Douglas C. Prasher cloned and sequence the genes for green fluorescent protein (GFP) and proposed to use GFP as a tracer molecule. He did not get NIH funding and left academia. He was driving a cab when Rodger Tsien, who fully acknowledged Prashers contributions, won the Nobel

@Gassensmith True, when I heard the news of Kariko, I thought, ‘not again’. I may be cynical but it didn’t change 10 yrs ago and it isn’t changing today. NIH wants safe but innovative grants… oxymoron. every thing needs to be done on a clock or else you get kicked out. No, not gonna change.