 days

We dream of a world where proteomic data collection with mass spectrometry is 100x faster - down to 3 seconds per sample: The Future of Proteomics is Up in the Air: Can Ion Mobility Replace Liquid Chromatography for High Throughput Proteomics?

The Future of Proteomics is Up in the Air: Can Ion Mobility Replace Liquid Chromatography for High...

The coevolution of liquid chromatography (LC) with mass spectrometry (MS) has shaped contemporary proteomics. LC hyphenated to MS now enables quantification of more than 10,000 proteins in a single...

pubs.acs.org

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Jesse G. Meyer, PhD

@J_my_sci

3 years

Excited to share the first paper from my new lab! "Peptide Correlation Analysis (PeCorA) Reveals Differential Proteoform Regulation" with @DermitMaria in @JProteomeRes

Peptide Correlation Analysis (PeCorA) Reveals Differential Proteoform Regulation

Shotgun proteomics techniques infer the presence and quantity of proteins using peptide proxies produced by cleavage of the proteome with a protease. Most protein quantitation strategies assume that...

pubs.acs.org

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Jesse G. Meyer, PhD

@J_my_sci

4 years

There are two types of models 1. Deep Learning 2. Deep Learning Total Landscaping #AcademicChatter

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Jesse G. Meyer, PhD

@J_my_sci

1 year

Good news #TeamMassSpec

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Jesse G. Meyer, PhD

@J_my_sci

4 years

THEY WANT TO HIRE ME @ ASSISTANT PROFESSOR! DM me with faculty startup package negotiation tips.... I'm hoping to get a new TOF TIMS pro or other ion mobility system included. #AcademicChatter #AcademicTwitter #phdchat

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Jesse G. Meyer, PhD

@J_my_sci

3 years

Want to publish in Science? Its easy. Just follow my step-by-step guide:

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Jesse G. Meyer, PhD

@J_my_sci

2 years

Live footage of new PI starting in 2020 @AcademicChatter @PhDVoice @OpenAcademics

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Jesse G. Meyer, PhD

@J_my_sci

2 years

I invite you all to contribute to a comprehensive tutorial about bottom up proteomics! We will use #manubot () to write collaboratively with github. Please retweet and consider contributing! Link to project: #TeamMassSpec

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Jesse G. Meyer, PhD

@J_my_sci

4 years

Delayed announcement: my wife and I decided to move to Milwaukee instead of West Lafayette. I joined Medical College of Wisconsin @Medicalcollege as Assistant Professor in Biochemistry. Excited to work with this incredible group of faculty!

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Jesse G. Meyer, PhD

@J_my_sci

2 years

NIH grant funding over the last decade for "Multi-Omics" via NIH RePORTER @NIH

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Jesse G. Meyer, PhD

@J_my_sci

3 years

Protein structure by: NMR vs crystallography

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Jesse G. Meyer, PhD

@J_my_sci

3 years

I quit caffeine for a week 0/10 - would not recommend

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Jesse G. Meyer, PhD

@J_my_sci

4 years

Reading reviews #AcademicChatter #AcademicTwitter #academicjokes

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Jesse G. Meyer, PhD

@J_my_sci

3 years

Excited to announce that we received a NoA for our R21 from the NIA These funds that will support a postdoc for two years to look for drug candidates for Alzheimer's disease using iPSC derived neurons, mass spectrometry, and machine learning apply here:

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Jesse G. Meyer, PhD

@J_my_sci

1 year

@Jameshearsawho @ContamClub Does it taste like cool ranch or original?

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Jesse G. Meyer, PhD

@J_my_sci

4 years

Holy shit look at this "... omics profiling for 105 individuals for up to 4 years... more than 1000 molecular seasonal variation changes in microbiome and host molecules; group into 2 major patterns... seasonal fluctuations depend on insulin resistance

Deep longitudinal multiomics profiling reveals two biological seasonal patterns in California

Nature Communications - Seasonal patterns of molecular markers in humans have not been extensively studied. Here, the authors combine host components (transcriptome, metabolome, proteome, immunome,...

www.nature.com

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Jesse G. Meyer, PhD

@J_my_sci

4 years

Wow, a new @NIH R01 funding opportunity where preliminary data IS NOT ALLOWED. Must be an early stage investigator. Must be a significant change in direction. First due date late January 2021 @OpenAcademics #AcademicChatter

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Jesse G. Meyer, PhD

@J_my_sci

2 years

@JTFouquier @AcademicChatter We are always looking for computational biologists in Los Angeles, if you want to discuss please reach out when you are ready to look for jobs

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Jesse G. Meyer, PhD

@J_my_sci

5 years

Real footage of my last peer review experience

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Jesse G. Meyer, PhD

@J_my_sci

3 years

UPDATE: 18 hours after receiving the vaccine, my wife is experiencing the major side effect of obsession with Christmas music

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Jesse G. Meyer, PhD

@J_my_sci

3 years

@SmartRF It's tired because it surfed and hit big bear in the same day

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Jesse G. Meyer, PhD

@J_my_sci

4 months

My group is seeking a wet lab postdoc with experience related to mass spectrometry. Come apply your skills and learn about data science and biology. Message or email me with your CV and interests to apply.

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Jesse G. Meyer, PhD

@J_my_sci

3 years

CRISPR is amazing

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Jesse G. Meyer, PhD

@J_my_sci

3 years

LIVE FOOTAGE: reviewer #2 blocking your path to publication #AcademicChatter #academicTwitter @OpenAcademics @PhDVoice

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Jesse G. Meyer, PhD

@J_my_sci

1 year

We are reading this paper for our group's journal club. If you like personalized multi-omics, you will like it too

Multi-omics microsampling for the profiling of lifestyle-associated changes in health

Nature Biomedical Engineering - Dense multi-omics microsampling for the frequent capture and analysis of thousands of molecules in blood alongside physiological information from wearables...

www.nature.com

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Jesse G. Meyer, PhD

@J_my_sci

4 years

Me trying to finish this grant #AcademicChatter

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Jesse G. Meyer, PhD

@J_my_sci

2 years

I'm hiring 1-2 data scientists to work on [single-cell] proteome informatics and/or multi-omic data integration. Postdoc or post-MS level. Pay is much more than NIH minimum postdoc salary. Please share w/ someone who might be interested. 2-yr exp.:

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Jesse G. Meyer, PhD

@J_my_sci

2 years

This is from a science news article 🙄

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Jesse G. Meyer, PhD

@J_my_sci

5 months

First day in the lab in over two years 🤦

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Jesse G. Meyer, PhD

@J_my_sci

11 months

New high throughput proteomics preprint. Move over "shotgun proteomics", get ready for "machine gun proteomics" 1,000 samples per day by capillary-flow LC/MS/MS Over 3k proteins from 100 ng w/ 0.8 min gradient

One thousand samples per day capillary-flow LC/MS/MS for high-speed, high-sensitivity and in-depth...

We developed a capillary-flow LC/MS/MS system with ultrahigh speed, enabling a throughput of 1,000 samples per day while maintaining high sensitivity and depth of analysis. In targeted LC/MS mode, 36...

www.biorxiv.org

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Jesse G. Meyer, PhD

@J_my_sci

2 years

My group's official Cedars-Sinai website is finally live

Meyer Research Lab

The Meyer Lab is a hybrid wet/dry lab that imagines and builds new methods for mass spectrometry-based proteomics and metabolomics.

www.cedars-sinai.edu

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Jesse G. Meyer, PhD

@J_my_sci

3 months

1 minute plasma proteomics by direct infusion and nano particle enrichment! A new way to think about fast plasma proteomics! 🏎️🏎️🏎️ Excellent work by postdoc @yumingjiang94

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Jesse G. Meyer, PhD

@J_my_sci

3 years

We finally got our mass spec running and my technician grew some yeast mutations to test a crazy prediction I made w/ machine learning, and it appears to be true

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Jesse G. Meyer, PhD

@J_my_sci

2 years

Read the first words of my last 5 tweets as a sentence

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Jesse G. Meyer, PhD

@J_my_sci

7 months

Still looking to fill this computational postdoc position 75k/year minimum starting salary, starting immediately. Open to many areas of research including single cell proteomics, multi-omics integration, deep learning applied to biology or chemistry

Jesse G. Meyer, PhD

@J_my_sci

8 months

Updated posting for a computational postdoc in my group with interests in single cell and/or machine learning. Minimum pay is 70k/yr plus benefits. Join a diverse team of wet lab and computational scientists and learn new skills to get to next career step

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Jesse G. Meyer, PhD

@J_my_sci

4 years

Do you think I could get an NIH grant for this? @OpenAcademics #AcademicChatter #AcademicTwitter "Scientists 3D print microscopic Star Trek spaceship that moves on its own"

Scientists 3D print microscopic Star Trek spaceship that moves on its own | CNN

A team of physicists at a university in the Netherlands have 3D-printed a microscopic version of the USS Voyager, an Intrepid-class starship from Star Trek.

www.cnn.com

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Jesse G. Meyer, PhD

@J_my_sci

3 years

Very excited to share the preprint for the second paper from my lab: "Positional SHAP for Interpretation of Deep Learning Models Trained from Biological Sequences"

Positional SHAP for Interpretation of Deep Learning Models Trained from Biological Sequences

Machine learning with artificial neural networks, also known as “deep learning”, accurately predicts biological phenomena such as disease diagnosis and protein structure. Despite the ability of deep...

www.biorxiv.org

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Jesse G. Meyer, PhD

@J_my_sci

5 years

How most people store their raw data

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Jesse G. Meyer, PhD

@J_my_sci

3 years

Flight attendant: Is there a doctor on board? Me: Yes, but I'm not that kind of… Flight attendant: We need relative quantities of about 5,000 proteins from cultured cells. Me: Okay. I’m here.

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Jesse G. Meyer, PhD

@J_my_sci

1 year

Please check out our new paper proposing a mechanism for non-enzymatic protein acetylation:

Coenzyme A binding sites induce proximal acylation across protein families

Scientific Reports - Coenzyme A binding sites induce proximal acylation across protein families

www.nature.com

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Jesse G. Meyer, PhD

@J_my_sci

2 years

After a long silence.. big update to the community proteomics tutorial by @neely615 with input from @pwilmarth ! New section on databases, especially what are they and where do you get them? Still many sections empty, please consider getting involved!

Comprehensive Overview of Bottom-Up Proteomics using Mass Spectrometry

jessegmeyerlab.github.io

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Jesse G. Meyer, PhD

@J_my_sci

1 year

The amount of supplemental material needed to publish in nature