Abstract. The International Working Group on the Diabetic Foot (IWGDF) has published evidence-based guidelines on the management and prevention of diabetes

Differential time to positivity is a simple test that can play a major role in ruling in or out central line–associated bloodstream infections. Meta-analys

Abstract. The International Working Group on the Diabetic Foot (IWGDF) has published evidence-based guidelines on the management and prevention of diabetes

In this study, short-course antibiotic therapy was non-inferior to prolonged-course therapy in terms of clinical outcomes in part of onco-hematological pat

This is the first trial to demonstrate that AIDS patients with disseminated histoplasmosis can be safely and effectively treated with a single high dose of

In this study, short-course antibiotic therapy was non-inferior to prolonged-course therapy in terms of clinical outcomes in part of onco-hematological pat

Persistent enterococcal bacteremia is a commonly encountered and morbid syndrome without a strong evidence base for optimal management practices. Here we h

In this study, short-course antibiotic therapy was non-inferior to prolonged-course therapy in terms of clinical outcomes in part of onco-hematological pat

Abstract. In the past decade, the prevalence of multidrug-resistant gram-negative (MDR-GN) bacterial infections has increased significantly, leading to hig

In a multicenter study of 1099 hospitalized adults with complicated urinary tract infections and associated bacteremia, 7 days of antibiotics was sufficien

Glucocorticoid-induced immunosuppression is linked to the dose, duration, and intensity, but the dose-dependent model may inaccurately predict the risk of

This study demonstrates a higher prevalence of concordant Candida endophthalmitis compared with the previous report by the American Academy of Ophthalmolog

This meta-analysis showed that adjunctive rifampin therapy may be associated with lower risk of Staphylococcus aureus native vertebral osteomyelitis treatm

Encephalitis is a potentially devastating neurologic disease associated with significant morbidity during the acute illness and often complicated by prolon

The degree of pyuria can help distinguish urinary tract infection (UTI) in older women from asymptomatic women with and without bacteriuria. We demonstrate

In this review, we seek to provide a comprehensive overview of the evaluation and management of Staphylococcus aureus bacteremia, with special focus on are

Immunocompromised patients are at high risk of mortality from coronavirus disease 2019 (COVID-19). Early initiation of remdesivir is associated with a sign

Abstract. In a retrospective multicenter study of 575 patients with bloodstream infections or pneumonia due to wild-type AmpC β-lactamase-producing Enterob

This meta-analysis showed that adjunctive rifampin therapy may be associated with lower risk of Staphylococcus aureus native vertebral osteomyelitis treatm

In this survey-based study we highlight the existence of large practice variations for Staphylococcus aureus bacteremia throughout the world.

EARLY-SIMPLIFIED is a 4-year open-label trial with randomized and observational phases showing noninferiority of dolutegravir monotherapy versus combinatio

This review describes the current state of care for periprosthetic joint infection, focusing on multidisciplinary collaboration, common diagnostic and mana

This meta-analysis showed that adjunctive rifampin therapy may be associated with lower risk of Staphylococcus aureus native vertebral osteomyelitis treatm

Abstract. In a retrospective multicenter study of 575 patients with bloodstream infections or pneumonia due to wild-type AmpC β-lactamase-producing Enterob

Abstract. We review key concepts in the diagnosis, treatment, and follow-up of individuals with neurosyphilis. We describe the epidemiology of syphilis in

Persistent enterococcal bacteremia is a commonly encountered and morbid syndrome without a strong evidence base for optimal management practices. Here we h

In this review, we seek to provide a comprehensive overview of the evaluation and management of Staphylococcus aureus bacteremia, with special focus on are

A new oral amphotericin B lipid nanocrystal formulation appears promising for cryptococcal meningitis with similar quantitative antifungal activity in huma

Abstract. The International Working Group on the Diabetic Foot (IWGDF) has published evidence-based guidelines on the management and prevention of diabetes

The source of an extensively drug-resistant Pseudomonas outbreak causing significant morbidity and mortality was a nationally distributed, over-the-counter

Abstract. We review key concepts in the diagnosis, treatment, and follow-up of individuals with neurosyphilis. We describe the epidemiology of syphilis in

Immunocompromised patients are at high risk of mortality from coronavirus disease 2019 (COVID-19). Early initiation of remdesivir is associated with a sign

Differential time to positivity is a simple test that can play a major role in ruling in or out central line–associated bloodstream infections. Meta-analys

Adjunctive systemic corticosteroid therapy in adult patients hospitalized with community-acquired pneumonia was associated with a reduction in all-cause mo

The degree of pyuria can help distinguish urinary tract infection (UTI) in older women from asymptomatic women with and without bacteriuria. We demonstrate

Among children aged 6–10 years, those living with patients with clinical, smear-positive tuberculosis or with subclinical, smear-positive tuberculosis had

This study reveals that patients with positive severe acute respiratory syndrome coronavirus 2 polymerase chain reaction tests are significantly more likel

The degree of pyuria can help distinguish urinary tract infection (UTI) in older women from asymptomatic women with and without bacteriuria. We demonstrate

Nirmatrelvir/ritonavir use for COVID-19 in vaccinated adults aged 18–50 years with serious comorbidities was associated with improved clinical outcomes. Ho

Navigating the use of antimicrobials at the end of life is a challenge for infectious diseases (ID) physicians who remain deeply committed to providing pat

A5324 assessed whether ART intensification with dolutegravir and maraviroc compared with placebo would benefit persons with human immunodeficiency virus an

In solid-organ transplant recipients, treatment of uncomplicated gram-negative bloodstream infections with oral antibiotics was safe, effective, and associ

This meta-analysis showed that adjunctive rifampin therapy may be associated with lower risk of Staphylococcus aureus native vertebral osteomyelitis treatm

Abstract. In a retrospective multicenter study of 575 patients with bloodstream infections or pneumonia due to wild-type AmpC β-lactamase-producing Enterob

In this study, short-course antibiotic therapy was non-inferior to prolonged-course therapy in terms of clinical outcomes in part of onco-hematological pat

We document how common analytic choices to characterize associations between time-to-antibiotics and mortality for suspected sepsis can generate misleading

We observed similar responses to bloodstream infection (BSI) in critically ill transplant and non-transplant recipients. Multivariable regression models ac

Abstract. We review key concepts in the diagnosis, treatment, and follow-up of individuals with neurosyphilis. We describe the epidemiology of syphilis in

A new oral amphotericin B lipid nanocrystal formulation appears promising for cryptococcal meningitis with similar quantitative antifungal activity in huma

In this phase 3 superiority study, ridinilazole, bactericidal bis-benzimidazole against C. difficile, versus vancomycin reduced recurrent disease by 53%, p

In a randomized trial of >15 000 older adults not selected for vitamin D deficiency, vitamin D supplementation did not prevent upper respiratory infecti

Little is known about antiretroviral therapy (ART) timing and mortality in people with human immunodeficiency virus and cryptococcal meningitis in high-inc

Adjunctive systemic corticosteroid therapy in adult patients hospitalized with community-acquired pneumonia was associated with a reduction in all-cause mo

Cumulative evidence has seeded the idea that the CD4/CD8 ratio could help monitor HIV. However, knowledge gaps exist. Here, we critically review the litera

AbstractBackground. High-dose daptomycin is increasingly used in patients with bone and joint infection (BJI). This raises concerns about a higher risk of