Nature Cell Biology - Pinho et al. show that VCAM1 and MHC-I cooperate to provide a ‘don’t-eat-me’ signal that prevents haematopoietic stem cells clearance by mononuclear...

Nature Cell Biology - Wang, Chen et al. describe cGAS–STING pathway overactivation in neurons in models of lysosome storage disorders (LSDs). Inactivation of neuronal cGAS–STING...

Nature Cell Biology - Mathiowetz and Olzmann review our current understanding of the mechanisms of lipid droplet biogenesis and turnover, the transfer of lipids and metabolites at membrane contact...

Nature Cell Biology - Chen et al. report that following genotoxic stress, a nuclear PI3K binds p53 to generate a p53–phosphoinositide signalosome that recruits AKT and its activators,...

Nature Cell Biology - Ramabadran et al. identify a DNA methylation-independent role for DNMT3A in stem cell activation, mediated through recruitment of SF3B1 and splicing regulation.

Nature Cell Biology - Weatherbee, Weberling, Gantner et al. find contrasting requirements for BMP in the anterior signalling centre and pre-implantation epiblast between mice and humans. They...

Nature Cell Biology - Xu et al. provide a single-cell transcriptomic atlas of 4–6 week human embryos, thereby profiling early human organogenesis.

Nature Cell Biology - Zhang et al. report that a non-canonical cGAS–STING pathway activates PERK–eIF2α to elaborate cap-dependent mRNA translation and contributes to senescence and...

Nature Cell Biology - Diehl et al. show that imbalance among nucleotide species is not sensed by canonical metabolic regulatory pathways, causing excessive cell growth despite a DNA replication...

Nature Cell Biology - Duplaquet, Li et al. identify and characterize KDM6A as an epigenetic regulator that impacts chromatin accessibility to modulate ASCL1-to-NEUROD1 subtype switching in small...

Nature Cell Biology - Mice deficient in the piRNA pathway display sterility only in males. Taking advantage of a more representative piRNA pathway in golden hamsters, three studies now demonstrate...

Nature Cell Biology - Bao et al. report that a cadherin code regulates the assembly and sorting of the first three cell lineages during mammalian development and can be manipulated to enhance the...

Nature Cell Biology - Son et al. show that AMPK- and PP2A-dependent p300 nucleocytoplasmic shuttling regulates mTORC1 activity in response to nutrient status. Models of Hutchinson–Gilford...

Nature Cell Biology - Huang et al. provide a method to generate human gastric stem cell-derived pancreatic islet-like organoids that are capable of restoring glucose homeostasis in diabetic mice.

Nature Cell Biology - Chung et al. identify the protein spartin, linked to Troyer syndrome, as a lipophagy receptor for lipid droplet clearance in vitro and in vivo. The data suggest that impaired...

Associate/Senior Editor, Nature Cell Biology

Nature Cell Biology - Kuchitsu et al. show that STING-positive vesicles of a recycling endosome origin are encapsulated into lysosomes after STING ubiquitination and this process requires ESCRT...

Nature Cell Biology - Papsdorf et al. show that mono-unsaturated fatty acids extend lifespan of C. elegans through induction of peroxisomes and lipid droplets in fat tissues and of a lipid...

Nature Cell Biology - Hoetker et al. show that H3K36 methylation exerts a dual role in cell identity maintenance: it integrates TGFβ signals at mesenchymal targets to keep them active and...

Nature Cell Biology - Reicher, Reiniš et al. report a method for multicolour tagging using genome-scale intron-targeting sgRNA libraries that, in combination with computer vision, enables the...

Nature Cell Biology - Newman et al. show that, upon mitochondrial DNA (mtDNA) replication stress, enlarged nucleoids are trafficked to endosomes. Endosomal rupture releases mtDNA into the...

Nature Cell Biology - As Nature Cell Biology turns 25 years old, we asked cell biologists across the globe to share their thoughts on what a productive mentor–mentee relationship looks like...

Nature Cell Biology - Yang, Gomez et al. show that the pioneer factor SOX9 regulates the switch from epidermal stem cell to hair follicle stem cell fate by binding and opening hair follicle...

Nature Cell Biology - Joyce, Pascual et al. identify luminal progenitors as likely cells-of-origin in BRCA2-mutant breast cancer, exhibiting dysregulated proteostasis and translation, which may be...

Nature Cell Biology - Son et al. show that AMPK- and PP2A-dependent p300 nucleocytoplasmic shuttling regulates mTORC1 activity in response to nutrient status. Models of Hutchinson–Gilford...

Nature Cell Biology - Wang, Qu et al. developed a genome-editing system, utilizing catalytically inactive Cas9 fused to microbial single-strand annealing proteins, for kilobase-scale insertion in...

Nature Cell Biology - Wang, Chen et al. describe cGAS–STING pathway overactivation in neurons in models of lysosome storage disorders (LSDs). Inactivation of neuronal cGAS–STING...

Nature Cell Biology - van der Weijden et al. perform genomic, proteomic and metabolic analyses and find that FOXO1-mediated fatty acid oxidation maintains mouse embryos in diapause.

Nature Cell Biology - Mylvaganam et al. report that an apical spectrin network in endothelial cells can transmit mechanical forces in response to shear flow-induced stress, requiring hyaluronic...

Nature Cell Biology - Using microscopy and Hi-C techniques, Leidescher et al. report that when transcribed, highly expressed genes form open-ended loops, which are decorated by elongating...

Nature Cell Biology - In this Review, Dai, Stockwell, Kroemer, Tang and colleagues offer a comprehensive discussion of the molecular regulation of ferroptosis and highlight how this may be...

Nature Cell Biology - Shroff and colleagues report that cell proliferation induces localized mechanical compression in the tissue, driving the formation of the main mouse tooth signalling centre...

Nature Cell Biology - Huang et al. report that Tetraspanin proteins assemble a rigid ring structure around the damaged plasma membrane to prevent the wound from expanding, thus facilitating...

Nature Cell Biology - Using modification-induced misincorporation tRNA sequencing, Gao and Behrens find that on differentiation, reduced mTORC1 signalling activates MAF1, which restricts RNA...

Nature Cell Biology - Schreier et al. report a previously undescribed cytoplasmic condensate, termed the paternal epigenetic inheritance (PEI) granule, that contains the Argonaute protein WAGO-3...

Nature Cell Biology - Intellectual freedom for scientists, unconstrained by commercial interests and direct application, fuels unexpected discoveries. Curiosity-driven, basic science has yielded a...

Nature Cell Biology - Newman et al. show that, upon mitochondrial DNA (mtDNA) replication stress, enlarged nucleoids are trafficked to endosomes. Endosomal rupture releases mtDNA into the...

Nature Cell Biology - Bhattacharya et al. describe a TFEB-independent lysosome membrane regeneration pathway that depends on TBC1D15, which stabilizes autophagic lysosomal reformation proteins,...

Nature Cell Biology - Shao et al. report that FUS interacts with the transcriptional coactivator TAZ, maintaining liquid-like properties of TAZ biomolecular condensates and enhancing TAZ...

Nature Cell Biology - Wu et al. report that a stiff extracellular matrix stimulates the release of exosomes from cancer cells under the control of Akt and Rab8. These exosomes in turn promote...

Nature Cell Biology - Evans, Blake, Longworth and colleagues identify and characterize a tumour-suppressive role for microglia that mediate a pro-inflammatory response to restrict brain metastasis...

Nature Cell Biology - Berg et al. describe Metaboverse, a tool for automated discovery and visualization of metabolic data. Metaboverse enhances the user’s ability to extract meaningful...

Nature Cell Biology - Intracellularly regulated PI3K activation. Thapa et al. find that phosphatidylinositol-3,4,5-trisphosphate generation and Akt activation occur at intracellular membranes,...

Nature Cell Biology - Efstathiou et al. describe an Argonaute-dependent endoplasmic reticulum (ER)-associated RNA silencing pathway that acts together with ER-associated protein degradation to...

Nature Cell Biology - Li, Guo, Wang and colleagues show that the ion channels TMEM63 in Drosophila and TMEM63A in mouse mediate lysosomal mechanosensitivity and modulate lysosomal morphology and...

Nature Cell Biology - Lotfollahi et al. present ExpiMap, a deep-learning model enabling interpretable reference mapping of RNA sequencing data using biologically defined entities, offering...

Nature Cell Biology - Timms, Mena et al. present a multiplex CRISPR screening platform capable of assigning E3 ligases to their substrates and degrons at scale.

Nature Cell Biology - Ali et al. show that, during heat shock, aggregation-prone orphan ribosomal proteins form nucleolar-associated condensates that are kept in a liquid-like and reusable state...

Nature Cell Biology - Pomp et al. show that specification of inner cell mass versus trophectoderm depends on a monoastral spindle that drives asymmetric cell division patterns, arguing against a...