Sholto David @addictedtoigno1 Twitter profile

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Sholto David

@addictedtoigno1

2 months

I was included on the #TIME100HEALTH list of 100 individuals who most influenced global health this year.

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Sholto David

@addictedtoigno1

7 months

@MattNachtrab Matt you keep posting this nonsense but it never actually comes with examples of Elizabeth making mistakes.

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Sholto David

@addictedtoigno1

2 months

Science retracts a paper by Dana-Farber CEO Laurie Glimcher. Dana-Farber claim to have started an investigation in 2021. The PubPeer thread on this paper has been active since 2014. The timeline doesn't seem very flattering...

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Sholto David

@addictedtoigno1

4 months

Nature Medicine recently corrected a figure after my PubPeer comment and email. The "corrected figure" contains a different version of the same error. Current APC $12290.00.

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Sholto David

@addictedtoigno1

8 months

Five different papers using the same image of nanoparticles. Are they selenium, aluminium, or silicon based nanoparticles? Who supplied them? No response on PubPeer so far... Usual suspects: MDPI, Frontiers, Scientific Reports

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Sholto David

@addictedtoigno1

10 months

I have posted a new preprint: 16% of papers with research images in the journal Toxicology Reports contain duplications. Thanks to everyone who helped!

A Quantitative Study of Inappropriate Image Duplication in the Journal Toxicology Reports

Inappropriate image duplication is a type of scientific error that can be detected by examining published literature. Few estimates of the frequency of this problem have been published. This study...

www.biorxiv.org

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Sholto David

@addictedtoigno1

5 months

Finally retracted by MDPI! I posted this in 2021. The paper includes lots of duplicated rat wounds, both within the paper, and shared with other papers. The authors initially disputed these findings.

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Sholto David

@addictedtoigno1

1 month

@mumumouse2 But it is Iranian honey!!

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Sholto David

@addictedtoigno1

7 months

@MattNachtrab It wasn't Elisabeth who did any of the "shaming" (if there was any). She just pointed to the errors. But for the record, all the authors on a paper should take responsibility for the data in it. You're just calling for people to stop pointing out errors 🤡

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Sholto David

@addictedtoigno1

2 months

Recycled images of rat livers. @ImageTwinAI Is great for finding these. Some controls reused, but descriptions of methods are not the same.

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Sholto David

@addictedtoigno1

15 days

Finally retracted, one of the authors initially responded on PubPeer to say "This mean the sample is homogeneous"

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Sholto David

@addictedtoigno1

5 months

The Harvard Crimson has covered allegations of misconduct at Dana-Farber. Very well written and researched (I may be biased)!

Dana-Farber Cancer Institute Researchers Accused of Manipulating Data | News | The Harvard Crimson

www.thecrimson.com

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Sholto David

@addictedtoigno1

3 months

Today's issue of AACR's journal Cancer Research Includes six retractions, all for DFCI researchers:

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Sholto David

@addictedtoigno1

8 months

Contacted the journal well over a year ago. No response or action taken @SpringerNature ??

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Sholto David

@addictedtoigno1

4 months

I have been blogging again!

Mice don’t count

“The mice probably wouldn’t care whether the experiment they suffered and died for was meaningful or not, but it does seem to matter to me. “- Sholto David

forbetterscience.com

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Sholto David

@addictedtoigno1

5 months

STAT news published an article related to my recent blog about DFCI

Dana-Farber cancer researchers moving to retract one paper, correct others in broad investigation...

“The frequency of these allegations has gone into some sort of hyper-exponential phase,” said the research integrity officer for Dana-Farber.

www.statnews.com

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Sholto David

@addictedtoigno1

9 months

Nature news wrote a story about my recent preprint:

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Sholto David

@addictedtoigno1

6 months

New blog post: Another scandal at Harvard. Senior Dana-Farber researchers have published a lot of photoshopped and mislabeled images:

Dana-Farberications at Harvard University

“Imagine what mistakes might be found in the raw data if anyone was allowed to look!” – Sholto David

forbetterscience.com

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Sholto David

@addictedtoigno1

3 months

A short story about a duplication I found 🔍

Nobel Prize winner’s paper to be corrected, according to co-author

A data sleuth flagged an apparent duplicate image in the 2015 prion study led by neurologist and biochemist Stanley Prusiner.

www.thetransmitter.org

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Sholto David

@addictedtoigno1

2 months

There are many people working on the same thing, both more articulate and prolific, I've just been one of the loudest [Images specifically, in no particular order] @MicrobiomDigest @SmutClyde @Thatsregrettab1 @mortenoxe @mumumouse @PSBROOKES and huge thanks goes to @ImageTwinAI

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Sholto David

@addictedtoigno1

8 months

Oh no! Guess the subject of these nine papers without looking at the titles....

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Sholto David

@addictedtoigno1

5 months

In just one paper, annotated by @ImageTwinAI 😐 If Springer Nature or Oncogene wanted to fix this, it wouldn't be difficult, so presumably they don't care. Cited nearly 200 times

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Sholto David

@addictedtoigno1

7 months

Following my commentary on PubPeer and blogging Francis Hornicek at @univmiami has three papers retracted, so I've made a new episode of Science Police! (With the full intro back by popular demand)

Science Police: Three Cancer Research Papers RETRACTED

https://twitter.com/addictedtoigno1Patreon: https://www.patreon.com/SholtoDavidFacebook: https://www.facebook.com/profile.php?id=100029444865535Blog Post: ht...

www.youtube.com

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Sholto David

@addictedtoigno1

7 months

Scientists from Harvard gain ethical approval to aspirate bone marrow from healthy volunteers and cancer patients, then mix up the images during publication. Surely this is an enormous ethical transgression. I would be furious if I volunteered!

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Sholto David

@addictedtoigno1

5 months

Not only blaming the graduate student, but also suing them, classy 🤡

For Better Science

@4BetterScience

5 months

Schneider Shorts 26.1.2024 – Personal humiliation, mental anguish and suffering

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Sholto David

@addictedtoigno1

2 years

Pinnacle of "green synthesis" use Photoshop to avoid carbon intensive lab equipment and polluting reagents.

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Sholto David

@addictedtoigno1

6 months

New video! A review of papers retracted following my commentary in 2023!

Science Police: Reviewing Retractions in 2023

Twitter: https://twitter.com/addictedtoigno1Patreon: https://www.patreon.com/SholtoDavidBlog Posts: https://forbetterscience.com/tag/Sholto-David/Facebook: h...

www.youtube.com

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Sholto David

@addictedtoigno1

8 months

MDPI in 2022 and T&F in 2023, authors pretend to do SEM but stole the image from a chemical suppliers' website. Perhaps they had to steal the image because apparently their SEM only has magnification of x10??

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Sholto David

@addictedtoigno1

3 months

I enjoyed this short video by the New York Times related to my blogging on Sam S Yoon. Very nicely made!

TikTok · The New York Times

54.1K likes, 637 comments. “The quiet withdrawal of a 2021 cancer study by Dr. Sam Yoon highlights scientific publishers’ lack of transparency around data problems. #cancerresearch Video by Benjamin...

www.tiktok.com

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Sholto David

@addictedtoigno1

6 months

A paper claims "camel urine applied a significant anti-cancer effect on breast cancer cells..." 🐪💧 There is an image duplication error:

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Sholto David

@addictedtoigno1

8 months

If you have a few minutes today, please read my latest blog 🙏 Researchers at MSK, Columbia, Penn Medicine, and more, caught in the kind of fraud that we would laugh at if it was published by MDPI.

Memorial Sloan Kettering Paper Mill

“Why do successful and apparently intelligent surgeons feel the need to play pretend at biology research? Has Sam S. Yoon ever performed an invasion or migration assay? […] if this is h…

forbetterscience.com

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Sholto David

@addictedtoigno1

5 months

I have just noticed a correction for one of the DFCI papers. New images have been sourced to replace these overlapping areas, the full text of the correction follows.

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Sholto David

@addictedtoigno1

9 months

I wrote a blog with some more interesting details about my recent preprint as well as other tomfoolery at Toxicology Reports!

For Better Science

@4BetterScience

9 months

Lashing out at Toxicology Reports

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Sholto David

@addictedtoigno1

2 months

Does Science have a policy of retracting obviously Photoshopped figures? They never responded to my enquiry in January about these neurons (published by a different team).

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Sholto David

@addictedtoigno1

1 year

Author response: "...note that 10% editing is acceptable as long as we didn't modify the significant features" I wasn't aware of this rule, so everyone please stay informed!!

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Sholto David

@addictedtoigno1

4 months

A paper on the E3 Ubiquitin Ligase "MARCH7" was sadly retracted on February 29th. I would have forgiven the journal for a slight delay on this one.

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Sholto David

@addictedtoigno1

5 months

I don't want to only post about DFCI, as I have many other projects going on, but this post really shocked me. I had no idea of the salaries of the individuals involved😲

Real Doc Speaks

@realdocspeaks

5 months

I just published Dana — Farber Cancer Institute Leadership Lacks Accountability as Scandal Continues

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Sholto David

@addictedtoigno1

8 months

A quote from a recent paper in BMC cancer about non-coding RNA: "Further information regarding the biological activity of SNHG1 in cancer is difficult to ascertain, due to the literature being corrupted by fabrication of papers for profit"

SNHG1 opposes quiescence and promotes docetaxel sensitivity in prostate cancer - BMC Cancer

Background A majority of prostate cancer cells are in a non-proliferating, G0 (quiescent) phase of the cell cycle and may lie dormant for years before activation into a proliferative, rapidly...

bmccancer.biomedcentral.com

Richard Van Noorden

@Richvn

8 months

Should add that while these fake papers are [hopefully] ignored by most scientists, they do in fact get citations -- because they're citing each other -- and some do get aggregated into systematic reviews, particularly in the medical literature.

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Sholto David

@addictedtoigno1

1 month

I asked GPT4o about this figure to see if it would spot the duplication between 3 and 4 (it does not, I added the red rectangles), although it did point out a contradiction in the figure legend that I did not see. Are the images samples of lung or stomach?

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Sholto David

@addictedtoigno1

2 months

Are we expecting another three years for Laurie to deal with more recently identified papers? How about this mess which Glimcher co-authored in Neuron, which I pointed out in January? To be retracted in 2027?

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Sholto David

@addictedtoigno1

6 months

"Peer-review is effective against papermills." - Certainly true, seems like high quality review is in short supply though 😥

Adam Day

@ClearSkiesAdam

6 months

A post about measuring the papermill problem with the Papermill Alarm. Many thanks to everyone who helped directly or indirectly: @CrossrefOrg @OpenAlex_org @gcabanac @MicrobiomDigest @SmutClyde @addictedtoigno1 @kaveh1000 @Thatsregrettab1 and others too!

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Sholto David

@addictedtoigno1

7 months

Another concerning Norman E. Sharpless error. How to show a remarkable reduction in bioluminescence... Just show the Day 1 image again and label it as Day 10😎

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Sholto David

@addictedtoigno1

4 months

@twillis209 Lots of different reasons, I think. Error in documentation, lost data, just thinks it looks nicer and doesn't really matter, outright fraud. This one involves Massimo Loda, so probably fraud.

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Sholto David

@addictedtoigno1

2 months

I have been blogging about MD Anderson.

Capybara’s Adventures in Medicinal Chemistry

“Every now and again, it is a good idea to open the door of the clown car that is MD Anderson, and see who climbs out. Today is the turn of Kapil N. Bhalla. If you say his name quickly, it so…

forbetterscience.com

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Sholto David

@addictedtoigno1

2 months

It's good to see some progress, but I don't see how this is a sensible way forwards. I've sent hundreds of emails about papers to different journals, most of which have not been acted on. I'll be lucky to get an automated response.

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Sholto David

@addictedtoigno1

2 months

STAT posted a story about nomenclature errors in the scientific literature, leading to a woman receiving an untested drug. I was peripherally involved because Tara asked me to help correct these errors in the literature.

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Sholto David

@addictedtoigno1

7 months

Norman Sharpless, Trump's pick for director of the National Cancer Institute, has published a string of unfortunate errors. Read my latest blog!

Sharpless Ned, or how half a mouse died

“The President’s goal of ending cancer as we know it today is grounded, in part, in the work of scientific discovery that Ned Sharpless has led at NCI”

forbetterscience.com

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Sholto David

@addictedtoigno1

9 months

I followed the GoFundMe campaigns for a scam cancer clinic over the last three years:

Hope4Cancer's GoFundMe Graveyard: Three year follow-up

Twitter: https://twitter.com/addictedtoigno1Facebook: https://www.facebook.com/Addictedtoignorance-599312487234194If you would like the spreadsheet with the ...

www.youtube.com

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Sholto David

@addictedtoigno1

6 months

LncRNA 🤡🤡🤡🤡🤡🤡

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Sholto David

@addictedtoigno1

8 months

Today's diagram, one already retracted (thanks to @SmutClyde ) @ImageTwinAI makes these easy to discover (although I usually add the rectangles myself), the only limitation is the number of colours, and amount of time in the day

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Sholto David

@addictedtoigno1

8 months

Several weeks ago, I annotated a series of papers on gastric ulcers with a large number of recycled and overlapping images. Today @PLOS retracted nine papers. I thought the methods in these papers were quite cruel to the rats, which were no doubt involved at some point.

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Sholto David

@addictedtoigno1

4 years

Is a virus an exosome? No. Sorry for the spoiler.

Andrew Kaufman and Kate Shemirani: Interview Response (Part 2)

Facebook: https://www.facebook.com/Addictedtoignorance-599312487234194Twitter: https://twitter.com/addictedtoigno1Part 1: https://youtu.be/LvDzkhYtqqYThis is...

www.youtube.com

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Sholto David

@addictedtoigno1

8 months

A couple of weeks ago, I posted this diagram. @DovePress has now retracted the four they are responsible for 🥳 Any progress on your three contributions @SpandidosP ?

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Sholto David

@addictedtoigno1

7 months

Reported to @HeliyonJournal over two months ago, multiple overlapping images, but also... Male ovaries and female testes 🤐 Authors tried to correct the male group, but still wrote about ovaries in the figure legend.

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Sholto David

@addictedtoigno1

5 months

Also useful in a correction, would be some assurance that the rest of the raw data has been reviewed and found to be sound.

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Sholto David

@addictedtoigno1

5 months

Also, I have seen authors express "regret" for missing an author's middle initial in a published Corrigendum previously (see link). No one saw fit to apologize for muddling patient's donated tissue here!

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Sholto David

@addictedtoigno1

11 months

I have been blogging at @4BetterScience again 👍

Miami Vice: Francis Hornicek & Zhenfeng Duan

Sholto David brings you a new true crime story. This time featuring two twisted orthopaedics professors from the University of Miami! Will they end up in Sholto’s science jail for their fake …

forbetterscience.com

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Sholto David

@addictedtoigno1

6 months

@MattNachtrab @Proofig @MicrobiomDigest Matt, you are completely clueless on how to improve quality in scientific research. It is trivial to organize thousands of images in folders. A typical paper contains less than a fifty, which should be directly compared to the raw data before publication.

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Sholto David

@addictedtoigno1

7 months

Fun game anyone can play: Choose a famous protein and a famous institution. Perform a scholar search. You will shortly find egregious cases of research misconduct. Here's one including Norman E Sharpless, until 2022 director of the National Cancer Institute.

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Sholto David

@addictedtoigno1

11 months

I wrote blog post!

For Better Science

@4BetterScience

11 months

Ken Suzuki: The King of Hearts at QMUL

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Sholto David

@addictedtoigno1

1 month

"Bee venom: A potential natural alternative to conventional preservatives for prolonging the shelf-life of soft cheese ‘Talaga’" Published by Elsevier's gutter Heliyon in April 2024, the images do not credibly depict the passage of time.

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Sholto David

@addictedtoigno1

2 months

@SmutClyde Finds a brilliant Figure 1...

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Sholto David

@addictedtoigno1

5 months

@MicrobiomDigest Something interesting about this, Tirosh and Ploegh were contacted by the Washington Post about this figure and were quoted in that piece effectively saying there's nothing wrong with the paper... It was later updated.

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Sholto David

@addictedtoigno1

7 months

@IvanOxygenLab Journals should be forced to either integrate PubPeer or allow prominent (moderated) comments on all papers. Letters to the editor are too slow and frequently rejected.

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Sholto David

@addictedtoigno1

2 years

New video.

WORLDS FIRST RESEARCH INTEGRITY SPEED RUN: BMC Complementary Medicine...

Twitter: https://twitter.com/addictedtoigno1Facebook: https://www.facebook.com/Addictedtoignorance-599312487234194PubPeer: https://pubpeer.com/search?q=Mycos...

www.youtube.com

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Sholto David

@addictedtoigno1

5 months

@ImageTwinAI Deserve an enormous amount of credit for developing a fantastic tool, and truly working towards their goal of improving the integrity of science.

imagetwin

@ImageTwinAI

5 months

Our mission is to increase quality and trust in science and research integrity and we would like to thank David Sholto ( @addictedtoigno1 ) for working on that mission alondside us.

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Sholto David

@addictedtoigno1

3 years

@MicrobiomDigest This western blot is fine right?

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Sholto David

@addictedtoigno1

6 months

Published in PLOS ONE in 2022, a clinical trial for an Ayurvedic COVID-19 treatment:

An efficacy and safety report based on randomized controlled single-blinded multi-centre clinical...

Objective Coronaviruses, hence named because of the crown-like spikes on the viral envelope, are members of Coronaviridae family and Order Nidovirales. SARS-CoV-2 is the seventh human pathogenic...

journals.plos.org

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Sholto David

@addictedtoigno1

6 months

Interesting finding, duplicated paw prints. Makes a change from western blots and invasion assays.

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Sholto David

@addictedtoigno1

6 months

Further problems including extremely unlikely demographics and dubious preclinical justification see here: @PLOS How can this kind of silliness be uncritically published?

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Sholto David

@addictedtoigno1

3 months

More Studies by Columbia Cancer Researchers Are Retracted

The studies, pulled because of copied data, illustrate the sluggishness of scientific publishers to address serious errors, experts said.

www.nytimes.com

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Sholto David

@addictedtoigno1

5 months

The correction does not acknowledge how the error was found. It does not explore why it happened, and it does not comment on how it could be avoided in the future. I think all would be relevant.

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Sholto David

@addictedtoigno1

6 months

The first and second authors are affiliated with the company that manufactures ZingiVir-H. And yet... "Funding: The authors received no specific funding for this work", also "Competing interests: The authors have declared that no competing interests exist."

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Sholto David

@addictedtoigno1

8 months

My nemesis, fake fruitarian "doctor" Robert Morse, finally loses his YouTube account.

Robert Morse "ND": YouTube Channel Deleted

Twitter: https://twitter.com/addictedtoigno1Facebook: https://www.facebook.com/Addictedtoignorance-599312487234194Blogs: https://forbetterscience.com/tag/Sho...

www.youtube.com

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Sholto David

@addictedtoigno1

1 month

@mumumouse2 I occasionally cry when looking at images of mice in papers. Something also worth considering is that with the generation of antibodies and serum, the average biology paper can rip up the whole barnyard and it's often for nothing.

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Sholto David

@addictedtoigno1

1 month

And I should add @ImageTwinAI absolutely does find the image overlap! Important!

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Sholto David

@addictedtoigno1

10 months

I have been blogging again! Unveiling a Saudi journal filled with crazy papers delivered to the scientific community by Elsevier ❤️

For Better Science

@4BetterScience

10 months

A Mecca for Bad Science

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Sholto David

@addictedtoigno1

5 months

Surely not @SpringerNature 😂

Cheshire

@Thatsregrettab1

5 months

It turns out that someone at the journal did tell them this. 🤡 Even though the email clearly says this is a request for an erratum.

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Sholto David

@addictedtoigno1

6 months

@MattNachtrab @Proofig @MicrobiomDigest Remember that image duplication is only a very narrow category of mislabelling (i.e. where the same image appears twice). Scientists need to develop procedures to avoid all types of mislabelling, including those which aren't duplicates. Proofig is completely inadequate.

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Sholto David

@addictedtoigno1

1 year

Interesting!

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Sholto David

@addictedtoigno1

4 months

The New York Times has covered findings from a previous blog of mine:

A Columbia Surgeon’s Study Was Pulled. He Kept Publishing Flawed Data.

The quiet withdrawal of a 2021 cancer study by Dr. Sam Yoon highlights scientific publishers’ lack of transparency around data problems.

www.nytimes.com

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Sholto David

@addictedtoigno1

5 months

@MouliVinod I hope more people engage with science critically in their own style. Being a science policeman is not very lucrative, so fair warning 😂

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Sholto David

@addictedtoigno1

2 years

A new video! Hope4Cancer selling "sigma anti bonding calcium carbonate" - which is an entirely made up molecule

Cancer Hospital sells IMAGINARY molecule: More scamming at Hope4Cancer

Facebook: https://www.facebook.com/Addictedtoignorance-599312487234194Twitter: https://twitter.com/addictedtoigno103:00 Calcium content of the human body: ht...

www.youtube.com

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Sholto David

@addictedtoigno1

3 months

@mumumouse2 @ElsevierConnect Good luck with Elsevier. They'd charge you if they could 😂

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Sholto David

@addictedtoigno1

6 months

Another RNA collage, I imagine @SmutClyde has annotated thousands more papers than I have, still I guess the majority have never been tagged.

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Sholto David

@addictedtoigno1

1 year

Published in @Nature : Four sets of duplicated images in three different experiments. Eighteen months since the authors accepted that errors were made... Curiously no correction.

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Sholto David

@addictedtoigno1

6 months

@LymeScience This looks like a typical quack list of diagnoses... ☹️

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Sholto David

@addictedtoigno1

2 years

Hate it when nanoparticles do this to experiments. @UNTsocial @SciReports

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Sholto David

@addictedtoigno1

1 month

Seems like GPT4o may be useful for analysing some types of errors in papers, with the cautionary note that it also misses some obvious problems, and gives superfluous commentary.

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Sholto David

@addictedtoigno1

3 years

Mark Steele finally drops his claims about 5G death rays... But he won't give the money back (of course)

Mark Steele FINALLY drops 5G death ray claims

Facebook: https://www.facebook.com/Addictedtoignorance-599312487234194Twitter: https://twitter.com/addictedtoigno1Previous video on Mark: https://youtu.be/Pz...

www.youtube.com

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Sholto David

@addictedtoigno1

8 months

At last! YouTube finally deletes Morse's channel... No way to repair all the harm he's caused but better late than never

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Sholto David

@addictedtoigno1

2 years

@jasonkotenko @TheCarnivoreKid @MycolePawket Carnivore kids still not learning here. It's not the cut of meat 😂

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Sholto David

@addictedtoigno1

2 years

Why do people do this?? 😂

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Sholto David

@addictedtoigno1

4 years

Kate Shemirani has been suspended by the Nursing and Midwifery council:

"Natural Nurse" Kate Shemirani SUSPENDED from Register

Facebook: https://www.facebook.com/Addictedtoignorance-599312487234194Twitter: https://twitter.com/addictedtoigno1From the NMC: https://www.nmc.org.uk/global...

www.youtube.com

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Sholto David

@addictedtoigno1

5 months

"In the version of the article initially published, three pairs of micrographs (in Fig. 5i and Supp. Figs. 3a and c) inadvertently contained overlapping areas. These figures have been amended with new micrographs and are available as Supplementary Information with this notice."

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Sholto David

@addictedtoigno1

2 years

New video!

Science Police Episode III: Muhammad Usman Minhas

Twitter: https://twitter.com/addictedtoigno1Facebook: https://www.facebook.com/Addictedtoignorance-599312487234194PubPeer: https://pubpeer.com/search?q=Mycos...

www.youtube.com

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Sholto David

@addictedtoigno1

2 years

Nanoparticles go crazy again. At least this time the authors thoughtfully published an unedited version of the same image (described as something else) so you can be certain which bits were photoshopped

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Sholto David

@addictedtoigno1

2 months

@MicrobiomDigest @SciReports I made a small contribution in that thread, this paper also includes long sections of plagiarised text... Seems like a lot of opportunities to catch this one 🤷

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Sholto David

@addictedtoigno1

1 month

@VennPeter @OxygenIvan @jillykid @JAByrneSci @Thatsregrettab1 @_captainscience @mumumouse @MicrobiomDigest @jim_bouldin @RetractionWatch @Adrian_H @DrLizaMD @AMCELL @Spottingthespot 10.1128/mbio. 00809-00816 10.1007/s11948-015-9668-7 10.1038/s41419-018-0430-3 10.1002/alr.23226 10.1101/2023.09.03.556099 10.1101/2024.02.13.580196 I made this for a slide a while ago.

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Sholto David

@addictedtoigno1

2 years

Someone please explain what motivates people to make figures like this, and what software offers this?

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