I'm putting this out again for those who might be interested showing my longstanding scepticsm to the notion of abnormal alpha synuclein aggregation as the cause of Parkinson's disease
@AlbertoEspay
An essay on the shaking palsy
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@ajlees
@AlbertoEspay
the interesting thing about aggregation hypotheses is that they can often be interpreted both as a gain of toxic oligomers / aggregates or loss of functional monomers. Much evidence doesn't really distinguish these two hypotheses, although some does (variant phenotypes e.g.)
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@KasperKepp
@AlbertoEspay
Aggregation into Lewy bodies may well be an attempt at protecting an injured neurone
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