Today’s
@UABPulmonary
Grand Rounds by
@Eickelberg_MD
😎🙌🏻! He will be speaking on Novel Mechanisms and Therapeutic Targets of Lung Fibrosis. Get excited- I will be live tweeting of this talk!
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To start,
@Eickelberg_MD
advises that work life balance is of paramount importance for the physician scientist
#doubledocs
. Talk about some beautiful wildlife photos! Check out
@oliver
.eickelberg on Instagram for more of this.
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IPF is characterized by deposition of ECM, shifting cell pop, ⬆️pro-fibrotic mediators, association with rare and common variants (MUC5B is common
#mucusmatters
), & protein misfolding
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Similar combined transcriptomics/proteomics approach in young/old mice
@NatureComms
. Computational integration of the aging proteome with sc-transcriptomes predicts the source of regulated proteins and creates an unbiased reference map of the aging lung.
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Deep Proteome Profiling Reveals Common Prevalence of MZB1-Positive Plasma B Cells in Human Lung and Skin Fibrosis
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Really cool model of orthotopic lung transplant developed by
@Natalia94901408
showed that inhibition of B cell–dependent lymphoid follicle formation prevented lymphocytic bronchiolitis after lung transplantation.
@jci_insight
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MZB1+ plasma cells are also found in human chronically rejected lung.
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“Microscopic pictures can be just as beautiful as wildlife macroscopic pictures. Science is similarly a conversation with nature.”
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Thank you
@Eickelberg_MD
for delivering a fantastic PGR
@UABPulmonary
! I am looking at B cells/plasma cells in a whole new light. It was such a pleasure seeing you and
@m_konigshoff
!
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🙈Apologies that the order got a bit scrambled- I’m was at the mercy of the conference room Wi-Fi. I swear the flow of the talk was more logical than that of my tweets...
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@jacepeabody
@UABPulmonary
@Eickelberg_MD
@m_konigshoff
@KaminskiMed
@drsunad
@CUmucus
@taylor_bono
@JeremieLever
@IPFdoc
Great talks
@Eickelberg_MD
and
@m_konigshoff
! Thanks for visiting UAB
@uabmedicine
@UABPulmonary
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@jacepeabody
@UABPulmonary
@Eickelberg_MD
@m_konigshoff
@KaminskiMed
@TejaswiniKulka5
@drsunad
@CUmucus
@taylor_bono
@JeremieLever
@IPFdoc
Enjoying the live tweeting of the Grand Rounds the past two days!
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@jacepeabody
@UABPulmonary
@Eickelberg_MD
@m_konigshoff
@KaminskiMed
@TejaswiniKulka5
@drsunad
@CUmucus
@taylor_bono
@JeremieLever
@IPFdoc
Thanks for sharing!
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