Viral persistence in Long Covid is a particularly hot topic. In this film I talk to @microbeminded2 about the evidence which is mounting up and why Occam’s razor starts to get more and more applicable. Tweet added by Gez Medinger @gezmedinger

Gez Medinger

2 years

Viral persistence in Long Covid is a particularly hot topic. In this film I talk to @microbeminded2 about the evidence which is mounting up and why Occam’s razor starts to get more and more applicable.

The Evidence For Why Viral Persistence Might be Causing Long Covid |...

The idea of viral persistence has been a hot topic since early in the Long Covid story. But as time has gone on, more and more evidence has been mounting up....

www.youtube.com

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Clare Daly

@clarejdaly

2 years

@gezmedinger @microbeminded2 My favourite so far. Fascinating listening to all the ideas come together. Can we help fund research @microbeminded2 ?

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Gez Medinger

@gezmedinger

2 years

@clarejdaly @microbeminded2 TBC!

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Herbert Renz-Polster

@RenzPolster

2 years

@gezmedinger @microbeminded2 Great interview, Gez! The ONLY question you forgot to ask is: If Long Covid is all about SARS-CoV-2 persistence, how comes that you can develop the EXACT same picture and clinical course without ever having encountered SARS-CoV-2 (I am referring to vaccine induced Long Covid).

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Gez Medinger

@gezmedinger

2 years

@RenzPolster @microbeminded2 It seems like vaccine induced LC is a subset of LC and doesn’t quite have the same number or volume of symptoms. Dysautonomia features very highly though. Presence of spike triggers some of the same autoantibodies that have the same effect on autonomic system maybe?

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CSL_2976 PhD

@2976Csl

2 years

@gezmedinger @microbeminded2 Such an interesting discussion; thanks! I have wondered whether prolonged/strenuous exercise while incubating the virus may in part contribute to impaired ability to clear it by inducing immune suppression. So many athletic people struggle with CFS and Long Covid.

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Gez Medinger

@gezmedinger

2 years

@L_Cathy_60 @microbeminded2 I ran about 50km in the period between exposure and developing symptoms, so maybe!

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isabell

@IsabellWelpe

2 years

@gezmedinger @IchBin_RO @microbeminded2 @kpalettakk

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Gerald Commissiong

@G_Commish

2 years

@gezmedinger @microbeminded2 Tollovid is available on Amazon or

Todos Medical

@todosmedical

2 years

$TOMDF CEO @G_Commish breaks down IC50 binding affinity in #Ivermectin (50), #Tollovid (<5), #Tollovir (0.8) and #Paxlovid (0.006). Smaller number = tighter binding affinity which stops from doing its job of helping virus replicate & damage immune system. #antiviral #stop3clpro

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Zoltan Kelemen

@MisterZed64

2 years

@gezmedinger @microbeminded2 Great interview, thanks for sharing! One interesting aspect, which does not seem to fit in the persistence narrative, is the symptoms of vax injured people. They seem to be similar to long covid symptoms.

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Bunk the Biologist

@BiologistBunk

2 years

@gezmedinger @microbeminded2 Great insights from Dr Amy Proal. Just surprised there wasn't any mention of the big NIH, NCI, University of Maryland autopsy preprint.

Study: Coronavirus can persist for months after traversing entire body

The coronavirus that causes COVID-19, SARS-CoV-2, can spread within days from the airways to the heart, brain and almost every organ system in the body, where it may persist for months, a study found.

www.ajc.com

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Edward Mitchell

@edwardm56067877

2 years

@gezmedinger @microbeminded2 Hi gez. This theory sounds likely for me personally. My symptoms just continued after the initial infection. I haven’t developed new symptoms and they have been extremely slowly improving over time.

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🧚

@LCinTirol

2 years

@gezmedinger @microbeminded2 @gezmedinger this is very interesting! Whenever I take the meds I took during acute Covid (Artemisia Annua) I feel relief from my Long Covid fatigue.

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Stephen Smith

@smithsj

2 years

@gezmedinger @microbeminded2 As a patient, this seems so intuitive. Before I had any clue wtf any of these acronyms meant, or even knew the different between EBV and mono, I went to my doctor and said, “I know this isn’t supposed to happen, but I think I got mono again”

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Tania J. Spencer

@TaniaJSpencer

2 years

@gezmedinger @microbeminded2 Many thanks, Gez. Excellent as always. Of particular resonance, Dr. Proal's observation that as soon as we see that antivirals like Paxlovid are effective in acute COVID-19, "it seems pretty logical to start trialling them in Long Covid".

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Hannah 😷 💙 @foxesgarden.bsky.social

@Foxes_Garden

2 years

@gezmedinger @microbeminded2 Thank you both, the theory of viral persistence makes a lot of sense. Great to hear the different aspects of long covid tied in together. Please keep going, the great research & communications, are appreciated.

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Anna Savory

@AnnaSavory

2 years

@gezmedinger @microbeminded2 Where does this leave V LH-ers? Are we still producing spike protein? Because if my left arm is the reservoir I don’t mind losing it if it leads to recovery... Alternately was considering reactivated viruses never clearing? I am clot filled if that builds a fuller picture.

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🏴󠁧󠁢󠁷󠁬󠁳󠁿 MaryR RN rtd, BA hons SW💙#FBLC

@MaryGR65

2 years

@gezmedinger @PutrinoLab @microbeminded2 Brilliant chat with @microbeminded2 Gez. Amy, I feel optimistic after 2 years of #LongCovid that we will have something soon that might just let us return to our previous lives. So happy you enjoy what you do and are driving forward, it makes all the difference to us. Thank you

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MattCR 🇪🇺🇩🇪

@mcr6uk

2 years

@gezmedinger @microbeminded2 Anecdotal perhaps but one of the symptoms I have had was stomach issues - lots of medication needed. Needed emergency appendectomy in January. Other long Covid symptoms persist but stomach issues improved - off the medication.

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