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Fingernail clubbing is associated with many systemic diseases, from lung cancer to TB to inflammatory bowel disease.
Why would such different diseases all manifest with clubbing?
The answer is surprisingly simple and elegant.
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Why can furosemide improve dyspnea/pulmonary edema from acute congestive heart failure within minutes of administration?
The answer does not involve diuresis.
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Ever wonder why corticosteroids like dexamethasone treat cerebral edema related to brain tumors?
I assumed the answer involved "anti-inflammatory effects", but there's much more going on.
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1/THREAD
Ever wonder why fluoroquinolones increase the risk of tendon rupture?
It seems so random that a whole class of antibiotics could cause tendon injuries, but the risk is real.
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Ever wonder why magnesium (Mg) is used to treat Torsades de Pointes?
The answer is fascinating, elegant, and also explains why Mg treats another clinical entity - eclampsia
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1/THREAD
Why would adenosine, a purine nucleoside, be able to treat supraventricular tachycardias (SVT)?
And why are its effects so short lived (e.g. <2 seconds)?
The answers will change the way you think about this drug.
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Why does catamenial pneumothorax (pneumothorax that recurs with menstruation) almost always occur on the right side?
Why doesn't it affect both sides of the chest equally?
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