Here are the tests we're currently considering. Does anybody have recommendations for additional ones that could help us narrow down hypotheses?
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@remissionbiome
Since a recent paper 👇🏾inadvertently (in Supp data) replicated a 2009 finding of elevated Streptococcus in ME, I would tend to favor GI360 over GI effects since it quantifies various Strep species.
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@remissionbiome
Cholesterol levels have a link with the microbiome, and metabolic issues have been linked. Might be worth looking into
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@remissionbiome
Aperiomics had a technology and the library of all known genetic sequencing for viruses,bacteria, parasites and fungi. They used NextGen sequencing on my blood revealing unexpected but actionable pathogens. Perhaps LabCorp would support your experiment.
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@remissionbiome
I wouldnt spend money (again) on non-functional autoantibodies (celltrend). See thread 👇🏻 (obvs n of 1), supported by speaking to
@ArturFedorowski
who doesnt view them particularly useful (also possibly explains some of the mixed evidence)
VERY NOVEL RESULTS ALERT (possibly a world first?!)
cc:
#LongCovid
&
#vaccineinjured
long haulers
earlier in the year i had a
#vaxlonghaul
relapse and got my autoantibodies measured. positive for:
anti-MAS1
anti-alpha-2-adrenergic
anti-ACE2
like many of us 🧵
#CovidVaccine
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@remissionbiome
I’m a casual, but are you looking at beta lactam inhibition of thromboxane synthesis as a possible mechanism? Vasoconstrictor (impaired perfusion in ME) & proinflammatory (has a role in IBD, for instance).
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@remissionbiome
Are you getting the Empatica Embrace Plus? I'm interested in knowing if that's available to consumers. Right now I use the Oura ring, which has provided A LOT of helpful tracking. After my antibiotics, my HR seems to be intermittently different. Still trying to figure out why.
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@remissionbiome
FAT/CD36 plays a role in the uptake of fatty acids by small intestinal enterocytes. If CD36 were over-expressed or under expressed, there could be enhanced or reduced fatty acid uptake, causing dysregulation in the body.
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@remissionbiome
As you are basically looking for "the sickness behavoiur switch", from my experience w postviral kid I'd say
- PEM is a metabolic cascade triggered by a kick-off event. HR spikes upon excertion, then normalizes in a normal path, but energy continues to be drained.
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@remissionbiome
@IncellDx
cytokine panel, cell trend (I think?) label with ACE2 et all from Europe. LYME & CO!
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