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JAMA Neurology

@JAMANeuro

4 years

In a retrospective study of 214 patients with #COVID19 , neurological symptoms were seen in 36.4%, and more common in severe cases (45.5%), which included acute cerebrovascular events (5.7%), impaired consciousness (14.8%) and muscle injury (19.3%)

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

This study investigates the neurologic manifestations of patients with coronavirus disease 2019.

jamanetwork.com

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JAMA Neurology

@JAMANeuro

4 years

Neuropathogenesis and Neurologic Manifestations of Coronaviruses in the Age of COVID-19

This narrative review identifies potential tissue targets and routes of entry of severe acute respiratory syndrome coronavirus 2 into the central nervous system and reported neurological complicati...

jamanetwork.com

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JAMA Neurology

@JAMANeuro

11 months

In this trial, among patients with aneurysmal subarachnoid hemorrhage, lumbar drainage improved clinical neurological outcomes at 6 months.

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JAMA Neurology

@JAMANeuro

1 year

Narrative review discusses the management of rare trigeminal autonomic cephalalgias over the last 20 years.

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JAMA Neurology

@JAMANeuro

10 months

TRAILBLAZER-ALZ 2: Among patients with early symptomatic #AlzheimerDisease and amyloid and tau pathology, donanemab treatment significantly slowed clinical progression at 76 weeks. #AAIC23

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JAMA Neurology

@JAMANeuro

1 month

In this meta-analysis, seizure prophylaxis was effective for mild and moderate TBI to reduce rates of early seizures.

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JAMA Neurology

@JAMANeuro

2 months

Review article illustrates the current, and likely future, landscapes of prognostic markers of neurologic recovery from disorders of consciousness caused by severe, acute brain injury.

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JAMA Neurology

@JAMANeuro

3 years

#COVID19 brain symptoms are a rising concern. Mechanisms of brain damage by the virus include lasting neuroinflammation, thrombotic events and alteration of neurotransmitters release. Consequently, people suffer cognitive, emotional and behavioral symptoms

How COVID-19 Affects the Brain

This article discusses possible pathogenic mechanisms of brain dysfunction in patients with COVID-19.

jamanetwork.com

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JAMA Neurology

@JAMANeuro

9 months

Patients with benign paroxysmal positional vertigo may recover more quickly using the Semont-plus maneuver rather than the Epley maneuver.

Semont-Plus vs Epley Maneuver in Posterior Canal Benign Paroxysmal Positional Vertigo

This randomized clinical trial compares the efficacy of the Semont-plus maneuver and the Epley maneuver in patients with posterior canal benign paroxysmal positional vertigo.

jamanetwork.com

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JAMA Neurology

@JAMANeuro

5 years

This is the first clinicopathological study to show that clinical subtypes of #Parkinson 's disease at diagnosis can predict disease course and survival. Read the details here

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JAMA Neurology

@JAMANeuro

1 year

Two inexpensive licensed medications (ISMN and cilostazol) may reduce adverse long-term outcomes of lacunar ischemic stroke, a form of cerebral small vessel disease. Definitive trials are needed to confirm these findings. #ESOC2023

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JAMA Neurology

@JAMANeuro

11 months

Patients with benign paroxysmal positional vertigo may recover more quickly using the Semont-plus maneuver rather than the Epley maneuver.

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JAMA Neurology

@JAMANeuro

6 years

Read about advances in lacunar #stroke pathophysiology. What’s the underlying vessel pathology? How are they related to other sequelae of small vessel disease, or to systemic processes? Find out

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JAMA Neurology

@JAMANeuro

3 years

Methylphenidate may be useful for the treatment of apathy in #Alzheimerdisease , reducing symptoms and caregiver burden

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JAMA Neurology

@JAMANeuro

5 years

Study shows that #physicalactivity protects against the detrimental effects of elevated amyloid burden on #cognitivedecline and brain volume loss #AAIC19

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JAMA Neurology

@JAMANeuro

11 months

Published Tuesday in @JAMA_current : “Dual Antiplatelet Therapy vs Alteplase for Patients With Minor Nondisabling Acute Ischemic Stroke: The ARAMIS Randomized Clinical Trial” by Drs Hui-Sheng Chen, @NguyenThanhMD , and colleagues. (1/2)

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JAMA Neurology

@JAMANeuro

3 years

CT for late endovascular reperfusion: CLEAR results @NguyenThanhMD @AbdalkaderMD @NagelSimon @MarcRiboJ @AliciaCastongu2 @OOZaidat @RaymondJeanMD1 @DiogoHaussen @MahmoudNeuro @SunilAShethMD @JimSiegler @CerebrovascLab @HMasoud_ @CheesemakerMD

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JAMA Neurology

@JAMANeuro

3 years

Patients with recent stroke should not be treated routinely with 20 mg daily of #fluoxetine to prevent or treat post-stroke #depression during the first 6 months after the stroke

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JAMA Neurology

@JAMANeuro

5 years

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JAMA Neurology

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3 years

Study says antiplatelet therapy seems safe and may be beneficial after intracerebral hemorrhage in extended follow-up of RESTART trial #ESOC2021

Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage

A follow-up of the Restart or Stop Antithrombotics Randomized Trial, this study further examines the long-term effects of antiplatelet therapy after stroke caused by intracerebral hemorrhage.

jamanetwork.com

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JAMA Neurology

@JAMANeuro

2 months

Study findings suggest that dual antiplatelet therapy, compared with aspirin alone, may be a superior treatment option for patients with acute mild to moderate ischemic stroke.

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JAMA Neurology

@JAMANeuro

3 months

A commercially available plasma p-tau217 immunoassay accurately identified biological AD, comparable with results using CSF biomarkers, with reproducible cut-offs across cohorts. It detected longitudinal changes, including at the preclinical stage.

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JAMA Neurology

@JAMANeuro

5 years

Dismissive attitudes and inadequate management of patients with 'functional' disorders has created a silent epidemic. Medicine needs a culture shift. @MattBurkeMD

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JAMA Neurology

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4 years

KLHL11 IgG is a novel paraneoplastic biomarker of testicular germ cell tumors and an aggressive CD8+T-cell-mediated cytotoxic encephalitis presenting with ataxia and #hearingloss

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JAMA Neurology

@JAMANeuro

3 years

In this exploratory analysis, rivaroxaban was superior to aspirin at reducing the risk of recurrent stroke or systemic embolism among NAVIGATE ESUS trial participants with left ventricular dysfunction

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JAMA Neurology

@JAMANeuro

3 years

In this randomized clinical trial, antiseizure drug levetiracetam improved performance on spatial memory and executive function tasks in patients #Alzheimerdisease with epileptiform activity

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JAMA Neurology

@JAMANeuro

5 years

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JAMA Neurology

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9 months

In the RACECAT trial, bypassing the nearest local stroke center resulted in worse functional outcome and higher mortality for patients with final diagnosis of ICH. @NeuroHGTiP @SantPauIctus @Ictus_Girona @annaramospa @natperezossa @ysilva87732184

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JAMA Neurology

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3 years

Current Concepts in the Diagnosis and Treatment of Functional Neurological Disorders #MostCited

Current Concepts in the Diagnosis and Treatment of Functional Neurological Disorders

This narrative review presents the definitions, diagnosis, and treatment of functional neurological disorders, a category of illnesses formerly known as conversion disorders.

jamanetwork.com

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JAMA Neurology

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9 months

IV tenecteplase is as safe and effective as IV alteplase in this substudy of 520 stroke patients with LVO from the Alteplase compared to Tenecteplase (AcT) trial.

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JAMA Neurology

@JAMANeuro

10 months

Lesion-related epilepsy maps to a human brain network which could help identify patients at risk for epilepsy after a brain lesion and guide brain stimulation therapies.

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JAMA Neurology

@JAMANeuro

1 year

Narrative review discusses the management of rare trigeminal autonomic cephalalgias over the last 20 years.

Management of Trigeminal Autonomic Cephalalgias Including Chronic Cluster

This narrative review discusses the management of rare trigeminal autonomic cephalalgias over the last 20 years.

jamanetwork.com

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JAMA Neurology

@JAMANeuro

6 years

Potential for the spontaneous disappearance of even a large #herniateddisk .

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JAMA Neurology

@JAMANeuro

6 months

Brexpiprazole 2 or 3 mg reduced agitation in Alzheimer dementia and was generally well tolerated over 12 weeks.

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JAMA Neurology

@JAMANeuro

2 months

Most viewed in the last 7 days from @JAMANeuro : Neuroprognostic markers are rapidly evolving as new ways of assessing the brain’s structural and functional integrity after brain injury are discovered.

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JAMA Neurology

@JAMANeuro

8 months

Lesion-related epilepsy maps to a human brain network which could help identify patients at risk for epilepsy after a brain lesion and guide brain stimulation therapies.

Mapping Lesion-Related Epilepsy to a Human Brain Network

This case-control study evaluates the locations of epilepsy-associated lesions with respect to specific brain regions and networks.

jamanetwork.com

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JAMA Neurology

@JAMANeuro

4 months

Study found that a commercially available plasma p-tau217 immunoassay accurately identified biological Alzheimer disease, comparable with results using cerebrospinal fluid biomarkers, with reproducible cut-offs across cohorts.

Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease Pathology

This cohort study examines data from 3 single-center observational cohorts to test the capabilities of a commercially available plasma phosphorylated tau 217 immunoassay to identify Alzheimer disease...

jamanetwork.com

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JAMA Neurology

@JAMANeuro

9 months

Hypothermia had no significant effect on societal participation or cognitive function compared to normothermia at 6 months in survivors of out-of-hospital cardiac arrest.

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JAMA Neurology

@JAMANeuro

5 years

This is the first clinicopathological study to show that clinical subtypes of Parkinson's disease at diagnosis can predict disease course and survival. Learn more

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JAMA Neurology

@JAMANeuro

8 months

In this trial, among patients with aneurysmal subarachnoid hemorrhage, lumbar drainage improved clinical neurological outcomes at 6 months.

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102

JAMA Neurology

@JAMANeuro

3 years

Current Concepts in the Diagnosis and Treatment of Functional Neurological Disorders #MostCited

Current Concepts in the Diagnosis and Treatment of Functional Neurological Disorders

This narrative review presents the definitions, diagnosis, and treatment of functional neurological disorders, a category of illnesses formerly known as conversion disorders.

jamanetwork.com

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JAMA Neurology

@JAMANeuro

4 years

In #Alzheimerdisease , #Minocycline at 200mg and 400mg per day offers no advantages over placebo on cognitive and functional decline over 24 months

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JAMA Neurology

@JAMANeuro

2 months

A 51-year-old woman presented with a 2-year history of progressive memory loss and left limb numbness. What is your diagnosis?

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JAMA Neurology

@JAMANeuro

4 years

Neurological signs & symptoms are reported in patients with #COVID19 . This review takes a deeper dive into the neurological complications of #coronavirus infections @LindsayMcA @ShelFarFar @YaleIMed @YaleMed @SpudichLabYale @SpudichSerena

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4 years

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2 months

Of all antiseizure medications with meaningful data, the lowest prevalence of major congenital malformations after prenatal exposure was observed in offspring exposed to levetiracetam, oxcarbazepine, and lamotrigine, finds longitudinal cohort study.

Risk of Major Congenital Malformations and Exposure to Antiseizure Medication Monotherapy

This cohort study investigates the risk of major congenital malformations associated with antiseizure medication (ASM) monotherapy in the offspring of mothers taking ASMs during pregnancy.

jamanetwork.com

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JAMA Neurology

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3 years

Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury #MostCited

Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury

This systematic review and meta-analysis investigates the clinical and therapeutic significance of magnetic resonance imaging markers of covert vascular brain injury (white matter hyperintensities,...

jamanetwork.com

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JAMA Neurology

@JAMANeuro

3 years

Nearly 50% of unselected patients undergoing brain MRI will have at least one MRI sign of intracranial hypertension, but this finding is rarely associated with papilledema @vbiouss

Intracranial Hypertension on Magnetic Resonance Imaging and Association With Papilledema

This cross-sectional study examines the prevalence of incidentally detected signs of intracranial hypertension on magnetic resonance imaging and assesses whether these radiographic signs are associ...

jamanetwork.com

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JAMA Neurology

@JAMANeuro

2 years

In this randomized clinical trial, antiseizure drug levetiracetam improved performance on spatial memory and executive function tasks in patients with #Alzheimerdisease with epileptiform activity

2

37

97

JAMA Neurology

@JAMANeuro

3 years

Neuropathogenesis and Neurologic Manifestations of Coronaviruses in the Age of COVID-19 #MostCited

Neuropathogenesis and Neurologic Manifestations of Coronaviruses in the Age of COVID-19

This narrative review identifies potential tissue targets and routes of entry of severe acute respiratory syndrome coronavirus 2 into the central nervous system and reported neurological complicati...

jamanetwork.com

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JAMA Neurology

@JAMANeuro

2 years

Treatable genetic diseases may mimic acquired neuroinflammatory disorders. Read this #review .

Adult-Onset Genetic CNS Disorders Masquerading as Acquired Neuroinflammatory Disorders

This narrative review outlines the main genetic neuroinflammatory disorders that can mimic acquired adult-onset neuroinflammatory diseases and describes the main diagnostic clues, including magnetic...

jamanetwork.com

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JAMA Neurology

@JAMANeuro

4 years

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JAMA Neurology

@JAMANeuro

4 months

Among patients with acute ischemic stroke who experience early neurological deterioration, argatroban was significantly associated with better neurological function.

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JAMA Neurology

@JAMANeuro

4 years

Metronidazole is an antimicrobial agent commonly used in the treatment of anaerobic and protozoal infections. To the best of our knowledge we present the first known case of metronidazole induced encephalopathy resulting from topical use of this drug

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JAMA Neurology

@JAMANeuro

7 years

A traveling exhibit of drawings by Cajal, the master of neurohistology, is a revelation of the brain’s beauty

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JAMA Neurology

@JAMANeuro

5 years

Low-dose #aspirin was associated with an overall increased risk of intracranial hemorrhage among people without symptomatic #cardiovasculardisease

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JAMA Neurology

@JAMANeuro

7 months

This comparative effectiveness study compares levetiracetam vs lamotrigine as first-line antiseizure medication in female patients with idiopathic generalized epilepsy.

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JAMA Neurology

@JAMANeuro

3 years

Current Concepts in the Diagnosis and Treatment of Functional Neurological Disorders #MostCited

Current Concepts in the Diagnosis and Treatment of Functional Neurological Disorders

This narrative review presents the definitions, diagnosis, and treatment of functional neurological disorders, a category of illnesses formerly known as conversion disorders.

jamanetwork.com

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JAMA Neurology

@JAMANeuro

4 years

Rare observation of cerebello-thalamic tract, plus deep nuclei, involvement in an intriguing autoantibody-tauopathy overlap syndrome

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18 days

Case report: describes a woman cold-induced reflex seizures.

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5 years

Diabetic striatopathy is a syndrome presenting with hemiballism/hemichorea despite aggressive correction with #insulin .

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JAMA Neurology

@JAMANeuro

4 years

Neuropathogenesis and Neurologic Manifestations of Coronaviruses in the Age of COVID-19

This narrative review identifies potential tissue targets and routes of entry of severe acute respiratory syndrome coronavirus 2 into the central nervous system and reported neurological complicati...

jamanetwork.com

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JAMA Neurology

@JAMANeuro

5 years

Endovascular therapy benefits #stroke patients with salvageable tissue on CT or MR, regardless of their age, symptom severity, and time since stroke. Learn more

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@JAMANeuro

11 months

Study results suggest that focal cortex stimulation with an epicranial electrode array may offer a safe and effective new treatment option for patients with drug-refractory focal #epilepsy .

Focal Cortex Stimulation With a Novel Implantable Device and Antiseizure Outcomes

This pooled analysis of 2 nonrandomized uncontrolled trials investigates the association between epicranial electrical focal cortex stimulation and seizure frequency in drug-refractory focal epilepsy.

jamanetwork.com

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4 years

Growing evidence suggest that by preventing cerebrovascular disease, it is also possible to start preventing some cases of #dementia .

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8 days

Review article illustrates the current, and likely future, landscapes of prognostic markers of neurologic recovery from disorders of consciousness caused by severe, acute brain injury.

Current and Emerging Approaches to Coma Prognostication After Acute Brain Injury

This narrative review evaluates the current and emerging landscapes of prognostic markers of neurologic recovery from disorders of consciousness caused by severe, acute brain injury.

jamanetwork.com

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JAMA Neurology

@JAMANeuro

5 years

Diabetic striatopathy is a syndrome presenting with hemiballism/hemichorea despite aggressive correction with #insulin . Read about a case in this clinical challenge

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JAMA Neurology

@JAMANeuro

3 years

Current Concepts in the Diagnosis and Treatment of Functional Neurological Disorders #MostCited

Current Concepts in the Diagnosis and Treatment of Functional Neurological Disorders

This narrative review presents the definitions, diagnosis, and treatment of functional neurological disorders, a category of illnesses formerly known as conversion disorders.

jamanetwork.com

0

33

84

JAMA Neurology

@JAMANeuro

1 month

Study highlights two cases of genetic Creutzfeldt-Jakob disease with atypical diffusion-weighted imaging changes.

Punctate Diffuse Cortex Signals in Creutzfeldt-Jakob Disease

This case report describes 2 patients with genetic Creutzfeldt-Jakob disease with atypical changes on diffusion-weighted imaging.

jamanetwork.com

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JAMA Neurology

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4 years

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5 years

The worldwide incidence of subarachnoid #hemorrhage has declined by 40% between 1980 and 2010 and in parallel to #bloodpressure and smoking prevalence

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6 months

Study suggests artificial intelligence-enabled automated large-vessel occlusion detection software for stroke triage can improve thrombectomy treatment times.

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4 years

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3 years

ANGIOCAT clinical trial: Direct transfer to angiography suite increased the odds of undergoing EVT, reduced hospital workflow time and improved clinical outcome among patients with large vessel occlusion admitted in early window

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4 years

Early immunosuppressive treatment may improve the disease course of cerebral amyloid angiopathy–related inflammation and reduce the likelihood of recurrence

Association Between Immunosuppressive Treatment and Outcomes of Cerebral Amyloid Angiopathy–Related...

This cohort study examines the clinical, neuroimaging, laboratory, pathologic, or treatment-related associations with outcomes after an episode of cerebral amyloid angiopathy-related inflammation.

jamanetwork.com

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2 months

Most viewed in the last 7 days from @JAMANeuro : Essay describes the difficulty in diagnosing dementia and the experiences and questions caregivers have regarding its diagnosis.

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4 years

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9 months

Treatment w/ teriflunomide resulted in an unadjusted risk reduction of 63% and adjusted risk reduction of 72%, relative to placebo, in preventing a first clinical demyelinating event. Data suggest a benefit to early treatment in the MS disease spectrum.

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1 month

Case report: a 54-year-old woman with naming deficits, comprehension impairment, and memory loss. Initial physical and neurological examination results were unremarkable.

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5 years

High #cognitivereserve accumulated throughout the lifespan is associated with a 40% reduced risk of #dementia in the presence of brain pathologies

Association of Lifespan Cognitive Reserve Indicator With Dementia Risk in the Presence of Brain...

This cohort study examines the association of lifespan cognitive reserve with dementia risk.

jamanetwork.com

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JAMA Neurology

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4 months

Study highlights two cases of genetic Creutzfeldt-Jakob disease with atypical diffusion-weighted imaging changes.

Punctate Diffuse Cortex Signals in Creutzfeldt-Jakob Disease

This case report describes 2 patients with genetic Creutzfeldt-Jakob disease with atypical changes on diffusion-weighted imaging.

jamanetwork.com

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JAMA Neurology

@JAMANeuro

2 years

Treatment with #rituximab shortly after onset of #myastheniagravis was effective, a placebo-controlled randomized study showed. #Research

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5 years

Trigeminal neuralgia is traditionally attributed to neurovascular compression. Yet, recent studies suggest #genetic factors in its pathogenesis.

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8 months

Among patients with acute ischemic stroke receiving intravenous thrombolysis and/or endovascular treatment, DL-3-n-butylphthalide was associated with a higher proportion of patients achieving a favorable functional outcome at 90 days vs placebo.

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1 year

Study findings suggest that optimal dosing for walking exercise for patients with chronic stroke may include at least 12 weeks of training at vigorous intensity.

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6 years

Potential for the spontaneous disappearance of even a large #herniateddisk .

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3 years

Black retired @NFL players undergoing #dementia evaluations must score lower than White players to qualify for a monetary award. This Viewpoint explains perils of race-norms and propose a new approach that adjusts for social determinants of #brainhealth

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3 years

In the 1st randomized control trial evaluating #bariatricsurgery in #IIH , intracranial pressure was significantly reduced at 12 and 24 months following bariatric surgery, as compared to weight watchers

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4 years

#Paraneoplastic #enchephalomyelitis with #GAD65 antibodies presenting as longitudinal pyramidal tract hyperintensity @caballol_nuria @oriol_miralles

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3 months

Among patients with acute ischemic stroke who experience early neurological deterioration, argatroban was significantly associated with better neurological function.

Argatroban in Patients With Acute Ischemic Stroke With Early Neurological Deterioration

This randomized clinical trial investigates if argatroban improves neurological function in patients with acute ischemic stroke who experience early neurological deterioration.

jamanetwork.com

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JAMA Neurology

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5 years

Can you solve this weeks clinical challenge? A teen with chronic gait abnormalities presents with stroke-like episodes and abnormal neuroimaging

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9 months

Study findings suggest that MOG-IgA may be a novel diagnostic biomarker in a distinct subgroup of AQP4-/MOG-IgG double-seronegative patients with central nervous system demyelination. @proebstellab @lakulsvehagen @akproebstel

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2 months

Most viewed in the last 7 days from @JAMANeuro : Is dual antiplatelet therapy superior to aspirin alone in patients with acute mild to moderate ischemic stroke?

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JAMA Neurology

@JAMANeuro

2 years

In this cohort study, nearly half of the survivors of intracerebral hemorrhage with poor-outcome in the early-phase recovered to a good outcome by 1-year. Including first 30-day events in prognostic models improved prediction of recovery.

One-Year Outcomes and Functional Recovery Among Survivors of Intracerebral and Intraventricular...

This secondary analysis of 2 phase 3 clinical trials evaluates 1-year functional recovery among patients with intracerebral and intraventricular hemorrhage and initial severe disability and assesses...

jamanetwork.com

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2 years

A phase 3 clinical trial found ultra-high dose methylcobalamin slowed functional decline in patients with early-stage amyotrophic lateral sclerosis.

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6 years

Read about advances in lacunar #stroke pathophysiology. What’s the underlying vessel pathology? How are they related to other sequelae of small vessel disease, or to systemic processes? Find out

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JAMA Neurology

@JAMANeuro

6 years

#Whitematter hyperintensity lesions (WMHs) in reversible cerebral vasoconstriction syndrome ( #RCVS ) are dynamic, partially reversible, and correlated with disease severity. Learn more

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2 months

In this study, T2 and/or FLAIR hyperintensities confined to the temporal lobes, without diffusion restriction or contrast enhancement, robustly distinguished LGI1/CASPR2-Ab-E from key differential diagnoses.

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4 years

The four horsemen of #dementia (Tau, Aβ, TDP-43, & α-syn) occurred with surprising frequency in the same brains @ErinAbnerPhD

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1 year

Case report: a patient with a 3-day history of acute blindness after using alcohol and methamphetamine for 3 consecutive nights before onset of visual impairment.

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