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JCellBiol

13 days

JCB is proud to share a collection of #immunology papers that most interested our readers over the past year. Explore new research on host-virus interactions, T cell development and activation, myeloid cells, B cells & more: #AAI2024

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JCellBiol

@JCellBiol

4 years

. @samjlord @KatrinaVelle @MullinsLab & @FritzLaylin propose a simple way to highlight both experimental #reproducibility and cell-to-cell variation, while avoiding pitfalls common in analysis of cell biology data.

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JCellBiol

@JCellBiol

2 years

. @kat_shkarina , @broz_lab @unil and colleagues report the development and characterization of a new optogenetic toolset for #apoptosis , #necroptosis , and #pyroptosis induction in humans, mice, and #zebrafish . #CellDeath #optogenetics #Immunology

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JCellBiol

@JCellBiol

10 months

. @EvaMariaWenzel , @harald_stenmark et al. review how the endoplasmic reticulum controls the positioning, dynamics, & functions of other #organelles via membrane contact sites. Part of our #Lipid and #Membrane Biology collection:

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JCellBiol

@JCellBiol

4 years

This poster-as-DM-thread from Jimmy Hsu in @GaryBrouhard ’s lab has got to be the most innovative poster idea I’ve seen! And it’s not just a gimmick - it clearly communicates some really cool science about microtubule dynamics. (Photo poster with permission.) #mweJCB #ASCBEMBO19

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JCellBiol

@JCellBiol

2 years

Wenzel, Elfmark, Stenmark, and Raiborg @Oslounivsykehus review how the endoplasmic reticulum controls the positioning, dynamics, and functions of other #organelles via membrane contact sites. #ER_literature #Biochemistry #Trafficking #Metabolism

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JCellBiol

@JCellBiol

5 months

We are pleased to introduce the members of the 2024 JCB Early Career Advisory Board. This initiative serves the journal’s ongoing goal to be representative of and responsive to every part of the cell biology community.

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JCellBiol

@JCellBiol

2 years

Using live imaging, optogenetics, & laser-induced tight junction injury, @saranya_raajan , Ann Miller et al @UMich_MCDB show that mechanosensitive channel-dependent calcium flashes promote sustained local activation of RhoA and tight junction repair

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JCellBiol

@JCellBiol

6 months

. @BruceLaneGoode , Eskin and @sshekhr review our current understanding of the cellular machinery and mechanisms driving actin network remodeling, disassembly, and turnover. #Cytoskeleton #Biochemistry

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JCellBiol

@JCellBiol

3 months

Image shows accumulation of mtDNAs in the cytosol stimulates the cGAS-STING-mediated immune response. In this review, Sookyung Kim, Theresa Ramalho, and @chaynes329 discuss how #mitochondria -to-nuclear communication promotes #proteostasis and #immunity .

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JCellBiol

@JCellBiol

8 months

JCB is pleased to present a special collection highlighting recent papers on the mechanical properties of cells and tissues, and the application & transmission of forces across scales relevant to cell biology. Gain new insights into #mechanobiology 👉

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JCellBiol

@JCellBiol

2 months

Tight junctions regulate the mechanical resistance of epithelial cell junctions. @tann_nguyen , @tetsuotani1 , Mikio Furuse et al. show that cell junctions fracture upon cell stretching in cells lacking TJ membrane proteins claudin, JAM-A, and CAR.

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JCellBiol

@JCellBiol

2 years

#Optogenetic activators of #apoptosis , #necroptosis , and #pyroptosis . Kateryna Shkarina ( @kat_shkarina ), @broz_lab @unil and colleagues report the development and characterization of a new optogenetic toolset. #Optogenetics #CellDeath #Immunology

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JCellBiol

@JCellBiol

4 years

Endogenous gene tagging by #PCR in mammalian cells made easy. #CRISPR #Cas12 enabled #GeneEditing with a comprehensive toolbox on @Addgene . Collaboration by the @LabKnop , @lemberg_lab and @PereiraLab1 @ZmbhH and @DKFZ

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JCellBiol

@JCellBiol

3 months

Video shows tomogram of an endosome in vps13Δ cells. Sho Suzuki ( @ShoSuzuki20 ) @CornellMBG et al propose that Vps13 may play a critical role in supplying #lipids to #endosomes , ensuring continuous ESCRT-mediated sorting during MVB biogenesis. #Trafficking

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JCellBiol

@JCellBiol

1 year

Fat is stiffer and more dangerous than you think, especially to the nucleus of a cell. Ivanovska and Tobin in the Discher lab @BB_UPenn measure the physical effects of fat droplets within cells. #Membrane #lipid #Biophysics #LipidDroplets

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JCellBiol

@JCellBiol

1 year

A live-cell marker to visualize the dynamics of stable #microtubules throughout the cell cycle. From Klara Jansen, Malina Iwanski @mkiwanski , Mithila Burute and Lukas Kapitein @KapiteinLukas @UniUtrecht : #Technology #Cytoskeleton

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JCellBiol

@JCellBiol

1 year

. @kat_shkarina , @broz_lab et al report the development & characterization of an #optogenetics toolset to induce #apoptosis , #necroptosis & #pyroptosis in humans, mice & #zebrafish From the Year in Cell Biology 2022: #CellBio2022

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JCellBiol

@JCellBiol

2 years

ER as master regulator of membrane trafficking and organelle function. A new review from Eva Maria Wenzel, Liv Anker Elfmark, @harald_stenmark , and Camilla Raiborg @Oslounivsykehus : #Biochemistry #Organelles #Trafficking #Metabolism #ER_literature

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JCellBiol

@JCellBiol

4 years

To assist researchers and institutions adjusting to working remotely, we are making all articles in @JCellBiol free to read until May 31, 2020. Learn more about the steps we’re taking and find COVID-19 relevant content:

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JCellBiol

@JCellBiol

3 months

The E4 variant of APOE is the strongest genetic risk factor for late-onset #Alzheimers . @ia_windham et al @cohenlaboratory find that APOE can traffic to the surface of #LipidDroplets in astrocytes. APOE4 on LDs causes defects in LD composition & morphology

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JCellBiol

@JCellBiol

4 years

New #optogenetic tools developed by @kapiteinlukas and colleagues @UniUtrecht enable reversible repositioning of cellular #organelles to dissect intracellular transport and spatial cell biology

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JCellBiol

@JCellBiol

1 year

. @freethepipette , @fran_bottanelli and colleagues combine gene editing and STED super-resolution #microscopy to reveal the nanoscale localization of ARF #GTPases in living cells

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JCellBiol

@JCellBiol

11 months

Spotlight: Cook and @TheHurleyLab @berkeleyMCB preview two related studies ( @tjolivas et al. & @DavidGBroadbent et al. ), examining the role of ATG9A in autophagosome biogenesis in mammalian cells #autophagy

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JCellBiol

@JCellBiol

4 years

This month, browse a collection of classic papers on #mitochondria for #JCB65 . The collection encompasses many groundbreaking studies examining mitochondrial structure, function, and dynamics

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JCellBiol

@JCellBiol

1 year

Using a combination of modern cell biology techniques, including #trafficking assays, #CRISPR , and secretomics, Pereira, Stalder, @dgershlick et al. @Cambridge_Uni reveal that the exocyst complex has a fundamental role in protein secretion.

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JCellBiol

@JCellBiol

3 months

APOE targets cytoplasmic #LipidDroplets via the ER and modulates LD composition and size. @ia_windham et al. @cohenlaboratory @UNC find that APOE can traffic to the surface of lipid droplets in #astrocytes . #Neuroscience #lipid #Metabolism #Alzheimers

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JCellBiol

@JCellBiol

1 year

. @TobiasKletter , @SimoneReber et al. introduce Spindle3D, an open-source image analysis tool that allows for consistent and automated morphometric quantification of the mitotic #spindle and #chromatin Part of our Tools collection:

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JCellBiol

@JCellBiol

1 year

Klara Jansen, @mkiwanski , @KapiteinLukas et al. @UniUtrecht introduce StableMARK (Stable Microtubule Associated Rigor-Kinesin), a live-cell marker to visualize stable #microtubules . #Technology #Cytoskeleton

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JCellBiol

@JCellBiol

2 years

A new probe for phosphorylated RNA polymerase II enables visualization of the sites of transcription in living cells. From Satoshi Uchino, Yuma Ito, Hiroshi Kimura @tokyotech_en and colleagues: #Technology #Biophysics #Chromatin #epigenetics

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JCellBiol

@JCellBiol

3 years

Monster et al. @GloerichLab show how epithelial cells can round up in #mitosis while maintaining epithelial barrier integrity. This requires an asymmetric composition of mitotic cell-cell junctions through an E-cadherin mechanoresponse in neighbor cells.

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JCellBiol

@JCellBiol

2 years

Ani Michaud, @GoryachevAndrew , George von Dassow, William Bement @BementLab , et al. identify a versatile cortical pattern-forming circuit based on #Rho , F- #actin , Ect2, and RGA-3/4. #CellCycle #CellDivision #Cytokinesis #cytoskeleton

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JCellBiol

@JCellBiol

3 years

Gaia Pigino ( @GaiaPigino ) @mpicbg studies the molecular mechanisms and principles of self-organization in #cilia using 3D cryo-electron microscopy. Learn more about her work in our latest #PeopleAndIdeas :

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JCellBiol

@JCellBiol

4 years

#Microtubule and dynein-mediated removal of cortical myosin II promotes polar relaxation and facilitates assembly of the actomyosin contractile ring #cytokinesis #anaphase @SPOREMOHAN @midbody

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JCellBiol

@JCellBiol

3 months

Fujiwara, Kusumi et al. developed an ultrafast camera system that enables the highest time resolutions in single fluorescent-molecule imaging to date: In our Tools collection:

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JCellBiol

@JCellBiol

3 months

. @ShoSuzuki20 et al @CornellMBG reveal a critical role for Vps13-mediated #lipid transfer at ER–endosome contact sites in ESCRT-mediated sorting, elucidating the contribution of the ER to membrane protein sorting at #endosomes #Trafficking #ER_literature

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JCellBiol

@JCellBiol

3 months

. @udi_yael et al. @RoutLab_RU present a new method for quantitative subcellular fractionation of a wide range of mammalian cells while maintaining nuclear integrity. In our Tools collection:

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JCellBiol

@JCellBiol

2 years

alpha-catenin regulates #integrin adhesions and ECM mechanosensing. A new study from @aavi1907 @Haguy_Wolfenson and colleagues #Mechanobiology #CellBiology #FocalAdhesion #Adhesion #Biophysics

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JCellBiol

@JCellBiol

1 year

Inhibition of endolysosome fusion increases #exosome secretion, say Ganesh Vilas Shelke @ganeshs98367397 , Chad Williamson @cd_w1 , Michal Jarnik, and Juan Bonifacino @BonifacinoJuan @NICHD_NIH : #Disease #Trafficking #Organelles #Cancer

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JCellBiol

@JCellBiol

2 years

A quantitative CLEM method by @JA_Beek , de Heus, @NalanLiv & @JKlumperman determines the ultrastructural distribution of Rab5, Rab7, EEA1, APPL1 & PI(3)P, revealing distinct endosomal subpopulations & an unexpected localization of EEA1 to late #endosomes

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JCellBiol

@JCellBiol

4 months

On our January cover: #mitochondria –ER contacts (white) in a COS-7 cell are speckled across the mitochondrial surface (purple) & are easily visualized in the absence of the ER (green). By @BenCardoen et al. JCB’s January issue ➡️

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JCellBiol

@JCellBiol

3 years

. @LuskingL and @TJ_MeliaLab @yalecellbio suggest an outside-in model of nuclear #autophagy that employs an outer nuclear membrane cargo adaptor, Atg39, that captures inner nuclear membrane into intralumenal vesicles for delivery to the autophagosome.

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JCellBiol

@JCellBiol

2 years

ER- #lysosome #lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling, say William Hancock-Cerutti, Pietro De Camilli @PDClab and colleagues #Neuroscience #Organelles #Immunology #Membrane #Parkinsons #ER_literature

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JCellBiol

@JCellBiol

3 years

In eukaryotes, VPS13 and related proteins act as channels to transfer #lipids between #organelle membranes, say PeiQi Li, et al. (). From our special collection on #StructuralBiology :

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JCellBiol

@JCellBiol

1 year

. @tjolivas , Yumei Wu, @shenliang_yu , @TJ_MeliaLab et al. @YaleCellBio show that ATG9 vesicles are the membrane seed for mammalian autophagosomes using nanodisc technology @PDClab @GuptaLab1 @1in_1uan @em_guinn @ShantaNag1 #autophagy

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JCellBiol

@JCellBiol

2 years

Video shows #optogenetic induction of apoptosis in #zebrafish larvae. @kat_shkarina , @broz_lab @unil et al. demonstrate optogenetic activators of #apoptosis , #necroptosis , and #pyroptosis #Biochemistry #CellDeath #Optogenetics #Immunology

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JCellBiol

@JCellBiol

9 months

. @dombingham et al from @christlet 's lab use bead-induced presynapses and CRISPR-tagging of endogenous #actin coupled to STORM to reveal distinct actin nanostructures within presynapses: a mesh at the active zone, rails, and perisynaptic corrals. @Dr_majio

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JCellBiol

@JCellBiol

4 years

. @alexandraflong @poojasuresh47 & @DumontLab show that individual #kinetochore - #microtubule fibers locally dissipate force to maintain robust mammalian #spindle structure #CellDivision

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JCellBiol

@JCellBiol

5 months

Arnold, Riegger, @mixmue et al. @goetheuni present hGRAD, a “one-fits-all” system that can be inserted in one step into any cell that expresses GFP-tagged proteins, allowing their rapid and inducible degradation. #RNAbiology #Biochemistry

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JCellBiol

@JCellBiol

4 years

Mu A, Henry Higgs @hhiggslab @GeiselMed and colleagues review the emerging field of cytoskeletal lysine acetylation, and discuss impacts of #actin acetylation on its cytoplasmic and nuclear functions. #Biochemistry #CellSignaling #Cytoskeleton

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JCellBiol

@JCellBiol

2 years

Cell migration orchestrates migrasome formation by shaping retraction fibers, say Changyuan Fan, Yaming Jiu and colleagues. #Migration #motility #Physiology #Biophysics #Organelles

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JCellBiol

@JCellBiol

2 years

. @TobiasKletter , @SimoneReber et al. @IRILifeSciences introduce Spindle3D, an open-source image analysis tool that allows for consistent and automated morphometric quantification of the mitotic #spindle and #chromatin in confocal images.

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JCellBiol

@JCellBiol

3 years

Nayanika Sengupta, Somnath Dutta @iiscbangalore and colleagues report the high resolution cryo-EM structure of oligomeric VCC, a pore-forming toxin from Vibrio cholerae, in a near-physiological lipid bilayer environment. #Membrane #lipid #StructuralBiology

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JCellBiol

@JCellBiol

4 years

Rediscover some of JCB’s most-read recent reviews about #mitochondria biology in this new special collection:

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JCellBiol

@JCellBiol

3 years

Rabas, Palmer, Norman et al. @CRUK_BI show that the metabolic state of #cancer cells can lead to release of #exosomes containing mitochondrial DNA which cause other cells to behave in a more invasive fashion. #CellMetabolism

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JCellBiol

@JCellBiol

5 months

Jones, Devenport et al. @PrincetonMolBio describe a new mouse model for live visualization of the basement membrane (BM) in which endogenous type IV collagen is fluorescently labeled. #Adhesion #Development

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JCellBiol

@JCellBiol

3 months

Quintanilla ( @fluoroforce ), Oakes ( @pwoakes ), Beach ( @myosincity ) and colleagues @LoyolaChicago demonstrate subcellular biophysical mechanisms that enable myosin 2 filament assembly. @MatthewAkamatsu @Coronin @taraskalab #Biophysics #Cytoskeleton

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JCellBiol

@JCellBiol

6 months

Integrated model of autophagosome, autolysosome, and lysosome transport along axons. From @sydneycason & @ErikaHolzbaur showing that axonal transport of autophagosomes is regulated by dynein activators JIP3/JIP4 and ARF/RAB GTPases #Neuroscience #autophagy

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JCellBiol

@JCellBiol

4 years

#Mitochondria as intracellular signaling platforms in health and disease - A new review by Jay X. Tan and Toren Finkel @AgingPitt

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JCellBiol

@JCellBiol

5 months

. @dombingham , @christlet et al. use bead-induced presynapses & CRISPR-tagging of endogenous #actin coupled to STORM to reveal distinct actin nanostructures within presynapse. From the Year in Cell Biology: #Cellbio2023

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JCellBiol

@JCellBiol

4 years

No microtubules? No problem! @KatrinaVelle and @FritzLaylin show Naegleria use #actin and Arp2/3 complex to crawl and eat, revealing an evolutionarily ancient origin for these phenotypes. #Cytoskeleton #Motility

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JCellBiol

@JCellBiol

3 years

Video shows that F-actin is necessary for glucose-induced arrest of neuronal mitochondrial motility. @himanishbasu , @GulcinPekkurnaz , Schwarz et al show that FHL2 anchors #mitochondria to #actin & adapts mitochondrial dynamics to glucose supply

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JCellBiol

@JCellBiol

3 months

Jansen, @mkiwanski , @KapiteinLukas et al. introduce StableMARK (Stable Microtubule Associated Rigor-Kinesin), a live-cell marker to visualize stable #microtubules : In our Tools collection:

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JCellBiol

@JCellBiol

4 years

Integrating recent findings, Zhiming Chen and Sandra L. Schmid @slschmid_lab present a more dynamic, flexible and non-linear model for clathrin-coated vesicle formation. #biochemistry #StructuralBiology

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JCellBiol

@JCellBiol

6 years

Adherent cells round up before dividing, but how this is linked to the cell cycle is unclear. @DrMCJones33 @JanetAskari @JDHL18 & @MJ_Humphries demonstrate that CDK1 promotes adhesion complex formation and increases cell adhesion area from G1 to S phase

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JCellBiol

@JCellBiol

2 years

. @zuhangsheng et al review how axonal endolysosomal trafficking, distribution, and lysosomal functionality support neuronal health & become disrupted in several neurodegenerative diseases From our Cellular Neurobiology 2022: #SfN22

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JCellBiol

@JCellBiol

9 months

You-An Su, Ya-Wen Liu et al. show that NME3 is a mitochondrial tethering complex that binds to phosphatidic acid derived from cardiolipin, selectively tethering #mitochondria w/ externalized cardiolipin to promote their fusion for functional homeostasis

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JCellBiol

@JCellBiol

2 years

Hancock-Cerutti et al. @PDClab demonstrate that deletion of the autosomal recessive #Parkinsons disease gene VPS13C in a model cell line causes significant perturbations of lysosomal lipid composition and leads to activation of the cGAS-STING pathway

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JCellBiol

@JCellBiol

10 months

Fuentes and Marin ( @zacsimile ) et al. @bewersdorflab @YaleCellBio use super-resolution microscopy to reveal that Rtn4 oligomers possess a unique nanoscale organization that helps shape elliptical ER tubules. @jtysonphd @DavidBaddeley5 #Membrane

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JCellBiol

@JCellBiol

3 years

Masashi Mori, Masahito Ikawa @osaka_univ_e and colleagues report that zygotes have active mechanisms that regulate the localization of paternal chromosomes during fertilization. #Development #Polarity

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JCellBiol

@JCellBiol

3 years

Ralhan, Chang, Lippincott-Schwartz @JLS_Lab and Ioannou @IoannouLab review the emerging role of #LipidDroplets in the nervous system in development, aging, and #disease . #Membrane #lipid #Neuroscience

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JCellBiol

@JCellBiol

1 year

Small #lipid droplets are rigid enough to indent a nucleus, dilute the lamina, and cause rupture, say Irena Ivanovska, Michael Tobin, Dennis Discher and colleagues @BB_UPenn : #Membrane #Biophysics #LipidDroplets

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JCellBiol

@JCellBiol

2 years

We are pleased to introduce the newest members of the JCB editorial board: @Alushin_Lab , @TamaraGenes , @c_eroglu , Andrew Ewald, @LLLackner , @LazarouLab , Kassandra Ori-McKenney, Tatiana Petrova, Elçin Ünal, @WickstromLab and Bo Zhong.

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JCellBiol

@JCellBiol

4 years

Adherens junction regulates cryptic #lamellipodia formation for epithelial cell migration, say Masayuki Ozawa, Masatoshi Takeichi @BDR_RIKEN & colleagues. #Cancer

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JCellBiol

@JCellBiol

2 years

Dorothy (Dori) Schafer @SchaferLabUMass investigates the role of #microglia in neural circuit development & plasticity with a special focus on neurological disorders. For our latest #PeopleAndIdeas , we talked with Dori about her current & future projects.

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JCellBiol

@JCellBiol

6 years

Michaux & colleagues @UChicago dissect the mechanism of pulsed actomyosin contractility in the #celegans embryo, revealing RhoA as a driving force in this process

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JCellBiol

@JCellBiol

5 years

We are pleased to announce our new JCB Early Career Advisory Board, created as part of our ongoing efforts to ensure that the journal is representative and responsive to the needs of the entire cell biology community

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JCellBiol

@JCellBiol

5 years

We are pleased to present the winners of the JCB Cover Contest for the January 2019 issue! "Nuclear organization" is a painting by Sam Khalouei. "wrap 'n' pack challenge" was created by Izabela Kaminksi. Learn more about the covers here:

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JCellBiol

@JCellBiol

5 years

Jost & Waters @harvardmed review best practices for validating quantitative #microscopy methods and discuss strategies to avoid unconscious bias in imaging experiments #reproducibility

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JCellBiol

@JCellBiol

8 months

Activated Src kinase drives cells to eat other cells alive. New study from Alba Yurani Torres, Denise Montell @montell_denise and colleagues @mcdbucsb : #Development #Cancer #Migration #motility

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JCellBiol

@JCellBiol

3 months

Alexander Fellows, Andrew Carter et al @MRC_LMB show that individual #dynein motors can move the entire axon length during retrograde transport. In the anterograde direction, dynein & dynactin are transported separately, keeping them apart until required.

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JCellBiol

@JCellBiol

3 years

Combining high content imaging, machine learning and photoactivation, Kanfer et al have developed a novel image-based #CRISPRi method to screen subcellular phenotypes: @gil_kanfer @youel_rj @LabYoule @JLS_Lab @Lluniz #autophagy #mitochondria #AI

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JCellBiol

@JCellBiol

3 years

Sołtysik, Fujimoto, et al. show that the inner nuclear membrane (INM) of U2OS cells harbors triglyceride synthesis enzymes, including ACSL3, AGPAT2, GPAT3/GPAT4, & DGAT1/DGAT2, and generates nuclear lipid droplets in situ. #Biochemistry #lipid #Organelles

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JCellBiol

@JCellBiol

6 months

Lipid exchange at ER–trans-Golgi contact sites governs polarized cargo sorting, say Dávid Kovács, Bruno Antonny and colleagues @Univ_CotedAzur @IPMC_sophia : #Biochemistry #Polarity #Trafficking

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JCellBiol

@JCellBiol

6 months

Image shows molecular mechanisms driving F-actin and G-actin turnover. @BruceLaneGoode , Eskin and @sshekhr review the molecular machinery and mechanisms employed in cells to drive the disassembly and turnover of actin networks. #Cytoskeleton

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JCellBiol

@JCellBiol

3 years

The VPS13 proteins are thought to mediate #lipid transport between organelles & are linked to distinct neurological disorders. Baldwin, @LabYoule et al. find that, in addition to mitochondrial morphology, VPS13D is essential for peroxisome biogenesis.

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JCellBiol

@JCellBiol

2 years

. @AGuillenSaman , @PDClab et al show that VPS13D interacts w/ VAP in the ER & Miro on #mitochondria & #peroxisomes , potentially providing a bridge for #lipid transport From the Year in Cell Biology: 2021 #CellBio2021 #ER_literature

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JCellBiol

@JCellBiol

6 years

#latticelightsheet #Microscopy used to discover new tent-pole ruffles for macropinosome formation. #Discoveries #LLSM @ProfJennyStow @DrAdamWall @DrNickCondon @LinLuo19 @AICJanelia @IMBatUQ @UQ_News

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JCellBiol

@JCellBiol

4 years

Paul et al. show that #microtubules can contain #actin filaments within their lumen, revealing a new and unexpected cytoskeletal form @MarkDodding @Daniellempaul @PaulVerkade @BorucuUfuk

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JCellBiol

@JCellBiol

2 years

. @saranya_raajan et al. show that mechanosensitive channel-dependent calcium flashes promote sustained local activation of RhoA and tight junction repair From our collection #Mechanobiology 2022:

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JCellBiol

@JCellBiol

3 years

. @bomba_ewa , Jeffrey Savas et al. @NMNeurology @NUFeinbergMed use stable isotope labeling of mice and tandem mass-spectrometry to discover a pool of mitochondrial proteins persisting for months in tissues containing post-mitotic cells. #mitochondria

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JCellBiol

@JCellBiol

2 years

Our June cover shows a HCT116 cell in the process of having the mitotic ER relocated to the plasma membrane. From a study by @Nufediaz , @roylelab and colleagues (). Read JCB’s June Issue:

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JCellBiol

@JCellBiol

11 months

Vines et al. from @jasonkinglab with collaborators @hannes_maib @soldatilab describe a new tool for imaging the mysterious signaling lipid PI(3,5)P2 in live cells for the first time. #Membrane #lipid

0

15

78

JCellBiol

@JCellBiol

2 years

Sara Wickström @WickstromLab @MPI_Muenster combines #biophysics , next-generation sequencing, and basic cell biology to investigate how cellular forces regulate the fate and position of #stemcells within epithelial tissues. In our latest #PeopleAndIdeas :

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6

77

JCellBiol

@JCellBiol

2 years

In the absence of central spindle #microtubules , astral microtubules bundled by the furrow tip during contractile ring constriction form a functional #midbody at the end of #cytokinesis , say @SophHirsch , @CanmanLab , and colleagues. #CellCycle #CellDivision

1

19

75

JCellBiol

@JCellBiol

5 years

To celebrate recent progress in mechanobiology, JCB Editorial Board member Martin Schwartz and Scientific Editor Andrea Marat assembled a collection of JCB studies shedding light on mechanosensitive pathways at the level of single cells and tissues

0

43

75

JCellBiol

@JCellBiol

4 years

Andrea Serra-Marques @Aserra_marques , Sophie Dumont @DumontLab and colleagues show that #NuMA keeps #chromosomes together at nuclear formation and promotes a mechanically robust nucleus, independently of its spindle function. #CellCycle #CellDivision

1

20

76

JCellBiol

@JCellBiol

8 months

Zhu, @paulconduit @CamZoology & colleagues show how mitotic #centrosomes recruit different types of gamma-tubulin complexes & can still nucleate #microtubules in the absence of these complexes. However, these microtubules have different dynamic properties.

1

29

75

JCellBiol

@JCellBiol

3 years

Congratulations JCB Editor-in-Chief Jodi Nunnari ( @jodi_nunnari ), Editor Richard Youle, and Editorial Board member Marino Zerial for being elected into the American Academy of Arts & Sciences @americanacad 🏆

New Academy Members

Elected in 2024

www.amacad.org

0

10

75

JCellBiol

@JCellBiol

7 months

What regulates the transport of autophagosomes along the axon? @sydneycason & @ErikaHolzbaur show that mature axonal autophagosomes are transported by the #microtubule motor #dynein , activated by JIP3/4, & regulated by ARF6 & RAB10 #Neuroscience #autophagy

0

15

75

JCellBiol

@JCellBiol

1 year

. @ganeshs98367397 , @cd_w1 , Jarnik & @BonifacinoJuan @NICHD_NIH show that disruption of the BORC–ARL8–HOPS pathway increases #exosome secretion by impairing fusion of multivesicular #endosomes with #lysosomes #Disease #Trafficking #Organelles #Cancer

1

17

75